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Volumn 105, Issue 4, 2005, Pages 1742-1749

Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 NAPHTHALEN 2 YLBUT 2 ENOYLAMINO)BENZOIC ACID; BENZOIC ACID DERIVATIVE; BIBR 1532; CD34 ANTIGEN; PROTEIN P53; TELOMERASE; TELOMERASE INHIBITOR; TELOMERIC REPEAT BINDING FACTOR 2; UNCLASSIFIED DRUG;

EID: 13544268344     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-12-4322     Document Type: Article
Times cited : (129)

References (43)
  • 1
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science. 1998;279:349-352.
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1    Ouellette, M.2    Frolkis, M.3
  • 2
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 0034020630 scopus 로고    scopus 로고
    • Mammalian telomeres and telomerase
    • Collins K. Mammalian telomeres and telomerase. Curr Opin Cell Biol. 2000;12:378-383.
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 378-383
    • Collins, K.1
  • 4
    • 0033553536 scopus 로고    scopus 로고
    • Mammalian telomeres end in a large duplex loop
    • Griffith JD, Comeau L, Rosenfield S, et al. Mammalian telomeres end in a large duplex loop. Cell. 1999;97:503-514.
    • (1999) Cell , vol.97 , pp. 503-514
    • Griffith, J.D.1    Comeau, L.2    Rosenfield, S.3
  • 5
    • 0037148277 scopus 로고    scopus 로고
    • Protection of mammalian telomeres
    • de Lange T. Protection of mammalian telomeres. Oncogene. 2002;21:532-540.
    • (2002) Oncogene , vol.21 , pp. 532-540
    • De Lange, T.1
  • 6
    • 0031027618 scopus 로고    scopus 로고
    • Control of telomere length by the human telomeric protein TRF1
    • van Steensel B, de Lange T. Control of telomere length by the human telomeric protein TRF1. Nature. 1997;385:740-743.
    • (1997) Nature , vol.385 , pp. 740-743
    • Van Steensel, B.1    De Lange, T.2
  • 7
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel B, Smogorzewska A, de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell. 1998;92:401-413.
    • (1998) Cell , vol.92 , pp. 401-413
    • Van Steensel, B.1    Smogorzewska, A.2    De Lange, T.3
  • 8
    • 0035476710 scopus 로고    scopus 로고
    • T-loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang
    • Stansel RM, de Lange T, Griffith JD. T-loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang. EMBO J. 2001;20:5532-5540.
    • (2001) EMBO J , vol.20 , pp. 5532-5540
    • Stansel, R.M.1    De Lange, T.2    Griffith, J.D.3
  • 9
    • 0033605145 scopus 로고    scopus 로고
    • p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
    • Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science. 1999;283:1321-1325.
    • (1999) Science , vol.283 , pp. 1321-1325
    • Karlseder, J.1    Broccoli, D.2    Dai, Y.3    Hardy, S.4    De Lange, T.5
  • 10
    • 0002149964 scopus 로고
    • Telomerase biochemistry and regulation
    • Blackburn EHG, Greider CW, ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
    • Greider CW. Telomerase biochemistry and regulation. In: Blackburn EHG, Greider CW, ed. Telomeres. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1995:35-68.
    • (1995) Telomeres , pp. 35-68
    • Greider, C.W.1
  • 11
    • 0029096515 scopus 로고
    • The RNA component of human telomerase
    • Feng J, Funk WD, Wang SS, et al. The RNA component of human telomerase. Science. 1995;269:1236-1241.
    • (1995) Science , vol.269 , pp. 1236-1241
    • Feng, J.1    Funk, W.D.2    Wang, S.S.3
  • 12
    • 0030745448 scopus 로고    scopus 로고
    • hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
    • Meyerson M, Counter CM, Eaton EN, et al. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell. 1997;90:785-795.
    • (1997) Cell , vol.90 , pp. 785-795
    • Meyerson, M.1    Counter, C.M.2    Eaton, E.N.3
  • 13
    • 0344441890 scopus 로고    scopus 로고
    • A DNA damage checkpoint response in telomere-initiated senescence
    • d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature. 2003;426:194-198.
    • (2003) Nature , vol.426 , pp. 194-198
    • D'Adda Di Fagagna, F.1    Reaper, P.M.2    Clay-Farrace, L.3
  • 14
    • 0002309826 scopus 로고
    • Telomere dynamics and genome instability in human cancer
    • Blackburn EHG, CW, ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
    • de Lange T. Telomere dynamics and genome instability in human cancer. In: Blackburn EHG, CW, ed. Telomeres. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1995:265-293.
    • (1995) Telomeres , pp. 265-293
    • De Lange, T.1
  • 15
    • 0034630432 scopus 로고    scopus 로고
    • Accumulation of short telomeres in human fibroblasts prior to replicative senescence
    • Martens UM, Chavez EA, Poon SS, Schmoor C, Lansdorp PM. Accumulation of short telomeres in human fibroblasts prior to replicative senescence. Exp Cell Res. 2000;256:291-299.
    • (2000) Exp Cell Res , vol.256 , pp. 291-299
    • Martens, U.M.1    Chavez, E.A.2    Poon, S.S.3    Schmoor, C.4    Lansdorp, P.M.5
  • 16
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer. 1997;33:787-791.
    • (1997) Eur J Cancer , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 20
    • 0037480961 scopus 로고    scopus 로고
    • Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation
    • Allsopp RC, Morin GB, DePinho R, Harley CB, Weissman IL. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood. 2003;102:517-520.
    • (2003) Blood , vol.102 , pp. 517-520
    • Allsopp, R.C.1    Morin, G.B.2    DePinho, R.3    Harley, C.B.4    Weissman, I.L.5
  • 21
    • 0036782884 scopus 로고    scopus 로고
    • Telomerase: A target for cancer therapeutics
    • Shay JW, Wright WE. Telomerase: a target for cancer therapeutics. Cancer Cell. 2002;2:257-265.
    • (2002) Cancer Cell , vol.2 , pp. 257-265
    • Shay, J.W.1    Wright, W.E.2
  • 23
    • 0041353443 scopus 로고    scopus 로고
    • Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: Involvement of ATM-dependent DNA damage response pathways
    • Tauchi T, Shin-Ya K, Sashida G. et al. Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways. Oncogene. 2003;22:5338-5347.
    • (2003) Oncogene , vol.22 , pp. 5338-5347
    • Tauchi, T.1    Shin-Ya, K.2    Sashida, G.3
  • 24
    • 0042674370 scopus 로고    scopus 로고
    • A novel telomerase template antagonist (GRN163) as a potential anticancer agent
    • Asai A, Oshima Y, Yamamoto Y, et al. A novel telomerase template antagonist (GRN163) as a potential anticancer agent. Cancer Res. 2003;63:3931-3939.
    • (2003) Cancer Res , vol.63 , pp. 3931-3939
    • Asai, A.1    Oshima, Y.2    Yamamoto, Y.3
  • 25
    • 0032828652 scopus 로고    scopus 로고
    • Inhibition of telomerase limits the growth of human cancer cells
    • Hahn WC, Stewart SA, Brooks MW, et al. Inhibition of telomerase limits the growth of human cancer cells. Nat Med. 1999;5:1164-1170.
    • (1999) Nat Med , vol.5 , pp. 1164-1170
    • Hahn, W.C.1    Stewart, S.A.2    Brooks, M.W.3
  • 26
    • 0033568462 scopus 로고    scopus 로고
    • Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
    • Zhang X, Mar V, Zhou W, Harrington L, Robinson MO. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev. 1999;13:2388-2399.
    • (1999) Genes Dev , vol.13 , pp. 2388-2399
    • Zhang, X.1    Mar, V.2    Zhou, W.3    Harrington, L.4    Robinson, M.O.5
  • 27
    • 0035812845 scopus 로고    scopus 로고
    • The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
    • Hemann MT, Strong MA, Hao LY, Greider CW. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell. 2001;107:67-77.
    • (2001) Cell , vol.107 , pp. 67-77
    • Hemann, M.T.1    Strong, M.A.2    Hao, L.Y.3    Greider, C.W.4
  • 28
    • 4243937106 scopus 로고    scopus 로고
    • A highly selective telomerase inhibitor limiting human cancer cell proliferation
    • Damm K, Hemmann U, Garin-Chesa P, et al. A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J. 2001;20:6958-6968.
    • (2001) EMBO J , vol.20 , pp. 6958-6968
    • Damm, K.1    Hemmann, U.2    Garin-Chesa, P.3
  • 29
    • 18544364628 scopus 로고    scopus 로고
    • Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate
    • Pascolo E, Wenz C, Lingner J, et al. Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate. J Biol Chem. 2002;277:15566-15572.
    • (2002) J Biol Chem , vol.277 , pp. 15566-15572
    • Pascolo, E.1    Wenz, C.2    Lingner, J.3
  • 30
    • 0028641618 scopus 로고
    • Primary fibroblasts from human adults as target cells for ex vivo transfection and gene therapy
    • Veelken H, Jesuiter H, Mackensen A, et al. Primary fibroblasts from human adults as target cells for ex vivo transfection and gene therapy. Hum Gene Ther. 1994;5:1203-1210.
    • (1994) Hum Gene Ther , vol.5 , pp. 1203-1210
    • Veelken, H.1    Jesuiter, H.2    Mackensen, A.3
  • 31
    • 4444382248 scopus 로고    scopus 로고
    • Effects of telomerase modulation in human hematopoietic progenitor cells
    • Zimmermann S, Glaser S, Ketteler R, et al. Effects of telomerase modulation in human hematopoietic progenitor cells. Stem Cells. 2004;22:741-749.
    • (2004) Stem Cells , vol.22 , pp. 741-749
    • Zimmermann, S.1    Glaser, S.2    Ketteler, R.3
  • 32
    • 2942529456 scopus 로고    scopus 로고
    • Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling
    • Satyanarayana A, Greenberg RA, Schaetzlein S, et al. Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling. Mol Cell Biol. 2004;24:5459-5474.
    • (2004) Mol Cell Biol , vol.24 , pp. 5459-5474
    • Satyanarayana, A.1    Greenberg, R.A.2    Schaetzlein, S.3
  • 33
    • 0028903933 scopus 로고
    • Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo
    • Zamzami N, Marchetti P, Castedo M, et al. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J Exp Med. 1995;181:1661-1672.
    • (1995) J Exp Med , vol.181 , pp. 1661-1672
    • Zamzami, N.1    Marchetti, P.2    Castedo, M.3
  • 34
    • 0034667624 scopus 로고    scopus 로고
    • Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1
    • Burger JA, Tsukada N, Burger M, et al. Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1. Blood. 2000;96:2655-2663.
    • (2000) Blood , vol.96 , pp. 2655-2663
    • Burger, J.A.1    Tsukada, N.2    Burger, M.3
  • 35
    • 18744405066 scopus 로고    scopus 로고
    • Telomere maintenance in human B lymphocytes
    • Martens UM, Brass V, Sedlacek L, et al. Telomere maintenance in human B lymphocytes. Br J Haematol. 2002;119:810-818.
    • (2002) Br J Haematol , vol.119 , pp. 810-818
    • Martens, U.M.1    Brass, V.2    Sedlacek, L.3
  • 36
    • 0030013075 scopus 로고    scopus 로고
    • CD95 (Fas/Apo-1)-induced apoptosis results in loss of glucose transporter function
    • Berridge M, Tan A, McCoy K, Kansara M, Rudert F. CD95 (Fas/Apo-1)-induced apoptosis results in loss of glucose transporter function. J Immunol. 1996;156:4092-4099.
    • (1996) J Immunol , vol.156 , pp. 4092-4099
    • Berridge, M.1    Tan, A.2    McCoy, K.3    Kansara, M.4    Rudert, F.5
  • 37
    • 0031984598 scopus 로고    scopus 로고
    • Short telomeres on human chromosome 17p
    • Martens UM, Zijlmans JM, Poon SS, et al. Short telomeres on human chromosome 17p. Nat Genet. 1998;18:76-80.
    • (1998) Nat Genet , vol.18 , pp. 76-80
    • Martens, U.M.1    Zijlmans, J.M.2    Poon, S.S.3
  • 38
    • 0036674425 scopus 로고    scopus 로고
    • Telomerase beyond telomeres
    • Blasco MA. Telomerase beyond telomeres. Nat Rev Cancer. 2002;2:627-633.
    • (2002) Nat Rev Cancer , vol.2 , pp. 627-633
    • Blasco, M.A.1
  • 39
    • 0037047643 scopus 로고    scopus 로고
    • Est1p as a cell cycle-regulated activator of telomere-bound telomerase
    • Taggart AK, Teng SC, Zakian VA. Est1p as a cell cycle-regulated activator of telomere-bound telomerase. Science. 2002;297:1023-1026.
    • (2002) Science , vol.297 , pp. 1023-1026
    • Taggart, A.K.1    Teng, S.C.2    Zakian, V.A.3
  • 40
    • 0043199578 scopus 로고    scopus 로고
    • Telomerase maintains telomere structure in normal human cells
    • Masutomi K, Yu EY, Khurts S, et al. Telomerase maintains telomere structure in normal human cells. Cell. 2003;114:241-253.
    • (2003) Cell , vol.114 , pp. 241-253
    • Masutomi, K.1    Yu, E.Y.2    Khurts, S.3
  • 41
    • 0842346436 scopus 로고    scopus 로고
    • Beginning to understand the end of the chromosome
    • Cech TR. Beginning to understand the end of the chromosome. Cell. 2004;116:273-279.
    • (2004) Cell , vol.116 , pp. 273-279
    • Cech, T.R.1
  • 42
    • 0037192462 scopus 로고    scopus 로고
    • Senescence induced by altered telomere state, not telomere loss
    • Karlseder J, Smogorzewska A, de Lange T. Senescence induced by altered telomere state, not telomere loss. Science. 2002;295:2446-2449.
    • (2002) Science , vol.295 , pp. 2446-2449
    • Karlseder, J.1    Smogorzewska, A.2    De Lange, T.3
  • 43
    • 0036323573 scopus 로고    scopus 로고
    • Loss of TRF2 by radiation-induced apoptosis in HL60 cells
    • Nakagami Y, Ito M, Hara T, Inoue T. Loss of TRF2 by radiation-induced apoptosis in HL60 cells. Radiat Med. 2002;20:121-129.
    • (2002) Radiat Med , vol.20 , pp. 121-129
    • Nakagami, Y.1    Ito, M.2    Hara, T.3    Inoue, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.