26 S proteasomes function as stable entities

Journal of Molecular Biology

Volumn 315, Issue 4, 2002, Pages 627-636

  Hendil, Klavs B ^a   Hartmann Petersen, Rasmus ^a   Tanaka, Keiji ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Proteasome; Protein degradation; Protein machine; Subunit exchange; Ubiquitin

Indexed keywords

CELL EXTRACT; PROTEASOME; UBIQUITIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEGRADATION; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME BINDING; ENZYME STABILITY; ENZYME SUBUNIT; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION;

EUKARYOTA;

EID: 0036304476     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5285     Document Type: Article

References (56)

1. The ubiquitin system
2. Themes and variations on ubiquitylation
3. The proteasome, a novel protease regulated by multiple mechanisms
4. The 26 S proteasome: A molecular machine designed for controlled proteolysis
5. Crystal structure of the 20 S proteasome from the archaeon T. acidophilum at 3.4 Å resolution
6. Structure of 20 S proteasome from yeast at 2.4 Å resolution
7. A gated channel into the proteasome core particle
8. The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release
9. ATP-dependent inactivation and sequestration of ornithine decarboxylase by the 26 S proteasome are prerequisites for degradation
10. The regulatory complex of Drosophila melanogaster 26 S proteasomes. Subunit composition and localization of a deubiquitylating enzyme
11. The base of the proteasome regulatory particle exhibits chaperone-like activity
12. Recogition of misfolding proteins by PA700, the regulatory subcomplex of the 26 S proteasome
13. +
14. Electron microscopy and image analysis reveal common principles of organization in two large protein complexes: groEL-type proteins and proteasomes
15. Structure and function in GroEL-mediated protein folding
16. ATP-dependent incorporation of 20 S protease into the 26 S complex that degrades proteins conjugated to ubiquitin
17. Assembly of the 26 S complex that degrades proteins ligated to ubiquitin is accompanied by the formation of ATPase activity
18. ATP-dependent reversible association of proteasomes with multiple protein components to form 26 S complexes that degrade ubiquitinated proteins in human HL-60 cells
19. Multiple forms of the 20-S multicatalytic and the 26-S ubiquitin/ATP-dependent proteases from rabbit reticulocyte lysate
20. The 26 S proteasome
21. ClpA and ClpP remain associated during multiple rounds of ATP-dependent protein degradation by ClpAP protease
22. A 26 S protease subunit that binds ubiquitin conjugates
23. Yeast counterparts of subunits S5a and p58 (S3) of the human 26 S proteasome are encoded by two multicopy suppressors of nin1-1
24. Proteins containing the UBA domain are able to bind to multi-ubiquitin chains
25. The multiubiquitin-chain-binding protein Mcb1 is a component of the 265 proteasome in Saccharomyces cerevisiae and plays a nonessential, substrate-specific role in protein turnover
26. Analysis of a gene encoding Rpn10 of the fission yeast proteasome reveals that the polyubiquitin-binding site of this subunit is essential when Rpn11/Mts3 activity is compromised
27. Cloning and sequencing a non-ATPase subunit of the regulatory complex of the Drosophila 26 S protease
28. Simultaneous binding of PA28 and PA700 activators to 20 S proteasomes
29. Hybrid proteasomes. Induction by interferon-γ and contribution to ATP-dependent proteolysis
30. Human proteasome subunits from 2-dimensional gels identified by partial sequencing
31. A rapid, sensitive method for detection of alkaline phosphatase-conjugated anti-antibody on Western blots
32. Demonstration that a human 26 S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms
33. 2-Macroglobulin: Fast and sensitive analysis with monoclonal antibodies
34. A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20 S proteasome) induces accumulation of ubiquitin protein conjugates in a neuronal cell
35. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
36. The 19 S multicatalytic "Prosome" proteinase is a constitutive enzyme in HeLa cells
37. A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3
38. The proteasome
39. Visualization of substrate binding and translocation by the ATPase-dependent protease, ClpXP
40. Translocation pathway of protein substrates in ClpAP protease
41. ClpA mediates directional translocation of substrate proteins into the ClpP protease
42. Crystal structures of the HslVU peptidase-ATPase complex reveal an ATP-dependent proteolysis mechanism
43. Functional analysis of the proteasome regulatory particle
44. Characteristics of 26 S proteases from fission yeast mutants, which arrest in mitosis
45. Degradation of oxidized insulin B chain by the multiproteinase complex macropain (Proteasome)
46. Processive degradation of proteins by the ATP-dependent Clp protease from Escherichia coli-requirement for the multiple array of active sites in ClpP but not ATP hydrolysis
47. Processive degradation of proteins and other catalytic properties of the proteasome from Thermoplasma acidophilum
48. Cleavage motifs of the yeast 20 S proteasome beta subunits deduced from digests of enolase 1
49. The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes-implications for understanding the degradative mechanism and antigen presentation
50. ATP-dependent proteases degrade their substrates by processively unraveling them from the degradation signal
51. Degradation of oxidized proteins by the 20 S proteasome
52. Degradation of ornithine decarboxylase by the 26 S proteasome
53. 26 S proteasome structure revealed by three-dimensional electron microscopy
54. Human proteasomes analysed with monoclonal antibodies
55. Effect of halogenated pyrimidines and thymidine on growth of L-cells and a subline lacking thymidine kinase
56. Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate