Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex

Genes and Development

Volumn 15, Issue 23, 2001, Pages 3104-3117

  Querido, Emmanuelle ^a,h   Blanchette, Paola ^a   Yan, Qin ^c,d   Kamura, Takumi ^e   Morrison, Megan ^a   Boivin, Dominique ^a   Kaelin, William G ^f   Conaway, Ronald C ^c,g   Conaway, Joan Weliky ^c,d,g   Branton, Philip E ^a,b  

^a Department of Biochemistry ^*  (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c STOWERS INSTITUTE FOR MEDICAL RESEARCH   (United States)

^d UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^e KYUSHU UNIVERSITY   (Japan)

^f HARVARD MEDICAL SCHOOL   (United States)

^g UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^h Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

Adenovirus; Cullin complexes; Elongin B; Elongin C; NEDD8; P53; Protein degradation; Ubiquitination

Indexed keywords

BINDING PROTEIN; PROTEIN MDM2; PROTEIN P53; VIRUS PROTEIN;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CHO CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN MODIFICATION; PROTEIN PURIFICATION; PROTEIN STABILITY; TEMPERATURE SENSITIVITY; VIRUS REPLICATION;

ADENOVIRUS E1B PROTEINS; ADENOVIRUS E4 PROTEINS; ANIMALS; BLOTTING, WESTERN; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL LINE; CHO CELLS; CRICETINAE; HUMANS; LIGASES; MACROMOLECULAR SUBSTANCES; MICE; MICROSCOPY, CONFOCAL; MODELS, BIOLOGICAL; MOLECULAR WEIGHT; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; TEMPERATURE; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

ADENOVIRIDAE; ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; HUMAN ADENOVIRUS;

EID: 0035577765     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.926401     Document Type: Article

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