메뉴 건너뛰기




Volumn 56, Issue 15, 1996, Pages 3499-3507

Inhibition of growth of human tumor cell lines in nude mice by an antisense oligonucleotide inhibitor of protein kinase C-α expression

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; ISIS 3521; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; PROTEIN KINASE C; UNCLASSIFIED DRUG;

EID: 8944231156     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (204)

References (50)
  • 1
    • 0026451081 scopus 로고
    • Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
    • Washington DC
    • Nishizuka, Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science (Washington DC), 258: 607-614, 1992.
    • (1992) Science , vol.258 , pp. 607-614
    • Nishizuka, Y.1
  • 3
    • 0028082161 scopus 로고
    • Protein kinase C - a question of specificity
    • Dekker, L. V., and Parker, P. J. Protein kinase C - a question of specificity. Trends Biochem. Sci., 19: 73-77, 1994.
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 73-77
    • Dekker, L.V.1    Parker, P.J.2
  • 4
    • 0028351556 scopus 로고
    • The pathogenesis of squamous cell cancer: Lessons learned from studies of skin carcinogenesis, thirty-third G. H. A. Clowes memorial award lecture
    • Yuspa, S. H. The pathogenesis of squamous cell cancer: Lessons learned from studies of skin carcinogenesis, thirty-third G. H. A. Clowes memorial award lecture. Cancer Res., 54: 1178-1189, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 1178-1189
    • Yuspa, S.H.1
  • 5
    • 0028609621 scopus 로고
    • Alterations in murine keratinocyte differentiation induced by activated Ha-ras genes are mediated by protein kinase C-α
    • Dlugosz, A., Cheng, C., Williams, E. K., Dharia, A. G., Denning, M. F., and Yuspa, S. H. Alterations in murine keratinocyte differentiation induced by activated Ha-ras genes are mediated by protein kinase C-α. Cancer Res., 54: 6413-6420, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 6413-6420
    • Dlugosz, A.1    Cheng, C.2    Williams, E.K.3    Dharia, A.G.4    Denning, M.F.5    Yuspa, S.H.6
  • 7
    • 0024284812 scopus 로고
    • Altered growth regulation and enhanced tumorigenicity of NlH 3T3 fibroblasts transfected with protein kinase C-1 cDNA
    • Persons, D. A., Wilkison, W. O., Bell, R. M., and Finn, O. J. Altered growth regulation and enhanced tumorigenicity of NlH 3T3 fibroblasts transfected with protein kinase C-1 cDNA. Cell, 52: 447-458, 1988.
    • (1988) Cell , vol.52 , pp. 447-458
    • Persons, D.A.1    Wilkison, W.O.2    Bell, R.M.3    Finn, O.J.4
  • 8
    • 0025167963 scopus 로고
    • Overexpression of protein kinase C in Ht29 colon cancer cells causes growth inhibition and tumor suppression
    • Choi, P. L., Tchou-Wong, K. M., and Weinstein, I. B. Overexpression of protein kinase C in Ht29 colon cancer cells causes growth inhibition and tumor suppression. Mol. Cell. Biol., 10: 4650-4657, 1990.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 4650-4657
    • Choi, P.L.1    Tchou-Wong, K.M.2    Weinstein, I.B.3
  • 9
    • 0028903545 scopus 로고
    • MCF-7 breast cancer cells transfected with with PKC-α exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype
    • Ways, D. K., Kukoly, C. A., deVente, J., Hooker, J. L., Bryant, W. O., Posekany, K. J., Fletcher, D. J., Cook, P. P., and Parker, P. P. MCF-7 breast cancer cells transfected with with PKC-α exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype. J. Clin. Invest., 95: 1906-1915, 1995.
    • (1995) J. Clin. Invest. , vol.95 , pp. 1906-1915
    • Ways, D.K.1    Kukoly, C.A.2    DeVente, J.3    Hooker, J.L.4    Bryant, W.O.5    Posekany, K.J.6    Fletcher, D.J.7    Cook, P.P.8    Parker, P.P.9
  • 10
    • 0027435064 scopus 로고
    • The potential of protein kinase C as a target for anticancer treatment
    • Basu, A. The potential of protein kinase C as a target for anticancer treatment. Pharmacol. & Ther., 59: 257-280, 1993.
    • (1993) Pharmacol. & Ther. , vol.59 , pp. 257-280
    • Basu, A.1
  • 11
    • 0026602120 scopus 로고
    • Elevated activities of protein kinase C and tyrosine kinase correlate to leukemic cell aggressiveness
    • Aflalo, E., Wolfson, M., Ofir, R., and Weinstein, Y. Elevated activities of protein kinase C and tyrosine kinase correlate to leukemic cell aggressiveness. Int. J. Cancer, 50: 136-141, 1992.
    • (1992) Int. J. Cancer , vol.50 , pp. 136-141
    • Aflalo, E.1    Wolfson, M.2    Ofir, R.3    Weinstein, Y.4
  • 13
    • 0026638357 scopus 로고
    • Expression pattern of α-protein kinase C in human astrocytomas indicates a role in malignant progression
    • Benzil, D. B., Finkelstein, S. D., Epstein, M. H., and Finch, P. W. Expression pattern of α-protein kinase C in human astrocytomas indicates a role in malignant progression. Cancer Res, 52: 2951-2956, 1992.
    • (1992) Cancer Res , vol.52 , pp. 2951-2956
    • Benzil, D.B.1    Finkelstein, S.D.2    Epstein, M.H.3    Finch, P.W.4
  • 14
    • 0024323584 scopus 로고
    • Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue
    • O'Brian, C., Vogel, V. G., Singletary, S. E., and Ward, N. E. Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue Cancer Res., 49: 3215-3217, 1989.
    • (1989) Cancer Res. , vol.49 , pp. 3215-3217
    • O'Brian, C.1    Vogel, V.G.2    Singletary, S.E.3    Ward, N.E.4
  • 15
    • 0026425687 scopus 로고
    • Cancer prevention recent progress and future opportunities
    • Weinstein, B. I. Cancer prevention recent progress and future opportunities. Cancer Res., 51 (Suppl.): 5080s-5085s, 1991.
    • (1991) Cancer Res. , vol.51 , Issue.SUPPL.
    • Weinstein, B.I.1
  • 16
    • 0024427150 scopus 로고
    • Protein kinase C - a novel target for rational anti-cancer drug design?
    • Gescher, A., and Dale, I. L. Protein kinase C - a novel target for rational anti-cancer drug design? Anti-Cancer Drag Des., 4: 93-105, 1995.
    • (1995) Anti-Cancer Drag Des. , vol.4 , pp. 93-105
    • Gescher, A.1    Dale, I.L.2
  • 17
    • 0003799677 scopus 로고
    • Protein kinase C inhibitors
    • J. F. Kuo (ed.), Oxford, United Kingdom: Oxford University Press
    • O'Brian, C. A., and Kuo, J. F. Protein kinase C inhibitors. In: J. F. Kuo (ed.), Protein Kinase C, pp. 96-120. Oxford, United Kingdom: Oxford University Press, 1994.
    • (1994) Protein Kinase C , pp. 96-120
    • O'Brian, C.A.1    Kuo, J.F.2
  • 18
    • 0003088186 scopus 로고
    • The future of new drug development
    • J. E. Neiderhuber (ed.), Philadelphia: B. C. Decker, Inc.
    • Boyd, M. The future of new drug development. In: J. E. Neiderhuber (ed.), Current Therapy in Oncology, pp. 11-22. Philadelphia: B. C. Decker, Inc., 1993.
    • (1993) Current Therapy in Oncology , pp. 11-22
    • Boyd, M.1
  • 19
    • 0004244327 scopus 로고
    • Antisense oligonucleotides in the context of modern molecular drug discovery and development
    • S. T. Crooke and B. LeBleu (eds.), Boca Raton, FL: CRC Press, Inc.
    • Mirabelli, C. K. and Crooke, S. T. Antisense oligonucleotides in the context of modern molecular drug discovery and development. In: S. T. Crooke and B. LeBleu (eds.), Antisense Research and Applications, pp. 7-35 Boca Raton, FL: CRC Press, Inc., 1993.
    • (1993) Antisense Research and Applications , pp. 7-35
    • Mirabelli, C.K.1    Crooke, S.T.2
  • 20
    • 0025766336 scopus 로고
    • Antisense agents in cancer research and therapeutics
    • Dolnick, B. J. Antisense agents in cancer research and therapeutics. Cancer Invest., 9: 185-194, 1991.
    • (1991) Cancer Invest. , vol.9 , pp. 185-194
    • Dolnick, B.J.1
  • 21
    • 0027376439 scopus 로고
    • Antisense oligonucleotides as therapeutic agents - is the bullet really magical?
    • Washington DC
    • Stein, C. A., and Cheng, Y-C. Antisense oligonucleotides as therapeutic agents - is the bullet really magical? Science (Washington DC), 267: 1004-1012, 1993.
    • (1993) Science , vol.267 , pp. 1004-1012
    • Stein, C.A.1    Cheng, Y.-C.2
  • 22
    • 0028019410 scopus 로고
    • Gene inhibition using antisense oligodeoxynucleotides
    • Wagner, R. W. Gene inhibition using antisense oligodeoxynucleotides. Nature (Lond.), 372: 333-335, 1994.
    • (1994) Nature (Lond.) , vol.372 , pp. 333-335
    • Wagner, R.W.1
  • 24
    • 0026041988 scopus 로고
    • Inhibition of protooncogene expression by antisense oligodeoxynucleotides: Biological and therapeutic implications
    • Calabretta, B. Inhibition of protooncogene expression by antisense oligodeoxynucleotides: biological and therapeutic implications. Cancer Res., 57: 4505-4510, 1991.
    • (1991) Cancer Res. , vol.57 , pp. 4505-4510
    • Calabretta, B.1
  • 25
    • 0028403167 scopus 로고
    • Antisense oligonucleotide technology in the development of cancer therapeutics
    • Tseng, B. Y., and Brown, K. D. Antisense oligonucleotide technology in the development of cancer therapeutics. Cancer Gene Ther., 1: 65-71, 1994.
    • (1994) Cancer Gene Ther. , vol.1 , pp. 65-71
    • Tseng, B.Y.1    Brown, K.D.2
  • 26
    • 0028292570 scopus 로고
    • Inhibition of protein kinase C-α expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters
    • Dean, N. M., McKay, R., Condon, T. P., and Bennett, C. F. Inhibition of protein kinase C-α expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters. J. Biol. Chem., 269: 16416-16424, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 16416-16424
    • Dean, N.M.1    McKay, R.2    Condon, T.P.3    Bennett, C.F.4
  • 27
    • 0028062847 scopus 로고
    • Inhibition of protein kinase C-α expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides
    • Dean, N. M., and McKay, R. Inhibition of protein kinase C-α expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides. Proc. Natl. Acad. Sci. USA, 91: 11762-11766, 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11762-11766
    • Dean, N.M.1    McKay, R.2
  • 28
    • 0029867162 scopus 로고    scopus 로고
    • Enhanced activity of an antisense oligonucleotide targeting murine PKC-α by the incorporation of 2′-O-propyl modifications
    • McKay, R. M., Cummins, L. L., Graham, M. J., Lesnick, E. A., Owens, S. R., Winniman, M., and Dean, N. M. Enhanced activity of an antisense oligonucleotide targeting murine PKC-α by the incorporation of 2′-O-propyl modifications. Nucleic Acids Res., 24: 411-417, 1996.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 411-417
    • McKay, R.M.1    Cummins, L.L.2    Graham, M.J.3    Lesnick, E.A.4    Owens, S.R.5    Winniman, M.6    Dean, N.M.7
  • 29
    • 0026550438 scopus 로고
    • In vitro toxicological evaluation of ISIS 1082, a phosphorothioate oligonucleotide inhibitor of herpes simplex virus
    • Crooke, R. M., Hoke, G. D., and Shoemaker, J. E. E. In vitro toxicological evaluation of ISIS 1082, a phosphorothioate oligonucleotide inhibitor of herpes simplex virus. Antimicrob. Agents Chemother., 36: 527-532, 1992.
    • (1992) Antimicrob. Agents Chemother. , vol.36 , pp. 527-532
    • Crooke, R.M.1    Hoke, G.D.2    Shoemaker, J.E.E.3
  • 30
    • 0027092897 scopus 로고
    • Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides
    • Bennett, C. F., Chiang, M-Y., Chan, H., Shoemaker, J. E. E., and Mirabelli, C. K. Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides Mol. Pharmacol., 41: 1023-1033, 1992.
    • (1992) Mol. Pharmacol. , vol.41 , pp. 1023-1033
    • Bennett, C.F.1    Chiang, M.-Y.2    Chan, H.3    Shoemaker, J.E.E.4    Mirabelli, C.K.5
  • 31
    • 0024379951 scopus 로고
    • A derivative of staurosporin (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity
    • Meyer, T., Regenass, U., Fabbro, D., Alten, E., Rosel, J., Muller, M., Caravatti, G., and Matter, A. A derivative of staurosporin (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity. Int. J. Cancer, 43: 851-856, 1989.
    • (1989) Int. J. Cancer , vol.43 , pp. 851-856
    • Meyer, T.1    Regenass, U.2    Fabbro, D.3    Alten, E.4    Rosel, J.5    Muller, M.6    Caravatti, G.7    Matter, A.8
  • 32
    • 0028001098 scopus 로고
    • Problems in interpretation of data derived from in vitro and in vivo use of antisense oligodeoxynucleotides
    • Stein, C. A., and Krieg, A. M. Problems in interpretation of data derived from in vitro and in vivo use of antisense oligodeoxynucleotides. Antisense Res. Dev., 4: 67-69, 1994.
    • (1994) Antisense Res. Dev. , vol.4 , pp. 67-69
    • Stein, C.A.1    Krieg, A.M.2
  • 33
    • 0002442281 scopus 로고
    • In vitro and in vivo toxicology of first generation analogs
    • S. T. Crooke and B. Lebleu (eds.), Boca Raton, FL: CRC Press, Inc.
    • Crooke, R. M. In vitro and in vivo toxicology of first generation analogs. In: S. T. Crooke and B. Lebleu (eds.), Antisense Research and Applications, pp. 471-492. Boca Raton, FL: CRC Press, Inc., 1993.
    • (1993) Antisense Research and Applications , pp. 471-492
    • Crooke, R.M.1
  • 34
    • 0028897029 scopus 로고
    • Review of in vivo pharmacokinetics and toxicology of phosphorothioate oligonucleotides
    • Srinivasan, S. K., and Iversen, P. Review of in vivo pharmacokinetics and toxicology of phosphorothioate oligonucleotides. J. Clin. Lab. Anal., 9: 129-137, 1995.
    • (1995) J. Clin. Lab. Anal. , vol.9 , pp. 129-137
    • Srinivasan, S.K.1    Iversen, P.2
  • 35
    • 0025743216 scopus 로고
    • Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice
    • Agrawal, S., Temsamani, J., and Tang, J. Y. Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice Proc. Natl. Acad. Sci. USA, 88: 7595-7599, 1991.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7595-7599
    • Agrawal, S.1    Temsamani, J.2    Tang, J.Y.3
  • 40
    • 0026073646 scopus 로고
    • Modified deoxyoligonucleotides stable to exonuclease degradation in serum
    • Shaw, J-P., Kent, K., Bird, J., Fishback, J., and Froehler, B. Modified deoxyoligonucleotides stable to exonuclease degradation in serum. Nucleic Acids Res., 19: 747-750, 1991.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 747-750
    • Shaw, J.-P.1    Kent, K.2    Bird, J.3    Fishback, J.4    Froehler, B.5
  • 41
    • 0027058137 scopus 로고
    • Ablation of transplanted HTLV-1 Tax-transformed tumors in mice by antisense inhibition of NF-KB
    • Washington DC
    • Kitajima, I., Shinohara, T., Bilakovics, J., Brown, D. A., Xiao, X., and Nerenberg, M. Ablation of transplanted HTLV-1 Tax-transformed tumors in mice by antisense inhibition of NF-KB. Science (Washington DC), 258: 1792-1795, 1992.
    • (1992) Science , vol.258 , pp. 1792-1795
    • Kitajima, I.1    Shinohara, T.2    Bilakovics, J.3    Brown, D.A.4    Xiao, X.5    Nerenberg, M.6
  • 42
  • 45
    • 0028037219 scopus 로고
    • Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice
    • Schwab, G., Chavany, C., Duroux, I., Goubin, G., Lebeau, J., Hélène, C., and Saison-Behmoaras, T. Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice. Proc. Natl. Acad. Sci. USA, 97: 10460-10464, 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10460-10464
    • Schwab, G.1    Chavany, C.2    Duroux, I.3    Goubin, G.4    Lebeau, J.5    Hélène, C.6    Saison-Behmoaras, T.7
  • 46
    • 0026295042 scopus 로고
    • In vivo modulation of N-myc expression by continuous perfusion with an antisense oligonucleotide
    • Whitesell, L., Rosolen, A., and Neckers, L. M. In vivo modulation of N-myc expression by continuous perfusion with an antisense oligonucleotide Antisense Res. Dev., 1: 343-350, 1991.
    • (1991) Antisense Res. Dev. , vol.1 , pp. 343-350
    • Whitesell, L.1    Rosolen, A.2    Neckers, L.M.3
  • 47
    • 0026010995 scopus 로고
    • Molecular themes in oncogenesis
    • Bishop, J. M. Molecular themes in oncogenesis. Cell, 64: 235-248, 1991.
    • (1991) Cell , vol.64 , pp. 235-248
    • Bishop, J.M.1
  • 48
    • 0026074818 scopus 로고
    • Cooperation between oncogenes
    • Hunter, T. Cooperation between oncogenes Cell, 64: 249-270, 1991.
    • (1991) Cell , vol.64 , pp. 249-270
    • Hunter, T.1
  • 49
    • 0026647742 scopus 로고
    • Acquisition of a growth-inhibitory response to phorbol ester involves DNA damage
    • Sun, Y., Pommier, Y., and Colburn, N. H. Acquisition of a growth-inhibitory response to phorbol ester involves DNA damage Cancer Res., 52: 1907-1915, 1992.
    • (1992) Cancer Res. , vol.52 , pp. 1907-1915
    • Sun, Y.1    Pommier, Y.2    Colburn, N.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.