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Volumn 16, Issue 20, 2002, Pages 2639-2649

Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation

Author keywords

Cell cycle control; DNA replication; G1 cyclin; Genomic instability; Oncogenesis; Prereplicative complex

Indexed keywords

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL CYCLE G1 PHASE; CHROMOSOME REARRANGEMENT; DNA REPLICATION; GENE CONTROL; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; YEAST; CELL CYCLE; CHROMOSOME; CHROMOSOME ABERRATION; COMPARATIVE STUDY; DNA FOOTPRINTING; GENETICS; HUMAN; IMMUNOBLOTTING; METABOLISM; NUCLEIC ACID HYBRIDIZATION; PHYSIOLOGY; PLASMID; SACCHAROMYCES CEREVISIAE;

EID: 0037107343     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1011002     Document Type: Article
Times cited : (130)

References (66)
  • 1
    • 0028969514 scopus 로고
    • Genetic instability as a consequence of inappropriate entry into and progression through S-phase
    • Almasan, A., Linke, S.P., Paulson, T.G., Huang, L.C., and Wahl, G.M. 1995. Genetic instability as a consequence of inappropriate entry into and progression through S-phase. Cancer Metast. Rev. 14: 59-73.
    • (1995) Cancer Metast. Rev. , vol.14 , pp. 59-73
    • Almasan, A.1    Linke, S.P.2    Paulson, T.G.3    Huang, L.C.4    Wahl, G.M.5
  • 3
    • 0035997368 scopus 로고    scopus 로고
    • DNA replication in eukaryotic cells
    • Bell, S.P. and Dutta, A. 2002. DNA replication in eukaryotic cells. Annu. Rev. Biochem. 71: 333-374.
    • (2002) Annu. Rev. Biochem. , vol.71 , pp. 333-374
    • Bell, S.P.1    Dutta, A.2
  • 4
    • 0035796407 scopus 로고    scopus 로고
    • New EMBO Member's Review: Control of chromosomal DNA replication in the early Xenopus embryo
    • Blow, J.J. 2001. New EMBO Member's Review: Control of chromosomal DNA replication in the early Xenopus embryo. EMBO J. 20: 3293-3297.
    • (2001) EMBO J. , vol.20 , pp. 3293-3297
    • Blow, J.J.1
  • 5
    • 0028804278 scopus 로고
    • The genomic instability of yeast cdc6-1/cdc6-1 mutants involves chromosome structure and recombination
    • Bruschi, C.V., McMillan, J.N., Coglievina, M., and Esposito, M.S. 1995. The genomic instability of yeast cdc6-1/cdc6-1 mutants involves chromosome structure and recombination. Mol. Gen. Genet. 249: 8-18.
    • (1995) Mol. Gen. Genet. , vol.249 , pp. 8-18
    • Bruschi, C.V.1    McMillan, J.N.2    Coglievina, M.3    Esposito, M.S.4
  • 7
    • 0039596393 scopus 로고    scopus 로고
    • The stability of the Cdc6 protein is regulated by cyclin-dependent kinase/cyclin B complexes in Saccharomyces cerevisiae
    • Calzada, A., Sanchez, M., Sanchez, E., and Bueno, A. 2000. The stability of the Cdc6 protein is regulated by cyclin-dependent kinase/cyclin B complexes in Saccharomyces cerevisiae. J. Biol. Chem. 275: 9734-9741.
    • (2000) J. Biol. Chem. , vol.275 , pp. 9734-9741
    • Calzada, A.1    Sanchez, M.2    Sanchez, E.3    Bueno, A.4
  • 8
    • 0032860479 scopus 로고    scopus 로고
    • Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants
    • Chen, C. and Kolodner, R.D. 1999. Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants. Nat. Genet. 23: 81-85.
    • (1999) Nat. Genet. , vol.23 , pp. 81-85
    • Chen, C.1    Kolodner, R.D.2
  • 9
    • 0026493684 scopus 로고
    • CDC46/MCM5, a yeast protein whose subcellular localization is cell cycle-regulated, is involved in DNA replication at autonomously replicating sequences
    • Chen, Y., Hennessy, K.M., Botstein, D., and Tye, B.-K. 1992. CDC46/MCM5, a yeast protein whose subcellular localization is cell cycle-regulated, is involved in DNA replication at autonomously replicating sequences. Proc. Natl. Acad. Sci. 89:10459-10463.
    • (1992) Proc. Natl. Acad. Sci. , vol.89 , pp. 10459-10463
    • Chen, Y.1    Hennessy, K.M.2    Botstein, D.3    Tye, B.-K.4
  • 10
    • 0034718483 scopus 로고    scopus 로고
    • Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control
    • Classon, M., Salama, S., Gorka, C., Mulloy, R., Braun, P., and Harlow, E. 2000. Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control. Proc. Natl. Acad. Sci. 97: 10820-10825.
    • (2000) Proc. Natl. Acad. Sci. , vol.97 , pp. 10820-10825
    • Classon, M.1    Salama, S.2    Gorka, C.3    Mulloy, R.4    Braun, P.5    Harlow, E.6
  • 13
    • 0028965145 scopus 로고
    • Cell-cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA-replication in budding yeast
    • Dalton, S. and Whitbread, L. 1995. Cell-cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA-replication in budding yeast. Proc. Natl. Acad. Sci. 92: 2514-2518.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 2514-2518
    • Dalton, S.1    Whitbread, L.2
  • 15
    • 0035336803 scopus 로고    scopus 로고
    • DNA Replication: Building the perfect switch
    • Diffley, J.F.X. 2001. DNA Replication: Building the perfect switch. Curr. Biol. 11: R367-R370.
    • (2001) Curr. Biol. , vol.11
    • Diffley, J.F.X.1
  • 16
    • 0028098812 scopus 로고
    • Two steps in the assembly of complexes at yeast replication origins in vivo
    • Diffley, J.F.X., Cocker, J.H., Dowell, S.J., and Rowley, A. 1994. Two steps in the assembly of complexes at yeast replication origins in vivo. Cell 78: 303-316.
    • (1994) Cell , vol.78 , pp. 303-316
    • Diffley, J.F.X.1    Cocker, J.H.2    Dowell, S.J.3    Rowley, A.4
  • 17
    • 0028213449 scopus 로고
    • Heat-inducible degron: A method for constructing temperature-sensitive mutants
    • Dohmen, R.J., Wu, P., and Varshavsky, A. 1994. Heat-inducible degron: A method for constructing temperature-sensitive mutants. Science 263: 1273-1276.
    • (1994) Science , vol.263 , pp. 1273-1276
    • Dohmen, R.J.1    Wu, P.2    Varshavsky, A.3
  • 18
    • 0030868430 scopus 로고    scopus 로고
    • The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast
    • Drury, L.S., Perkins, G., and Diffley, J.F.X. 1997. The Cdc4/34/ 53 pathway targets Cdc6p for proteolysis in budding yeast. EMBO J. 16: 5966-5976.
    • (1997) EMBO J. , vol.16 , pp. 5966-5976
    • Drury, L.S.1    Perkins, G.2    Diffley, J.F.X.3
  • 19
    • 0034624819 scopus 로고    scopus 로고
    • The cyclin dependent kinase Cdc28p regulates distinct modes of Cdc6p proteolysis during the budding yeast cell cycle
    • _. 2000. The cyclin dependent kinase Cdc28p regulates distinct modes of Cdc6p proteolysis during the budding yeast cell cycle. Curr. Biol. 10: 231-240.
    • (2000) Curr. Biol. , vol.10 , pp. 231-240
  • 20
    • 0033711708 scopus 로고    scopus 로고
    • 1 cyclin-dependent kinases in the mammalian cell cycle
    • 1 cyclin-dependent kinases in the mammalian cell cycle. Curr. Opin. Cell Biol. 12: 676-684.
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 676-684
    • Ekholm, S.V.1    Reed, S.I.2
  • 21
    • 0032865839 scopus 로고    scopus 로고
    • Phosphorylation controls timing of Cdc6p destruction: A biochemical analysis
    • Elsasser, S., Chi, Y., Yang, P., and Campbell, J.L. 1999. Phosphorylation controls timing of Cdc6p destruction: A biochemical analysis. Mol. Biol. Cell 10: 3263-3277.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 3263-3277
    • Elsasser, S.1    Chi, Y.2    Yang, P.3    Campbell, J.L.4
  • 22
    • 0028859923 scopus 로고
    • Cell cycle-dependent phosphorylation and dephosphorylation of the yeast DNA polymerase α-primase B subunit
    • Foiani, M., Liberi, G., Lucchini, G., and Plevani, P. 1995. Cell cycle-dependent phosphorylation and dephosphorylation of the yeast DNA polymerase α-primase B subunit. Mol. Cell Biol. 15: 883-891.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 883-891
    • Foiani, M.1    Liberi, G.2    Lucchini, G.3    Plevani, P.4
  • 24
    • 0025633842 scopus 로고
    • Subcellular localization of yeast CDC46 varies with the cell cycle
    • Hennessy, K.M., Clark, C.D., and Botstein, D. 1990. Subcellular localization of yeast CDC46 varies with the cell cycle. Genes & Dev. 4: 2252-2263.
    • (1990) Genes & Dev. , vol.4 , pp. 2252-2263
    • Hennessy, K.M.1    Clark, C.D.2    Botstein, D.3
  • 25
    • 0036467506 scopus 로고    scopus 로고
    • 1 cell-cycle progression by oncogenes and tumor suppressor genes
    • 1 cell-cycle progression by oncogenes and tumor suppressor genes. Curr. Opin. Genet. Dev. 12: 47-52.
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 47-52
    • Ho, A.1    Dowdy, S.F.2
  • 26
    • 0032878307 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitory domain of the yeast Sic1 protein is contained within the C-terminal 70 amino acids
    • Hodge, A. and Mendenhall, M. 1999. The cyclin-dependent kinase inhibitory domain of the yeast Sic1 protein is contained within the C-terminal 70 amino acids. Mol. Gen. Genet. 262: 55-64.
    • (1999) Mol. Gen. Genet. , vol.262 , pp. 55-64
    • Hodge, A.1    Mendenhall, M.2
  • 27
    • 0026506383 scopus 로고
    • Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiae
    • Hogan, E. and Koshland, D. 1992. Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. 89: 3098-3102.
    • (1992) Proc. Natl. Acad. Sci. , vol.89 , pp. 3098-3102
    • Hogan, E.1    Koshland, D.2
  • 28
    • 4243918022 scopus 로고    scopus 로고
    • Mitotic exit: Delaying the end without FEAR
    • Jensen, S., Geymonat, M., and Johnston, L.H. 2002. Mitotic exit: Delaying the end without FEAR. Curr. Biol. 12: R221-R223.
    • (2002) Curr. Biol. , vol.12
    • Jensen, S.1    Geymonat, M.2    Johnston, L.H.3
  • 29
    • 0033790340 scopus 로고    scopus 로고
    • Regulation of chromosome replication
    • Kelly, T.J. and Brown, G.W. 2000. Regulation of chromosome replication. Annu. Rev. Biochem. 69: 829-880.
    • (2000) Annu. Rev. Biochem. , vol.69 , pp. 829-880
    • Kelly, T.J.1    Brown, G.W.2
  • 30
    • 0033224310 scopus 로고    scopus 로고
    • 1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus
    • 1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus. Nat. Cell Biol. 1: 415-422.
    • (1999) Nat. Cell Biol. , vol.1 , pp. 415-422
    • Labib, K.1    Diffley, J.F.X.2    Kearsey, S.E.3
  • 31
    • 0034595448 scopus 로고    scopus 로고
    • Uninterrupted MCM2-7 function required for DNA replication fork progression
    • Labib, K., Tercero, J.A., and Diffley, J.F.X. 2000. Uninterrupted MCM2-7 function required for DNA replication fork progression. Science 288: 1643-1647.
    • (2000) Science , vol.288 , pp. 1643-1647
    • Labib, K.1    Tercero, J.A.2    Diffley, J.F.X.3
  • 32
    • 0035201229 scopus 로고    scopus 로고
    • 1-phase, and are required to establish, but not maintain, the S-phase checkpoint
    • 1-phase, and are required to establish, but not maintain, the S-phase checkpoint. Mol. Biol. Cell 12: 3658-3667.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 3658-3667
    • Labib, K.1    Kearsey, S.E.2    Diffley, J.F.X.3
  • 34
    • 0029910628 scopus 로고    scopus 로고
    • Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
    • Macleod, K.F., Hu, Y., and Jacks, T. 1996. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J. 15: 6178-6188.
    • (1996) EMBO J. , vol.15 , pp. 6178-6188
    • Macleod, K.F.1    Hu, Y.2    Jacks, T.3
  • 35
    • 0035754080 scopus 로고    scopus 로고
    • To cycle or not to cycle: A critical decision in cancer
    • Malumbres, M. and Barbacid, M. 2001. To cycle or not to cycle: A critical decision in cancer. Nat. Rev. Cancer 1: 222-231.
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 222-231
    • Malumbres, M.1    Barbacid, M.2
  • 36
    • 0037034048 scopus 로고    scopus 로고
    • S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast
    • Masumoto, H., Muramatsu, S., Kamimura, Y., and Araki, H. 2002. S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast. Nature 415: 651-655.
    • (2002) Nature , vol.415 , pp. 651-655
    • Masumoto, H.1    Muramatsu, S.2    Kamimura, Y.3    Araki, H.4
  • 37
    • 0030915139 scopus 로고    scopus 로고
    • Inactivation of p53 results in high rates of homologous recombination
    • Mekeel, K.L., Tang, W., Kachnic, L.A., Luo, C.M., DeFrank, J.S., and Powell, S.N. 1997. Inactivation of p53 results in high rates of homologous recombination. Oncogene 14: 1847-1857.
    • (1997) Oncogene , vol.14 , pp. 1847-1857
    • Mekeel, K.L.1    Tang, W.2    Kachnic, L.A.3    Luo, C.M.4    DeFrank, J.S.5    Powell, S.N.6
  • 38
    • 0027934570 scopus 로고
    • p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
    • Morgenbesser, S.D., Williams, B.O., Jacks, T., and DePinho, R.A. 1994. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 371: 72-74.
    • (1994) Nature , vol.371 , pp. 72-74
    • Morgenbesser, S.D.1    Williams, B.O.2    Jacks, T.3    DePinho, R.A.4
  • 39
    • 0035830498 scopus 로고    scopus 로고
    • Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae
    • Myung, K., Datta, A., and Kolodner, R.D. 2001. Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae. Cell 104: 397-408.
    • (2001) Cell , vol.104 , pp. 397-408
    • Myung, K.1    Datta, A.2    Kolodner, R.D.3
  • 41
    • 0034708063 scopus 로고    scopus 로고
    • Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7
    • Nguyen, V.Q., Co, C., Irie, K., and Li, J.J. 2000. Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7. Curr. Biol. 10: 195-205.
    • (2000) Curr. Biol. , vol.10 , pp. 195-205
    • Nguyen, V.Q.1    Co, C.2    Irie, K.3    Li, J.J.4
  • 42
    • 0035963372 scopus 로고    scopus 로고
    • Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms
    • Nguyen, V.Q., Co, C., and Li, J.J. 2001. Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms. Nature 411: 1068-1073.
    • (2001) Nature , vol.411 , pp. 1068-1073
    • Nguyen, V.Q.1    Co, C.2    Li, J.J.3
  • 43
    • 0037006806 scopus 로고    scopus 로고
    • CDK phosphorylation of Drc1 regulates DNA replication in fission yeast
    • Noguchi, E., Shanahan, P., Noguchi, C., and Russell, P. 2002. CDK phosphorylation of Drc1 regulates DNA replication in fission yeast. Curr. Biol. 12: 599-605.
    • (2002) Curr. Biol. , vol.12 , pp. 599-605
    • Noguchi, E.1    Shanahan, P.2    Noguchi, C.3    Russell, P.4
  • 45
    • 0033974957 scopus 로고    scopus 로고
    • CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis
    • Noton, E.A. and Diffley, J.F.X. 2000. CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis. Mol. Cell 5: 85-95.
    • (2000) Mol. Cell , vol.5 , pp. 85-95
    • Noton, E.A.1    Diffley, J.F.X.2
  • 46
    • 0028206855 scopus 로고
    • An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells
    • Nugroho, T.T. and Mendenhall, M.D. 1994. An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells. Mol. Cell. Biol. 14: 3320-3328.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3320-3328
    • Nugroho, T.T.1    Mendenhall, M.D.2
  • 47
    • 0031893222 scopus 로고    scopus 로고
    • Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage
    • Paulson, T.G., Almasan, A., Brody, L.L., and Wahl, G.M. 1998. Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage. Mol. Cell. Biol. 18: 3089-3100.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 3089-3100
    • Paulson, T.G.1    Almasan, A.2    Brody, L.L.3    Wahl, G.M.4
  • 48
    • 0032110626 scopus 로고    scopus 로고
    • Nucleotide dependent prereplicative complex assembly by Cdc6p, a homologue of eukaryotic and prokaryotic clamp-loaders
    • Perkins, G. and Diffley, J.F.X. 1998. Nucleotide dependent prereplicative complex assembly by Cdc6p, a homologue of eukaryotic and prokaryotic clamp-loaders. Mol. Cell 2: 23-32.
    • (1998) Mol. Cell , vol.2 , pp. 23-32
    • Perkins, G.1    Diffley, J.F.X.2
  • 49
    • 0035801406 scopus 로고    scopus 로고
    • CDC4 recognition elements target Cdc6 for proteolysis in S phase and mitosis
    • CDC4 recognition elements target Cdc6 for proteolysis in S phase and mitosis. EMBO J. 20: 4836-4845.
    • (2001) EMBO J. , vol.20 , pp. 4836-4845
    • Perkins, G.1    Drury, L.S.2    Diffley, J.F.X.3
  • 50
    • 0036134935 scopus 로고    scopus 로고
    • Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence
    • Rane, S.G., Cosenza, S.C., Mettus, R.V., and Reddy, E.P. 2002. Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence. Mol. Cell. Biol. 22: 644-656.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 644-656
    • Rane, S.G.1    Cosenza, S.C.2    Mettus, R.V.3    Reddy, E.P.4
  • 51
    • 0026445628 scopus 로고
    • Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: Evidence for separate mitochondrial and nuclear functions
    • Reenan, R.A. and Kolodner, R.D. 1992. Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: Evidence for separate mitochondrial and nuclear functions. Genetics 132: 975-985.
    • (1992) Genetics , vol.132 , pp. 975-985
    • Reenan, R.A.1    Kolodner, R.D.2
  • 52
    • 0029831706 scopus 로고    scopus 로고
    • ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae
    • Santocanale, C. and Diffley, J.F.X. 1996. ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae. EMBO J. 15: 6671-6679.
    • (1996) EMBO J. , vol.15 , pp. 6671-6679
    • Santocanale, C.1    Diffley, J.F.X.2
  • 53
    • 0036190501 scopus 로고    scopus 로고
    • The FEAR factor
    • Saunders, W.S. 2002. The FEAR factor. Mol. Cell 9: 207-209.
    • (2002) Mol. Cell , vol.9 , pp. 207-209
    • Saunders, W.S.1
  • 54
    • 0035830497 scopus 로고    scopus 로고
    • Spontaneous DNA damage, genome instability, and cancer-When DNA replication escapes control
    • Schar, P. 2001. Spontaneous DNA damage, genome instability, and cancer-When DNA replication escapes control. Cell 104: 329-332.
    • (2001) Cell , vol.104 , pp. 329-332
    • Schar, P.1
  • 55
    • 0034687677 scopus 로고    scopus 로고
    • Stepwise assembly of initiation proteins at budding yeast replication origins in vitro
    • Seki, T. and Diffley, J.F.X. 2000. Stepwise assembly of initiation proteins at budding yeast replication origins in vitro. Proc. Natl. Acad. Sci. 97: 14115-14120.
    • (2000) Proc. Natl. Acad. Sci. , vol.97 , pp. 14115-14120
    • Seki, T.1    Diffley, J.F.X.2
  • 56
    • 0034660892 scopus 로고    scopus 로고
    • The Pezcoller lecture: Cancer cell cycles revisited
    • Sherr, C.J. 2000. The Pezcoller lecture: Cancer cell cycles revisited. Cancer Res. 60: 3689-3695.
    • (2000) Cancer Res. , vol.60 , pp. 3689-3695
    • Sherr, C.J.1
  • 57
    • 0033575920 scopus 로고    scopus 로고
    • Deregulated cyclin E induces chromosome instability
    • Spruck, C.H., Won, K.A., and Reed, S.I. 1999. Deregulated cyclin E induces chromosome instability. Nature 401: 297-300.
    • (1999) Nature , vol.401 , pp. 297-300
    • Spruck, C.H.1    Won, K.A.2    Reed, S.I.3
  • 60
    • 0033011006 scopus 로고    scopus 로고
    • Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog
    • Tomlinson, I. and Bodmer, W. 1999. Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog. Nat. Med. 5: 11-12.
    • (1999) Nat. Med. , vol.5 , pp. 11-12
    • Tomlinson, I.1    Bodmer, W.2
  • 61
    • 0030751470 scopus 로고    scopus 로고
    • Getting started: Regulating the initiation of DNA replication in yeast
    • Toone, W.M., Aerne, B.L., Morgan, B.A., and Johnston, L.H. 1997. Getting started: Regulating the initiation of DNA replication in yeast. Annu. Rev. Microbiol. 51: 125-149.
    • (1997) Annu. Rev. Microbiol. , vol.51 , pp. 125-149
    • Toone, W.M.1    Aerne, B.L.2    Morgan, B.A.3    Johnston, L.H.4
  • 63
    • 0035195557 scopus 로고    scopus 로고
    • The evolution of diverse biological responses to DNA damage: Insights from yeast and p53
    • Wahl, G.M. and Carr, A.M. 2001. The evolution of diverse biological responses to DNA damage: Insights from yeast and p53. Nat. Cell Biol. 3: E277-E286.
    • (2001) Nat. Cell Biol. , vol.3
    • Wahl, G.M.1    Carr, A.M.2
  • 64
    • 0033582262 scopus 로고    scopus 로고
    • The Cdc6p nucleotide-binding motif is required for loading Mcm proteins onto chromatin
    • Weinreich, M., Liang, C., and Stillman, B. 1999. The Cdc6p nucleotide-binding motif is required for loading Mcm proteins onto chromatin. Proc. Natl. Acad. Sci. 96: 441-446.
    • (1999) Proc. Natl. Acad. Sci. , vol.96 , pp. 441-446
    • Weinreich, M.1    Liang, C.2    Stillman, B.3
  • 65
    • 0035855661 scopus 로고    scopus 로고
    • Ectopic expression of Cdk6 circumvents transforming growth factor-β mediated growth inhibition
    • Zhang, F., Taipale, M., Heiskanen, A., and Laiho, M. 2001. Ectopic expression of Cdk6 circumvents transforming growth factor-β mediated growth inhibition. Oncogene 20: 5888-5896.
    • (2001) Oncogene , vol.20 , pp. 5888-5896
    • Zhang, F.1    Taipale, M.2    Heiskanen, A.3    Laiho, M.4
  • 66
    • 0030048969 scopus 로고    scopus 로고
    • Overexpression of cyclin D1 enhances gene amplification
    • Zhou, P., Jiang, W., Weghorst, C.M., and Weinstein, I.B. 1996. Overexpression of cyclin D1 enhances gene amplification. Cancer Res. 56: 36-39.
    • (1996) Cancer Res. , vol.56 , pp. 36-39
    • Zhou, P.1    Jiang, W.2    Weghorst, C.M.3    Weinstein, I.B.4


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