메뉴 건너뛰기




Volumn 181, Issue 1, 2003, Pages 68-78

α-Synuclein fibrils constitute the central core of oligodendroglial inclusion filaments in multiple system atrophy

Author keywords

Electron microscopy; Image analysis; Multiple system atrophy; Oligodendroglial inclusions; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; AMINO ACID; EPITOPE;

EID: 0037404112     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4886(03)00004-9     Document Type: Article
Times cited : (73)

References (38)
  • 1
    • 0031715398 scopus 로고    scopus 로고
    • NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy
    • Arima K., Uéda K., Sunohara N., Arakawa K., Hirai S., Nakamura M., Tonozuka-Uehara H., Kawai M. NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy. Acta Neuropathol. 96:1998;439-444.
    • (1998) Acta Neuropathol. , vol.96 , pp. 439-444
    • Arima, K.1    Uéda, K.2    Sunohara, N.3    Arakawa, K.4    Hirai, S.5    Nakamura, M.6    Tonozuka-Uehara, H.7    Kawai, M.8
  • 2
    • 0037155197 scopus 로고    scopus 로고
    • Lipid droplet binding and oligomerization properties of the Parkinson's disease protein α-synuclein
    • Cole N.B., Murphy D.D., Grider T., Rueter S., Brasaemle D., Nussbaum R.L. Lipid droplet binding and oligomerization properties of the Parkinson's disease protein α-synuclein. J. Biol. Chem. 277:2002;6344-6352.
    • (2002) J. Biol. Chem. , vol.277 , pp. 6344-6352
    • Cole, N.B.1    Murphy, D.D.2    Grider, T.3    Rueter, S.4    Brasaemle, D.5    Nussbaum, R.L.6
  • 3
    • 0031787871 scopus 로고    scopus 로고
    • Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease
    • Conway K.A., Harper J.D., Lansbury P.T. Jr. Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease. Nat. Med. 11:1998;1318-1320.
    • (1998) Nat. Med. , vol.11 , pp. 1318-1320
    • Conway, K.A.1    Harper, J.D.2    Lansbury P.T., Jr.3
  • 4
    • 0034646391 scopus 로고    scopus 로고
    • Fibrils formed in vitro from α-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid
    • Conway K.A., Harper J.D., Lansbury P.T. Jr. Fibrils formed in vitro from α-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid. Biochemistry. 39:2000;2551-2563.
    • (2000) Biochemistry , vol.39 , pp. 2551-2563
    • Conway, K.A.1    Harper, J.D.2    Lansbury P.T., Jr.3
  • 5
    • 0034613450 scopus 로고    scopus 로고
    • Characterisation of isolated α-synuclein filaments from substantia nigra of Parkinson's disease brain
    • Crowther R.A., Daniel S.E., Goedert M. Characterisation of isolated α-synuclein filaments from substantia nigra of Parkinson's disease brain. Neurosci. Lett. 292:2000;128-130.
    • (2000) Neurosci. Lett. , vol.292 , pp. 128-130
    • Crowther, R.A.1    Daniel, S.E.2    Goedert, M.3
  • 7
    • 0037135205 scopus 로고    scopus 로고
    • Oligodendrocytes from neural stem cells express α-synuclein: Increased numbers from presenilin I deficient mice
    • Culvenor J.G., Rietze R.L., Bartlett P.F., Masters C.L., Li Q.-X. Oligodendrocytes from neural stem cells express α-synuclein increased numbers from presenilin I deficient mice. NeuroReport. 19:2002;1305-1308.
    • (2002) NeuroReport , vol.19 , pp. 1305-1308
    • Culvenor, J.G.1    Rietze, R.L.2    Bartlett, P.F.3    Masters, C.L.4    Li, Q.-X.5
  • 10
    • 0035815115 scopus 로고    scopus 로고
    • Conformational proterties of α-synuclein in its free and lipid-associated states
    • Eliezer D., Kutluay E., Bussell R. Jr., Browne G. Conformational proterties of α-synuclein in its free and lipid-associated states. J. Mol. Biol. 307:2001;1061-1073.
    • (2001) J. Mol. Biol. , vol.307 , pp. 1061-1073
    • Eliezer, D.1    Kutluay, E.2    Bussell R., Jr.3    Browne, G.4
  • 11
    • 0029981526 scopus 로고    scopus 로고
    • Neuropathology of Parkinson's disease
    • Forno L.S. Neuropathology of Parkinson's disease. J. Neuropathol. Exp. Neurol. 55:1996;259-272.
    • (1996) J. Neuropathol. Exp. Neurol. , vol.55 , pp. 259-272
    • Forno, L.S.1
  • 12
    • 0032692501 scopus 로고    scopus 로고
    • α-Synuclein immunoisolation of glial inclusions from multiple system atrophy brain tissue reveals multiprotein components
    • Gai W.P., Power J.H.T., Blumbergs P.C., Culvenor J.G., Jensen P.H. α-Synuclein immunoisolation of glial inclusions from multiple system atrophy brain tissue reveals multiprotein components. J. Neurochem. 73:1999;2093-2100.
    • (1999) J. Neurochem. , vol.73 , pp. 2093-2100
    • Gai, W.P.1    Power, J.H.T.2    Blumbergs, P.C.3    Culvenor, J.G.4    Jensen, P.H.5
  • 13
    • 0033669319 scopus 로고    scopus 로고
    • In situ and in vitro study of colocalization and segregation of α-synuclein, ubiquitin, and lipids in Lewy bodies
    • Gai W.P., Yuan H.X., Li X.Q., Power J.T.H., Blumbergs P.C., Jensen P.H. In situ and in vitro study of colocalization and segregation of α-synuclein, ubiquitin, and lipids in Lewy bodies. Exp. Neurol. 166:2000;324-333.
    • (2000) Exp. Neurol. , vol.166 , pp. 324-333
    • Gai, W.P.1    Yuan, H.X.2    Li, X.Q.3    Power, J.T.H.4    Blumbergs, P.C.5    Jensen, P.H.6
  • 14
    • 0026563548 scopus 로고
    • Filaments of Lewy bodies contain insoluble cytoskeletal elements
    • Galloway P.G., Mulvihill P., Perry G. Filaments of Lewy bodies contain insoluble cytoskeletal elements. Am. J. Pathol. 140:1992;809-822.
    • (1992) Am. J. Pathol. , vol.140 , pp. 809-822
    • Galloway, P.G.1    Mulvihill, P.2    Perry, G.3
  • 15
    • 0035951869 scopus 로고    scopus 로고
    • A hydrophobic stretch of 12 amino acid residues in the middle of α-synuclein is essential for filament assembly
    • Giasson B.I., Murray I.V., Trojanowski J.Q., Lee V.M. A hydrophobic stretch of 12 amino acid residues in the middle of α-synuclein is essential for filament assembly. J. Biol. Chem. 276:2001;2380-2386.
    • (2001) J. Biol. Chem. , vol.276 , pp. 2380-2386
    • Giasson, B.I.1    Murray, I.V.2    Trojanowski, J.Q.3    Lee, V.M.4
  • 16
    • 0033583215 scopus 로고    scopus 로고
    • Mutant and wild type human α-synucleins assemble into elongated filaments with distinct morphologies in vitro
    • Giasson B.I., Uryu K., Trojanowski J.Q., Lee V.M.-Y. Mutant and wild type human α-synucleins assemble into elongated filaments with distinct morphologies in vitro. J. Biol. Chem. 274:1999;7619-7622.
    • (1999) J. Biol. Chem. , vol.274 , pp. 7619-7622
    • Giasson, B.I.1    Uryu, K.2    Trojanowski, J.Q.3    Lee, V.M.-Y.4
  • 18
    • 0035409575 scopus 로고    scopus 로고
    • α-Synuclein and neurodegenerative diseases
    • Goedert M. α-Synuclein and neurodegenerative diseases. Nat. Rev. Neurosci. 2:2001;492-501.
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 492-501
    • Goedert, M.1
  • 19
    • 0028985267 scopus 로고
    • The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
    • Iwai A., Masliah E., Yoshimoto M., Ge N., Flanagan L., de Silva H.A.R., Kittel A., Saitoh T. The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron. 14:1995;467-475.
    • (1995) Neuron , vol.14 , pp. 467-475
    • Iwai, A.1    Masliah, E.2    Yoshimoto, M.3    Ge, N.4    Flanagan, L.5    De Silva, H.A.R.6    Kittel, A.7    Saitoh, T.8
  • 21
    • 0034647557 scopus 로고    scopus 로고
    • Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds α-synuclein filaments
    • Jensen P.H., Islam K., Kenney J., Nielsen M.S., Power J., Gai W.P. Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds α-synuclein filaments. J. Biol. Chem. 275:2000;21500-21507.
    • (2000) J. Biol. Chem. , vol.275 , pp. 21500-21507
    • Jensen, P.H.1    Islam, K.2    Kenney, J.3    Nielsen, M.S.4    Power, J.5    Gai, W.P.6
  • 23
    • 0025359394 scopus 로고
    • Cytoplasmic argyrophilic inclusions in neurons of pontine nuclei in patients with olivopontocerebellar atrophy: Immunohistochemical and ultrastructural studies
    • Kato S., Nakamura H. Cytoplasmic argyrophilic inclusions in neurons of pontine nuclei in patients with olivopontocerebellar atrophy immunohistochemical and ultrastructural studies. Acta Neuropathol. 79:1990;584-594.
    • (1990) Acta Neuropathol. , vol.79 , pp. 584-594
    • Kato, S.1    Nakamura, H.2
  • 24
    • 0025999502 scopus 로고
    • Argyrophilic ubiquitinated cytoplasmic inclusions of Leu-7-positive glial cells in olivopontocerebellar atrophy (multiple system atrophy)
    • Kato S., Nakamura H., Hirano A., Ito H., Llena J.F., Yen S.H. Argyrophilic ubiquitinated cytoplasmic inclusions of Leu-7-positive glial cells in olivopontocerebellar atrophy (multiple system atrophy). Acta Neuropathol. 82:1991;488-493.
    • (1991) Acta Neuropathol. , vol.82 , pp. 488-493
    • Kato, S.1    Nakamura, H.2    Hirano, A.3    Ito, H.4    Llena, J.F.5    Yen, S.H.6
  • 25
    • 0031774904 scopus 로고    scopus 로고
    • The definition of multiple system atrophy: A review of recent developments
    • Lantos P.L. The definition of multiple system atrophy a review of recent developments. J. Neuropathol. Exp. Neurol. 57:1998;1099-1111.
    • (1998) J. Neuropathol. Exp. Neurol. , vol.57 , pp. 1099-1111
    • Lantos, P.L.1
  • 26
    • 0037166267 scopus 로고    scopus 로고
    • Biochemical characterization of the core structure of alpha-synuclein filaments
    • Miake H., Mizusawa H., Iwatsubo T., Hasegawa M. Biochemical characterization of the core structure of alpha-synuclein filaments. J. Biol. Chem. 277:2002;19213-19219.
    • (2002) J. Biol. Chem. , vol.277 , pp. 19213-19219
    • Miake, H.1    Mizusawa, H.2    Iwatsubo, T.3    Hasegawa, M.4
  • 29
    • 0034890258 scopus 로고    scopus 로고
    • Analysis of the expression level of α-synuclein mRNA using postmortem brain samples from pathologically confirmed cases of multiple system atrophy
    • Ozawa T., Okuizumi K., Ikeuchi T., Wakabayashi K., Takahashi H., Tsuji S. Analysis of the expression level of α-synuclein mRNA using postmortem brain samples from pathologically confirmed cases of multiple system atrophy. Acta Neuropathol. 102:2001;188-190.
    • (2001) Acta Neuropathol. , vol.102 , pp. 188-190
    • Ozawa, T.1    Okuizumi, K.2    Ikeuchi, T.3    Wakabayashi, K.4    Takahashi, H.5    Tsuji, S.6
  • 30
    • 0024843373 scopus 로고
    • Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)
    • Papp M.I., Kahn J.E., Lantos P.L. Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome). J. Neurol. Sci. 94:1989;79-100.
    • (1989) J. Neurol. Sci. , vol.94 , pp. 79-100
    • Papp, M.I.1    Kahn, J.E.2    Lantos, P.L.3
  • 31
    • 0034602271 scopus 로고    scopus 로고
    • Interaction of human α-synuclein and Parkinson's disease variatnts with phospholipids
    • Perrin R.J., Woods W.S., Clayton D.F., George J.M. Interaction of human α-synuclein and Parkinson's disease variatnts with phospholipids. J. Biol. Chem. 275:2000;34393-34398.
    • (2000) J. Biol. Chem. , vol.275 , pp. 34393-34398
    • Perrin, R.J.1    Woods, W.S.2    Clayton, D.F.3    George, J.M.4
  • 33
    • 0034712918 scopus 로고    scopus 로고
    • Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross conformation
    • Serpell L.C., Berruman J., Jakes R., Goedert M., Crowther R.A. Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross conformation. Proc. Natl. Acad. Sci. USA. 97:2000;4897-4902.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 4897-4902
    • Serpell, L.C.1    Berruman, J.2    Jakes, R.3    Goedert, M.4    Crowther, R.A.5
  • 34
    • 0032584686 scopus 로고    scopus 로고
    • Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
    • Spillantini M.G., Crowther R.A., Jakes R., Cairns N.J., Lantos P.L., Goedert M. Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci. Lett. 251:1998;205-208.
    • (1998) Neurosci. Lett. , vol.251 , pp. 205-208
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Cairns, N.J.4    Lantos, P.L.5    Goedert, M.6
  • 35
    • 0031661141 scopus 로고    scopus 로고
    • Abnormal distribution of the non-ab component of Alzheimer's disease precursor/a-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment
    • Takeda A., Hashimoto M., Mallory M., Sundsumo M., Hansen L., Sisk A., Masliah E. Abnormal distribution of the non-ab component of Alzheimer's disease precursor/a-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment. Lab. Invest. 78:1998;1169-1177.
    • (1998) Lab. Invest. , vol.78 , pp. 1169-1177
    • Takeda, A.1    Hashimoto, M.2    Mallory, M.3    Sundsumo, M.4    Hansen, L.5    Sisk, A.6    Masliah, E.7
  • 37
    • 0029904487 scopus 로고    scopus 로고
    • NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded
    • Weinreb P.H., Zhen W., Poon A.W., Conway K.A., Lansbury P.T. Jr. NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry. 35:1996;13709-13715.
    • (1996) Biochemistry , vol.35 , pp. 13709-13715
    • Weinreb, P.H.1    Zhen, W.2    Poon, A.W.3    Conway, K.A.4    Lansbury P.T., Jr.5
  • 38
    • 0029919723 scopus 로고    scopus 로고
    • Expression and distribution of surfactant proteins and lysozyme after prolonged hyperpnea
    • Yogalingam G., Doyle I.R., Power J.H.T. Expression and distribution of surfactant proteins and lysozyme after prolonged hyperpnea. Am. J. Physiol. 270:1996;L320-L330.
    • (1996) Am. J. Physiol. , vol.270
    • Yogalingam, G.1    Doyle, I.R.2    Power, J.H.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.