Identification of p53 sequence elements that are required for MDM2-mediated nuclear export

Molecular and Cellular Biology

Volumn 21, Issue 24, 2001, Pages 8533-8546

  Gu, J ^a   Nie, L ^a   Wiederschain, D ^a   Yuan, Z M ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CHIMERIC PROTEIN; LYSINE; PROTEIN MDM2; PROTEIN P53; PROTEIN P73; TETRAMER;

ARTICLE; BINDING SITE; CELL NUCLEUS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA BINDING; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SEQUENCE ANALYSIS;

ACTIVE TRANSPORT, CELL NUCLEUS; CELL LINE; CELL NUCLEUS; DNA; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; GENES, P53; GENES, TUMOR SUPPRESSOR; GLUTATHIONE TRANSFERASE; HUMANS; LYSINE; MICROSCOPY, FLUORESCENCE; MODELS, GENETIC; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RECOMBINANT FUSION PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN;

NES;

EID: 0035196861     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.24.8533-8546.2001     Document Type: Article

References (22)

1. The contribution of the acidic domain of MDM2 to p53 and MDM2 stability
2. Regulation of p53 stability
3. An intact HDM2 RING-finger domain is required for nuclear exclusion of p53
4. Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
5. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
6. The MDM2 RING-finger domain is required to promote p53 nuclear export
7. Identification of a sequence element from p53 that signals for Mdm2-targeted degradation
8. Subcellular distribution of p53 and p73 are differentially regulated by MDM2
9. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
10. Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms
11. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
12. An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs
13. Solution structure of the tetrameric minimum transforming domain of p53
14. The nuclear import of p53 is determined by the presence of a basic domain and its relative position to the nuclear localization signal
15. C-terminal ubiquitination of p53 contributes to nuclear export
16. Regulation and function of the p53-related proteins: Same family, different rules
17. The tumor suppressor p53 is subject to both nuclear import and export, and both are fast, energy-dependent and lectin-inhibited
18. Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination
19. Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation
20. A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
21. Importins and exportins: How to get in and out of the nucleus
22. The potential tumor suppressor p73 differentially regulates cellular p53 target genes