Src protein-tyrosine kinase structure and regulation

Biochemical and Biophysical Research Communications

Volumn 324, Issue 4, 2004, Pages 1155-1164

  Roskoski Jr , Robert ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Activation loop; ATP binding site; Csk binding protein; Hck; Membrane protein; Myristoylation; Non receptor protein tyrosine kinase; Oncogene; Phosphoserine; Phosphothreonine; Phosphotyrosine; Polyproline type II helix; Protein kinase A; Helix

Indexed keywords

AMINO ACID; EPIDERMAL GROWTH FACTOR RECEPTOR; PEPTIDE LIBRARY; PROTEIN SH2; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE P50(CSK);

ALPHA HELIX; AMINO ACID SEQUENCE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CELL STIMULATION; CELL SURVIVAL; CRYSTAL STRUCTURE; ENDOSOME; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS REGULATION; PROTO ONCOGENE; REVIEW; ROUS SARCOMA ONCOVIRUS; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; PHYSIOLOGY;

BINDING SITES; HUMANS; MODELS, MOLECULAR; SRC-FAMILY KINASES;

EID: 13544256790     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.09.171     Document Type: Short Survey

References (47)

1. G.S. Martin The hunting of the Src Nat. Rev. Mol. Cell Biol. 2 2001 467 775 An excellent summary of the discovery and elucidation of the properties of v-Src and Src
2. M.T. Brown, and J.A. Cooper Regulation, substrates and functions of src Biochim. Biophys. Acta 1287 1996 121 149 A thorough review of the biochemical properties of Src
3. S.M. Thomas, and J.S. Brugge Cellular functions regulated by Src family kinases Annu. Rev. Cell Dev. Biol. 13 1997 513 609 A comprehensive review of the physiology and substrates of Src and Src-family kinases
4. G. Manning, D.B. Whyte, R. Martinez, T. Hunter, and S. Sudarsanam The protein kinase complement of the human genome Science 298 2002 1912 1934
5. Mouse Genome Sequencing Consortium, Initial analysis and comparative analysis of the mouse genome, Nature 420 (2002) 520-562
6. X.S. Puente, and C. López-Otín A genomic analysis of rat proteases and protease inhibitors Genome Res. 14 2004 609 622
7. M.C. Frame Src in cancer: deregulation and consequences for cell behaviour Biochim. Biophys. Acta 1602 2002 114 130
8. V.A. Levin Basis and importance of Src as a target in cancer Cancer Treat. Res. 119 2004 89 119
9. src Mol. Cell. Biol. 4 1984 973 977
10. R.B. Irby, and T.J. Yeatman Role of Src expression and activation in human cancer Oncogene 19 2000 5636 5642
11. src, a retroviral transforming protein Science 227 1985 427 429
12. D.A. Towler, J.I. Gordon, S.P. Adams, and L. Glaser The biology and enzymology of eukaryotic protein acylation Annu. Rev. Biochem. 57 1988 69 99
13. R. Roskoski Jr. STI-571: an anticancer protein-tyrosine kinase inhibitor Biochem. Biophys. Res. Commun. 309 2003 709 717
14. G.B. Cohen, R. Ren, and D. Baltimore Modular binding domains in signal transduction proteins Cell 80 1995 237 248
15. Z. Songyang, and L.C. Cantley Recognition and specificity in protein-tyrosine kinase-mediated signaling Trends Biochem. Sci. 20 1995 470 475
16. G. Waksman, and J. Kuriyan Structure and specificity of the SH2 domain Cell 116 2004 S45 S48
17. X.M. Zheng, R.J. Resnick, and D. Shalloway A phosphotyrosine displacement mechanism for activation of Src by PTPα EMBO J. 19 2000 964 978
18. c-src: implications for regulation Science 231 1986 1431 1434
19. c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation Cell 49 1987 65 73
20. c-src function J. Biol. Chem. 264 1989 20886 20893
21. S. Zrihan-Licht, J. Lim, I. Keydar, M.X. Sliwkowski, J.E. Groopman, and H. Avraham Association of Csk-homologous kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in breast cancer cells J. Biol. Chem. 272 1997 1856 1863
22. M. Porter, T. Schindler, J. Kuriyan, and W.T. Miller Reciprocal regulation of Hck activity by phosphorylation of Tyr (527) and Tyr (416). Effect of introducing a high affinity intramolecular SH2 ligand J. Biol. Chem. 275 2000 2721 2726
23. W. Xu, S.C. Harrison, and M.J. Eck Three-dimensional structure of the tyrosine kinase c-Src Nature 385 1997 595 602
24. F. Sicheri, I. Moarefi, and J. Kuriyan Crystal structure of the Src family tyrosine kinase Hck Nature 385 1997 602 609
25. J.C. Williams, A. Weijland, S. Gonfloni, A. Thompson, S.A. Courtneidge, G. Superti-Furga, and R.K. Wierenga The 2.35 Å crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions J. Mol. Biol. 274 1997 757 775
26. W. Xu, A. Doshi, M. Lei, M.J. Eck, and S.C. Harrison Crystal structures of c-Src reveal features of its autoinhibitory mechanism Mol. Cell 1999 629 638
27. D.R. Knighton, J.H. Zheng, L.F. Ten Eyck, V.A. Ashford, N.H. Xuong, S.S. Taylor, and J.M. Sowadski Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase Science 253 1991 407 414 The first description of the tertiary structure of a protein kinase that serves as a model for all protein kinases
28. S.K. Hanks, A.M. Quinn, and T. Hunter The protein kinase family: conserved features and deduced phylogeny of the catalytic domains Science 241 1988 42 52
29. M. Huse, and J. Kuriyan The conformational plasticity of protein kinases Cell 109 2002 275 282
30. S.C. Harrison Variation on an Src-like theme Cell 112 2003 737 740
31. G. Sun, L. Ramdas, W. Wang, J. Vinci, J. McMurray, and R.J. Budde Effect of autophosphorylation on the catalytic and regulatory properties of protein-tyrosine kinase Src Arch. Biochem. Biophys. 397 2002 11 17
32. G. Sun, A.K. Sharma, and R.J. Budde Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation Oncogene 17 1998 1587 1595
33. D. Wang, X.Y. Huang, and P.A. Cole Molecular determinants for Csk-catalyzed tyrosine phosphorylation of the Src tail Biochemistry 40 2001 2004 2010
34. S. Takeuchi, Y. Takayama, A. Ogawa, K. Tamura, and M. Okada Transmembrane phosphoprotein Cbp positively regulates the activity of the carboxyl-terminal Src kinase, Csk J. Biol. Chem. 275 2000 29183 29186
35. A. Ogawa, Y. Takayama, H. Sakai, K.T. Chong, S. Takeuchi, A. Nakagawa, S. Nada, M. Okada, and T. Tsukihara Structure of the carboxyl-terminal Src kinase, Csk J. Biol. Chem. 277 2002 14351 14354
36. X. Lin, S. Lee, and G. Sun Functions of the activation loop in Csk protein-tyrosine kinase J. Biol. Chem. 278 2003 24072 24077
37. Y.P. Chong, T.D. Mulhern, H.J. Zhu, D.J. Fujita, J.D. Bjorge, J.P. Tantiongco, N. Sotirellis, D.S. Lio, G. Scholz, and H.C. Cheng A novel non-catalytic mechanism employed by the C-terminal Src-homologous kinase to inhibit Src-family kinase activity J. Biol. Chem. 279 2004 20752 20766
38. D. Sondhi, W. Xu, Z. Songyang, M.J. Eck, and P.A. Cole Peptide and protein phosphorylation by protein tyrosine kinase Csk: insights into specificity and mechanism Biochemistry 37 1998 165 172
39. S. Lee, X. Lin, N.H. Nam, K. Parang, and G. Sun Determination of the substrate-docking site of protein tyrosine kinase C-terminal Src kinase Proc. Natl. Acad. Sci. USA 100 2003 14707 14712
40. R. Roskoski Jr. The ErbB/HER receptor protein-tyrosine kinases and cancer Biochem. Biophys. Res. Commun. 319 2004 1 11
41. B.E. Kemp, D.J. Graves, E. Benjamini, and E.G. Krebs Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase J. Biol. Chem. 252 1977 4888 4894
42. E.H. Fischer, H. Charbonneau, and N.K. Tonks Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes Science 253 1991 401 406
43. J.S. Brugge, and R.L. Erikson Identification of a transformation-specific antigen induced by an avian sarcoma virus Nature 269 1977 346 348
44. M.S. Collett, and R.L. Erikson Protein kinase activity associated with the avian sarcoma virus src gene product Proc. Natl. Acad. Sci. USA 75 1978 2021 2024
45. A.D. Levinson, H. Oppermann, L. Levintow, H.E. Varmus, and J.M. Bishop Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein Cell 15 1978 561 572
46. T. Hunter, and B.M. Sefton Transforming gene product of Rous sarcoma virus phosphorylates tyrosine Proc. Natl. Acad. Sci. USA 77 1980 1311 1315
47. D. Stehelin, H.E. Varmus, J.M. Bishop, and P.K. Vogt DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA Nature 260 1976 170 173