Regulation of the p73 protein stability and degradation

Biochemical and Biophysical Research Communications

Volumn 331, Issue 3, 2005, Pages 707-712

  Oberst, Andrew ^a   Rossi, Mario ^b   Salomoni, Paolo ^b   Pandolfi, Pier Paolo ^c   Oren, Moshe ^d   Melino, Gerry ^a,b   Bernassola, Francesca ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Apoptosis; Cell cycle; Cell death; DNA damage; Itch; Nedd8; p53; p73; Protein stability; Ubiquitination

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NEDD8 PROTEIN; NITROGEN; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN P300; PROTEIN P73;

ACETYLATION; APOPTOSIS; CANCER; CELL NUCLEUS INCLUSION BODY; CELL PROLIFERATION; GENE MUTATION; HUMAN; ISOMERIZATION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; REVIEW; TRANSACTIVATION; UBIQUITINATION;

EID: 18144426821     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.03.158     Document Type: Review

References (49)

1. A. Yang, and F. McKeon P63 and P73: P53 mimics, menaces and more Nat. Rev. Mol. Cell Biol. 1 2000 199 207
2. G. Melino, V. De Laurenzi, and K.H. Vousden p73: Friend or foe in tumorigenesis Nat. Rev. Cancer 2 2002 605 615
3. A. Yang, M. Kaghad, D. Caput, and F. McKeon On the shoulders of giants: p63, p73 and the rise of p53 Trends Genet. 18 2002 90 95
4. W.C. Weinberg, C.G. Azzoli, K. Chapman, A.J. Levine, and S.H. Yuspa p53-mediated transcriptional activity increases in differentiating epidermal keratinocytes in association with decreased p53 protein Oncogene 10 1995 2271 2279
5. D. Lane, and E. Harlow Two different viral transforming proteins bind the same host tumour antigen Nature 298 1982 517
6. M. Oren, N.C. Reich, and A.J. Levine Regulation of the cellular p53 tumor antigen in teratocarcinoma cells and their differentiated progeny Mol. Cell. Biol. 2 1982 443 449
7. M. Kaghad, H. Bonnet, A. Yang, L. Creancier, J.C. Biscan, A. Valent, A. Minty, P. Chalon, J.M. Lelias, X. Dumont, P. Ferrara, F. McKeon, and D. Caput Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers Cell 90 1997 809 819
8. C.A. Jost, M.C. Marin, and W.G. Kaelin Jr. p73 is a simian [correction of human] p53-related protein that can induce apoptosis Nature 389 1997 191 194
9. H. Schmale, and C. Bamberger A novel protein with strong homology to the tumor suppressor p53 Oncogene 15 1997 1363 1367
10. M. Osada, M. Ohba, C. Kawahara, C. Ishioka, R. Kanamaru, I. Katoh, Y. Ikawa, Y. Nimura, A. Nakagawara, M. Obinata, and S. Ikawa Cloning and functional analysis of human p51, which structurally and functionally resembles p53 Nat. Med. 4 1998 839 843
11. V. De Laurenzi, A. Costanzo, D. Barcaroli, A. Terrinoni, M. Falco, M. Annicchiarico-Petruzzelli, M. Levrero, and G. Melino Two new p73 splice variants, gamma and delta, with different transcriptional activity J. Exp. Med. 188 1998 1763 1768
12. A.E. Sayan, M. Rossi, G. Melino, and R.A. Knight p73: in silico evidence for a putative third promoter region Biochem. Biophys. Res. Commun. 313 2004 765 770
13. T.J. Grob, U. Novak, C. Maisse, D. Barcaroli, A.U. Luthi, F. Pirnia, B. Hugli, H.U. Graber, V. De Laurenzi, M.F. Fey, G. Melino, and A. Tobler Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53 Cell Death Differ. 8 2001 1213 1223
14. S. Ichimiya, Y. Nimura, H. Kageyama, N. Takada, M. Sunahara, T. Shishikura, Y. Nakamura, S. Sakiyama, N. Seki, M. Ohira, Y. Kaneko, F. McKeon, D. Caput, and A. Nakagawara p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent Oncogene 18 1999 1061 1066
15. A.I. Zaika, N. Slade, S.H. Erster, C. Sansome, T.W. Joseph, M. Pearl, E. Chalas, and U.M. Moll DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors J. Exp. Med. 196 2002 765 780
16. B.M. Putzer, S. Tuve, A. Tannapfel, and T. Stiewe Increased DeltaN-p73 expression in tumors by upregulation of the E2F1-regulated, TA-promoter-derived DeltaN′-p73 transcript Cell Death Differ. 10 2003 612 614
17. I. Casciano, K. Mazzocco, L. Boni, G. Pagnan, B. Banelli, G. Allemanni, M. Ponzoni, G.P. Tonini, and M. Romani Expression of DeltaNp73 is a molecular marker for adverse outcome in neuroblastoma patients Cell Death Differ. 9 2002 246 251
18. N. Concin, K. Becker, N. Slade, S. Erster, E. Mueller-Holzner, H. Ulmer, G. Daxenbichler, A. Zeimet, R. Zeillinger, C. Marth, and U.M. Moll Transdominant DeltaTAp73 isoforms are frequently up-regulated in ovarian cancer. Evidence for their role as epigenetic p53 inhibitors in vivo Cancer Res. 64 2004 2449 2460
19. A. Yang, N. Walker, R. Bronson, M. Kaghad, M. Oosterwegel, J. Bonnin, C. Vagner, H. Bonnet, P. Dikkes, A. Sharpe, F. McKeon, and D. Caput p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours Nature 404 2000 99 103
20. C.D. Pozniak, F. Barnabe-Heider, V.V. Rymar, A.F. Lee, A.F. Sadikot, and F.D. Miller p73 is required for survival and maintenance of CNS neurons J. Neurosci. 22 2002 9800 9809
21. C.D. Pozniak, S. Radinovic, A. Yang, F. McKeon, D.R. Kaplan, and F.D. Miller An anti-apoptotic role for the p53 family member, p73, during developmental neuron death Science 289 2000 304 306
22. V. De Laurenzi, G. Raschella, D. Barcaroli, M. Annicchiarico-Petruzzelli, M. Ranalli, M.V. Catani, B. Tanno, A. Costanzo, M. Levrero, and G. Melino Induction of neuronal differentiation by p73 in a neuroblastoma cell line J. Biol. Chem. 275 2000 15226 15231
23. F. Bernassola, P. Salomoni, A. Oberst, C.J. Di Como, M. Pagano, G. Melino, and P.P. Pandolfi Ubiquitin-dependent degradation of p73 is inhibited by PML J. Exp. Med. 199 2004 1545 1557
24. E. Balint, S. Bates, and K.H. Vousden Mdm2 binds p73 alpha without targeting degradation Oncogene 18 1999 3923 3929
25. R. Agami, G. Blandino, M. Oren, and Y. Shaul Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis Nature 399 1999 809 813
26. Z.M. Yuan, H. Shioya, T. Ishiko, X. Sun, J. Gu, Y.Y. Huang, H. Lu, S. Kharbanda, R. Weichselbaum, and D. Kufe p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage Nature 399 1999 814 817
27. D. Bergamaschi, M. Gasco, L. Hiller, A. Sullivan, N. Syed, G. Trigiante, I. Yulug, M. Merlano, G. Numico, A. Comino, M. Attard, O. Reelfs, B. Gusterson, A.K. Bell, V. Heath, M. Tavassoli, P.J. Farrell, P. Smith, X. Lu, and T. Crook p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis Cancer Cell 3 2003 387 402
28. C. Maisse, E. Munarriz, D. Barcaroli, G. Melino, and V. De Laurenzi DNA damage induces the rapid and selective degradation of the DeltaNp73 isoform, allowing apoptosis to occur Cell Death Differ. 11 2004 685 687
29. M. Rossi, V. De Laurenzi, E. Munarriz, D.R. Green, Y.C. Liu, K.H. Vousden, G. Cesareni, and G. Melino The ubiquitin-protein ligase Itch regulates p73 stability EMBO J. 2005
30. X. Wu, J.H. Bayle, D. Olson, and A.J. Levine The p53-mdm-2 autoregulatory feedback loop Genes Dev. 7 1993 1126 1132
31. J. Gu, D. Chen, J. Rosenblum, R.M. Rubin, and Z.M. Yuan Identification of a sequence element from p53 that signals for Mdm2-targeted degradation Mol. Cell. Biol. 20 2000 1243 1253
32. X. Zeng, L. Chen, C.A. Jost, R. Maya, D. Keller, X. Wang, W.G. Kaelin Jr., M. Oren, J. Chen, and H. Lu MDM2 suppresses p73 function without promoting p73 degradation Mol. Cell. Biol. 19 1999 3257 3266
33. J. Gu, L. Nie, D. Wiederschain, and Z.M. Yuan Identification of p53 sequence elements that are required for MDM2-mediated nuclear export Mol. Cell. Biol. 21 2001 8533 8546
34. X.Q. Wang, W.M. Ongkeko, A.W. Lau, K.M. Leung, and R.Y. Poon A possible role of p73 on the modulation of p53 level through MDM2 Cancer Res. 61 2001 1598 1603
35. M. Ohh, W.Y. Kim, J.J. Moslehi, Y. Chen, V. Chau, M.A. Read, and W.G. Kaelin Jr. An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells EMBO Rep. 3 2002 177 182
36. E. Querido, P. Blanchette, Q. Yan, T. Kamura, M. Morrison, D. Boivin, W.G. Kaelin, R.C. Conaway, J.W. Conaway, and P.E. Branton Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex Genes Dev. 15 2001 3104 3117
37. D.P. Xirodimas, M.K. Saville, J.C. Bourdon, R.T. Hay, and D.P. Lane Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity Cell 118 2004 83 97
38. W.H. Toh, M.M. Siddique, L. Boominathan, K.W. Lin, and K. Sabapathy c-Jun regulates the stability and activity of the p53 homologue, p73 J. Biol. Chem. 279 2004 44713 44722
39. C.W. Lee, and N.B. La Thangue Promoter specificity and stability control of the p53-related protein p73 Oncogene 18 1999 4171 4181
40. J.G. Gong, A. Costanzo, H.Q. Yang, G. Melino, W.G. Kaelin Jr., M. Levrero, and J.Y. Wang The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage Nature 399 1999 806 809
41. R. Sanchez-Prieto, J.M. Rojas, Y. Taya, and J.S. Gutkind A role for the p38 mitogen-activated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents Cancer Res. 60 2000 2464 2472
42. A. Costanzo, P. Merlo, N. Pediconi, M. Fulco, V. Sartorelli, P.A. Cole, G. Fontemaggi, M. Fanciulli, L. Schiltz, G. Blandino, C. Balsano, and M. Levrero DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes Mol. Cell 9 2002 175 186
43. A. Minty, X. Dumont, M. Kaghad, and D. Caput Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif J. Biol. Chem. 275 2000 36316 36323
44. F. Mantovani, S. Piazza, M. Gostissa, S. Strano, P. Zacchi, R. Mantovani, G. Blandino, and G. Del Sal Pin1 links the activities of c-Abl and p300 in regulating p73 function Mol. Cell 14 2004 625 636
45. A. Guo, P. Salomoni, J. Luo, A. Shih, S. Zhong, W. Gu, and P. Paolo Pandolfi The function of PML in p53-dependent apoptosis Nat. Cell Biol. 2 2000 730 736
46. M. Pearson, R. Carbone, C. Sebastiani, M. Cioce, M. Fagioli, S. Saito, Y. Higashimoto, E. Appella, S. Minucci, P.P. Pandolfi, and P.G. Pelicci PML regulates p53 acetylation and premature senescence induced by oncogenic Ras Nature 406 2000 207 210
47. P. Zacchi, M. Gostissa, T. Uchida, C. Salvagno, F. Avolio, S. Volinia, Z. Ronai, G. Blandino, C. Schneider, and G. Del Sal The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults Nature 419 2002 853 857
48. K. Miyazaki, T. Ozaki, C. Kato, T. Hanamoto, T. Fujita, S. Irino, K. Watanabe, T. Nakagawa, and A. Nakagawara A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity Biochem. Biophys. Res. Commun. 308 2003 106 113
49. G. Asher, P. Tsvetkov, C. Kahana, and Y. Shaul A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73 Genes Dev. 19 2005 316 321