A possible role of p73 on the modulation of p53 level through MDM2

Cancer Research

Volumn 61, Issue 4, 2001, Pages 1598-1603

  Wang, Xiao Qi ^a,c   Ongkeko, Weg M ^b   Lau, Anita W S ^a   Leung, Ka Man ^a   Poon, Randy Y C ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; PROTEIN MDM2; PROTEIN P53; PROTEIN P73;

ARTICLE; DNA DAMAGE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEIN STABILITY; RECEPTOR DOWN REGULATION; TARGET CELL; TRANSACTIVATION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

DNA DAMAGE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 0035866337     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

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2. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
3. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
4. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
5. An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to UIA-positive nuclear bodies associated with the PODs
6. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
7. Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53
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11. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
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13. Enhanced phosphorylation of p53 by ATM in response to DNA damage
14. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
15. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
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19. ARFstabilizes p53 by blocking nucleo-cytoplasmic shuttling of mdm2
20. Nucleolar Arf sequesters Mdm2 and activates p53
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23. Two new p73 splice variants, γ and Δ, with different transcriptional activity
24. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
25. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
26. Cloning and functional analysis of human p51, which structurally and functionally resembles p53
27. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
28. A new human p53 homologue
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30. Mdm2 binds p73 α without targeting degradation
31. MDM2 and MDMX bind and stabilize the tumor suppressor p53-related protein p73
32. Inactivation of the p53-homologue p73 by the mdm2-oncoprotein
33. MDM2 suppresses p73 function without promoting p73 degradation
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35. Interaction of c-Abl and p73 and their collaboration to induce apoptosis
36. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatininduced DNA damage
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38. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
39. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
40. p63 is a p53 homologue required for limb and epidermal morphogenesis
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42. Redistribution of the CDK inhibitor p27 between different cyclin-CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or UV irradiation
43. MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins
44. Regulation of cyclin A-Cdk2 by the SCF component Skp1 and the F-box protein Skp2
45. 15phosphorylation after UV-induced DNA damage
46. The potential tumor suppressor p73 differentially regulates cellular p53 target genes
47. Promoter specificity and stability control of the p53-related protein p73
48. p73 function is inhibited by tumorderived p53 mutants in mammalian cells
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50. Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53
51. Regulation and activation of p53 and its family members
52. Regulation of Mdm2-directed degradation by the C terminus of p53
53. Identification of a sequence element from p53 that signals for Mdm2-targeted degradation
54. MDM2 interacts with MDMX through their RING finger domains
55. Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
56. p73 competes with p53 and attenuates its response in a human ovarian cancer cell line