-
1
-
-
0035502598
-
Antisense and/or immunostimulatory oligonucleotide therapeutics
-
Agrawal, S., and Kandimalla, E.R. 2001. Antisense and/ or immunostimulatory oligonucleotide therapeutics. Curr. Cancer Drug Targets. 1:197-209.
-
(2001)
Curr. Cancer Drug Targets
, vol.1
, pp. 197-209
-
-
Agrawal, S.1
Kandimalla, E.R.2
-
2
-
-
0034012647
-
Antisense inhibition of P-glycoprotein expression using peptide-oligonucleotide conjugates
-
Astriab-Fisher, A., Sergueev, D.S., Fisher, M., Shaw, B.R., and Juliano, R.L. 2000. Antisense inhibition of P-glycoprotein expression using peptide-oligonucleotide conjugates. Biochem. Pharmacol. 60: 83-90.
-
(2000)
Biochem. Pharmacol.
, vol.60
, pp. 83-90
-
-
Astriab-Fisher, A.1
Sergueev, D.S.2
Fisher, M.3
Shaw, B.R.4
Juliano, R.L.5
-
3
-
-
0036844766
-
In vivo characteristics of cationic liposomes as delivery vectors for gene therapy
-
Audouy, S.A.L., de Leij, L.F.M.H., Hoekstra, D., and Molema, G. 2002. In vivo characteristics of cationic liposomes as delivery vectors for gene therapy. Pharm. Res. 19:1599-1605.
-
(2002)
Pharm. Res.
, vol.19
, pp. 1599-1605
-
-
Audouy, S.A.L.1
de Leij, L.F.M.H.2
Hoekstra, D.3
Molema, G.4
-
4
-
-
0001388461
-
Adenoviral gene therapy for cancer: From vectors to targeted and replication competent agents
-
Bauerschmitz, G.J., Barker, S.D., and Hemminki, A. 2002. Adenoviral gene therapy for cancer: from vectors to targeted and replication competent agents. Int. J. Oncol. 21:1161-1174.
-
(2002)
Int. J. Oncol.
, vol.21
, pp. 1161-1174
-
-
Bauerschmitz, G.J.1
Barker, S.D.2
Hemminki, A.3
-
5
-
-
0031788404
-
Designing ribozymes for the inhibition of gene expresion
-
Bramlage, B., Luzi, E., and Eckstein, F. 1998. Designing ribozymes for the inhibition of gene expresion. Trends in Biotech. 16: 434-438.
-
(1998)
Trends in Biotech.
, vol.16
, pp. 434-438
-
-
Bramlage, B.1
Luzi, E.2
Eckstein, F.3
-
6
-
-
0025838699
-
Efficient trans cleavage and a common structural motif for the ribozymes of the human hepatitis δ agent
-
Branch, A.D., and Robertson, J.D. 1991. Efficient trans cleavage and a common structural motif for the ribozymes of the human hepatitis δ agent. Proc. Natl. Acad. Sci. USA. 88: 10163-10167.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 10163-10167
-
-
Branch, A.D.1
Robertson, J.D.2
-
7
-
-
0035965501
-
Gene delivery with synthetic (non viral) carriers
-
Brown, M.D., Schatzlein, A.G., and Uchegbu, I.F. 2001. Gene delivery with synthetic (non viral) carriers. Int. J. Pharm. 229: 1-21.
-
(2001)
Int. J. Pharm.
, vol.229
, pp. 1-21
-
-
Brown, M.D.1
Schatzlein, A.G.2
Uchegbu, I.F.3
-
8
-
-
0037134020
-
A system for stable expression of short interfering RNAs in mammalian cells
-
Brummelkamp, T.R., Bernards, R., and Agami, R. 2002a. A system for stable expression of short interfering RNAs in mammalian cells. Science. 296: 550-553.
-
(2002)
Science
, vol.296
, pp. 550-553
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
9
-
-
0036726313
-
Stable suppression of tumorigenicity by virus-mediated RNA interference
-
Brummelkamp, T.R., Bernards, R., and Agami, R. 2002b. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell. 2:243-247.
-
(2002)
Cancer Cell
, vol.2
, pp. 243-247
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
10
-
-
0035525965
-
Introduction to retroviruses and retroviral vectors
-
Buchschacher, G.L. Jr. 2001. Introduction to retroviruses and retroviral vectors. Somat. Cell Mol. Genet. 26:1-11.
-
(2001)
Somat. Cell Mol. Genet.
, vol.26
, pp. 1-11
-
-
Buchschacher Jr., G.L.1
-
11
-
-
0023055382
-
Nucleotide sequence and newly formed phophodiester bond of spontaneously limaged satellite tobacco ringspot virus RNA
-
Buzayan, J.M., Hampel, A., and Bruening, F. 1986. Nucleotide sequence and newly formed phophodiester bond of spontaneously limaged satellite tobacco ringspot virus RNA. Nucleic Acids Res. 14: 9729-9743.
-
(1986)
Nucleic Acids Res.
, vol.14
, pp. 9729-9743
-
-
Buzayan, J.M.1
Hampel, A.2
Bruening, F.3
-
12
-
-
0029364471
-
Suppression of lung cancer cell growth by ribozyme-mediated modification of p53 pre-mRNA
-
Cai, D.W., Mukhopadhyay, T., and Roth, J.A. 1995. Suppression of lung cancer cell growth by ribozyme-mediated modification of p53 pre-mRNA. Cancer Gene Ther. 2:199-205.
-
(1995)
Cancer Gene Ther.
, vol.2
, pp. 199-205
-
-
Cai, D.W.1
Mukhopadhyay, T.2
Roth, J.A.3
-
14
-
-
0028284281
-
Effects of BCL-2 antisense oligodeoxynucleotides on in vitro proliferation and survival of normal marrow progenitors and leukemic cells
-
Campos, L., Sabido, O., Rouault, J.P., and Guyotat, D. 1994. Effects of BCL-2 antisense oligodeoxynucleotides on in vitro proliferation and survival of normal marrow progenitors and leukemic cells. Blood. 84:595-600.
-
(1994)
Blood
, vol.84
, pp. 595-600
-
-
Campos, L.1
Sabido, O.2
Rouault, J.P.3
Guyotat, D.4
-
15
-
-
0035859929
-
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
-
Caplen, N.J., Parrish, S., Imani, F., Fire, A., and Morgan, R.A. 2001. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc. Natl. Acad. Sci. USA. 98:9742-9747.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9742-9747
-
-
Caplen, N.J.1
Parrish, S.2
Imani, F.3
Fire, A.4
Morgan, R.A.5
-
16
-
-
0034648765
-
Angiogenesis in cancer and other diseases
-
Carmeliet, P., and Jain, R.K. 2000. Angiogenesis in cancer and other diseases. Nature. 407: 249-257.
-
(2000)
Nature
, vol.407
, pp. 249-257
-
-
Carmeliet, P.1
Jain, R.K.2
-
17
-
-
0036864328
-
Intracellular ribozyme applications
-
Castanotto, D., Li, J.R., Michienzi, A., Langlois, M.A., Lee, N.S., Puymirat, J., and Rossi, J.J. 2002. Intracellular ribozyme applications. Biochem. Soc. Trans. 30:1140-1145.
-
(2002)
Biochem. Soc. Trans.
, vol.30
, pp. 1140-1145
-
-
Castanotto, D.1
Li, J.R.2
Michienzi, A.3
Langlois, M.A.4
Lee, N.S.5
Puymirat, J.6
Rossi, J.J.7
-
18
-
-
0019856947
-
In vitro splicing of the ribosomal RNA precursor of Tetrahymena: Involvement of a guanosine nucleotide in the excision of the intervening sequence
-
Cech, T.R., Zaug, A. J. and Grobowzski, P.J. 1981. In vitro splicing of the ribosomal RNA precursor of Tetrahymena: Involvement of a guanosine nucleotide in the excision of the intervening sequence. Cell. 27:487-496.
-
(1981)
Cell
, vol.27
, pp. 487-496
-
-
Cech, T.R.1
Zaug, A.J.2
Grobowzski, P.J.3
-
19
-
-
0026077284
-
Antisense inhibition of ras p21 expression that is sensitive to a point mutation
-
Chang, E.H., Miller, P.S., Cushman, C., Devadas, K., Pirollo, K.F., Ts'o, P.O. and Yu, Z.P. 1991. Antisense inhibition of ras p21 expression that is sensitive to a point mutation. Biochemistry 30:8283-8286.
-
(1991)
Biochemistry
, vol.30
, pp. 8283-8286
-
-
Chang, E.H.1
Miller, P.S.2
Cushman, C.3
Devadas, K.4
Pirollo, K.F.5
Ts'o, P.O.6
Yu, Z.P.7
-
20
-
-
20244380289
-
A safety and pharmacokinetic study of a mixed-backbone oligonucleotide (GEM231) targeting the type I protein kinase A by two-hour infusions in patients with refractory solid tumors
-
Chen, H.X., Marshall, J.L., Ness, E., Martin, R.R., Dvorchik, B., Rizvi, N., Marquis, J., McKinlay, M., Dahut, W. and Hawkins, M.J., 2000. A safety and pharmacokinetic study of a mixed-backbone oligonucleotide (GEM231) targeting the type I protein kinase A by two-hour infusions in patients with refractory solid tumors. Clin. Cancer Res. 6:1259-1266.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 1259-1266
-
-
Chen, H.X.1
Marshall, J.L.2
Ness, E.3
Martin, R.R.4
Dvorchik, B.5
Rizvi, N.6
Marquis, J.7
McKinlay, M.8
Dahut, W.9
Hawkins, M.J.10
-
21
-
-
0029782859
-
Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor
-
Cheng, S.Y., Huang, H.J., Nagane, M., Ji, X.D., Wang, D., Shih, C.C., Arap, W., Huang, C.M., and Cavenee, W.K. 1996. Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor. Proc. Natl. Acad. Sci. USA 93:8502-8507.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 8502-8507
-
-
Cheng, S.Y.1
Huang, H.J.2
Nagane, M.3
Ji, X.D.4
Wang, D.5
Shih, C.C.6
Arap, W.7
Huang, C.M.8
Cavenee, W.K.9
-
22
-
-
0037329372
-
RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines
-
2003
-
Cioca, D.P., Aoki, Y., and Kiyosawa, K. 2003. RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines. Cancer Gene Ther. 2003 10:125-133.
-
(2003)
Cancer Gene Ther.
, vol.10
, pp. 125-133
-
-
Cioca, D.P.1
Aoki, Y.2
Kiyosawa, K.3
-
23
-
-
0034783583
-
Phase II trial with ISIS 5132 in patients with small-cell (SCLC) and non-small cell (NSCLC) lung cancer
-
European Organization for Research and Treatment of Cancer (EORTC) and Fumoleau, P. A European Organization for Research and Treatment of Cancer (EORTC) Early Clinical Studies Group Report
-
Coudert, B., Anthoney, A., Fiedler, W., Droz, J.P., Dieras, V., Borner, M., Smyth, J.F., Morant, R., de Vries, M.J., Roelvink, M., European Organization for Research and Treatment of Cancer (EORTC) and Fumoleau, P. 2001. Phase II trial with ISIS 5132 in patients with small-cell (SCLC) and non-small cell (NSCLC) lung cancer. A European Organization for Research and Treatment of Cancer (EORTC) Early Clinical Studies Group Report. Eur. J. Cancer 37:2194-2198.
-
(2001)
Eur. J. Cancer
, vol.37
, pp. 2194-2198
-
-
Coudert, B.1
Anthoney, A.2
Fiedler, W.3
Droz, J.P.4
Dieras, V.5
Borner, M.6
Smyth, J.F.7
Morant, R.8
de Vries, M.J.9
Roelvink, M.10
-
24
-
-
0037148329
-
Telomerase inhibition, oligonucleotides, and clinical trials
-
Corey, D.R. 2002. Telomerase inhibition, oligonucleotides, and clinical trials. Oncogene. 21:631-637.
-
(2002)
Oncogene
, vol.21
, pp. 631-637
-
-
Corey, D.R.1
-
25
-
-
0036716281
-
The Bcl2 family: Regulators of the cellular life-or-death switch
-
Cory, S., and Adams, J.M. 2002. The Bcl2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer. 2: 647-656.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 647-656
-
-
Cory, S.1
Adams, J.M.2
-
26
-
-
0032700656
-
Molecular mechanisms of action of antisense drugs
-
Crooke, S.T., 1999. Molecular mechanisms of action of antisense drugs. Biochim. Biophys. Acta. 1489:31-44.
-
(1999)
Biochim. Biophys. Acta
, vol.1489
, pp. 31-44
-
-
Crooke, S.T.1
-
27
-
-
0003325879
-
Multicenter phase II trial of an antisense inhibitor of H-ras (ISIS-2503) in advanced non-small cell lung cancer (NSCLC)
-
Dang, T., Johnson, D., Kelly, K., Rizvi, N., Holmlund, J. and Dorr, A. 2001. Multicenter phase II trial of an antisense inhibitor of H-ras (ISIS-2503) in advanced non-small cell lung cancer (NSCLC). Proc. Am. Soc. Clin. Oncol. 20: 332a.
-
(2001)
Proc. Am. Soc. Clin. Oncol.
, vol.20
-
-
Dang, T.1
Johnson, D.2
Kelly, K.3
Rizvi, N.4
Holmlund, J.5
Dorr, A.6
-
28
-
-
0036229451
-
Cytotoxicity issues pertinent to lipoplex-mediated gene therapy in-vivo
-
Dass, C.R. 2002. Cytotoxicity issues pertinent to lipoplex-mediated gene therapy in-vivo. J. Pharm. Pharmacol. 54:593-601.
-
(2002)
J. Pharm. Pharmacol.
, vol.54
, pp. 593-601
-
-
Dass, C.R.1
-
29
-
-
0036811085
-
Cellular uptake, distribution, and stability of 10-23 deoxyribozymes
-
Dass, C.R., Saravolac E.G., Li, Y., and Sun L.Q. 2002. Cellular uptake, distribution, and stability of 10-23 deoxyribozymes. Antisense Nucleic Acid Drug Dev. 12: 289-299.
-
(2002)
Antisense Nucleic Acid Drug Dev.
, vol.12
, pp. 289-299
-
-
Dass, C.R.1
Saravolac, E.G.2
Li, Y.3
Sun, L.Q.4
-
30
-
-
8944231156
-
Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-expression
-
Dean, N., McKay, R., Miraglia, L., Howard, R., Cooper, S., Giddings, J., Nicklin, P., Meister, L., Ziel, R., Geiger, T., Muller, M. and Fabbro, D. 1996. Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-expression. Cancer Res. 56:3499-3507.
-
(1996)
Cancer Res.
, vol.56
, pp. 3499-3507
-
-
Dean, N.1
McKay, R.2
Miraglia, L.3
Howard, R.4
Cooper, S.5
Giddings, J.6
Nicklin, P.7
Meister, L.8
Ziel, R.9
Geiger, T.10
Muller, M.11
Fabbro, D.12
-
31
-
-
0030229774
-
Ribozyme-mediated suppression of v-myc expression abrogates apoptosis in transformed monocytes
-
Dolnikov, A., King, A., Luxford, C., Symonds, G., and Sun, L.Q. 1996. Ribozyme-mediated suppression of v-myc expression abrogates apoptosis in transformed monocytes. Cancer Gene Ther. 3:289-295.
-
(1996)
Cancer Gene Ther.
, vol.3
, pp. 289-295
-
-
Dolnikov, A.1
King, A.2
Luxford, C.3
Symonds, G.4
Sun, L.Q.5
-
32
-
-
0033623635
-
Induced p21WAF1 expression acts to reverse myc myelomonocytic cell transformation
-
Dolnikov, A., Millington, M., Sun, L-Q., and Symonds, G. 2000. Induced p21WAF1 expression acts to reverse myc myelomonocytic cell transformation. Cancer Gene Ther. 7:1491-1503.
-
(2000)
Cancer Gene Ther.
, vol.7
, pp. 1491-1503
-
-
Dolnikov, A.1
Millington, M.2
Sun, L.-Q.3
Symonds, G.4
-
33
-
-
0141919611
-
A sensitive dual fluorescence reporter system enables positive selection of ras suppressors by suppression of ras-induced apoptosis
-
In Press
-
Dolnikov, A., Shen, S., Millington, M., Passioura, T., Pedler, M., Rasko, J.E.J., and Symonds, G. 2003. A sensitive dual fluorescence reporter system enables positive selection of ras suppressors by suppression of ras-induced apoptosis. Cancer Gene Ther. In Press.
-
(2003)
Cancer Gene Ther.
-
-
Dolnikov, A.1
Shen, S.2
Millington, M.3
Passioura, T.4
Pedler, M.5
Rasko, J.E.J.6
Symonds, G.7
-
34
-
-
0035237649
-
Chronic myelogenous leukemia
-
Druker, B.J., Sawyers, C.L., Capdeville, R., Ford, J.M., Baccarani, M., and Goldman, J.M. 2001a. Chronic myelogenous leukemia. Hematology (Am. Soc. Hematol. Educ. Program). 87-112.
-
(2001)
Hematology (Am. Soc. Hematol. Educ. Program)
, pp. 87-112
-
-
Druker, B.J.1
Sawyers, C.L.2
Capdeville, R.3
Ford, J.M.4
Baccarani, M.5
Goldman, J.M.6
-
35
-
-
0035810142
-
Activity of a specific inhibitor of the bcr-abl tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the philadelphia chromosome
-
Druker, B.J., Sawyers, C.L., Kantarjian, H., Resta, D.J., Reese, S.F., Ford, J.M., Capdeville, R., and Talpaz, M. 2001b. Activity of a specific inhibitor of the bcr-abl tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the philadelphia chromosome. N. Engl. J. Med. 344:1038-1042.
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
Resta, D.J.4
Reese, S.F.5
Ford, J.M.6
Capdeville, R.7
Talpaz, M.8
-
36
-
-
0035810147
-
Efficacy and safetey of a specific inhibitor of the bcr-abl tyrosine kinase in chronic myeloid leukemia
-
Druker, B.J., Talpaz, M., Resta D.J., Peng, B., Buchdinger, E., Ford, J.M., Lydon, N.B., Kantarjian, H., Capdeville, R., Ohno-Jones, S., and Sawyers, C.L. 2001c. Efficacy and safetey of a specific inhibitor of the bcr-abl tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 344: 1031-1037.
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdinger, E.5
Ford, J.M.6
Lydon, N.B.7
Kantarjian, H.8
Capdeville, R.9
Ohno-Jones, S.10
Sawyers, C.L.11
-
37
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir, S.M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., and Tuschl, T. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 411:494-498.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
38
-
-
0036351317
-
Analysis of gene function in somatic mammalian cells using small interfering RNAs
-
Elbashir, S.M., Harborth, J., Weber, K., and Tuschl, T. 2002. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods. 26:199-213.
-
(2002)
Methods
, vol.26
, pp. 199-213
-
-
Elbashir, S.M.1
Harborth, J.2
Weber, K.3
Tuschl, T.4
-
39
-
-
0023663396
-
Self-cleavage of plus and minus RNAs of a virusoid and structural model for the active sites
-
Forster, A.C., and Symons, R.H. 1987. Self-cleavage of plus and minus RNAs of a virusoid and structural model for the active sites. Cell. 49:211-220.
-
(1987)
Cell
, vol.49
, pp. 211-220
-
-
Forster, A.C.1
Symons, R.H.2
-
40
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by bcr-abl gene mutation or amplification
-
Gorre, M.E., Mohammad, M., Ellwood, K., Hsu, N., Paquette, R., Rao, P.N., and Sawyers, C.L. 2001. Clinical resistance to STI-571 cancer therapy caused by bcr-abl gene mutation or amplification. Science. 293:876-880.
-
(2001)
Science
, vol.293
, pp. 876-880
-
-
Gorre, M.E.1
Mohammad, M.2
Ellwood, K.3
Hsu, N.4
Paquette, R.5
Rao, P.N.6
Sawyers, C.L.7
-
41
-
-
0037130565
-
Chitosan and its derivatives - A promising non-viral vector for gene transfection
-
Guang Liu, W., and De Yao, K. 2002. Chitosan and its derivatives - a promising non-viral vector for gene transfection. J. Control Release. 83: 1-11.
-
(2002)
J. Control Release
, vol.83
, pp. 1-11
-
-
Guang Liu, W.1
De Yao, K.2
-
42
-
-
0021013526
-
The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
-
Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N., and Altman, S. 1983. The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme. Cell. 35:849-857.
-
(1983)
Cell
, vol.35
, pp. 849-857
-
-
Guerrier-Takada, C.1
Gardiner, K.2
Marsh, T.3
Pace, N.4
Altman, S.5
-
43
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan, D., and Weinberg, R.A. 2000. The hallmarks of cancer. Cell. 100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
44
-
-
0024291288
-
Simple RNA enzymes with new and highly specific endoribonuclease activities
-
Haseloff, J., and Gerlach, W.L. 1988. Simple RNA enzymes with new and highly specific endoribonuclease activities. Nature. 334:585-591.
-
(1988)
Nature
, vol.334
, pp. 585-591
-
-
Haseloff, J.1
Gerlach, W.L.2
-
45
-
-
0029824947
-
Inhibition of matrix metalloproteinase 9 expression by a ribozyme blocks metastasis in a rat sarcoma model system
-
Hua, J., and Muschel, R.J. 1996. Inhibition of matrix metalloproteinase 9 expression by a ribozyme blocks metastasis in a rat sarcoma model system. Cancer Res. 56:5279-5284.
-
(1996)
Cancer Res.
, vol.56
, pp. 5279-5284
-
-
Hua, J.1
Muschel, R.J.2
-
46
-
-
0023047510
-
Self-cleavage of plus and minus RNA transcripts of avocado sunblotch viroid
-
Hutchins, C.J., Rathjen, P.D., Forster, A.C., and Symons, R.H. 1986. Self-cleavage of plus and minus RNA transcripts of avocado sunblotch viroid. Nucleic Acids Res. 14:3627-3640.
-
(1986)
Nucleic Acids Res.
, vol.14
, pp. 3627-3640
-
-
Hutchins, C.J.1
Rathjen, P.D.2
Forster, A.C.3
Symons, R.H.4
-
47
-
-
0037190048
-
The encapsulation of ribozymes in biodegradable polymeric matrices
-
Jackson, J.K., Liang, L.S., Hunter, W.L., Reynolds, M., Sandberg, J.A., Springate, C., and Burt, H.M. 2002. The encapsulation of ribozymes in biodegradable polymeric matrices. Int. J. Pharm. 243: 43-55.
-
(2002)
Int. J. Pharm.
, vol.243
, pp. 43-55
-
-
Jackson, J.K.1
Liang, L.S.2
Hunter, W.L.3
Reynolds, M.4
Sandberg, J.A.5
Springate, C.6
Burt, H.M.7
-
48
-
-
0031907428
-
bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice
-
Jansen, B., Schlagbauer-Wadl, H., Brown, B.D., Bryan, R.N., van Elsas, A., Muller, M., Wolff, K., Eichler, H.G., and Pehamberger, H. 1998. bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice. Nat. Med. 4:232-234.
-
(1998)
Nat. Med.
, vol.4
, pp. 232-234
-
-
Jansen, B.1
Schlagbauer-Wadl, H.2
Brown, B.D.3
Bryan, R.N.4
van Elsas, A.5
Muller, M.6
Wolff, K.7
Eichler, H.G.8
Pehamberger, H.9
-
49
-
-
0034684471
-
Chemosensitisation of malignant melanoma by BCL2 antisense therapy
-
Jansen, B., Wacheck, V., Heere-Ress, E., Schlagbauer-Wadl, H., Hoeller, C., Lucas, T., Hoermann, M., Hollenstein, U., Wolff, K., and Pehamberger, H. 2000. Chemosensitisation of malignant melanoma by BCL2 antisense therapy. Lancet. 356:1728-1733.
-
(2000)
Lancet
, vol.356
, pp. 1728-1733
-
-
Jansen, B.1
Wacheck, V.2
Heere-Ress, E.3
Schlagbauer-Wadl, H.4
Hoeller, C.5
Lucas, T.6
Hoermann, M.7
Hollenstein, U.8
Wolff, K.9
Pehamberger, H.10
-
50
-
-
0030668865
-
HER-2/neu is rate-limiting for ovarian cancer growth. Conditional depletion of HER-2/neu by ribozyme targeting
-
Juhl, H., Downing, S.G., Wellstein, A., and Czubayko, F. 1997. HER-2/neu is rate-limiting for ovarian cancer growth. Conditional depletion of HER-2/neu by ribozyme targeting. J. Biol. Chem. 272:29482-29486.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 29482-29486
-
-
Juhl, H.1
Downing, S.G.2
Wellstein, A.3
Czubayko, F.4
-
51
-
-
0033709117
-
Catalytic DNAs as potential therapeutic agents and sequence-specific molecular tools to dissect biological function
-
Kachigian, L.M. 2000. Catalytic DNAs as potential therapeutic agents and sequence-specific molecular tools to dissect biological function. J. Clin. Investigation. 106:1189-1195.
-
(2000)
J. Clin. Investigation
, vol.106
, pp. 1189-1195
-
-
Kachigian, L.M.1
-
52
-
-
0030583250
-
Hammerhead ribozyme-mediated inhibition of telomerase activity in extracts of human hepatocellular carcinoma cells
-
Kanazawa, Y., Ohkawa, K., Ueda, K., Mira, E., Takehara, T., Sasaki, Y., Kasahara, A., and Hayashi, N. 1996. Hammerhead ribozyme-mediated inhibition of telomerase activity in extracts of human hepatocellular carcinoma cells. Biochem. Biophys. Res. Commun. 225:570-576.
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.225
, pp. 570-576
-
-
Kanazawa, Y.1
Ohkawa, K.2
Ueda, K.3
Mira, E.4
Takehara, T.5
Sasaki, Y.6
Kasahara, A.7
Hayashi, N.8
-
53
-
-
0026836512
-
Reversal of the malignant phenotype by an anti-ras ribozyme
-
Kashani-Sabat, M., Funato, T., Tone, T., Jiao, L., Wang, W., Yoshida, E., Kashfinn, B.I., Shitara, T., Wu, A.M., Moreno, J.G., Traweek, S.T., Ahlering, T.E., and Scanlon K.J. 1992. Reversal of the malignant phenotype by an anti-ras ribozyme. Antisense Res. Dev. 2:3-15.
-
(1992)
Antisense Res. Dev.
, vol.2
, pp. 3-15
-
-
Kashani-Sabat, M.1
Funato, T.2
Tone, T.3
Jiao, L.4
Wang, W.5
Yoshida, E.6
Kashfinn, B.I.7
Shitara, T.8
Wu, A.M.9
Moreno, J.G.10
Traweek, S.T.11
Ahlering, T.E.12
Scanlon, K.J.13
-
54
-
-
0026510193
-
Oncogenic forms of p53 inhibit p53-regulated gene expression
-
Kern, S.E., Pietenpol, J.A., Thiagalingam, S., Seymour, A., Kinzler, K.W., and Vogelstein, B. 1992. Oncogenic forms of p53 inhibit p53-regulated gene expression. Science. 256:827-830.
-
(1992)
Science
, vol.256
, pp. 827-830
-
-
Kern, S.E.1
Pietenpol, J.A.2
Thiagalingam, S.3
Seymour, A.4
Kinzler, K.W.5
Vogelstein, B.6
-
55
-
-
0033992633
-
Biochemical and clinical implications of the ErbB/ HER signaling network of growth factor receptors
-
Klapper, L.N., Kirschbaum, M.H., Sela, M. and Yarden, Y. 2000. Biochemical and clinical implications of the ErbB/ HER signaling network of growth factor receptors. Adv. Cancer Res. 77:25-79.
-
(2000)
Adv. Cancer Res.
, vol.77
, pp. 25-79
-
-
Klapper, L.N.1
Kirschbaum, M.H.2
Sela, M.3
Yarden, Y.4
-
56
-
-
0034083410
-
Eradication of human non-Hodgkin's lymphoma in SCID mice by BCL-2 antisense oligonucleotides combined with low-dose cyclophosphamide
-
Klasa, R.J., Bally, M.B., Ng, R., Goldie, J.H., Gascoyne, R.D., and Wong, F.M. 2000. Eradication of human non-Hodgkin's lymphoma in SCID mice by BCL-2 antisense oligonucleotides combined with low-dose cyclophosphamide. Clin. Cancer Res. 6:2492-2500.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2492-2500
-
-
Klasa, R.J.1
Bally, M.B.2
Ng, R.3
Goldie, J.H.4
Gascoyne, R.D.5
Wong, F.M.6
-
57
-
-
0034660068
-
Liposomal Bcl-2 antisense oligonucleotides enhance proliferation, sensitize acute myeloid leukemia to cytosine-arabinoside, and induce apoptosis independent of other antiapoptotic proteins
-
Konopleva, M., Tari, A.M., Estrov, Z., Harris, D., Xie, Z., Zhao, S., Lopez-Berestein, G., and Andreeff, M. 2000. Liposomal Bcl-2 antisense oligonucleotides enhance proliferation, sensitize acute myeloid leukemia to cytosine-arabinoside, and induce apoptosis independent of other antiapoptotic proteins. Blood. 95:3929-3938.
-
(2000)
Blood.
, vol.95
, pp. 3929-3938
-
-
Konopleva, M.1
Tari, A.M.2
Estrov, Z.3
Harris, D.4
Xie, Z.5
Zhao, S.6
Lopez-Berestein, G.7
Andreeff, M.8
-
58
-
-
0347904503
-
Inhibition of telomerase activity in human cancer cells by RNA interference
-
Kosciolek, B.A., Kalantidis, K., Tabler, M., and Rowley, P.T. 2003. Inhibition of telomerase activity in human cancer cells by RNA interference. Mol. Cancer Ther. 2: 209-216.
-
(2003)
Mol. Cancer Ther.
, vol.2
, pp. 209-216
-
-
Kosciolek, B.A.1
Kalantidis, K.2
Tabler, M.3
Rowley, P.T.4
-
59
-
-
0020417286
-
Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena
-
Kruger, K., Grabowski, P.J., Zaug, A.J., Sands, J., Gottschling, D.E., and Cech, T.R. 1982. Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell.31:147-157.
-
(1982)
Cell
, vol.31
, pp. 147-157
-
-
Kruger, K.1
Grabowski, P.J.2
Zaug, A.J.3
Sands, J.4
Gottschling, D.E.5
Cech, T.R.6
-
60
-
-
0029119820
-
Artificial evolution and natural ribozymes
-
Kumar, P.K.R., and Ellington, A.D. 1995. Artificial evolution and natural ribozymes. FASEB J. 9:1183-1195.
-
(1995)
FASEB J.
, vol.9
, pp. 1183-1195
-
-
Kumar, P.K.R.1
Ellington, A.D.2
-
61
-
-
0036311178
-
Gene silencing in mammalian cells by preformed small RNA duplexes
-
Leirdal, M., and Sioud, M. 2002. Gene silencing in mammalian cells by preformed small RNA duplexes. Biochem. Biophys. Res. Commun. 295:744-748.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.295
, pp. 744-748
-
-
Leirdal, M.1
Sioud, M.2
-
62
-
-
0036727416
-
Efficient delivery of siRNA for inhibition of gene expression in postnatal mice
-
Lewis, D.L., Hagstrom, J.E., Loomis, A.G., Wolff, J.A., and Herweijer, H. 2002. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat. Genet. 2002 32:107-108.
-
(2002)
Nat. Genet.
, vol.32
, pp. 107-108
-
-
Lewis, D.L.1
Hagstrom, J.E.2
Loomis, A.G.3
Wolff, J.A.4
Herweijer, H.5
-
63
-
-
0036727416
-
Efficient delivery of siRNA for inhibition of gene expression in postnatal mice
-
Lewis, D.L., Hagstrom, J.E., Loomis, A.G., Wolff, J.A., and Werweijer, H. 2002. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat. Genet. 32:107-108.
-
(2002)
Nat. Genet.
, vol.32
, pp. 107-108
-
-
Lewis, D.L.1
Hagstrom, J.E.2
Loomis, A.G.3
Wolff, J.A.4
Werweijer, H.5
-
64
-
-
0037347131
-
Downregulation of bcl-2 expression in lymphoma cells by bcl-2 ARE-targeted modified, synthetic ribozyme
-
Luzi, E., Papucci, L., Schiavone, N., Donnini, M., Lapucci, A., Tempestini, A., Witort, E., Nicolin, A., and Capaccioli, S. 2003. Downregulation of bcl-2 expression in lymphoma cells by bcl-2 ARE-targeted modified, synthetic ribozyme. Cancer Gene Ther. 10:201-208.
-
(2003)
Cancer Gene Ther.
, vol.10
, pp. 201-208
-
-
Luzi, E.1
Papucci, L.2
Schiavone, N.3
Donnini, M.4
Lapucci, A.5
Tempestini, A.6
Witort, E.7
Nicolin, A.8
Capaccioli, S.9
-
65
-
-
0242455819
-
Randomized phase III trial of chemotherapy and antisense oligonucleotide LY900003 (ISIS 3521) in patients with advanced NSCLC: Initial report
-
Lynch, T.J., Raju, R., Lind, M., Riviere, A., Gatzemeier, U., Drorr, A., Holmlund, J., Yuen, A., and Sikic, B. 2003. Randomized phase III trial of chemotherapy and antisense oligonucleotide LY900003 (ISIS 3521) in patients with advanced NSCLC: Initial report. Proc. Am. Soc. Clin. Oncol. 22:623.
-
(2003)
Proc. Am. Soc. Clin. Oncol.
, vol.22
, pp. 623
-
-
Lynch, T.J.1
Raju, R.2
Lind, M.3
Riviere, A.4
Gatzemeier, U.5
Drorr, A.6
Holmlund, J.7
Yuen, A.8
Sikic, B.9
-
66
-
-
0037438586
-
Phase 1 and pharmacodynamic studies of G3139, a bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia
-
Marcucci, G., Byrd, J.C., Dai, G., Klisovic, M.I., Kourlas, P.J., Young, D.C., Cataland, S.R., Fisher, D.B., Lucas, D., Chan, K.K., Porcu, P., Lin, Z-P., Farag, S.F., Frankel, S.R., Zweibel, J.A., Kraut, E.H., Balcerzak, S.P., Bloomfield, C.D., Grever, M.R., and Caligiuri, M.A. 2003. Phase 1 and pharmacodynamic studies of G3139, a bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia. Blood. 101:425-432.
-
(2003)
Blood
, vol.101
, pp. 425-432
-
-
Marcucci, G.1
Byrd, J.C.2
Dai, G.3
Klisovic, M.I.4
Kourlas, P.J.5
Young, D.C.6
Cataland, S.R.7
Fisher, D.B.8
Lucas, D.9
Chan, K.K.10
Porcu, P.11
Lin, Z-P.12
Farag, S.F.13
Frankel, S.R.14
Zweibel, J.A.15
Kraut, E.H.16
Balcerzak, S.P.17
Bloomfield, C.D.18
Grever, M.R.19
Caligiuri, M.A.20
more..
-
67
-
-
0037069330
-
Synthetic small inhibiting RNAs: Efficient tools to inactivate oncogenic mutations and restore p53 pathways
-
Martinez, L.A., Naguibneva, I., Lehrmann, H., Vervisch, A., Tchenio, T., Lozano, G., and Harel-Bellan, A. 2002. Synthetic small inhibiting RNAs: efficient tools to inactivate oncogenic mutations and restore p53 pathways. Proc. Natl. Acad. Sci. USA. 99:14849-14854.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 14849-14854
-
-
Martinez, L.A.1
Naguibneva, I.2
Lehrmann, H.3
Vervisch, A.4
Tchenio, T.5
Lozano, G.6
Harel-Bellan, A.7
-
68
-
-
0028876993
-
Ribozymes cleave the AML1/MTG8 fusion transcript and inhibit proliferation of leukemic cells with t(8;21)
-
Matsushita, H., Kobayashi, H., Mori, S., Kizaki, M., and Ikeda, Y. 1995. Ribozymes cleave the AML1/MTG8 fusion transcript and inhibit proliferation of leukemic cells with t(8;21). Biochem Biophys Res Commun. 215:431-437.
-
(1995)
Biochem. Biophys. Res. Commun.
, vol.215
, pp. 431-437
-
-
Matsushita, H.1
Kobayashi, H.2
Mori, S.3
Kizaki, M.4
Ikeda, Y.5
-
69
-
-
0037019339
-
RNA interference in adult mice
-
McCaffrey, A.P., Meuse, L., Pham, T.T., Conklin, D.S., Hannon, G.J., and Kay, M.A. 2002. RNA interference in adult mice. Nature. 418:38-39.
-
(2002)
Nature
, vol.418
, pp. 38-39
-
-
McCaffrey, A.P.1
Meuse, L.2
Pham, T.T.3
Conklin, D.S.4
Hannon, G.J.5
Kay, M.A.6
-
70
-
-
0032692170
-
RNA-polymerase III-driven expression cassettes in human gene therapy
-
Medina, M.F., and Joshi, S. 1999. RNA-polymerase III-driven expression cassettes in human gene therapy. Curr. Opin. Mol. Ther. 1:580-594.
-
(1999)
Curr. Opin. Mol. Ther.
, vol.1
, pp. 580-594
-
-
Medina, M.F.1
Joshi, S.2
-
71
-
-
0343314893
-
Colony formation of soft tissue sarcoma cells is inhibited by lipid-mediated antisense oligodeoxynucleotides targeting the human mdm2 oncogene
-
Meye, A., Wurl, P., Bache, M., Bartel, F., Grunbaum, U., Mansa-ard, J., Schmidt, H., and Taubert, H. 2000. Colony formation of soft tissue sarcoma cells is inhibited by lipid-mediated antisense oligodeoxynucleotides targeting the human mdm2 oncogene. Cancer Lett. 149:181-188.
-
(2000)
Cancer Lett.
, vol.149
, pp. 181-188
-
-
Meye, A.1
Wurl, P.2
Bache, M.3
Bartel, F.4
Grunbaum, U.5
Mansa-ard, J.6
Schmidt, H.7
Taubert, H.8
-
72
-
-
0036467391
-
The p53 and Mdm2 families in cancer
-
Michael, D., and Oren, M. 2002. The p53 and Mdm2 families in cancer. Curr. Opin. Genet. Dev. 12:53-59.
-
(2002)
Curr. Opin. Genet. Dev.
, vol.12
, pp. 53-59
-
-
Michael, D.1
Oren, M.2
-
73
-
-
0029977448
-
Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase
-
Monia, B.P., Johnston, J.F., Geiger, T., Muller, M. and Fabbro, D. 1996. Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase. Nat. Med. 2:668-675.
-
(1996)
Nat. Med.
, vol.2
, pp. 668-675
-
-
Monia, B.P.1
Johnston, J.F.2
Geiger, T.3
Muller, M.4
Fabbro, D.5
-
74
-
-
0037446068
-
Small interfering RNAs suppress the expression of endogenous and GFP-fused epidermal growth factor receptor (erbB1) and induce apoptosis in erbB1-overexpressing cells
-
Nagy, P., Arndt-Jovin, D.J., and Jovin, T.M. 2003. Small interfering RNAs suppress the expression of endogenous and GFP-fused epidermal growth factor receptor (erbB1) and induce apoptosis in erbB1-overexpressing cells. Exp. Cell Res. 285:39-49.
-
(2003)
Exp. Cell Res.
, vol.285
, pp. 39-49
-
-
Nagy, P.1
Arndt-Jovin, D.J.2
Jovin, T.M.3
-
75
-
-
0032148358
-
Targeting of PML/ RARalpha is lethal to retinoic acid-resistant promyelocytic leukemia cells
-
Nason-Burchenal, K., Allopenna, J., Begue, A., Stehelin, D., Dmitrovsky, E., and Martin, P. 1998. Targeting of PML/ RARalpha is lethal to retinoic acid-resistant promyelocytic leukemia cells. Blood. 92:1758-1767.
-
(1998)
Blood
, vol.92
, pp. 1758-1767
-
-
Nason-Burchenal, K.1
Allopenna, J.2
Begue, A.3
Stehelin, D.4
Dmitrovsky, E.5
Martin, P.6
-
76
-
-
12444281703
-
Pilot trial of intravenous infusion of a replication-selective adenovirus (ONYX-015) in combination with chemotherapy or IL-2 treatment in refractory cancer patients
-
Nemunaitis, J., Cunningham, C., Tong, A.W., Post, L., Netto, G., Paulson, A.S., Rich, D., Blackburn, A., Sands, B., Gibson, B., Randlev, B., and Freeman, S. 2003. Pilot trial of intravenous infusion of a replication-selective adenovirus (ONYX-015) in combination with chemotherapy or IL-2 treatment in refractory cancer patients. Cancer Gene Ther. 10:341-352.
-
(2003)
Cancer Gene Ther.
, vol.10
, pp. 341-352
-
-
Nemunaitis, J.1
Cunningham, C.2
Tong, A.W.3
Post, L.4
Netto, G.5
Paulson, A.S.6
Rich, D.7
Blackburn, A.8
Sands, B.9
Gibson, B.10
Randlev, B.11
Freeman, S.12
-
77
-
-
0031608678
-
p53 tumour suppressor gene therapy for cancer
-
Nielsen L.L., and Maneval, D.C. 1998. p53 tumour suppressor gene therapy for cancer. Cancer Gene Ther. 5:52-63.
-
(1998)
Cancer Gene Ther.
, vol.5
, pp. 52-63
-
-
Nielsen, L.L.1
Maneval, D.C.2
-
78
-
-
0037089589
-
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
-
Paddison, P.J., Caudy, A.A., Bernstein, E., Hannon, G.J., and Conklin D.S. 2002. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev. 16:948-958.
-
(2002)
Genes Dev.
, vol.16
, pp. 948-958
-
-
Paddison, P.J.1
Caudy, A.A.2
Bernstein, E.3
Hannon, G.J.4
Conklin, D.S.5
-
79
-
-
0036653097
-
RNA interference: The new somatic cell genetics?
-
Paddison, P.J., and Hannon, G.J. 2002. RNA interference: the new somatic cell genetics?. Cancer Cell. 2:17-23.
-
(2002)
Cancer Cell
, vol.2
, pp. 17-23
-
-
Paddison, P.J.1
Hannon, G.J.2
-
80
-
-
0033168947
-
Bioactivity of antiangiogenic ribozymes targeting Flt-1 and KDR mRNA
-
Parry, T.J., Cushman, C., Gallegos, A.M., Agrawal, A.B., Richardson, M., Andrews, L.E., Maloney, L., Mokler, V.R., Wincott, F.E., and Pavco, P.A. 1999. Bioactivity of antiangiogenic ribozymes targeting Flt-1 and KDR mRNA. Nucleic Acids Res. 27:2569-2577.
-
(1999)
Nucleic Acids Res.
, vol.27
, pp. 2569-2577
-
-
Parry, T.J.1
Cushman, C.2
Gallegos, A.M.3
Agrawal, A.B.4
Richardson, M.5
Andrews, L.E.6
Maloney, L.7
Mokler, V.R.8
Wincott, F.E.9
Pavco, P.A.10
-
81
-
-
0034069028
-
Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors
-
Pavco, P.A., Bouhana, K.S., Gallegos, A.M., Agrawal, A., Blanchard, K.S., Grimm, S.L., Jensen, K.L., Andrews, L.E., Wincott, F.E., Pitot, P.A., Tressler, R.J., Cushman, C., Reynolds, M.A., and Parry, T.J. 2000. Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors. Clin. Cancer Res. 6:2094-2103.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2094-2103
-
-
Pavco, P.A.1
Bouhana, K.S.2
Gallegos, A.M.3
Agrawal, A.4
Blanchard, K.S.5
Grimm, S.L.6
Jensen, K.L.7
Andrews, L.E.8
Wincott, F.E.9
Pitot, P.A.10
Tressler, R.J.11
Cushman, C.12
Reynolds, M.A.13
Parry, T.J.14
-
83
-
-
0038540242
-
Antisense therapeutics: From theory to clinical practice
-
Pirollo, K.F., Rait, A., Sleer, L.S., and Chang, E.H. 2003. Antisense therapeutics: from theory to clinical practice. Pharmacol. Ther. 99:55-77.
-
(2003)
Pharmacol. Ther.
, vol.99
, pp. 55-77
-
-
Pirollo, K.F.1
Rait, A.2
Sleer, L.S.3
Chang, E.H.4
-
84
-
-
0036968555
-
Lentiviral vectors for gene delivery into cells
-
Quinonez, R., and Sutton R.E. 2002. Lentiviral vectors for gene delivery into cells. DNA Cell Biol. 21:937-951.
-
(2002)
DNA Cell Biol.
, vol.21
, pp. 937-951
-
-
Quinonez, R.1
Sutton, R.E.2
-
85
-
-
0001183658
-
Sensitization of breast cancer cells to taxol by antisense HER-2 oligonucleotides
-
Rait, A., Krygier, J.E., Pirollo, K.F. and Chang, E.H. 1999. Sensitization of breast cancer cells to taxol by antisense HER-2 oligonucleotides. Antisense Nucleic Acid Drug Dev. 9:403-408.
-
(1999)
Antisense Nucleic Acid Drug Dev.
, vol.9
, pp. 403-408
-
-
Rait, A.1
Krygier, J.E.2
Pirollo, K.F.3
Chang, E.H.4
-
86
-
-
0036713389
-
Antiproliferative effect in chronic myeloid leukaemia cells by antisense peptide nucleic acids
-
Rapozzi, V., Burm, B.E., Cogoi, S., van der Marel, G.A., van Boom, J.H., Quadrifoglio, F., and Xodo, L.E. 2002. Antiproliferative effect in chronic myeloid leukaemia cells by antisense peptide nucleic acids. Nucleic Acids Res. 30:3712-3721.
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 3712-3721
-
-
Rapozzi, V.1
Burm, B.E.2
Cogoi, S.3
van der Marel, G.A.4
van Boom, J.H.5
Quadrifoglio, F.6
Xodo, L.E.7
-
87
-
-
0041808932
-
Gene therapy progress and prospects: Adenoviral vectors
-
St George, J.A. 2003. Gene therapy progress and prospects: adenoviral vectors. Gene Ther. 10:1135-1141.
-
(2003)
Gene. Ther.
, vol.10
, pp. 1135-1141
-
-
St George, J.A.1
-
88
-
-
0141480922
-
Matrix metalloproteinase-9 silencing by RNA interference triggers the migratory-adhesive switch in ewing sarcoma cells
-
In Press
-
Sanceau, J., Truchet, S., and Bauvois, B. 2003. Matrix metalloproteinase-9 silencing by RNA interference triggers the migratory-adhesive switch in ewing sarcoma cells. J. Biol. Chem. In Press.
-
(2003)
J. Biol. Chem.
-
-
Sanceau, J.1
Truchet, S.2
Bauvois, B.3
-
89
-
-
0032800329
-
Pharmocokinetics of an antiangiogenic ribozyme (ANGIOZYME) in the mouse
-
Sandberg, J.A., Bouhana, K.S., Gallegos, A.M., Agrawal, A.B., Grimm, S.L., Wincott, F.E., Reynolds, M.A., Pavco, P.A., and Parry T.J. 1999. Pharmocokinetics of an antiangiogenic ribozyme (ANGIOZYME) in the mouse. Antisense Nucleic Acid Drug Dev. 9:271-277.
-
(1999)
Antisense Nucleic Acid Drug Dev.
, vol.9
, pp. 271-277
-
-
Sandberg, J.A.1
Bouhana, K.S.2
Gallegos, A.M.3
Agrawal, A.B.4
Grimm, S.L.5
Wincott, F.E.6
Reynolds, M.A.7
Pavco, P.A.8
Parry, T.J.9
-
90
-
-
0033750282
-
Pharmacokinetics and tolerability of an antiangiogenic ribozyme (ANGIOZYME) in healthy volunteers
-
Sandberg, J.A., Parker, V.P., Blanchard, K.S., Sweedler, D., Powell, J.A., Kachensky, A., Bellon, L., Usman, N., Rossing, T., Borden, E., and Blatt, L.M. 2000. Pharmacokinetics and tolerability of an antiangiogenic ribozyme (ANGIOZYME) in healthy volunteers. J. Clin. Pharmacol. 40:1462-1469.
-
(2000)
J. Clin. Pharmacol.
, vol.40
, pp. 1462-1469
-
-
Sandberg, J.A.1
Parker, V.P.2
Blanchard, K.S.3
Sweedler, D.4
Powell, J.A.5
Kachensky, A.6
Bellon, L.7
Usman, N.8
Rossing, T.9
Borden, E.10
Blatt, L.M.11
-
92
-
-
0028110360
-
Ribozyme-mediated reversal of the multidrug-resistant phenotype
-
Scanlon, K.J., Ishida, H., and Kashani-Sabet, M. 1994. Ribozyme-mediated reversal of the multidrug-resistant phenotype. Proc. Natl. Acad. Sci. USA. 91:11123-7.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 11123-11127
-
-
Scanlon, K.J.1
Ishida, H.2
Kashani-Sabet, M.3
-
93
-
-
0030920066
-
Specific hammerhead ribozyme-mediated cleavage of mutant N-ras mRNA in vitro and ex vivo
-
Scherr, M., Grez, M., Ganser, A., and Engels, J.W. 1997. Specific hammerhead ribozyme-mediated cleavage of mutant N-ras mRNA in vitro and ex vivo. J. Biol. Chem. 272:14304-14313.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 14304-14313
-
-
Scherr, M.1
Grez, M.2
Ganser, A.3
Engels, J.W.4
-
94
-
-
0031693324
-
Effective reversal of a transformed phenotype by retrovirus-mediated transfer of a ribozyme directed against mutant N-ras
-
Scherr, M., Maurer, A.B., Klein, S., Ganser, A., Engels, J.W., and Grez, M. 1998. Effective reversal of a transformed phenotype by retrovirus-mediated transfer of a ribozyme directed against mutant N-ras. Gene Therapy. 5:1227-1234.
-
(1998)
Gene Therapy
, vol.5
, pp. 1227-1234
-
-
Scherr, M.1
Maurer, A.B.2
Klein, S.3
Ganser, A.4
Engels, J.W.5
Grez, M.6
-
95
-
-
0037441756
-
Specific inhibition of bcr-abl gene expression by small interfering RNA
-
Scherr, M., Battmer, K., Winkler, T., Heidenreich, O., Ganser, A., and Eder, M. 2002. Specific inhibition of bcr-abl gene expression by small interfering RNA. Blood. 101:1566-1569.
-
(2002)
Blood
, vol.101
, pp. 1566-1569
-
-
Scherr, M.1
Battmer, K.2
Winkler, T.3
Heidenreich, O.4
Ganser, A.5
Eder, M.6
-
96
-
-
0033993970
-
Bcl-2 antisense oligonucleotides (G3139) inhibit Merkel cell carcinoma growth in SCID mice
-
Schlagbauer-Wadl, H., Klosner, G., Heere-Ress, E., Waltering, S., Moll, I., Wolff, K., Pehamberger, H., and Jansen, B. 2000. Bcl-2 antisense oligonucleotides (G3139) inhibit Merkel cell carcinoma growth in SCID mice. J. Invest. Dermatol. 114: 725-730.
-
(2000)
J. Invest. Dermatol.
, vol.114
, pp. 725-730
-
-
Schlagbauer-Wadl, H.1
Klosner, G.2
Heere-Ress, E.3
Waltering, S.4
Moll, I.5
Wolff, K.6
Pehamberger, H.7
Jansen, B.8
-
97
-
-
0038121109
-
Specificity of short interfering RNA determined through gene expression signatures
-
Semizarov, D., Frost, L., Sarthy, A., Kroeger, P., Halbert, DN., and Fesik, S.W. 2003. Specificity of short interfering RNA determined through gene expression signatures. Proc. Natl. Acad. Sci. USA. 100:6347-6352.
-
(2003)
Proc. Natl. Acad. Sci. USA.
, vol.100
, pp. 6347-6352
-
-
Semizarov, D.1
Frost, L.2
Sarthy, A.3
Kroeger, P.4
Halbert, D.N.5
Fesik, S.W.6
-
98
-
-
0001686739
-
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
Shah, N.P., Nicoll, J.M., Nagar, B., Gorre, M.E., Paquette, R.L., Kuriyan, J., and Sawyers, C.L. 2002. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell. 2:117-125.
-
(2002)
Cancer Cell
, vol.2
, pp. 117-125
-
-
Shah, N.P.1
Nicoll, J.M.2
Nagar, B.3
Gorre, M.E.4
Paquette, R.L.5
Kuriyan, J.6
Sawyers, C.L.7
-
99
-
-
0036782884
-
Telomerase: A target for cancer therapeutics
-
Shay, J.W., and Wright, W.E. 2002. Telomerase: a target for cancer therapeutics. Cancer Cell. 2:257-265.
-
(2002)
Cancer Cell
, vol.2
, pp. 257-265
-
-
Shay, J.W.1
Wright, W.E.2
-
100
-
-
0037468660
-
Gene silencing by adenovirus-delivered siRNA
-
Shen, C., Buck, A., Liu, X., Winkler, M., and Reske, S.N. 2003. Gene silencing by adenovirus-delivered siRNA. FEBS lett. 539:111-114.
-
(2003)
FEBS Lett.
, vol.539
, pp. 111-114
-
-
Shen, C.1
Buck, A.2
Liu, X.3
Winkler, M.4
Reske, S.N.5
-
101
-
-
0030670482
-
Myeloproliferative disease and myelodysplastic syndrome induced by transplantation of bone marrow cells expressing mutant p53
-
Shounan, Y., MacKenzie, K., Dolnikov, A., Miller, M., and Symonds, G. 1997. Myeloproliferative disease and myelodysplastic syndrome induced by transplantation of bone marrow cells expressing mutant p53. Leukemia. 11:1641-1649.
-
(1997)
Leukemia
, vol.11
, pp. 1641-1649
-
-
Shounan, Y.1
MacKenzie, K.2
Dolnikov, A.3
Miller, M.4
Symonds, G.5
-
102
-
-
0029785634
-
Retroviral transduction of hematopoietic progenitor cells with mutant p53 promotes survival and proliferation, modifies differentiation potential and inhibits apoptosis
-
Shounan, Y., Dolnikov, A., MacKenzie, K.L., Chan, Y-Y., and Symonds, G. 1996. Retroviral transduction of hematopoietic progenitor cells with mutant p53 promotes survival and proliferation, modifies differentiation potential and inhibits apoptosis. Leukemia. 10:1619-1628.
-
(1996)
Leukemia
, vol.10
, pp. 1619-1628
-
-
Shounan, Y.1
Dolnikov, A.2
MacKenzie, K.L.3
Chan, Y-Y.4
Symonds, G.5
-
103
-
-
0034711950
-
Design of nuclease resistant protein kinase C-alpha DNA enzymes with potential tharapeutic application
-
Sioud, M., and Leirdal, M., 2000. Design of nuclease resistant protein kinase C-alpha DNA enzymes with potential tharapeutic application. J. Mol. Biol. 296:937-947.
-
(2000)
J. Mol. Biol.
, vol.296
, pp. 937-947
-
-
Sioud, M.1
Leirdal, M.2
-
104
-
-
0031864708
-
A nuclease-resistant protein kinase C alpha ribozyme blocks glioma cell growth
-
Sioud, M., and Sorensen, D.R. 1998. A nuclease-resistant protein kinase C alpha ribozyme blocks glioma cell growth. Nat. Biotechnol. 16:556-561.
-
(1998)
Nat. Biotechnol.
, vol.16
, pp. 556-561
-
-
Sioud, M.1
Sorensen, D.R.2
-
105
-
-
0027218359
-
Ribozyme-mediated inhibition of bcr-abl gene expression in a Philadelphia chromosome-positive cell line
-
Snyder, D.S., Wu, Y., Wang, J.L., Rossi, J.J., Swiderski, P., Kaplan, B.E., and Forman, S.J. 1993. Ribozyme-mediated inhibition of bcr-abl gene expression in a Philadelphia chromosome-positive cell line. Blood. 82:600-605.
-
(1993)
Blood
, vol.82
, pp. 600-605
-
-
Snyder, D.S.1
Wu, Y.2
Wang, J.L.3
Rossi, J.J.4
Swiderski, P.5
Kaplan, B.E.6
Forman, S.J.7
-
106
-
-
0037348329
-
RNA interference targeting Fas protects mice form fulminant hepatitis
-
Song, E., Lee, S.-K., Wang, J., Ince, N., Ouyang, N., Min, J., Chen, J., Shankar, P., and Lieberman, J. 2003. RNA interference targeting Fas protects mice form fulminant hepatitis. Nat. Med. 9:347-351.
-
(2003)
Nat. Med.
, vol.9
, pp. 347-351
-
-
Song, E.1
Lee, S.-K.2
Wang, J.3
Ince, N.4
Ouyang, N.5
Min, J.6
Chen, J.7
Shankar, P.8
Lieberman, J.9
-
107
-
-
0037119966
-
Hyaluronan-CD44 interaction hampers migration of osteoclast-like cells by down-regulating MMP-9
-
Spessotto, P., Rossi, F.M., Degan, M., Di Francia, R., Perris, R., Colombatti, A., and Gattei, V. 2002. Hyaluronan-CD44 interaction hampers migration of osteoclast-like cells by down-regulating MMP-9. J. Cell Biol. 158:1133-1144.
-
(2002)
J. Cell Biol.
, vol.158
, pp. 1133-1144
-
-
Spessotto, P.1
Rossi, F.M.2
Degan, M.3
Di Francia, R.4
Perris, R.5
Colombatti, A.6
Gattei, V.7
-
108
-
-
0033546334
-
Suppression of smooth muscle cell proliferation by a c-myc RNA-cleaving deoxyribozyme
-
Sun, L.Q., Cairns, M.J., Gerlach, W.L., Witherington, C., Wang, L., and King, A. 1999. Suppression of smooth muscle cell proliferation by a c-myc RNA-cleaving deoxyribozyme. J. Biol. Chem. 274:17236-17241.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17236-17241
-
-
Sun, L.Q.1
Cairns, M.J.2
Gerlach, W.L.3
Witherington, C.4
Wang, L.5
King, A.6
-
109
-
-
0034601488
-
Oncogene inactivation in a mouse model
-
Tanabe, T., Kuwabara, T., Warashina, M., Tani, K., Taira, K., and Asano, S. 2000. Oncogene inactivation in a mouse model. Nature. 406:473-474.
-
(2000)
Nature
, vol.406
, pp. 473-474
-
-
Tanabe, T.1
Kuwabara, T.2
Warashina, M.3
Tani, K.4
Taira, K.5
Asano, S.6
-
110
-
-
0034576957
-
A novel MDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer
-
Tortora, G., Caputo, R., Damiano, V., Bianco, R., Chen, J., Agrawal, S., Bianco, A.R., and Ciardiello, F. 2000. A novel MDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer. Int. J. Cancer. 88: 804-809.
-
(2000)
Int. J. Cancer
, vol.88
, pp. 804-809
-
-
Tortora, G.1
Caputo, R.2
Damiano, V.3
Bianco, R.4
Chen, J.5
Agrawal, S.6
Bianco, A.R.7
Ciardiello, F.8
-
111
-
-
0023221419
-
A small catalytic oligoribonucleotide
-
Uhlenbeck, O.C. 1987. A small catalytic oligoribonucleotide. Nature. 328:596-600.
-
(1987)
Nature
, vol.328
, pp. 596-600
-
-
Uhlenbeck, O.C.1
-
112
-
-
0037265811
-
Chemosensitization of myeloma plasma cells by an antisense-mediated downregulation of bcl-2 protein
-
van de Donk, N.W.C.J., Kamphuis, M.M.J., van Dijk, M., Borst, H.P.E., Bloem, A.C., and Lokhurst, H.M. 2003. Chemosensitization of myeloma plasma cells by an antisense-mediated downregulation of bcl-2 protein. Leukemia. 17:211-219.
-
(2003)
Leukemia
, vol.17
, pp. 211-219
-
-
van de Donk, N.W.C.J.1
Kamphuis, M.M.J.2
van Dijk, M.3
Borst, H.P.E.4
Bloem, A.C.5
Lokhurst, H.M.6
-
113
-
-
0035186743
-
Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: In vitro and in vivo activities and mechanisms
-
Wang, H., Nan, L., Yu, D., Agrawal, S., and Zhang, R. 2001. Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: in vitro and in vivo activities and mechanisms. Clin. Cancer Res. 7:3613-3624.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 3613-3624
-
-
Wang, H.1
Nan, L.2
Yu, D.3
Agrawal, S.4
Zhang, R.5
-
114
-
-
0033117651
-
Extremely high and specific activity of DNA enzymes in cells with a philadelphia chromosome
-
Warashina, M., Kuwabara, T., Nakamatsu, T., and Taira, K. 1999. Extremely high and specific activity of DNA enzymes in cells with a philadelphia chromosome. Chem. Biol. 6:237-250.
-
(1999)
Chem. Biol.
, vol.6
, pp. 237-250
-
-
Warashina, M.1
Kuwabara, T.2
Nakamatsu, T.3
Taira, K.4
-
115
-
-
0034682505
-
Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts
-
Watanabe, T., and Sullenger, B.A. 2000 Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts. Proc. Natl. Acad. Sci. USA. 97:8490-8494.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 8490-8494
-
-
Watanabe, T.1
Sullenger, B.A.2
-
116
-
-
0034015672
-
Phase I Clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-hodgkin's lymphoma
-
Waters, J.S., Webb, A., Cunningham, D., Clarke, P.A., Raynaud, F., di Stefano, F., and Cotter, F.E. 2000. Phase I Clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-hodgkin's lymphoma. J. Clin. Oncol. 18:1812-1823.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 1812-1823
-
-
Waters, J.S.1
Webb, A.2
Cunningham, D.3
Clarke, P.A.4
Raynaud, F.5
di Stefano, F.6
Cotter, F.E.7
-
117
-
-
0037158901
-
Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi)
-
Wilda, M., Fuchs, U., Wössmann, W., and Borkhardt, A. 2002. Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi). Oncogene. 21:5716-5724.
-
(2002)
Oncogene
, vol.21
, pp. 5716-5724
-
-
Wilda, M.1
Fuchs, U.2
Wössmann, W.3
Borkhardt, A.4
-
118
-
-
0141790842
-
Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571)
-
In Press
-
Wohlbold L., van der Kuip, H., Miething, C., Vornlocher, H-P., Knabbe, C., Duyster, J., and Aulitzky, W.E. 2003. Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571). Blood. In Press.
-
(2003)
Blood
-
-
Wohlbold, L.1
van der Kuip, H.2
Miething, C.3
Vornlocher, H-P.4
Knabbe, C.5
Duyster, J.6
Aulitzky, W.E.7
-
119
-
-
0037380839
-
Small interfering RNA-induced suppression of MDR1 (P-glycoprotein) restores sensitivity to multidrug-resistant cancer cells
-
Wu, H., Hait, W.N., and Yang, J-M. 2003. Small interfering RNA-induced suppression of MDR1 (P-glycoprotein) restores sensitivity to multidrug-resistant cancer cells. Cancer Res. 63:1515-1519.
-
(2003)
Cancer Res.
, vol.63
, pp. 1515-1519
-
-
Wu, H.1
Hait, W.N.2
Yang, J.-M.3
-
120
-
-
0032403264
-
Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cells
-
Yokoyama, Y., Takahashi, Y., Shinohara, A., Lian, Z., Wan, X., Niwa, K., and Tamaya, T. 1998. Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cells. Cancer Res. 58:5406-5410.
-
(1998)
Cancer Res.
, vol.58
, pp. 5406-5410
-
-
Yokoyama, Y.1
Takahashi, Y.2
Shinohara, A.3
Lian, Z.4
Wan, X.5
Niwa, K.6
Tamaya, T.7
-
121
-
-
0000262572
-
Phase I/II trial of ISIS 3521, an antisense inhibitor of PKC-alpha, with carboplatin and paclitaxel in non-small cell lung cancer
-
Yuen, A., Halsey, J., Fisher, G., Advani, R., Moore, M., Saleh, M., Ritch, P., Harker, G., Ahmed, F., Jones, C., Polikoff, J., Keiser, W., Kwoh, T., Holmlund, J., Dorr, A. and Sikic, B., 2001. Phase I/II trial of ISIS 3521, an antisense inhibitor of PKC-alpha, with carboplatin and paclitaxel in non-small cell lung cancer. Proc. Am. Soc. Clin. Oncol. 20:309a.
-
(2001)
Proc. Am. Soc. Clin. Oncol.
, vol.20
-
-
Yuen, A.1
Halsey, J.2
Fisher, G.3
Advani, R.4
Moore, M.5
Saleh, M.6
Ritch, P.7
Harker, G.8
Ahmed, F.9
Jones, C.10
Polikoff, J.11
Keiser, W.12
Kwoh, T.13
Holmlund, J.14
Dorr, A.15
Sikic, B.16
-
122
-
-
0344211452
-
Vector-based RNAi, a novel tool for isoform-specific knock-down of VEGF and anti-angiogenesis gene therapy of cancer
-
Zhang, L., Yang, N., Mohamed-Hadley, A., Rubin, S.C., and Coukos, G. 2003. Vector-based RNAi, a novel tool for isoform-specific knock-down of VEGF and anti-angiogenesis gene therapy of cancer. Biochem. Biophys. Res. Commun. 303:1169-1178.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.303
, pp. 1169-1178
-
-
Zhang, L.1
Yang, N.2
Mohamed-Hadley, A.3
Rubin, S.C.4
Coukos, G.5
-
123
-
-
0030807543
-
Induction of apoptosis in small-cell lung cancer cells by an antisense oligodeoxynucleotide targeting the Bcl-2 coding sequence
-
Ziegler, A., Luedke, G.H., Fabbro, D., Altmann, K.H., Stahel, R.A., and Zangemeister-Wittke, U. 1997. Induction of apoptosis in small-cell lung cancer cells by an antisense oligodeoxynucleotide targeting the Bcl-2 coding sequence. J. Natl. Cancer Inst. 89:1027-1036.
-
(1997)
J. Natl. Cancer Inst.
, vol.89
, pp. 1027-1036
-
-
Ziegler, A.1
Luedke, G.H.2
Fabbro, D.3
Altmann, K.H.4
Stahel, R.A.5
Zangemeister-Wittke, U.6
-
124
-
-
0028932288
-
Comparative analysis of cleavage rates after systematic permutation of the NUX consensus target motif for hammerhead ribozymes
-
Zoumadakis, M., and Tabler, M. 1995. Comparative analysis of cleavage rates after systematic permutation of the NUX consensus target motif for hammerhead ribozymes. Nucleic Acids Res. 23:1192-96.
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 1192-1196
-
-
Zoumadakis, M.1
Tabler, M.2
|