Cytosine methylation and human cancer

Current Opinion in Oncology

Volumn 12, Issue 1, 2000, Pages 68-73

  Warnecke, Peter M ^a   Bestor, Timothy H ^a  

^a Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLCYTOSINE; CYTOSINE; DNA METHYLTRANSFERASE;

CANCER; CARCINOGENESIS; CELL TRANSFORMATION; COLORECTAL CANCER; DEMETHYLATION; DNA METHYLATION; GENE OVEREXPRESSION; GENOME IMPRINTING; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; TUMOR SUPPRESSOR GENE;

CELL TRANSFORMATION, NEOPLASTIC; CYTOSINE; DNA METHYLATION; HUMANS; NEOPLASMS;

EID: 0034523641     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001622-200001000-00012     Document Type: Review

References (45)

1. Cytosine methylation anc the ecology of intragenomic parasites
2. Cytosine methylation and mammalian development
3. The host defence function of genomic methylation patterns
4. IARC database of p53 gene mutations in human tumors and cell lines: Updated compilation, revised formats and new visualisation tools
5. Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer
6. The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites
7. Carcinogens preferentially bind at methylated CpG in the p53 mutational hot spots
8. Cytosine methylation in a CpG sequence leads to enhanced reactivity with Benzo[a]pyrene diol epoxide that correlates with a conformational change
9. Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor
10. Genomic imprinting and cancer
11. DNA methylation and genetic instability in colorectal cancer cells
12. Hypermethylation of the 5′ region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies
13. Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma
14. Aging and DNA methylation in colorectal mucosa and cancer
15. Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: The predominant role of hMLH1
16. High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines
17. Methylation profiling of CpG islands in human breast cancer cells
18. Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors
19. High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer
20. Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells
21. De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyl-transferase
22. CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression
23. 5′-cytosine DNA methyltransferase mRNA levels in hereditary colon carcinoma
24. The human DNA methyltransferases (DNMTs) 1, 3a and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors
25. Increased DNA methyltransferase expression in rhabdomyosarcomas
26. Increased DNA methyltranferase expression in leukaemia
27. Mechanisms for the involvement of DNA methylation in colon carcinogenesis
28. Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis
29. De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
30. Semi-quantitative RT-PCR for comparison of mRNAs in cells with different amounts of housekeeping gene transcripts
31. Pitfalls in the use of several "housekeeping" genes as standards for quantitation of mRNA: The example of thyroid cells
32. Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray
33. Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays
34. Genome-wide analysis of DNA copy-number changes using cDNA microarrays
35. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene
36. Reduced genomic 5-methylcytosine content in human colonic neoplasia
37. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
38. DNA hypomethylation leads to elevated mutation rates
39. Transcription of IAP endogenous retroviruses is constrained by cytosine methylation
40. Treatment of mice with 5-azacytidine efficiently activates silent retroviral genomes in different tissues
41. Production of aberrant promoter transcripts contributes to methylation and silencing of unlinked homologous promoters in trans
42. DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas
43. Metastatic rat carcinoma cells express a new retrotransposon
44. Identification of a 3 kb Alu-mediated BRCA1 gene rearrangement in two breast/ovarian cancer families
45. High frequency of alterations in DNA methylation in adenocarcinoma of the prostate