-
1
-
-
0025141337
-
What is the evidence that tumors are angiogenesis dependent?
-
Folkman J What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990, 82:4-6
-
(1990)
J. Natl. Cancer Inst.
, vol.82
, pp. 4-6
-
-
Folkman, J.1
-
3
-
-
0030614893
-
Interstitial pH and pO2 gradients in solid tumors in vivo: High resolution measurements reveal a lack of correlation
-
Helmlinger G, Yuan F, Dellian M and Jain RK Interstitial pH and pO2 gradients in solid tumors in vivo: High resolution measurements reveal a lack of correlation Nat Med 1997, 3:177-182
-
(1997)
Nat. Med.
, vol.3
, pp. 177-182
-
-
Helmlinger, G.1
Yuan, F.2
Dellian, M.3
Jain, R.K.4
-
4
-
-
0036359548
-
Hypoxia-a key regulatory factor in tumour growth
-
Harris AL Hypoxia-a key regulatory factor in tumour growth Nature Rev Cancer 2002, 2:38-47
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
5
-
-
0036467999
-
Tumor hypoxia: Chicken, egg, or a piece of the farm?
-
Coleman CN, Mitchell JB and Camphausen K Tumor hypoxia: chicken, egg, or a piece of the farm? J Clin Oncol 2002, 20:610-615
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 610-615
-
-
Coleman, C.N.1
Mitchell, J.B.2
Camphausen, K.3
-
6
-
-
0031057890
-
Hypoxia/reoxygenation stimulates Jun kinase activity through redox signaling in rat cardiac myocytes
-
Laderoute KR and Webster KA Hypoxia/reoxygenation stimulates Jun kinase activity through redox signaling in rat cardiac myocytes Circ Res 1997, 80:336-344
-
(1997)
Circ. Res.
, vol.80
, pp. 336-344
-
-
Laderoute, K.R.1
Webster, K.A.2
-
7
-
-
0033617186
-
Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironment
-
Laderoute KR, Mendonca HL, Calaoagan JM, Knapp AM, Giaccia AJ and Stork PJS Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironment J Biol Chem 1999, 274:12890-12897
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 12890-12897
-
-
Laderoute, K.R.1
Mendonca, H.L.2
Calaoagan, J.M.3
Knapp, A.M.4
Giaccia, A.J.5
Stork, P.J.S.6
-
8
-
-
0034920088
-
Activation of c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) is critical for hypoxia-induced apoptosis of human malignant melanoma
-
Kunz M, Ibrahim S, Koczan D, Thiesen HJ, Koehler HJ, Acker T, Plate KH, Ludwig S, Rapp UR and Broecker EB Activation of c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) is critical for hypoxia-induced apoptosis of human malignant melanoma Cell Growth Differ 2001, 12:137-145
-
(2001)
Cell Growth Differ.
, vol.12
, pp. 137-145
-
-
Kunz, M.1
Ibrahim, S.2
Koczan, D.3
Thiesen, H.J.4
Koehler, H.J.5
Acker, T.6
Plate, K.H.7
Ludwig, S.8
Rapp, U.R.9
Broecker, E.B.10
-
9
-
-
0032851468
-
Protein expression of brain endothelial cell E-cadherin after hypoxia/aglycemia: Influence of astrocyte contact
-
Abbruscato TJ and Davis TP Protein expression of brain endothelial cell E-cadherin after hypoxia/aglycemia: influence of astrocyte contact Brain Res 1999, 842:277-286
-
(1999)
Brain Res.
, vol.842
, pp. 277-286
-
-
Abbruscato, T.J.1
Davis, T.P.2
-
10
-
-
0030025773
-
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors
-
Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW and Giaccia AJ Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors Nature 1996, 379:88-91
-
(1996)
Nature
, vol.379
, pp. 88-91
-
-
Graeber, T.G.1
Osmanian, C.2
Jacks, T.3
Housman, D.E.4
Koch, C.J.5
Lowe, S.W.6
Giaccia, A.J.7
-
12
-
-
0035282334
-
Mammalian MAP kinase signalling cascades
-
Chang L and Karin M Mammalian MAP kinase signalling cascades Nature 2001, 410:37-40
-
(2001)
Nature
, vol.410
, pp. 37-40
-
-
Chang, L.1
Karin, M.2
-
13
-
-
0028104204
-
The ins and outs of Raf kinases
-
Daum G, Eisenmann-Tappe I, Fries HW, Troppmair J and Rapp UR The ins and outs of Raf kinases Trends Biochem Sci 1994, 19:474-480
-
(1994)
Trends Biochem. Sci.
, vol.19
, pp. 474-480
-
-
Daum, G.1
Eisenmann-Tappe, I.2
Fries, H.W.3
Troppmair, J.4
Rapp, U.R.5
-
14
-
-
0031044561
-
MEKKs, GCKs, MLKs, PAKs, TAKs, and Tpls: Upstream regulators of the c-Jun amino-terminal kinases
-
Fanger GR, Gerwins P, Widmann C, Jarpe MB and Johnson GL MEKKs, GCKs, MLKs, PAKs, TAKs, and Tpls: upstream regulators of the c-Jun amino-terminal kinases Curr Opin Gen Dev 1997, 7:67-74
-
(1997)
Curr. Opin. Gen. Dev.
, vol.7
, pp. 67-74
-
-
Fanger, G.R.1
Gerwins, P.2
Widmann, C.3
Jarpe, M.B.4
Johnson, G.L.5
-
15
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
Davis RJ Signal transduction by the JNK group of MAP kinases Cell 2000, 103:239-252
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
16
-
-
1842290997
-
Hypoxia alters the subcellular distribution of the protein kinase C isoforms in neonatal rat ventricular myocytes
-
Goldberg M, Zhang HL and Steinberg SF Hypoxia alters the subcellular distribution of the protein kinase C isoforms in neonatal rat ventricular myocytes J Clin Invest 1997, 99:55-61
-
(1997)
J. Clin. Invest.
, vol.99
, pp. 55-61
-
-
Goldberg, M.1
Zhang, H.L.2
Steinberg, S.F.3
-
17
-
-
0037103797
-
Hypoxia/reoxygenation induction of monocyte chemoattractant protein-1 in melanoma cells: Involvement of nuclear factor-kappaB, stimulatory protein-1 transcription factors and mitogen-activated protein kinase pathways
-
Kunz M, Bloss G, Gillitzer R, Gross G, Goebeler M, Rapp UR and Ludwig S Hypoxia/reoxygenation induction of monocyte chemoattractant protein-1 in melanoma cells: involvement of nuclear factor-kappaB, stimulatory protein-1 transcription factors and mitogen-activated protein kinase pathways Biochem J 2002, 366:299-306
-
(2002)
Biochem. J.
, vol.366
, pp. 299-306
-
-
Kunz, M.1
Bloss, G.2
Gillitzer, R.3
Gross, G.4
Goebeler, M.5
Rapp, U.R.6
Ludwig, S.7
-
18
-
-
0035065836
-
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
-
Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K, Minowa O, Miyazono K, Noda T and Ichijo H ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis EMBO Rep 2001, 2:222-228
-
(2001)
EMBO Rep.
, vol.2
, pp. 222-228
-
-
Tobiume, K.1
Matsuzawa, A.2
Takahashi, T.3
Nishitoh, H.4
Morita, K.5
Takeda, K.6
Minowa, O.7
Miyazono, K.8
Noda, T.9
Ichijo, H.10
-
20
-
-
0030977312
-
Endothelial apoptosis in Braf-deficient mice
-
Wojnowski L, Zimmer AM, Beck TW, Hahn H, Bernal R, Rapp UR and Zimmer A Endothelial apoptosis in Braf-deficient mice Nat Genet 1997, 16:293-297
-
(1997)
Nat. Genet.
, vol.16
, pp. 293-297
-
-
Wojnowski, L.1
Zimmer, A.M.2
Beck, T.W.3
Hahn, H.4
Bernal, R.5
Rapp, U.R.6
Zimmer, A.7
-
21
-
-
0030943461
-
Abnormal angiogenesis and response to glucose and oxygen deprivation in mice lacking the protein ARNT
-
Maltepe E, Schmidt JV, Baunoch D, Bradfield CA and Simon MC Abnormal angiogenesis and response to glucose and oxygen deprivation in mice lacking the protein ARNT Nature 1997, 386:403-407
-
(1997)
Nature
, vol.386
, pp. 403-407
-
-
Maltepe, E.1
Schmidt, J.V.2
Baunoch, D.3
Bradfield, C.A.4
Simon, M.C.5
-
22
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ and Bottomley W Mutations of the BRAF gene in human cancer Nature 2002, 417:949-954
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
-
23
-
-
0034104590
-
The Ras branch of small GTPases: Ras family members don't fall far from the tree
-
Reuther GW and Der CJ The Ras branch of small GTPases: Ras family members don't fall far from the tree Curr Opin Cell Biol 2000, 12:157-165
-
(2000)
Curr. Opin. Cell Biol.
, vol.12
, pp. 157-165
-
-
Reuther, G.W.1
Der, C.J.2
-
24
-
-
0024376173
-
Ras oncogenes in human cancer: A review
-
Bos JL ras oncogenes in human cancer: a review Cancer Res 1989, 49:4682-4689
-
(1989)
Cancer Res.
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
25
-
-
85047695603
-
Cell density mediated pericellular hypoxia leads to induction of HIF-1alpha via nitric oxide and Ras/MAP kinase mediated signaling pathways
-
Sheta EA, Trout H, Gildea JJ, Harding MA and Theodorescu D Cell density mediated pericellular hypoxia leads to induction of HIF-1alpha via nitric oxide and Ras/MAP kinase mediated signaling pathways Oncogene 2001, 20:7624-7634
-
(2001)
Oncogene
, vol.20
, pp. 7624-7634
-
-
Sheta, E.A.1
Trout, H.2
Gildea, J.J.3
Harding, M.A.4
Theodorescu, D.5
-
26
-
-
0034668187
-
Signaling angiogenesis via p42/p44 MAP kinase and hypoxia
-
Berra E, Milanini J, Richard DE, Le Gall M, Vinals F, Gothie E, Roux D, Pages G and Pouyssegur J Signaling angiogenesis via p42/p44 MAP kinase and hypoxia Biochem Pharmacol 2000, 60:1171-1178
-
(2000)
Biochem. Pharmacol.
, vol.60
, pp. 1171-1178
-
-
Berra, E.1
Milanini, J.2
Richard, D.E.3
Le Gall, M.4
Vinals, F.5
Gothie, E.6
Roux, D.7
Pages, G.8
Pouyssegur, J.9
-
27
-
-
0034601487
-
Genomic analysis of metastasis reveals an essential role for RhoC
-
Clark EA, Golub TR, Lander ES and Hynes RO Genomic analysis of metastasis reveals an essential role for RhoC Nature 2000, 406:532-535
-
(2000)
Nature
, vol.406
, pp. 532-535
-
-
Clark, E.A.1
Golub, T.R.2
Lander, E.S.3
Hynes, R.O.4
-
28
-
-
0035812772
-
HIF-1, O(2), and the 3 PHDs. 2001. How animal cells signal hypoxia to the nucleus
-
Semenza GL HIF-1, O(2), and the 3 PHDs. 2001. How animal cells signal hypoxia to the nucleus Cell 2001, 107:1-3
-
(2001)
Cell
, vol.107
, pp. 1-3
-
-
Semenza, G.L.1
-
29
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor 1
-
Wang GL and Semenza GL Purification and characterization of hypoxia-inducible factor 1 J Biol Chem 1995, 270:1230-1237
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
-
30
-
-
0034107952
-
Mammalian oxygen sensing, signalling and gene regulation
-
Wenger RH Mammalian oxygen sensing, signalling and gene regulation J Exp Biol 2000, 203:1253-1263
-
(2000)
J. Exp. Biol.
, vol.203
, pp. 1253-1263
-
-
Wenger, R.H.1
-
31
-
-
0036320934
-
2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression
-
2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression FASEB J 2002, 16:1151-1162
-
(2002)
FASEB J.
, vol.16
, pp. 1151-1162
-
-
Wenger, R.H.1
-
32
-
-
0034676331
-
Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
-
Krieg M, Haas R, Brauch H, Acker T, Flamme I and Plate KH Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function Oncogene 2000, 19:5435-5443
-
(2000)
Oncogene
, vol.19
, pp. 5435-5443
-
-
Krieg, M.1
Haas, R.2
Brauch, H.3
Acker, T.4
Flamme, I.5
Plate, K.H.6
-
33
-
-
0035917313
-
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
-
Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS and Kaelin WG Jr HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing Science 2001, 292:464-468
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
34
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon PC, Hirota K and Semenza GL FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity Genes Dev 2001, 15:2675-1686
-
(2001)
Genes Dev.
, vol.15
, pp. 1686-2675
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
35
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML and Bruick RK FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor Genes Dev 2002, 16:1466-1471
-
(2002)
Genes Dev.
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
36
-
-
0034531952
-
MAP kinases and hypoxia in the control of VEGF expression
-
Berra E, Pages G and Pouyssegur J MAP kinases and hypoxia in the control of VEGF expression Cancer Metastasis Rev 2000, 19:139-145
-
(2000)
Cancer Metastasis Rev.
, vol.19
, pp. 139-145
-
-
Berra, E.1
Pages, G.2
Pouyssegur, J.3
-
37
-
-
0033870727
-
Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth
-
Ryan HE, Poloni M, McNulty W, Elson D, Gassmann M, Arbeit JM and Johnson RS Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth Cancer Res 2000, 60:4010-4015
-
(2000)
Cancer Res.
, vol.60
, pp. 4010-4015
-
-
Ryan, H.E.1
Poloni, M.2
McNulty, W.3
Elson, D.4
Gassmann, M.5
Arbeit, J.M.6
Johnson, R.S.7
-
38
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
-
Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng Q, Dillehay LE, Madan A, Semenza GL and Bedi A Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha Genes Dev 2000, 14:34-44
-
(2000)
Genes Dev.
, vol.14
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.M.3
Sutter, C.H.4
Artemov, D.5
Zeng, Q.6
Dillehay, L.E.7
Madan, A.8
Semenza, G.L.9
Bedi, A.10
-
39
-
-
0034529914
-
Suppression of tumor growth through disruption of hypoxia-inducible transcription
-
Kung AL, Wang S, Klco JM, Kaelin WG and Livingston DM Suppression of tumor growth through disruption of hypoxia-inducible transcription Nat Med 2000, 6:1335-1340
-
(2000)
Nat. Med.
, vol.6
, pp. 1335-1340
-
-
Kung, A.L.1
Wang, S.2
Klco, J.M.3
Kaelin, W.G.4
Livingston, D.M.5
-
40
-
-
0037098081
-
How oxygen makes its presence felt
-
Kaelin WG Jr How oxygen makes its presence felt Genes Dev 2002, 16:1441-1445
-
(2002)
Genes Dev.
, vol.16
, pp. 1441-1445
-
-
Kaelin Jr., W.G.1
-
41
-
-
0025720735
-
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
-
Angel P and Karin M The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation Biochim Biophys Acta 1991, 1072:129-157
-
(1991)
Biochim. Biophys. Acta
, vol.1072
, pp. 129-157
-
-
Angel, P.1
Karin, M.2
-
42
-
-
0028841622
-
The genomic response of tumor cells to hypoxia and reoxygenation. Differential activation of transcription factors AP-1 and NF-κB
-
Rupec RA and Baeuerle PA The genomic response of tumor cells to hypoxia and reoxygenation. Differential activation of transcription factors AP-1 and NF-κB Eur J Biochem 1995, 234:632-640
-
(1995)
Eur. J. Biochem.
, vol.234
, pp. 632-640
-
-
Rupec, R.A.1
Baeuerle, P.A.2
-
43
-
-
0027936404
-
Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia
-
Yao KS, Xanthoudakis S, Curran T and O'Dwyer PJ Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia Mol Cell Biol 1994, 14:5997-6003
-
(1994)
Mol. Cell Biol.
, vol.14
, pp. 5997-6003
-
-
Yao, K.S.1
Xanthoudakis, S.2
Curran, T.3
O'Dwyer, P.J.4
-
44
-
-
0033580218
-
Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma
-
Desbaillets I, Diserens AC, de Tribolet N, Hamou MF and van Meir EG Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma Oncogene 1999, 18:1447-1456
-
(1999)
Oncogene
, vol.18
, pp. 1447-1456
-
-
Desbaillets, I.1
Diserens, A.C.2
de Tribolet, N.3
Hamou, M.F.4
van Meir, E.G.5
-
45
-
-
0032887299
-
Anoxia-induced up-regulation of interleukin-8 in human malignant melanoma. A potential mechanism for high tumor aggressiveness
-
Kunz M, Hartmann A, Flory E, Toksoy A, Koczan D, Thiesen HJ, Mukaida N, Neumann M, Rapp UR, Bröcker EB and Gillitzer R Anoxia-induced up-regulation of interleukin-8 in human malignant melanoma. A potential mechanism for high tumor aggressiveness Am J Pathol 1999, 155:753-763
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 753-763
-
-
Kunz, M.1
Hartmann, A.2
Flory, E.3
Toksoy, A.4
Koczan, D.5
Thiesen, H.J.6
Mukaida, N.7
Neumann, M.8
Rapp, U.R.9
Bröcker, E.B.10
Gillitzer, R.11
-
46
-
-
0036139795
-
HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: Role of MAP kinases
-
Michiels C, Minet E, Michel G, Mottet D, Piret JP and Raes M HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases IUBMB Life 2001, 52:49-53
-
(2001)
IUBMB Life
, vol.52
, pp. 49-53
-
-
Michiels, C.1
Minet, E.2
Michel, G.3
Mottet, D.4
Piret, J.P.5
Raes, M.6
-
47
-
-
0028268629
-
Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues
-
Koong AC, Chen EY and Giaccia AJ Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues Cancer Res 1994, 54:1425-1430
-
(1994)
Cancer Res.
, vol.54
, pp. 1425-1430
-
-
Koong, A.C.1
Chen, E.Y.2
Giaccia, A.J.3
-
48
-
-
16044365828
-
Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. NF-κ B signalling
-
Imbert V, Rupec RA, Livolsi A, Pahl HL, Traenckner EB, Mueller-Dieckmann C, Farahifar D, Rossi B, Auberger P and Baeuerle PA Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. NF-κB signalling Cell 1996, 86:787-798
-
(1996)
Cell
, vol.86
, pp. 787-798
-
-
Imbert, V.1
Rupec, R.A.2
Livolsi, A.3
Pahl, H.L.4
Traenckner, E.B.5
Mueller-Dieckmann, C.6
Farahifar, D.7
Rossi, B.8
Auberger, P.9
Baeuerle, P.A.10
-
49
-
-
0030713446
-
Activator-protein-1 binding potentiates the hypoxia-induciblefactor-1-mediated hypoxiainduced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells
-
Damert A, Ikeda E and Risau W Activator-protein-1 binding potentiates the hypoxia-induciblefactor-1-mediated hypoxiainduced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells Biochem J 1997, 327:419-423
-
(1997)
Biochem. J.
, vol.327
, pp. 419-423
-
-
Damert, A.1
Ikeda, E.2
Risau, W.3
-
50
-
-
0036210708
-
The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent
-
Laderoute KR, Calaoagan JM, Gustafson-Brown C, Knapp AM, Li GC, Mendonca HL, Ryan HE, Wang Z and Johnson RS The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent Mol Cell Biol 2002, 22:2515-2523
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 2515-2523
-
-
Laderoute, K.R.1
Calaoagan, J.M.2
Gustafson-Brown, C.3
Knapp, A.M.4
Li, G.C.5
Mendonca, H.L.6
Ryan, H.E.7
Wang, Z.8
Johnson, R.S.9
-
51
-
-
0036132872
-
c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription
-
Alfranca A, Gutierrez MD, Vara A, Aragones J, Vidal F and Landazuri MO c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription Mol Cell Biol 2002, 22:12-22
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 12-22
-
-
Alfranca, A.1
Gutierrez, M.D.2
Vara, A.3
Aragones, J.4
Vidal, F.5
Landazuri, M.O.6
-
52
-
-
0026497472
-
Sp1 and the subfamily of zinc finger proteins with guanine-rich binding sites
-
Berg JM Sp1 and the subfamily of zinc finger proteins with guanine-rich binding sites Proc Natl Acad Sci U S A 1992, 89:11109-11110
-
(1992)
Proc. Natl. Acad. Sci. U S A
, vol.89
, pp. 11109-11110
-
-
Berg, J.M.1
-
53
-
-
0034637541
-
Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure
-
Xu Q, Ji YS and Schmedtje JF Jr Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure J Biol Chem 2000, 275:24583-24589
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 24583-24589
-
-
Xu, Q.1
Ji, Y.S.2
Schmedtje Jr., J.F.3
-
54
-
-
0030576517
-
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
-
Hanahan D and Folkman J Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis Cell 1996, 86:353-364
-
(1996)
Cell
, vol.86
, pp. 353-364
-
-
Hanahan, D.1
Folkman, J.2
-
55
-
-
0034648765
-
Angiogenesis in cancer and other diseases
-
Carmeliet P and Jain RK Angiogenesis in cancer and other diseases Nature 2000, 407:249-257
-
(2000)
Nature
, vol.407
, pp. 249-257
-
-
Carmeliet, P.1
Jain, R.K.2
-
56
-
-
0023157363
-
Angiogenic factors
-
Folkman J and Klagsbrun M Angiogenic factors Science 1987, 235:442-447
-
(1987)
Science
, vol.235
, pp. 442-447
-
-
Folkman, J.1
Klagsbrun, M.2
-
57
-
-
0028114985
-
The implications of angiogenesis for the biology and therapy of cancer metastasis
-
Fidler IJ and Ellis LM The implications of angiogenesis for the biology and therapy of cancer metastasis Cell 1994, 79:185-188
-
(1994)
Cell
, vol.79
, pp. 185-188
-
-
Fidler, I.J.1
Ellis, L.M.2
-
58
-
-
0033848994
-
CXC chemokines in angiogenesis
-
Belperio JA, Keane MP, Arenberg DA, Addison CL, Ehlert JE, Burdick MD and Strieter RM CXC chemokines in angiogenesis J Leukoc Biol 2000, 68:1-8
-
(2000)
J. Leukoc. Biol.
, vol.68
, pp. 1-8
-
-
Belperio, J.A.1
Keane, M.P.2
Arenberg, D.A.3
Addison, C.L.4
Ehlert, J.E.5
Burdick, M.D.6
Strieter, R.M.7
-
60
-
-
0028364780
-
Expression of interleukin-8 correlates withe metastatic potential of human melanoma cells in nude mice
-
Singh RK, Gutman M, Radinsky R, Bucana CD and Fiedler IJ Expression of interleukin-8 correlates withe metastatic potential of human melanoma cells in nude mice Cancer Res 1994, 54:3242-3247
-
(1994)
Cancer Res.
, vol.54
, pp. 3242-3247
-
-
Singh, R.K.1
Gutman, M.2
Radinsky, R.3
Bucana, C.D.4
Fiedler, I.J.5
-
61
-
-
0026485002
-
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
-
Shweiki D, Itin A, Soffer D and Keshet E Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis Nature 1992, 359:843-845
-
(1992)
Nature
, vol.359
, pp. 843-845
-
-
Shweiki, D.1
Itin, A.2
Soffer, D.3
Keshet, E.4
-
62
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD and Semenza GL Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1 Mol Cell Biol 1996, 16:4604-4613
-
(1996)
Mol. Cell Biol.
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
Agani, F.4
Leung, S.W.5
Koos, R.D.6
Semenza, G.L.7
-
63
-
-
0029070920
-
Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells
-
Kuwabara K, Ogawa S, Matsumoto M, Koga S, Clauss M, Pinsky DJ, Lyn P, Leavy J, Witte L and Joseph-Silverstein J Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells Proc Natl Acad Sci U S A 1995, 92:4606-4610
-
(1995)
Proc. Natl. Acad. Sci. U S A
, vol.92
, pp. 4606-4610
-
-
Kuwabara, K.1
Ogawa, S.2
Matsumoto, M.3
Koga, S.4
Clauss, M.5
Pinsky, D.J.6
Lyn, P.7
Leavy, J.8
Witte, L.9
Joseph-Silverstein, J.10
-
64
-
-
0033119037
-
Hypoxia-induced up-regulation of angiogenin in human malignant melanoma
-
Hartmann A, Kunz M, Köstlin S, Gillitzer R, Toksoy A, Bröcker EB and Klein CE Hypoxia-induced up-regulation of angiogenin in human malignant melanoma Cancer Res 1999, 59:1578-1583
-
(1999)
Cancer Res.
, vol.59
, pp. 1578-1583
-
-
Hartmann, A.1
Kunz, M.2
Köstlin, S.3
Gillitzer, R.4
Toksoy, A.5
Bröcker, E.B.6
Klein, C.E.7
-
65
-
-
0033571167
-
Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells
-
Xu L, Xie K, Mukaida N, Matsushima K and Fidler IJ Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells Cancer Res 1999, 59:5822-5829
-
(1999)
Cancer Res.
, vol.59
, pp. 5822-5829
-
-
Xu, L.1
Xie, K.2
Mukaida, N.3
Matsushima, K.4
Fidler, I.J.5
-
66
-
-
0034652779
-
Candidate genes for the hypoxic tumor phenotype
-
Koong AC, Denko NC, Hudson KM, Schindler C, Swiersz L, Koch C, Evans S, Ibrahim H, Le QT and Terris DJ Candidate genes for the hypoxic tumor phenotype Cancer Res 2000, 60:883-887
-
(2000)
Cancer Res.
, vol.60
, pp. 883-887
-
-
Koong, A.C.1
Denko, N.C.2
Hudson, K.M.3
Schindler, C.4
Swiersz, L.5
Koch, C.6
Evans, S.7
Ibrahim, H.8
Le, Q.T.9
Terris, D.J.10
-
67
-
-
0035812284
-
Transcriptional response to hypoxia in human tumors
-
Lal A, Peters H, St Croix B, Haroon ZA, Dewhirst MW, Strausberg RL, Kaanders JH, van der Kogel AJ and Riggins GJ Transcriptional response to hypoxia in human tumors J Natl Cancer Inst 2001, 93:1337-1343
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 1337-1343
-
-
Lal, A.1
Peters, H.2
St. Croix, B.3
Haroon, Z.A.4
Dewhirst, M.W.5
Strausberg, R.L.6
Kaanders, J.H.7
van der Kogel, A.J.8
Riggins, G.J.9
-
68
-
-
0030856117
-
Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis
-
Desbaillets I, Diserens AC, de Tribolet N, Hamou MF and van Meir EG Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis J Exp Med 1997, 8:1201-1212
-
(1997)
J. Exp. Med.
, vol.8
, pp. 1201-1212
-
-
Desbaillets, I.1
Diserens, A.C.2
de Tribolet, N.3
Hamou, M.F.4
van Meir, E.G.5
-
69
-
-
0030701960
-
Halting angiogenesis suppresses carcinoma cell invasion
-
Skobe M, Rockwell P, Goldstein N, Vosseler S and Fusenig NE Halting angiogenesis suppresses carcinoma cell invasion Nat Med 1997, 3:1222-1227
-
(1997)
Nat. Med.
, vol.3
, pp. 1222-1227
-
-
Skobe, M.1
Rockwell, P.2
Goldstein, N.3
Vosseler, S.4
Fusenig, N.E.5
-
70
-
-
0024801035
-
Vascular permeability factor, an endothelial cell mitogen related to PDGF
-
Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J and Connolly DT Vascular permeability factor, an endothelial cell mitogen related to PDGF Science 1989, 246:1309-1312
-
(1989)
Science
, vol.246
, pp. 1309-1312
-
-
Keck, P.J.1
Hauser, S.D.2
Krivi, G.3
Sanzo, K.4
Warren, T.5
Feder, J.6
Connolly, D.T.7
-
71
-
-
0029006696
-
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
-
Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML and Schuh AC Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice Nature 1995, 376:62-66
-
(1995)
Nature
, vol.376
, pp. 62-66
-
-
Shalaby, F.1
Rossant, J.2
Yamaguchi, T.P.3
Gertsenstein, M.4
Wu, X.F.5
Breitman, M.L.6
Schuh, A.C.7
-
72
-
-
0026446102
-
Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo
-
Plate KH, Breier G, Weich HA and Risau W Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo Nature 1992, 359:845-848
-
(1992)
Nature
, vol.359
, pp. 845-848
-
-
Plate, K.H.1
Breier, G.2
Weich, H.A.3
Risau, W.4
-
73
-
-
0030031898
-
Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis
-
Claffey KP, Brown LF, del Aguila LF, Tognazzi K, Yeo KT, Manseau EJ and Dvorak HF Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis Cancer Res 1996, 56:172-181
-
(1996)
Cancer Res.
, vol.56
, pp. 172-181
-
-
Claffey, K.P.1
Brown, L.F.2
del Aguila, L.F.3
Tognazzi, K.4
Yeo, K.T.5
Manseau, E.J.6
Dvorak, H.F.7
-
74
-
-
0022399773
-
Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells
-
Fett JW, Strydom DJ, Lobb RR, Alderman EM, Bethune JL, Riordan JF and Vallee BL Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells Biochemistry 1985, 24:5480-5486
-
(1985)
Biochemistry
, vol.24
, pp. 5480-5486
-
-
Fett, J.W.1
Strydom, D.J.2
Lobb, R.R.3
Alderman, E.M.4
Bethune, J.L.5
Riordan, J.F.6
Vallee, B.L.7
-
75
-
-
0030975693
-
A putative angiogenin receptor in angiogenin-responsive human endothelial cells
-
Hu GF, Riordan JF and Vallee BL A putative angiogenin receptor in angiogenin-responsive human endothelial cells Proc Natl Acad Sci U S A 1997, 94:2204-2209
-
(1997)
Proc. Natl. Acad. Sci. U S A
, vol.94
, pp. 2204-2209
-
-
Hu, G.F.1
Riordan, J.F.2
Vallee, B.L.3
-
76
-
-
0028869431
-
Angiogenin antagonists prevent tumor growth in vivo
-
Olson KA, Fett JW, French TC, Key ME and Vallee BL Angiogenin antagonists prevent tumor growth in vivo Proc Natl Acad Sci USA 1995, 92:442-446
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 442-446
-
-
Olson, K.A.1
Fett, J.W.2
French, T.C.3
Key, M.E.4
Vallee, B.L.5
-
78
-
-
0027097806
-
Interleukin-8 as a macrophage derived mediator of angiogenesis
-
Koch AE, Polverini PJ, Kunkel SL, Harlow LA, DiPietro LA, Elner VM, Elner SG and Strieter RM Interleukin-8 as a macrophage derived mediator of angiogenesis Science 1992, 258:1798-1801
-
(1992)
Science
, vol.258
, pp. 1798-1801
-
-
Koch, A.E.1
Polverini, P.J.2
Kunkel, S.L.3
Harlow, L.A.4
DiPietro, L.A.5
Elner, V.M.6
Elner, S.G.7
Strieter, R.M.8
-
79
-
-
0025601628
-
Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines
-
Mukaida N, Mahe Y and Matsushima K Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines J Biol Chem 1990, 265:21128-21133
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 21128-21133
-
-
Mukaida, N.1
Mahe, Y.2
Matsushima, K.3
-
80
-
-
0025288872
-
Expression of cyr61, a growth factor-inducible immediate-early gene
-
O'Brien TP, Yang GP, Sanders L and Lau LF Expression of cyr61, a growth factor-inducible immediate-early gene Mol Cell Biol 1990, 10:3569-3577
-
(1990)
Mol. Cell Biol.
, vol.10
, pp. 3569-3577
-
-
O'Brien, T.P.1
Yang, G.P.2
Sanders, L.3
Lau, L.F.4
-
81
-
-
0035060101
-
NOV (nephroblastoma overexpressed) and the CCN family of genes: Structural and functional issues
-
Perbal B NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues Mol Pathol 2001, 54:57-79
-
(2001)
Mol. Pathol.
, vol.54
, pp. 57-79
-
-
Perbal, B.1
-
82
-
-
0032568608
-
CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth
-
Babic AM, Kireeva ML, Kolesnikova TV and Lau LF CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth Proc Natl Acad Sci U S A 1998, 95:6355-6360
-
(1998)
Proc. Natl. Acad. Sci. U S A
, vol.95
, pp. 6355-6360
-
-
Babic, A.M.1
Kireeva, M.L.2
Kolesnikova, T.V.3
Lau, L.F.4
-
83
-
-
0034667466
-
Expression and function of CYR61, an angiogenic factor, in breast cancer cell lines and tumor biopsies
-
Tsai MS, Hornby AE, Lakins J and Lupu R Expression and function of CYR61, an angiogenic factor, in breast cancer cell lines and tumor biopsies Cancer Res 2000, 60:5603-5607
-
(2000)
Cancer Res.
, vol.60
, pp. 5603-5607
-
-
Tsai, M.S.1
Hornby, A.E.2
Lakins, J.3
Lupu, R.4
-
84
-
-
0035841946
-
Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line
-
Shimo T, Kubota S, Kondo S, Nakanishi T, Sasaki A, Mese H, Matsumura T and Takigawa M Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line Cancer Lett 2001, 174:57-64
-
(2001)
Cancer Lett.
, vol.174
, pp. 57-64
-
-
Shimo, T.1
Kubota, S.2
Kondo, S.3
Nakanishi, T.4
Sasaki, A.5
Mese, H.6
Matsumura, T.7
Takigawa, M.8
-
85
-
-
0028951043
-
Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
-
Holmgren L, O'Reilly MS and Folkman J Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression Nat Med 1995, 1:149-153
-
(1995)
Nat. Med.
, vol.1
, pp. 149-153
-
-
Holmgren, L.1
O'Reilly, M.S.2
Folkman, J.3
-
86
-
-
0031929106
-
Tumor vascularity, proliferation, and apoptosis in human melanoma micrometastases and macrometastases
-
Barnhill RL, Piepkorn MW, Cochran AJ, Flynn E, Karaoli T and Folkman J Tumor vascularity, proliferation, and apoptosis in human melanoma micrometastases and macrometastases Arch Dermatol 1998, 134:991-994
-
(1998)
Arch. Dermatol.
, vol.134
, pp. 991-994
-
-
Barnhill, R.L.1
Piepkorn, M.W.2
Cochran, A.J.3
Flynn, E.4
Karaoli, T.5
Folkman, J.6
-
88
-
-
0030715323
-
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
-
Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES and Wang X Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade Cell 1997, 91:479-489
-
(1997)
Cell
, vol.91
, pp. 479-489
-
-
Li, P.1
Nijhawan, D.2
Budihardjo, I.3
Srinivasula, S.M.4
Ahmad, M.5
Alnemri, E.S.6
Wang, X.7
-
89
-
-
0032585644
-
Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury
-
Saikumar P, Dong Z, Patel Y, Hall K, Hopfer U, Weinberg JM and Venkatachalam MA Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury Oncogene 1998, 17:3401-3415
-
(1998)
Oncogene
, vol.17
, pp. 3401-3415
-
-
Saikumar, P.1
Dong, Z.2
Patel, Y.3
Hall, K.4
Hopfer, U.5
Weinberg, J.M.6
Venkatachalam, M.A.7
-
90
-
-
0028950645
-
Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL
-
Shimizu S, Eguchi Y, Kosaka H, Kamiike W, Matsuda H and Tsujimoto Y Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL Nature 1995, 374:811-813
-
(1995)
Nature
, vol.374
, pp. 811-813
-
-
Shimizu, S.1
Eguchi, Y.2
Kosaka, H.3
Kamiike, W.4
Matsuda, H.5
Tsujimoto, Y.6
-
91
-
-
0028939139
-
Programmed cell death and Bcl-2 protection in very low oxygen
-
Jacobson MD and Raff MC Programmed cell death and Bcl-2 protection in very low oxygen Nature 1995, 374:814-816
-
(1995)
Nature
, vol.374
, pp. 814-816
-
-
Jacobson, M.D.1
Raff, M.C.2
-
92
-
-
0034255036
-
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
-
Bruick RK Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia Proc Natl Acad Sci U S A 2000, 97:9082-9087
-
(2000)
Proc. Natl. Acad. Sci. U S A
, vol.97
, pp. 9082-9087
-
-
Bruick, R.K.1
-
93
-
-
0035199915
-
Hypoxia induces apoptosis via two independent pathways in Jurkat cells: Differential regulation by glucose
-
Malhotra R, Lin Z, Vincenz C and Brosius FC 3rd Hypoxia induces apoptosis via two independent pathways in Jurkat cells: differential regulation by glucose Am J Physiol Cell Physiol 2001, 281:C1596-C1603
-
(2001)
Am. J. Physiol. Cell Physiol.
, vol.281
-
-
Malhotra, R.1
Lin, Z.2
Vincenz, C.3
Brosius III, F.C.4
-
94
-
-
0034699330
-
Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression
-
Grotzer MA, Eggert A, Zuzak TJ, Janss AJ, Marwaha S, Wiewrodt BR, Ikegaki N, Brodeur GM and Phillips PC Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression Oncogene 2000, 19:4604-4610
-
(2000)
Oncogene
, vol.19
, pp. 4604-4610
-
-
Grotzer, M.A.1
Eggert, A.2
Zuzak, T.J.3
Janss, A.J.4
Marwaha, S.5
Wiewrodt, B.R.6
Ikegaki, N.7
Brodeur, G.M.8
Phillips, P.C.9
-
96
-
-
0031918244
-
Regulation of proliferation-survival decisions during tumor cell hypoxia
-
Schmaltz C, Hardenbergh PH, Wells A and Fisher DE Regulation of proliferation-survival decisions during tumor cell hypoxia Mol Cell Biol 1998, 18:2845-2854
-
(1998)
Mol. Cell Biol.
, vol.18
, pp. 2845-2854
-
-
Schmaltz, C.1
Hardenbergh, P.H.2
Wells, A.3
Fisher, D.E.4
-
97
-
-
0032568150
-
Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
-
An WG, Kanekal M, Simon MC, Maltepe E, Blagosklonny MV and Neckers LM Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha Nature 1998, 392:405-408
-
(1998)
Nature
, vol.392
, pp. 405-408
-
-
An, W.G.1
Kanekal, M.2
Simon, M.C.3
Maltepe, E.4
Blagosklonny, M.V.5
Neckers, L.M.6
-
98
-
-
0035855668
-
Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia
-
Suzuki H, Tomida A and Tsuruo T Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia Oncogene 2001, 20:5779-5788
-
(2001)
Oncogene
, vol.20
, pp. 5779-5788
-
-
Suzuki, H.1
Tomida, A.2
Tsuruo, T.3
-
99
-
-
0030884103
-
PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond
-
Marte BM and Downward J PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond Trends Biochem Sci 1997, 22:355-358
-
(1997)
Trends Biochem. Sci.
, vol.22
, pp. 355-358
-
-
Marte, B.M.1
Downward, J.2
-
100
-
-
0036710512
-
The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network
-
Mayo LD and Donner DB The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network Trends Biochem Sci 2002, 27:462-467
-
(2002)
Trends Biochem. Sci.
, vol.27
, pp. 462-467
-
-
Mayo, L.D.1
Donner, D.B.2
-
101
-
-
0035933726
-
Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: Protective role in apoptosis
-
Alvarez-Tejado M, Naranjo-Suarez S, Jimenez C, Carrera AC, Landazuri MO and del Peso L Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis J Biol Chem 2001, 276:22368-22374
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 22368-22374
-
-
Alvarez-Tejado, M.1
Naranjo-Suarez, S.2
Jimenez, C.3
Carrera, A.C.4
Landazuri, M.O.5
del Peso, L.6
-
102
-
-
0037118575
-
AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival
-
Bacus SS, Altomare DA, Lyass L, Chin DM, Farrell MP, Gurova K, Gudkov A and Testa JR AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival Oncogene 2002, 21:3532-3540
-
(2002)
Oncogene
, vol.21
, pp. 3532-3540
-
-
Bacus, S.S.1
Altomare, D.A.2
Lyass, L.3
Chin, D.M.4
Farrell, M.P.5
Gurova, K.6
Gudkov, A.7
Testa, J.R.8
-
103
-
-
17144436629
-
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
-
Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T and Davis T Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers Nat Genet 1997, 15:356-362
-
(1997)
Nat. Genet.
, vol.15
, pp. 356-362
-
-
Steck, P.A.1
Pershouse, M.A.2
Jasser, S.A.3
Yung, W.K.4
Lin, H.5
Ligon, A.H.6
Langford, L.A.7
Baumgard, M.L.8
Hattier, T.9
Davis, T.10
-
104
-
-
0030817576
-
PTEN gene mutations are seen in high-grade but not in low-grade gliomas
-
Rasheed BK, Stenzel TT, McLendon RE, Parsons R, Friedman AH, Friedman HS, Bigner DD and Bigner SH PTEN gene mutations are seen in high-grade but not in low-grade gliomas Cancer Res 1997, 57:4187-4190
-
(1997)
Cancer Res.
, vol.57
, pp. 4187-4190
-
-
Rasheed, B.K.1
Stenzel, T.T.2
McLendon, R.E.3
Parsons, R.4
Friedman, A.H.5
Friedman, H.S.6
Bigner, D.D.7
Bigner, S.H.8
-
105
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L and McCombie R PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer Science 1997, 275:1943-1947
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
-
106
-
-
0031004088
-
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
-
Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI, Zheng Z, Bose S, Call KM, Tsou HC and Peacocke M Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome Nat Genet 1997, 16:64-67
-
(1997)
Nat. Genet.
, vol.16
, pp. 64-67
-
-
Liaw, D.1
Marsh, D.J.2
Li, J.3
Dahia, P.L.4
Wang, S.I.5
Zheng, Z.6
Bose, S.7
Call, K.M.8
Tsou, H.C.9
Peacocke, M.10
-
107
-
-
0032506011
-
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
-
Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP and Tonks NK The lipid phosphatase activity of PTEN is critical for its tumor supressor function Proc Natl Acad Sci U S A 1998, 95:13513-13518
-
(1998)
Proc. Natl. Acad. Sci. U S A
, vol.95
, pp. 13513-13518
-
-
Myers, M.P.1
Pass, I.2
Batty, I.H.3
Van der Kaay, J.4
Stolarov, J.P.5
Hemmings, B.A.6
Wigler, M.H.7
Downes, C.P.8
Tonks, N.K.9
-
108
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F, Chen E, Gottschalk AR, Ryan HE, Johnson RS and Jefferson AB Loss of PTEN facilitates HIF-1-mediated gene expression Genes Dev 2000, 14:391-396
-
(2000)
Genes Dev.
, vol.14
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
Koong, A.4
Kaper, F.5
Chen, E.6
Gottschalk, A.R.7
Ryan, H.E.8
Johnson, R.S.9
Jefferson, A.B.10
-
109
-
-
0034854091
-
Regulation of PTEN transcription by p53
-
Stambolic V, MacPherson D, Sas D, Lin Y, Snow B, Jang Y, Benchimol S and Mak TW Regulation of PTEN transcription by p53 Mol Cell 2001, 8:317-325
-
(2001)
Mol. Cell
, vol.8
, pp. 317-325
-
-
Stambolic, V.1
MacPherson, D.2
Sas, D.3
Lin, Y.4
Snow, B.5
Jang, Y.6
Benchimol, S.7
Mak, T.W.8
-
110
-
-
0033572417
-
Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation
-
Alarcon R, Koumenis C, Geyer RK, Maki CG and Giaccia AJ Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation Cancer Res 1999, 59:6046-6051
-
(1999)
Cancer Res.
, vol.59
, pp. 6046-6051
-
-
Alarcon, R.1
Koumenis, C.2
Geyer, R.K.3
Maki, C.G.4
Giaccia, A.J.5
-
111
-
-
0034003005
-
Stress signals utilize multiple pathways to stabilize p53
-
Ashcroft M, Taya Y and Vousden KH Stress signals utilize multiple pathways to stabilize p53 Mol Cell Biol 2000, 20:3224-3233
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 3224-3233
-
-
Ashcroft, M.1
Taya, Y.2
Vousden, K.H.3
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