-
1
-
-
0037148277
-
Protection of mammalian telomeres
-
DE LANGE T: Protection of mammalian telomeres. Oncogene (2002) 21:532-540.
-
(2002)
Oncogene
, vol.21
, pp. 532-540
-
-
De Lange, T.1
-
2
-
-
0037382414
-
Erosion of the telomeric single-strand overhang at replicative senescence
-
STEWART SA, BEN-PORATH I, CAREY VJ, O'CONNOR BF, HAHN WC, WEINBERG RA: Erosion of the telomeric single-strand overhang at replicative senescence. Nat. Genet. (2003) 33:492-496.
-
(2003)
Nat. Genet.
, vol.33
, pp. 492-496
-
-
Stewart, S.A.1
Ben-Porath, I.2
Carey, V.J.3
O'connor, B.F.4
Hahn, W.C.5
Weinberg, R.A.6
-
3
-
-
0033553536
-
Mammalian telomeres end in a large duplex loop
-
GRIFFITH JD, COMEAU L, ROSENFIELD S et al.: Mammalian telomeres end in a large duplex loop. Cell (1999) 97:503-514.
-
(1999)
Cell
, vol.97
, pp. 503-514
-
-
Griffith, J.D.1
Comeau, L.2
Rosenfield, S.3
-
4
-
-
0033605145
-
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
-
KARLSEDER J, BROCCOLI D, DAI Y, HARDY S, DE LANGE T: p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science (1999) 283:1321-1325.
-
(1999)
Science
, vol.283
, pp. 1321-1325
-
-
Karlseder, J.1
Broccoli, D.2
Dai, Y.3
Hardy, S.4
De Lange, T.5
-
5
-
-
0036782884
-
Telomerase: A target for cancer therapeutics
-
SHAY JW, WRIGHT WE: Telomerase: a target for cancer therapeutics. Cancer Cell (2002) 2:257-265.
-
(2002)
Cancer Cell
, vol.2
, pp. 257-265
-
-
Shay, J.W.1
Wright, W.E.2
-
6
-
-
0034597794
-
Telomere states and cell fates
-
BLACKBURN EH: Telomere states and cell fates. Nature (2000) 408:53-6.
-
(2000)
Nature
, vol.408
, pp. 53-56
-
-
Blackburn, E.H.1
-
7
-
-
2942644725
-
The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex
-
LARRIVEE M, LEBEL C, WELLINGER RJ: The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex. Genes Dev. (2004) 18:1391-1396.
-
(2004)
Genes Dev.
, vol.18
, pp. 1391-1396
-
-
Larrivee, M.1
Lebel, C.2
Wellinger, R.J.3
-
8
-
-
0036629255
-
Oxidative stress shortens telomeres
-
VON ZGLINICKI T: Oxidative stress shortens telomeres. Trends Biochem. Sci. (2002) 27:339-344.
-
(2002)
Trends Biochem. Sci.
, vol.27
, pp. 339-344
-
-
Von Zglinicki, T.1
-
9
-
-
21244478520
-
Senescence and immortalization: Role of telomeres and telomerase
-
In press
-
SHAY JW, WRIGHT WE: Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis (2004) In press.
-
(2004)
Carcinogenesis
-
-
Shay, J.W.1
Wright, W.E.2
-
10
-
-
0037687623
-
Alternative lengthening of telomeres, telomerase, and cancer
-
REDDEL RR: Alternative lengthening of telomeres, telomerase, and cancer. Cancer Lett. (2003) 194:155-162.
-
(2003)
Cancer Lett.
, vol.194
, pp. 155-162
-
-
Reddel, R.R.1
-
11
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
BODNAR AG, OUELLETTE M, FROLKIS M et al.: Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 279:349-352.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
-
12
-
-
0032485416
-
Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase
-
COUNTER CM, MEYERSON M, EATON EN et al.: Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. Oncogene (1998) 16:1217-1222.
-
(1998)
Oncogene
, vol.16
, pp. 1217-1222
-
-
Counter, C.M.1
Meyerson, M.2
Eaton, E.N.3
-
13
-
-
0035853058
-
Telomere dysfunction alters the chemotherapeutic profile of transformed cells
-
LEE KH, RUDOLPH KL, JU YJ et al.: Telomere dysfunction alters the chemotherapeutic profile of transformed cells. Proc. Natl. Acad. Sci. USA (2001) 98:3381-3386.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 3381-3386
-
-
Lee, K.H.1
Rudolph, K.L.2
Ju, Y.J.3
-
14
-
-
21244500097
-
Telomerase - Strategies to exploit an important chemotherapeutic target
-
FLETCHER TM: Telomerase - strategies to exploit an important chemotherapeutic target. Expert Opin. Ther. Targets (2001) 5:363-378.
-
(2001)
Expert Opin. Ther. Targets
, vol.5
, pp. 363-378
-
-
Fletcher, T.M.1
-
15
-
-
3042762532
-
A human telomerase-associated nuclease
-
OULTON R, HARRINGTON L: A human telomerase-associated nuclease. Mol. Biol. Cell (2004) 15:3244-3256.
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 3244-3256
-
-
Oulton, R.1
Harrington, L.2
-
16
-
-
0031949642
-
Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by 3′-azido-3′-deoxythymidine
-
MELANA SM, HOLLAND JF, POGO BG: Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by 3′-azido-3′-deoxythymidine. Clin. Cancer Res. (1998) 4:693-696.
-
(1998)
Clin. Cancer Res.
, vol.4
, pp. 693-696
-
-
Melana, S.M.1
Holland, J.F.2
Pogo, B.G.3
-
17
-
-
0037308546
-
Simultaneous targeting of telomeres and telomerase as a cancer therapeutic approach
-
MO Y, GAN Y, SONG S et al.: Simultaneous targeting of telomeres and telomerase as a cancer therapeutic approach. Cancer Res. (2003) 63:579-585.
-
(2003)
Cancer Res.
, vol.63
, pp. 579-585
-
-
Mo, Y.1
Gan, Y.2
Song, S.3
-
18
-
-
0033289721
-
Cell death in paclitaxel-dependent chinese hamster ovary cells is initiated by the loss of telomeric DNA repeats
-
MULTANI AS, CHANDRA J, MCCONKER J, SEN S, CABRAL TF, PATHAK S: Cell death in paclitaxel-dependent chinese hamster ovary cells is initiated by the loss of telomeric DNA repeats. Oncol. Res. (1999) 11:455-460.
-
(1999)
Oncol. Res.
, vol.11
, pp. 455-460
-
-
Multani, A.S.1
Chandra, J.2
Mcconker, J.3
Sen, S.4
Cabral, T.F.5
Pathak, S.6
-
19
-
-
0037070594
-
Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle
-
NAKAMURA M, ZHOU XZ, KISHI S, LU KP: Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. FEBS Lett. (2002) 514:193-198.
-
(2002)
FEBS Lett.
, vol.514
, pp. 193-198
-
-
Nakamura, M.1
Zhou, X.Z.2
Kishi, S.3
Lu, K.P.4
-
20
-
-
1542649544
-
Telomerase inhibition using azidothymidine in the HT-29 colon cancer cell line
-
BROWN T, SIGURDSON E, ROGATKO A, BROCCOLI D: Telomerase inhibition using azidothymidine in the HT-29 colon cancer cell line. Ann. Surg. Oncol. (2003) 10:910-915.
-
(2003)
Ann. Surg. Oncol.
, vol.10
, pp. 910-915
-
-
Brown, T.1
Sigurdson, E.2
Rogatko, A.3
Broccoli, D.4
-
21
-
-
0033455559
-
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
-
HERBERT B, PITTS AE, BAKER SI et al.: Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc. Natl. Acad. Sci. USA (1999) 96:14276-14281.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 14276-14281
-
-
Herbert, B.1
Pitts, A.E.2
Baker, S.I.3
-
22
-
-
0035870755
-
Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: Effect of length, phosphorothioate substitution and time inside cells
-
ELAYADI AN, DEMIEVILLE A, WANCEWICZ EV, MONIA BP, COREY DR: Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells. Nucleic Acids Res. (2001) 29:1683-1689.
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 1683-1689
-
-
Elayadi, A.N.1
Demieville, A.2
Wancewicz, E.V.3
Monia, B.P.4
Corey, D.R.5
-
23
-
-
0037079670
-
Allosteric inhibitors of telomerase: Oligonucleotide N3′- > P5′ phosphoramidates
-
PRUZAN R, PONGRACZ K, GIETZEN K, WALLWEBER G, GRYAZNOV S: Allosteric inhibitors of telomerase: oligonucleotide N3′- > P5′ phosphoramidates. Nucleic Acids Res. (2002) 30:559-568.
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 559-568
-
-
Pruzan, R.1
Pongracz, K.2
Gietzen, K.3
Wallweber, G.4
Gryaznov, S.5
-
24
-
-
0037148567
-
Oligonucleotide N3′- > P5′ phosphoramidates as efficient telomerase inhibitors
-
HERBERT BS, PONGRACZ K, SHAY JW, GRYAZNOV SM, SHEA-HERBERT B: Oligonucleotide N3′- > P5′ phosphoramidates as efficient telomerase inhibitors. Oncogene (2002) 21:638-642.
-
(2002)
Oncogene
, vol.21
, pp. 638-642
-
-
Herbert, B.S.1
Pongracz, K.2
Shay, J.W.3
Gryaznov, S.M.4
Shea-Herbert, B.5
-
25
-
-
0038701811
-
Telomerase inhibition as cancer therapy
-
SARETZKI G: Telomerase inhibition as cancer therapy. Cancer Lett. (2003) 194:209-219.
-
(2003)
Cancer Lett.
, vol.194
, pp. 209-219
-
-
Saretzki, G.1
-
26
-
-
0033568462
-
Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
-
ZHANG X, MAR V, ZHOU W, HARRINGTON L, ROBINSON MO: Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev. (1999) 13:2388-2399.
-
(1999)
Genes Dev.
, vol.13
, pp. 2388-2399
-
-
Zhang, X.1
Mar, V.2
Zhou, W.3
Harrington, L.4
Robinson, M.O.5
-
27
-
-
0037427086
-
hTERT associates with human telomeres and enhances genomic stability and DNA repair
-
SHARMA GG, GUPTA A, WANG H et al.: hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene (2003) 22:131-146.
-
(2003)
Oncogene
, vol.22
, pp. 131-146
-
-
Sharma, G.G.1
Gupta, A.2
Wang, H.3
-
28
-
-
12444305353
-
Telomerase reverse transcriptase (hTERT) mRNA and telomerase RNA (hTR) as targets for downregulation of telomerase activity
-
NATARAJAN S, CHEN Z, WANCEWICZ EV, MONIA BP, COREY DR: Telomerase reverse transcriptase (hTERT) mRNA and telomerase RNA (hTR) as targets for downregulation of telomerase activity. Oligonucleotides (2004) 14:263-273.
-
(2004)
Oligonucleotides
, vol.14
, pp. 263-273
-
-
Natarajan, S.1
Chen, Z.2
Wancewicz, E.V.3
Monia, B.P.4
Corey, D.R.5
-
29
-
-
0141791288
-
Antisense-mediated hTERT inhibition specifically reduces the growth of human bladder cancer cells
-
KRAEMER K, FUESSEL S, SCHMIDT U et al.: Antisense-mediated hTERT inhibition specifically reduces the growth of human bladder cancer cells. Clin. Cancer Res. (2003) 9:3794-3800.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 3794-3800
-
-
Kraemer, K.1
Fuessel, S.2
Schmidt, U.3
-
30
-
-
14544287303
-
Combination of telomerase antisense oligonucleotides simultaneously targeting hTR and hTERT produces synergism of inhibition of telomerase activity and growth in human colon cancer cell line
-
FU XH, ZHANG JS, ZHANG N, ZHANG YD: Combination of telomerase antisense oligonucleotides simultaneously targeting hTR and hTERT produces synergism of inhibition of telomerase activity and growth in human colon cancer cell line. World J. Gastroenterol. (2005) 11:785-790.
-
(2005)
World J. Gastroenterol.
, vol.11
, pp. 785-790
-
-
Fu, X.H.1
Zhang, J.S.2
Zhang, N.3
Zhang, Y.D.4
-
31
-
-
0032403264
-
Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cells
-
YOKOYAMA Y, TAKAHASHI Y, SHINOHARA A et al.: Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cells. Cancer Res. (1998) 58:5406-5410.
-
(1998)
Cancer Res.
, vol.58
, pp. 5406-5410
-
-
Yokoyama, Y.1
Takahashi, Y.2
Shinohara, A.3
-
32
-
-
0035300424
-
Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase
-
LUDWIG A, SARETZKI G, HOLM PS et al.: Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase. Cancer Res. (2001) 61:3053-3061.
-
(2001)
Cancer Res.
, vol.61
, pp. 3053-3061
-
-
Ludwig, A.1
Saretzki, G.2
Holm, P.S.3
-
33
-
-
0042169025
-
Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms
-
HORIKAWA I, BARRETT JC: Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms. Carcinogenesis (2003) 24:1167-76.
-
(2003)
Carcinogenesis
, vol.24
, pp. 1167-1176
-
-
Horikawa, I.1
Barrett, J.C.2
-
35
-
-
0037321689
-
Cancer therapy: Switching off oncogenes
-
POMPETTI F, PILLA D, GIANCOLA R: Cancer therapy: switching off oncogenes. Bioessays (2003) 25:104-107.
-
(2003)
Bioessays
, vol.25
, pp. 104-107
-
-
Pompetti, F.1
Pilla, D.2
Giancola, R.3
-
36
-
-
0032911694
-
Direct activation of TERT transcription by c-MYC
-
WU KJ, GRANDORI C, AMACKER M et al.: Direct activation of TERT transcription by c-MYC. Nat. Genet. (1999) 21:220-224.
-
(1999)
Nat. Genet.
, vol.21
, pp. 220-224
-
-
Wu, K.J.1
Grandori, C.2
Amacker, M.3
-
37
-
-
0035957406
-
Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells
-
XU D, POPOV N, HOU M et al.: Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. Proc. Natl. Acad. Sci. USA (2001) 98:3826-3831.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 3826-3831
-
-
Xu, D.1
Popov, N.2
Hou, M.3
-
38
-
-
0037478697
-
Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter
-
VELDMAN T, LIU X, YUAN H, SCHLEGEL R: Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter. Proc. Natl. Acad. Sci. USA (2003) 100:8211-8216.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 8211-8216
-
-
Veldman, T.1
Liu, X.2
Yuan, H.3
Schlegel, R.4
-
39
-
-
0038107350
-
Genomically complex lymphomas undergo sustained tumor regression upon MYC inactivation unless they acquire novel chromosomal translocations
-
KARLSSON A, GIURIATO S, TANG F, FUNG-WEIER J, LEVAN G, FELSHER DW: Genomically complex lymphomas undergo sustained tumor regression upon MYC inactivation unless they acquire novel chromosomal translocations. Blood (2003) 101:2797-2803.
-
(2003)
Blood
, vol.101
, pp. 2797-2803
-
-
Karlsson, A.1
Giuriato, S.2
Tang, F.3
Fung-Weier, J.4
Levan, G.5
Felsher, D.W.6
-
40
-
-
0041669582
-
Prostatic androgen repressed message-1 (PARM-1) may play a role in prostatic cell immortalisation
-
CORNET AM, HANON E, REITER ER et al.: Prostatic androgen repressed message-1 (PARM-1) may play a role in prostatic cell immortalisation. Prostate (2003) 56:220-230.
-
(2003)
Prostate
, vol.56
, pp. 220-230
-
-
Cornet, A.M.1
Hanon, E.2
Reiter, E.R.3
-
41
-
-
0035895934
-
Induction of duplex to G-quadruplex transition in the c-myc promoter region by a small molecule
-
RANGAN A, FEDOROFF OY, HURLEY LH: Induction of duplex to G-quadruplex transition in the c-myc promoter region by a small molecule. J. Biol. Chem. (2001) 276:4640-4646.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 4640-4646
-
-
Rangan, A.1
Fedoroff, O.Y.2
Hurley, L.H.3
-
42
-
-
0034142386
-
Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT)
-
KYO S, TAKAKURA M, TAIRA T et al.: Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT). Nucleic Acids Res. (2000) 28:669-677.
-
(2000)
Nucleic Acids Res.
, vol.28
, pp. 669-677
-
-
Kyo, S.1
Takakura, M.2
Taira, T.3
-
43
-
-
0141730399
-
Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide
-
KANZAWA T, GERMANO IM, KONDO Y, ITO H, KYO S, KONDO S: Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide. Br. J. Cancer (2003) 89:922-929.
-
(2003)
Br. J. Cancer
, vol.89
, pp. 922-929
-
-
Kanzawa, T.1
Germano, I.M.2
Kondo, Y.3
Ito, H.4
Kyo, S.5
Kondo, S.6
-
44
-
-
0033406452
-
Estrogen activates telomerase
-
KY0 S, TAKAKURA M, KANAYA T et al.: Estrogen activates telomerase. Cancer Res. (1999) 59:5917-5921.
-
(1999)
Cancer Res.
, vol.59
, pp. 5917-5921
-
-
Kyo, S.1
Takakura, M.2
Kanaya, T.3
-
45
-
-
18444400222
-
Tamoxifen regulates human telomerase reverse transcriptase (hTERT) gene expression differently in breast and endometrial cancer cells
-
WANG Z, KYO S, MAIDA Y et al.: Tamoxifen regulates human telomerase reverse transcriptase (hTERT) gene expression differently in breast and endometrial cancer cells. Oncogene (2002) 21:3517-3524.
-
(2002)
Oncogene
, vol.21
, pp. 3517-3524
-
-
Wang, Z.1
Kyo, S.2
Maida, Y.3
-
46
-
-
0034107095
-
Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells
-
MISITI S, NANNI S, FONTEMAGGI G et al.: Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells. Mol. Cell. Biol. (2000) 20:3764-3771.
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 3764-3771
-
-
Misiti, S.1
Nanni, S.2
Fontemaggi, G.3
-
47
-
-
0038820037
-
Evidence for a relief of repression mechanism for activation of the human telomerase reverse transcriptase promoter
-
WANG S, ZHU J: Evidence for a relief of repression mechanism for activation of the human telomerase reverse transcriptase promoter. J. Biol. Chem. (2003) 278:18842-18850.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 18842-18850
-
-
Wang, S.1
Zhu, J.2
-
48
-
-
11244349707
-
The hTERT gene is embedded in a nuclease-resistant chromatin domain
-
WANG S, ZHU J: The hTERT gene is embedded in a nuclease-resistant chromatin domain. J. Biol. Chem. (2004) 279:55401-55410.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 55401-55410
-
-
Wang, S.1
Zhu, J.2
-
50
-
-
0041630614
-
Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells
-
LOPATINA NG, POOLE JC, SALDANHA SN et al.: Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells. Biochem. Biophys. Res. Commun. (2003) 306:650-659.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.306
, pp. 650-659
-
-
Lopatina, N.G.1
Poole, J.C.2
Saldanha, S.N.3
-
51
-
-
3342913667
-
Epigenetic regulation of human telomerase reverse transcriptase promoter activity during cellular differentiation
-
LIU L, SALDANHA SN, PATE MS, ANDREWS LG, TOLLEFSBOL TO: Epigenetic regulation of human telomerase reverse transcriptase promoter activity during cellular differentiation. Genes Chromosomes Cancer (2004) 41:26-37.
-
(2004)
Genes Chromosomes Cancer
, vol.41
, pp. 26-37
-
-
Liu, L.1
Saldanha, S.N.2
Pate, M.S.3
Andrews, L.G.4
Tollefsbol, T.O.5
-
52
-
-
8444247426
-
Unusual distribution of DNA methylation within the hTERT CpG island in tissues and cell lines
-
GUILLERET I,BENHATTAR J: Unusual distribution of DNA methylation within the hTERT CpG island in tissues and cell lines. Biochem. Biophys. Res. Commun. (2004) 325:1037-1043.
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.325
, pp. 1037-1043
-
-
Guilleret, I.1
Benhattar, J.2
-
53
-
-
0034662616
-
2-5A antisense telomerase RNA therapy for intracranial malignant gliomas
-
MUKAI S, KONDO Y, KOGA S, KOMATA T, BARNA BP, KONDO S: 2-5A antisense telomerase RNA therapy for intracranial malignant gliomas. (2000) 60:4461-4467.
-
(2000)
, vol.60
, pp. 4461-4467
-
-
Mukai, S.1
Kondo, Y.2
Koga, S.3
Komata, T.4
Barna, B.P.5
Kondo, S.6
-
54
-
-
0036019380
-
2-5A antisense therapy directed against human telomerase RNA inhibits telomerase activity and induces apoptosis without telomere impairment in cervical cancer cells
-
YATABE N, KYO S, KONDO S et al.: 2-5A antisense therapy directed against human telomerase RNA inhibits telomerase activity and induces apoptosis without telomere impairment in cervical cancer cells. Cancer Gene Ther. (2002) 9:624-630.
-
(2002)
Cancer Gene Ther.
, vol.9
, pp. 624-630
-
-
Yatabe, N.1
Kyo, S.2
Kondo, S.3
-
55
-
-
14044279867
-
Attenuation of telomerase activity by hammerhead ribozyme targeting human telomerase RNA induces growth retardation and apoptosis in human breast tumor cells
-
YEO M, RHA SY, JEUNG HC et al.: Attenuation of telomerase activity by hammerhead ribozyme targeting human telomerase RNA induces growth retardation and apoptosis in human breast tumor cells. Int. J. Cancer (2005) 114:484-489.
-
(2005)
Int. J. Cancer
, vol.114
, pp. 484-489
-
-
Yeo, M.1
Rha, S.Y.2
Jeung, H.C.3
-
56
-
-
0036711651
-
Subnuclear shuttling of human telomerase induced by transformation and DNA damage
-
WONG JM, KUSDRA L, COLLINS K: Subnuclear shuttling of human telomerase induced by transformation and DNA damage. Nat. Cell. Biol. (2002) 4:731-736.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 731-736
-
-
Wong, J.M.1
Kusdra, L.2
Collins, K.3
-
57
-
-
0036219609
-
Hsp90 inhibitors as novel cancer chemotherapeutic agents
-
NECKERS L: Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol. Med. (2002) 8:S55-S61.
-
(2002)
Trends Mol. Med.
, vol.8
-
-
Neckers, L.1
-
58
-
-
0033118355
-
Functional requirement of p23 and Hsp90 in telomerase complexes
-
HOLT SE, AISNER DL, BAUR J et al.: Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev. (1999) 13:817-826.
-
(1999)
Genes Dev.
, vol.13
, pp. 817-826
-
-
Holt, S.E.1
Aisner, D.L.2
Baur, J.3
-
59
-
-
0035844136
-
Stable association of hsp90 and p23, but Not hsp70, with active human telomerase
-
FORSYTHE HL, JARVIS JL, TURNER JW, ELMORE LW, HOLT SE: Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. J. Biol. Chem. (2001) 276:15571-15574.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 15571-15574
-
-
Forsythe, H.L.1
Jarvis, J.L.2
Turner, J.W.3
Elmore, L.W.4
Holt, S.E.5
-
60
-
-
0038309566
-
Inhibition of telomerase activity by geldanamycin and 17-allylamino, 17-demethoxygeldanamycin in human melanoma cells
-
VILLA R, FOLINI M, PORTA CD et al.: Inhibition of telomerase activity by geldanamycin and 17-allylamino, 17-demethoxygeldanamycin in human melanoma cells. Carcinogenesis (2003) 24:851-859.
-
(2003)
Carcinogenesis
, vol.24
, pp. 851-859
-
-
Villa, R.1
Folini, M.2
Porta, C.D.3
-
61
-
-
0035158605
-
The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku
-
PETERSON SE, STELLWAGEN AE, DIEDE SJ et al.: The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku. Nat. Genet. (2001) 27:64-67.
-
(2001)
Nat. Genet.
, vol.27
, pp. 64-67
-
-
Peterson, S.E.1
Stellwagen, A.E.2
Diede, S.J.3
-
62
-
-
13744263069
-
hnRNP A2, a potential ssDNA/RNA molecular adapter at the telomere
-
MORAN-JONES K, WAYMAN L, KENNEDY DD et al.: hnRNP A2, a potential ssDNA/RNA molecular adapter at the telomere. Nucleic Acids Res. (2005) 33:486-496.
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. 486-496
-
-
Moran-Jones, K.1
Wayman, L.2
Kennedy, D.D.3
-
63
-
-
12844265975
-
Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection
-
LEI M, PODELL ER, CECH TR: Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Nat. Struct. Mol. Biol. (2004) 11:1223-1229.
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 1223-1229
-
-
Lei, M.1
Podell, E.R.2
Cech, T.R.3
-
64
-
-
6944232071
-
TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres
-
YE JZ, DONIGIAN JR, VAN OVERBEEK M et al.: TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J. Biol. Chem. (2004) 279:47264-47271.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 47264-47271
-
-
Ye, J.Z.1
Donigian, J.R.2
Van Overbeek, M.3
-
65
-
-
0038451396
-
POT1 as a terminal transducer of TRF1 telomere length control
-
LOAYZA D, DE LANGE T: POT1 as a terminal transducer of TRF1 telomere length control. Nature (2003) 424:1013-1018.
-
(2003)
Nature
, vol.424
, pp. 1013-1018
-
-
Loayza, D.1
De Lange, T.2
-
66
-
-
11844280894
-
Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro
-
KELLEHER C, KURTH I, LINGNER J: Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro. Mol. Cell. Biol. (2005) 25:808-818.
-
(2005)
Mol. Cell Biol.
, vol.25
, pp. 808-818
-
-
Kelleher, C.1
Kurth, I.2
Lingner, J.3
-
67
-
-
1842557510
-
Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1
-
ARMBRUSTER BN, LINARDIC CM, VELDMAN T, BANSAL NP, DOWNIE DL, COUNTER CM: Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1. Mol. Cell. Biol. (2004) 24:3552-3561.
-
(2004)
Mol. Cell Biol.
, vol.24
, pp. 3552-3561
-
-
Armbruster, B.N.1
Linardic, C.M.2
Veldman, T.3
Bansal, N.P.4
Downie, D.L.5
Counter, C.M.6
-
68
-
-
1642556797
-
Expression of POT1 is associated with tumor stage and telomere length in gastric carcinoma
-
KONDO T, OUE N, YOSHIDA K et al.: Expression of POT1 is associated with tumor stage and telomere length in gastric carcinoma. Cancer Res. (2004) 64:523-529.
-
(2004)
Cancer Res.
, vol.64
, pp. 523-529
-
-
Kondo, T.1
Oue, N.2
Yoshida, K.3
-
69
-
-
0035798379
-
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
-
ZHOU XZ, LU KP: The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell (2001) 107:347-359.
-
(2001)
Cell
, vol.107
, pp. 347-359
-
-
Zhou, X.Z.1
Lu, K.P.2
-
70
-
-
10644232937
-
Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR
-
BANIK SS, COUNTER CM: Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR. J. Biol. Chem. (2004) 279:51745-1748.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 51745-51748
-
-
Banik, S.S.1
Counter, C.M.2
-
71
-
-
0031027618
-
Control of telomere length by the human telomeric protein TRF1
-
VAN STEENSEL B, DE LANGE T: Control of telomere length by the human telomeric protein TRF1. Nature (1997) 385:740-3.
-
(1997)
Nature
, vol.385
, pp. 740-743
-
-
Van Steensel, B.1
De Lange, T.2
-
72
-
-
0032553473
-
Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
-
SMITH S, GIRIAT I, SCHMITT A, DE LANGE T: Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science (1998) 282:1484-1487.
-
(1998)
Science
, vol.282
, pp. 1484-1487
-
-
Smith, S.1
Giriat, I.2
Schmitt, A.3
De Lange, T.4
-
73
-
-
12344320413
-
Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics
-
SEIMIYA H, MURAMATSU Y, OHISHI T, TSURUO T: Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics. Cancer Cell (2005) 7:25-37.
-
(2005)
Cancer Cell
, vol.7
, pp. 25-37
-
-
Seimiya, H.1
Muramatsu, Y.2
Ohishi, T.3
Tsuruo, T.4
-
74
-
-
6944229908
-
Tankyrase, a positive regulator of telomere elongation, is over expressed in human breast cancer
-
GELMINI S, POGGESI M, DISTANTE V et al.: Tankyrase, a positive regulator of telomere elongation, is over expressed in human breast cancer. Cancer Lett. (2004) 216:81-87.
-
(2004)
Cancer Lett.
, vol.216
, pp. 81-87
-
-
Gelmini, S.1
Poggesi, M.2
Distante, V.3
-
77
-
-
0027918585
-
Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex
-
WANG Y, PATEL DJ: Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex. Structure (1993) 1:263-282.
-
(1993)
Structure
, vol.1
, pp. 263-282
-
-
Wang, Y.1
Patel, D.J.2
-
79
-
-
0032554620
-
Effect of DNA secondary structure on human telomerase activity
-
FLETCHER TM, SUN D, SALAZAR M, HURLEY LH: Effect of DNA secondary structure on human telomerase activity. Biochemistry (1998) 37:5536-5541.
-
(1998)
Biochemistry
, vol.37
, pp. 5536-5541
-
-
Fletcher, T.M.1
Sun, D.2
Salazar, M.3
Hurley, L.H.4
-
80
-
-
0033616833
-
Regulation of catalytic activity and processivity of human telomerase
-
SUN D, LOPEZ-GUAJARDO CC, QUADA J, HURLEY LH, VON HOFF DD: Regulation of catalytic activity and processivity of human telomerase. Biochemistry (1999) 38:4037-4044.
-
(1999)
Biochemistry
, vol.38
, pp. 4037-4044
-
-
Sun, D.1
Lopez-Guajardo, C.C.2
Quada, J.3
Hurley, L.H.4
Von Hoff, D.D.5
-
81
-
-
10344256183
-
Defective telomere tagging strand synthesis in cells lacking WRN helicase activity
-
CRABBE L, VERDUN RE, HAGGBLOM CI, KARLSEDER J: Defective telomere tagging strand synthesis in cells lacking WRN helicase activity. Science (2004) 306:1951-1953.
-
(2004)
Science
, vol.306
, pp. 1951-1953
-
-
Crabbe, L.1
Verdun, R.E.2
Haggblom, C.I.3
Karlseder, J.4
-
82
-
-
0037364415
-
RecQ helicases: Caretakers of the genome
-
HICKSON ID: RecQ helicases: caretakers of the genome. Nat. Rev. Cancer (2003) 3:169-78.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 169-178
-
-
Hickson, I.D.1
-
83
-
-
12844270590
-
DNA scructure-dependent recruitment of telomeric proteins to single-stranded/ double-stranded DNA junctions
-
in press:
-
YANEZ G, KHAN S, LOCOVEI A, PEDROSO I, FLETCHER T: DNA scructure-dependent recruitment of telomeric proteins to single-stranded/ double-stranded DNA junctions. Biochem. Biophys. Res. Commun. (2005) in press:
-
(2005)
Biochem. Biophys. Res. Commun.
-
-
Yanez, G.1
Khan, S.2
Locovei, A.3
Pedroso, I.4
Fletcher, T.5
-
85
-
-
0034122135
-
G-Quadruplex DNA as a target for drug design
-
KERWIN SM: G-Quadruplex DNA as a target for drug design. Curr. Pharm. Des. (2000) 6:441-478.
-
(2000)
Curr. Pharm. Des.
, vol.6
, pp. 441-478
-
-
Kerwin, S.M.1
-
86
-
-
0030786928
-
Inhibition of human telomerase by a G-quadruplex-interactive compound
-
SUN D, THOMPSON B, CATHERS BE et al.: Inhibition of human telomerase by a G-quadruplex-interactive compound. J. Med. Chem. (1997) 40:2113-2116.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 2113-2116
-
-
Sun, D.1
Thompson, B.2
Cathers, B.E.3
-
87
-
-
0032514479
-
1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase
-
PERRY PJ, GOWAN SM, RESZKA AP et al.: 1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase. J. Med. Chem. (1998) 41:3253-3260.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 3253-3260
-
-
Perry, P.J.1
Gowan, S.M.2
Reszka, A.P.3
-
88
-
-
0026465344
-
Substituent position dictates the intercalative DNA-binding mode for anthracene-9,10-dione antitumor drugs
-
TANIOUS FA, JENKINS TC, NEIDLE S, WILSON WD: Substituent position dictates the intercalative DNA-binding mode for anthracene-9,10-dione antitumor drugs. Biochemistry (1992) 31:11632-11640.
-
(1992)
Biochemistry
, vol.31
, pp. 11632-11640
-
-
Tanious, F.A.1
Jenkins, T.C.2
Neidle, S.3
Wilson, W.D.4
-
89
-
-
0033083378
-
Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells
-
IZBICKA E, WHEELHOUSE RT, RAYMOND E et al.: Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells. Cancer Res. (1999) 59:639-644.
-
(1999)
Cancer Res.
, vol.59
, pp. 639-644
-
-
Izbicka, E.1
Wheelhouse, R.T.2
Raymond, E.3
-
90
-
-
0032497405
-
NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.PG - 12367-74
-
FEDOROFF OY, SALAZAR M, HAN H, CHEMERIS VV, KERWIN SM, HURLEY LH: NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.PG - 12367-74. Biochemistry (1998) 37:12367-12374.
-
(1998)
Biochemistry
, vol.37
, pp. 12367-12374
-
-
Fedoroff, O.Y.1
Salazar, M.2
Han, H.3
Chemeris, V.V.4
Kerwin, S.M.5
Hurley, L.H.6
-
91
-
-
0037167611
-
The relationship between ligand aggregation and G-quadruplex DNA selectivity in a series of 3,4,9,10-perylenetetracarboxylic acid diimides
-
KERN JT, THOMAS PW, KERWIN SM: The relationship between ligand aggregation and G-quadruplex DNA selectivity in a series of 3,4,9,10-perylenetetracarboxylic acid diimides. Biochemistry (2002) 41:11379-11389.
-
(2002)
Biochemistry
, vol.41
, pp. 11379-11389
-
-
Kern, J.T.1
Thomas, P.W.2
Kerwin, S.M.3
-
92
-
-
0035942270
-
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors
-
READ M, HARRISON RJ, ROMAGNOLI B et al.: Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors. Proc. Natl. Acad. Sci. USA (2001) 98:4844-4849.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 4844-4849
-
-
Read, M.1
Harrison, R.J.2
Romagnoli, B.3
-
93
-
-
0035909817
-
Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands
-
LI JL, HARRISON RJ, RESZKA AP et al.: Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands. Biochemistry (2001) 40:15194-15202.
-
(2001)
Biochemistry
, vol.40
, pp. 15194-15202
-
-
Li, J.L.1
Harrison, R.J.2
Reszka, A.P.3
-
94
-
-
0036899106
-
The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis
-
STAVROPOULOS DJ, BRADSHAW PS, LI X et al.: The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis. Hum. Mol. Genet. (2002) 11:3135-3144.
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 3135-3144
-
-
Stavropoulos, D.J.1
Bradshaw, P.S.2
Li, X.3
-
95
-
-
7444237059
-
A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells
-
INCLES CM, SCHULTES CM, KEMPSKI H, KOEHLER H, KELLAND LR, NEIDLE S: A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells. Mol. Cancer Ther. (2004) 3:1201-1206.
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 1201-1206
-
-
Incles, C.M.1
Schultes, C.M.2
Kempski, H.3
Koehler, H.4
Kelland, L.R.5
Neidle, S.6
-
96
-
-
0037022658
-
Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands
-
RIOU JF, GUITTAT L, MAILLIET P et al.: Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands. Proc. Natl. Acad. Sci. USA (2002) 99:2672-2677.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 2672-2677
-
-
Riou, J.F.1
Guittat, L.2
Mailliet, P.3
-
97
-
-
1242342930
-
Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing
-
GOMEZ D, LEMARTELEUR T, LACROIX L, MAILLIET P, MERGNY JL, RIOU JF: Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing. Nucleic Acids Res. (2004) 32:371-379.
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 371-379
-
-
Gomez, D.1
Lemarteleur, T.2
Lacroix, L.3
Mailliet, P.4
Mergny, J.L.5
Riou, J.F.6
-
98
-
-
0035857396
-
Telomestatin,: A novel telomerase inhibitor from Streptomyces anulatus
-
SHIN-YA K, WIERZBA K, MATSUO K et al.: Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus. J. Am. Chem. Soc. (2001) 123: 1262-1263.
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 1262-1263
-
-
Shin-Ya, K.1
Wierzba, K.2
Matsuo, K.3
-
99
-
-
0037070575
-
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex
-
KIM MY, VANKAYALAPATI H, SHIN-YA K, WIERZBA K, HURLEY LH: Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex. J. Am. Chem. Soc. (2002) 124:2098-2099.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 2098-2099
-
-
Kim, M.Y.1
Vankayalapati, H.2
Shin-Ya, K.3
Wierzba, K.4
Hurley, L.H.5
-
100
-
-
0037731436
-
The Different Biological Effects of Telomestatin and TMPyP4 Can Be Attributed to Their Selectivity for Interaction with Intramolecular or Intermolecular G-Quadruplex Structures
-
KIM MY, GLEASON-GUZMAN M, IZBICKA E, NISHIOKA D, HURLEY LH: The Different Biological Effects of Telomestatin and TMPyP4 Can Be Attributed to Their Selectivity for Interaction with Intramolecular or Intermolecular G-Quadruplex Structures. Cancer Res. (2003) 63:3247-3256.
-
(2003)
Cancer Res.
, vol.63
, pp. 3247-3256
-
-
Kim, M.Y.1
Gleason-Guzman, M.2
Izbicka, E.3
Nishioka, D.4
Hurley, L.H.5
-
101
-
-
0041353443
-
Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: Involvement of ATM-dependent DNA damage response pathways
-
TAUCHI T, SHIN-YA K, SASHIDA G et al.: Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways. Oncogene (2003) 22:5338-5347.
-
(2003)
Oncogene
, vol.22
, pp. 5338-5347
-
-
Tauchi, T.1
Shin-Ya, K.2
Sashida, G.3
-
102
-
-
13944253127
-
A G-quadruplex-interactive agent, telomestatin (SOT-095), induces telomere shortening with apoptosis and enhances chemosensitivity in acute myeloid leukemia
-
SUMI M, TAUCHI T, SASHIDA G et al.: A G-quadruplex-interactive agent, telomestatin (SOT-095), induces telomere shortening with apoptosis and enhances chemosensitivity in acute myeloid leukemia. Int. J. Oncol. (2004) 24:1481-1487.
-
(2004)
Int. J. Oncol.
, vol.24
, pp. 1481-1487
-
-
Sumi, M.1
Tauchi, T.2
Sashida, G.3
-
103
-
-
4744357958
-
Interaction of telomestatin with the telomeric single-strand overhang
-
GOMEZ D, PATERSKI R, LEMARTELEUR T, SHIN-YA K, MERGNY JL, RIOU JF: Interaction of telomestatin with the telomeric single-strand overhang. J. Biol. Chem. (2004) 279:41487-41494.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 41487-41494
-
-
Gomez, D.1
Paterski, R.2
Lemarteleur, T.3
Shin-Ya, K.4
Mergny, J.L.5
Riou, J.F.6
-
104
-
-
0035176221
-
Characterization of HLA-A3-restricted cytotoxic T lymphocytes reactive against the widely expressed tumor antigen telomerase
-
VONDERHEIDE RH, ANDERSON KS, HAHN WC, BUTLER MO, SCHULTZE JL, NADLER LM: Characterization of HLA-A3-restricted cytotoxic T lymphocytes reactive against the widely expressed tumor antigen telomerase. Clin. Cancer Res. (2001) 7:3343-3348.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 3343-3348
-
-
Vonderheide, R.H.1
Anderson, K.S.2
Hahn, W.C.3
Butler, M.O.4
Schultze, J.L.5
Nadler, L.M.6
-
105
-
-
10744221022
-
Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes
-
VONDERHEIDE RH, DOMCHEK SM, SCHULTZE JL et al.: Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes. Clin. Cancer Res. (2004) 10:828-839.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 828-839
-
-
Vonderheide, R.H.1
Domchek, S.M.2
Schultze, J.L.3
-
106
-
-
3442880456
-
Cancer vaccines: A critical review on clinical impact
-
BITTON RJ: Cancer vaccines: a critical review on clinical impact. Curr. Opin. Mol. Ther. (2004) 6:17-26.
-
(2004)
Curr. Opin. Mol. Ther.
, vol.6
, pp. 17-26
-
-
Bitton, R.J.1
-
108
-
-
0842329844
-
A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent
-
ZOU W, LUO C, ZHANG Z et al.: A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent. Oncogene (2004) 23:457-464.
-
(2004)
Oncogene
, vol.23
, pp. 457-464
-
-
Zou, W.1
Luo, C.2
Zhang, Z.3
-
109
-
-
0038745637
-
A telomerase-dependent conditionally replicating adenovirus for selective treatment of cancer
-
WIRTH T, ZENDER L, SCHULTE B et al.: A telomerase-dependent conditionally replicating adenovirus for selective treatment of cancer. Cancer Res. (2003) 63:3181-3188.
-
(2003)
Cancer Res.
, vol.63
, pp. 3181-3188
-
-
Wirth, T.1
Zender, L.2
Schulte, B.3
-
110
-
-
0022656387
-
Antibody development to viral and allogeneic tumor cell-associated antigens in patients with malignant melanoma and ovarian carcinoma treated with lysates of virus-infected tumor cells
-
SAVAGE HE, ROSSEN RD, HERSH EM, FREEDMAN RS, BOWEN JM, PLAGER C: Antibody development to viral and allogeneic tumor cell-associated antigens in patients with malignant melanoma and ovarian carcinoma treated with lysates of virus-infected tumor cells. Cancer Res. (1986) 46:2127-33.
-
(1986)
Cancer Res.
, vol.46
, pp. 2127-2133
-
-
Savage, H.E.1
Rossen, R.D.2
Hersh, E.M.3
Freedman, R.S.4
Bowen, J.M.5
Plager, C.6
-
111
-
-
0030591663
-
DNA adducts from chemotherapeutic agents
-
LAWLEY PD, PHILLIPS DH: DNA adducts from chemotherapeutic agents. Mutat. Res. (1996) 355:13-40.
-
(1996)
Mutat. Res.
, vol.355
, pp. 13-40
-
-
Lawley, P.D.1
Phillips, D.H.2
-
112
-
-
0942279488
-
Generating mutations but providing chemosensitivity: The role of O6-methylguanine DNA methyltransferase in human cancer
-
ESTELLER M, HERMAN JG: Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer. Oncogene (2004) 23:1-8.
-
(2004)
Oncogene
, vol.23
, pp. 1-8
-
-
Esteller, M.1
Herman, J.G.2
-
113
-
-
13944263628
-
Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage
-
BRADSHAW PS, STAVROPOULOS DJ, MEYN MS: Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage. Nat. Genet. (2005) 37:193-197.
-
(2005)
Nat. Genet.
, vol.37
, pp. 193-197
-
-
Bradshaw, P.S.1
Stavropoulos, D.J.2
Meyn, M.S.3
-
114
-
-
0142244336
-
DNA damage transiently increases TRF2 mRNA expression and telomerase activity
-
KLAPPER W, QIAN W, SCHULTE C, PARWARESCH R: DNA damage transiently increases TRF2 mRNA expression and telomerase activity. Leukemia (2003) 17:2007-2015.
-
(2003)
Leukemia
, vol.17
, pp. 2007-2015
-
-
Klapper, W.1
Qian, W.2
Schulte, C.3
Parwaresch, R.4
-
115
-
-
0035158605
-
The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku
-
PETERSON SE, STELLWAGEN AE, DIEDE SJ et al.: The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku. Nature Genet. (2001) 27:64-67.
-
(2001)
Nature Genet.
, vol.27
, pp. 64-67
-
-
Peterson, S.E.1
Stellwagen, A.E.2
Diede, S.J.3
-
116
-
-
0033838428
-
Characterization of terminal deletions at 7q32 and 22q13.3 healed by De novo telomere addition
-
VARLEY H, DI S, SCHERER SW, ROYLE NJ: Characterization of terminal deletions at 7q32 and 22q13.3 healed by De novo telomere addition. Am. J. Hum. Genet. (2000) 67:610-622.
-
(2000)
Am. J. Hum. Genet.
, vol.67
, pp. 610-622
-
-
Varley, H.1
Di, S.2
Scherer, S.W.3
Royle, N.J.4
-
117
-
-
14844301658
-
hTERT antagonizes p53-induced apoptosis independently of telomerase activity
-
RAHMAN R, LATONEN L, WIMAN KG: hTERT antagonizes p53-induced apoptosis independently of telomerase activity. Oncogene (2005) 24:1320-1327.
-
(2005)
Oncogene
, vol.24
, pp. 1320-1327
-
-
Rahman, R.1
Latonen, L.2
Wiman, K.G.3
-
118
-
-
13544268344
-
Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532
-
EL-DALY H, KULL M, ZIMMERMANN S, PANTIC M, WALLER CF, MARTENS UM: Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532. Blood (2005) 105:1742-1749.
-
(2005)
Blood
, vol.105
, pp. 1742-1749
-
-
El-Daly, H.1
Kull, M.2
Zimmermann, S.3
Pantic, M.4
Waller, C.F.5
Martens, U.M.6
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