P73: In silico evidence for a putative third promoter region

Biochemical and Biophysical Research Communications

Volumn 313, Issue 3, 2004, Pages 765-770

  Sayan, A Emre ^a   Rossi, Mario ^a   Melino, Gerry ^a,b   Knight, Richard A ^c  

^a MRC TOXICOLOGY UNIT   (United Kingdom)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Apoptosis; Genomic organization; p73; Promoter region

Indexed keywords

PROTEIN P73; TRANSCRIPTION FACTOR;

ARTICLE; COMPUTER MODEL; COMPUTER PROGRAM; CONTROLLED STUDY; GENE STRUCTURE; HUMAN; INTRON; MOUSE; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN MOTIF; RNA SPLICING; TRANSCRIPTION INITIATION;

EID: 0347063996     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.12.014     Document Type: Article

References (32)

1. Kaghad M., Bonnet H., Yang A., Creancier L., Biscan J., Valent A., Minty A., Chalon P., Lelias J., Dumont X., Ferrara P., McKeon F., Caput D. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell. 90:1997;809-819.
2. Catani M.V., Costanzo A., Savini I., Levrero M., de Laurenzi V., Wang J.Y., Melino G., Avigliano L. Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage. Biochem. J. 364:2002;441-447.
3. Pucci B., Claudio P.P., Masciullo V., Bellincampi L., Terrinoni A., Khalili K., Melino G., Giordano A. pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation. Oncogene. 21:2002;5897-5905.
4. De Laurenzi V., Rossi A., Terrinoni A., Barcaroli D., Levrero M., Costanzo A., Knight R.A., Guerrieri P., Melino G. p63 and p73 transactivate differentiation gene promoters in human keratinocytes. Biochem. Biophys. Res. Commun. 273:2000;342-346.
5. Gong J.G., Costanzo A., Yang H.Q., Melino G., Kaelin W.G. Jr., Levrero M., Wang J.Y. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature. 399:1999;806-809.
6. De Laurenzi V., Raschella G., Barcaroli D., Annicchiarico-Petruzzelli M., Ranalli M., Catani M.V., Tanno B., Costanzo A., Levrero M., Melino G. Induction of neuronal differentiation by p73 in a neuroblastoma cell line. J. Biol. Chem. 275:2000;15226-15231.
7. De Laurenzi V., Costanzo A., Barcaroli D., Terrinoni A., Falco M., Annicchiarico-Petruzzelli M., Levrero M., Melino G. Two new p73 splice variants, gamma and delta, with different transcriptional activity. J. Exp. Med. 188:1998;1763-1768.
8. Melino G., De Laurenzi V., Vousden K. p73: friend or foe in tumorigenesis. Nat. Rev. Cancer. 2:2002;605-615.
9. Yang A., Kaghad M., Caput D., McKeon F. On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet. 18:2002;90-95.
10. Yang A., McKeon F. P63 and P73: P53 mimics, menaces and more. Nat. Rev. Mol. Cell Biol. 1:2000;199-207.
11. Stiewe T., Putzer B.M. Role of p73 in malignancy: tumor suppressor or oncogene? Cell Death Differ. 9:2002;237-245.
12. Zaika A.I., Kovalev S., Marchenko N.D., Moll U.M. Overexpression of the wild type p73 gene in breast cancer tissues and cell lines. Cancer Res. 59:1999;3257-3263.
13. De Laurenzi V.D., Catani M.V., Terrinoni A., Corazzari M., Melino G., Costanzo A., Levrero M., Knight R.A. Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants epsilon and zeta. Cell Death Differ. 6:1999;389-390.
14. Yang A., Walker N., Bronson R., Kaghad M., Oosterwegel M., Bonnin J., Vagner C., Bonnet H., Dikkes P., Sharpe A., McKeon F., Caput D. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature. 404:2000;99-103.
15. ′ -p73 transcript Cell Death Differ. 10:2003;612-614.
16. Fillippovich I., Sorokina N., Gatei M., Haupt Y., Hobson K., Moallem E., Spring K., Mould M., McGuckin M.A., Lavin M.F., Khanna K.K. Transactivation- deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53. Oncogene. 20:2001;514-522.
17. Stiewe T., Theseling C.C., Putzer B.M. Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis. J. Biol. Chem. 277:2002;14177-14185.
18. Grob T.J., Novak U., Maisse C., Barcaroli D., Luthi A.U., Pirnia F., Hugli B., Graber H.U., De Laurenzi V., Fey M.F., Melino G., Tobler A. Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53. Cell Death Differ. 8:2001;1213-1223.
19. Casciano I., Mazzocco K., Boni L., Pagnan G., Banelli B., Allemanni G., Ponzoni M., Tonini G., Romani M. Expression of DeltaNp73 is a molecular marker for adverse outcome in neuroblastoma patients. Cell Death Differ. 9:2002;246-251.
20. Douc-Rasy S., Barrois M., Echeynne M., Kaghad M., Blanc E., Raguenez G., Goldschneider D., Terrier-Lacombe M.J., Hartmann O., Moll U., Caput D., Benard J. DeltaN-p73alpha accumulates in human neuroblastic tumors. Am. J. Pathol. 160:2002;631-639.
21. Zaika A.I., Slade N., Erster S.H., Sansome C., Joseph T.W., Pearl M., Chalas E., Moll U.M. DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors. J. Exp. Med. 196:2002;765-780.
22. Sayan A.E., Sayan B.S., Findikli N., Ozturk M. Acquired expression of transcriptionally active p73 in hepatocellular carcinoma cells. Oncogene. 20:2001;5111-5117.
23. Fontemaggi G., Gurtner A., Strano S., Higashi Y., Sacchi A., Piaggio G., Blandino G. The transcriptional repressor ZEB regulates p73 expression at the crossroad between proliferation and differentiation. Mol. Cell. Biol. 21:2001;8461-8470.
24. Solvyev V. Finding genes by computer: probabilistic and discriminative approaches. Jiang T., Smith T., Xu Y., Zhang M. Current Topics in Computational Biology. 2002;MIT Press.
25. Rogic S., Ouellette B.F., Mackworth A.K. Improving gene recognition accuracy by combining predictions from two gene-finding programs. Bioinformatics. 18:2002;1034-1045.
26. Parra G., Blanco E., Guigo R. GeneID in Drosophila. Genome Res. 10:2000;511-515.
27. Davuluri R.V., Grosse I., Zhang M.Q. Computational identification of promoters and first exons in the human genome. Nat. Genet. 29:2001;412-417.
28. Koshizuka Y., Ikegawa S., Sano M., Nakamura K., Nakamura Y. Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family. Genomics. 72:2001;252-259.
29. Levrero M., De Laurenzi V., Costanzo A., Gong J., Wang J.Y., Melino G. The p53/p63/p73 family of transcription factors: overlapping and distinct functions. J. Cell Sci. 113(Pt 10):2000;1661-1670.
30. Melino G., Lu X., Gasco M., Crook T., Knight R.A. Functional regulation of p73 and p63: development and cancer. Trends Biochem. Sci. 28:2003;663-670.
31. Stiewe T., Zimmermann S., Frilling A., Esche H., Putzer B. Transactivation-deficient DeltaTA-p73 acts as an oncogene. Cancer Res. 62:2002;3598-3602.
32. Vossio S., Palescandolo E., Pediconi N., Moretti F., Balsano C., Levrero M., Costanzo A. DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest. Oncogene. 21:2002;3796-3803.