p73 is required for survival and maintenance of CNS neurons

Journal of Neuroscience

Volumn 22, Issue 22, 2002, Pages 9800-9809

  Pozniak, Christine D ^a   Barnabé Heider, Fanie ^a,b   Rymar, Vladimir V ^a   Lee, Anna F ^a,b   Sadikot, Abbas F ^a   Miller, Freda D ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

Author keywords

Camptothecin; Cortical neurons; Facial motor neurons; Neuronal apoptosis; Neuronal degeneration; Neuronal development; Neuronal survival; Olfactory bulb; P13 kinase; p53; p73

Indexed keywords

CAMPTOTHECIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P73;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CELL; BRAIN CORTEX; CELL DEATH; CELL MATURATION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; MOTONEURON; MOUSE; NERVE CELL; NERVE CELL DEGENERATION; NONHUMAN; OLFACTORY BULB; PERINATAL PERIOD; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0037112245     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-22-09800.2002     Document Type: Article

References (42)

1. Aloyz RS, Bamji SX, Pozniak CD, Toma JG, Atwal J, Kaplan DR, Miller FD (1998) p53 is essential for developmental neuron death as regulated by the TrkA and p73 neurotrophin receptors. J Cell Biol 143:1691-1703.
2. Alvarez-Buylla A, Garcia-Verdugo JM (2002) Neurogenesis in adult subventricular zone. J Neurosci 22:629-634.
3. Couper LJM, Devine AH, Brunjes PC (2000) Focal denervation alters cellular phenotypes and survival in the rat olfactory bulb: A developmental analysis. J Comp Neurol 425:409-421.
4. Cregan SP, MacLaurin JG, Craig CG, Robertson GS, Nicholson DW, Park DS, Slack RS (1999) Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons. J Neurosci 19:7860-7869.
5. Enokido Y, Araki T, Tanaka K, Aizawa S, Hatanaka H (1996) Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons. Eur J Neurosci 8:1812-1821.
6. Fillippovich I, Sorokina N, Gatei M, Haupt Y, Hobson K, Moallem E, Spring K, Mould M, McGuckin MA, Lavin MF, Khanna KK (2001) Transactivation-deficient p73 alpha (p73Deltaexon2) inhibits apoptosis and competes with p53. Oncogene 20:514-522.
7. Fiske BK, Brunjes PC (2001) Cell death in the developing and sensory-deprived rat olfactory bulb. J Comp Neurol 431:311-319.
8. Fortin A, Cregan SP, MacLaurin JG, Kushwaha N, Hickman ES, Thompson CS, Hakim A, Albert PR, Cecconi F, Helin K, Park DS, Slack RS (2001) Apaf1 is a key transcriptional target for p53 in the regulation of neuronal cell death. J Cell Biol 155:207-216.
9. Franklin KBJ, Paxinos G (1997) The Mouse Brain in Stereotaxic Coordinates. New York: Academic.
10. Govoni G, Kaplan DR, Miller FD (2001) Analysis of the p53 family member, p63, during neuronal development and apoptosis. Soc Neurosci Abstr 27:595.37.
11. Grieshammer U, Lewandoski M, Prevette D, Oppenheim RW, Martin GR, Pettmann B, Henderson CE (1998) Muscle-specific cell ablation conditional upon Cre-mediated DNA recombination in transgenic mice leads to massive spinal and cranial motoneuron loss. Neuron 20:633-647.
12. Grob TJ, Novak U, Maisse C, Barcaroli D, Luthi AU, Pirnia F, Hugli B, Graber HU, De Laurenzi V, Fey MF, Melino G, Tobler A (2001) Human deltaNp73 regulates dominant-negative feedback loop for TAp73 and p53. Cell Death Differ 8:1213-1223.
13. Hetman M, Kanning K, Cavanaugh JE, Xia Z (1999) Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. J Biol Chem 274:22569-22580.
14. Jacobowitz DM, Abbott LC (1998) Chemoarchitectonic Atlas of the Developing Mouse Brain. Boca Raton, FL: CRC.
15. Jordan J, Galindo MF, Prehn JG, Weichselbaum RR, Beckett M, Ghadge GD, Roos RP, Leiden JM, Miller RJ (1997) p53 expression induces apoptosis in hippocampal pyramidal neuron cultures. J Neurosci 17:1397-1405.
16. Jost CA, Marin MC, Kaelin Jr WG (1997) p73 is a human p53 related protein that can induce apoptosis. Nature 389:191-194.
17. Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty A, Chalon P, Lelias JM, Dumont X, Ferrara P, McKeon F, Caput D (1997) Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other cancers. Cell 90:809-819.
18. Leo JM, Devine AH, Brunjes PC (2000) Focal denervation alters cellular phenotypes and survival in the developing rat olfactory bulb. J Comp Neurol 417:325-336.
19. Luk K, Sadikot AF (2001) GABA promotes survival but not proliferation of the parvalbumin-immunoreactive interneurons in rodent neo-striatum: An in vivo study with stereology. Neuroscience 104:93-103.
20. Majdan M, Lachance C, Gloster A, Aloyz R, Zeindler C, Bamji S, Bhakar A, Belliveau D, Fawcett J, Miller FD, Barker PA (1997) Transgenic mice expressing the intracellular domain of the p75 neurotrophin receptor undergo neuronal apoptosis. J Neurosci 17:6988-6998.
21. Majdan M, Walsh GS, Aloyz R, Miller FD (2001) TrkA mediates developmental sympathetic neuron survival in vivo by silencing an ongoing p75NTR-mediated death signal. J Cell Biol 155:1275-1286.
22. Michaelidis TM, Sendtner M, Cooper JD, Airaksinen MS, Holtmann B, Meyer M, Thoenen H (1996) Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development. Neuron 17:75-89.
23. Miller FD, Pozniak CD, Walsh G (2000) Neuronal life and death: An essential role for the p53 family. Cell Death Differ 7:880-888.
24. Miyashita T, Reed JC (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299.
25. Moroni MC, Hickman ES, Denchi EL, Caprara G, Colli E, Cecconi F, Muller H, Helin K (2001) Apaf-1 is a transcriptional target for E2F and p53. Nat Cell Biol 3:552-558.
26. Morrison RS, Kinoshita Y (2000) The role of p53 in neuronal cell death. Cell Death Differ 7:868-879.
27. Morrison RS, Wenzel HJ, Kinoshita Y, Robbins CA, Donehower LA, Schwartzkroin PA (1996) Loss of the p53 tumor suppressor gene protects from kainate-induced cell death. J Neurosci 16:1337-1347.
28. Motoyama N, Wang F, Roth KA, Sawa H, Nakayama K, Negishi I, Senju S, Zhang Q, Fujii S, Loh DY (1995) Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267:1506-1510.
29. Nemchinsky EA, Young WG, Yeung G, Shah RA, Gordon JW, Bloom FE, Morrison JH, Hof PR (2000) Differential vulnerability of oculomotor, facial, and hypoglossal nuclei in G86R superoxide dismutase transgenic mice. J Comp Neurol 416:112-125.
30. Oppenheim RW, Wiese S, Prevette D, Armanini M, Wang S, Houenou LJ, Holtmann B, Götz R, Pennica D, Sendtner M (2001) Cardiotrophin-1, a muscle-derived cytokine, is required for the survival of subpopulations of developing motoneurons. J Neurosci 21:1283-1291.
31. Pozniak CD, Radinovic S, Yang A, McKeon F, Kaplan DR, Miller FD (2000) An anti-apoptotic role for the p53 family member, p73, during developmental neuron death. Science 289:304-306.
32. Ranger AM, Malynn BA, Korsmeyer SJ (2001) Mouse models of cell death. Nat Genet 28:113-118.
33. Sakhi S, Bruce A, Sun N, Tocco G, Baudry M, Schreiber SS (1994) p53 induction is associated with neuronal damage in the central nervous system. Proc Natl Acad Sci USA 91:7525-7529.
34. Slack RS, Belliveau DJ, Rosenberg M, Atwal J, Lochmuller H, Aloyz R, Haghighi A, Lach B, Seth P, Cooper E, Miller FD (1996) Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons. J Cell Biol 135:1085-1096.
35. Stiewe T, Putzer BM (2001) p73 in apoptosis. Apoptosis 6:447-452.
36. Toma JG, El-Bizri H, Barnabé-Heider F, Aloyz R, Miller FD (2000) Evidence that helix-loop-helix proteins collaborate with retinoblastoma tumor suppressor protein to regulate cortical neurogenesis. J Neurosci 20:7648-7656.
37. Wartiovaara K, Barnabé-Heider F, Miller FD, Kaplan DR (2002) N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons. J Neurosci 22:815-824.
38. West MJ, Østergaard K, Andreasen OA, Finsen B (1996) Estimation of the number of somatostatin neurons in the striatum: An in situ hybridization study using the optical fractionator method. J Comp Neurol 370:11-22.
39. Xiang H, Hochman DW, Saya H, Fujiwara T, Schwartzkroin PA, Morrison RS (1996) Evidence for p53-mediated modulation of neuronal viability. J Neurosci 16:6753-6765.
40. Xu B, Zang K, Ruff NL, Zhang YA, McConnell SK, Stryker MP, Reichardt L (2001) Cortical degeneration in the absence of neurotrophin signaling: Dendritic retraction and neuronal loss after removal of the receptor TrkB. Neuron 26:233-245.
41. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dotsch V, Andrews NC, Caput D, McKeon F (1998) p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 2:305-316.
42. Yang A, Walker N, Bronson R, Kaghad M, Oosterwegel M, Bonnin J, Vagner C, Bonnet H, Dikkes P, Sharpe A, McKeon F, Caput D (2000) p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumors. Nature 404:99-103.