Mutation of hCDC4 Leads to Cell Cycle Deregulation of Cyclin E in Cancer

Cancer Research

Volumn 64, Issue 3, 2004, Pages 795-800

  Reed, Susanna Ekholm ^a,b   Spruck, Charles H ^a   Sangfelt, Olle ^a   Van Drogen, Frank ^a   Mueller Holzner, Elisabeth ^c   Widschwendter, Martin ^c   Zetterberg, Anders ^b   Reed, Steven I ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN E; F BOX PROTEIN; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CANCER CELL; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; COMPLEX FORMATION; GENE; GENE INACTIVATION; GENE MUTATION; GENETIC CODE; HCDC4 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RETROVIRUS; SIGNAL TRANSDUCTION; UBIQUITINATION;

BREAST NEOPLASMS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CYCLIN E; F-BOX PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MUTATION; RETROVIRIDAE; RNA, SMALL INTERFERING; TRANSDUCTION, GENETIC; UBIQUITIN-PROTEIN LIGASES;

EID: 0842325857     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-3417     Document Type: Article

References (24)

1. Ekholm, S. V., Zickert, P., Reed, S. I., and Zetterberg, A. Accumulation of cyclin E is not a prerequisite for passage through the restriction point. Mol. Cell. Biol., 21: 3256-3265, 2001.
2. 1-S phase protein kinase. Science (Wash. DC), 257: 1958-1961, 1992.
3. 1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-β. Science (Wash. DC), 260: 536-539, 1993.
4. Won, K. A., and Reed, S. I. Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E. EMBO J., 15: 4182-4193, 1996.
5. Clurman, B. E., Sheaff, R. J., Thress, K., Groudine, M., and Roberts, J. M. Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev., 10: 1979-1990, 1996.
6. Ekholm, S. V., and Reed, S. I. Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle. Curr. Opin. Cell Biol., 12: 676-684, 2000.
7. Strohmaier, H., Spruck, C. H., Kaiser, P., Won, K. A., Sangfelt, O., and Reed, S. I. Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature (Lond.), 413: 316-322, 2001.
8. Moberg, K. H., Bell, D. W., Wahrer, D. C., Haber, D. A., and Hariharan, I. K. Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines. Nature (Lond.), 413: 311-316, 2001.
9. Koepp, D. M., Schaefer, L. K., Ye, X., Keyomarsi, K., Chu, C., Harper, J. W., and Elledge, S. J. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science (Wash. DC), 294: 173-177, 2001.
10. Erlandsson, F., Wahlby, C., Ekholm-Reed, S., Hellstrom, A. C., Bengtsson, E., and Zetterberg, A. Abnormal expression pattern of cyclin E in tumour cells. Int. J. Cancer, 104: 369-375, 2003.
11. Erlanson, M., and Landberg, G. Prognostic implications of p27 and cyclin E protein contents in malignant lymphomas. Leuk. Lymphoma, 40: 461-470, 2001.
12. Keyomarsi, K., Conte, D., Jr., Toyofuku, W., and Fox, M. P. Deregulation of cyclin E in breast cancer. Oncogene, 11: 941-950, 1995.
13. Schraml, P., Bucher, C., Bissig, H., Nocito, A., Haas, P., Wilber, K., Seelig, S., Kononen, J., Mihatsch, M. J., Dirnhofer, S., and Sauter, G. Cyclin E overexpression and amplification in human tumours. J. Pathol., 200: 375-382, 2003.
14. Sandhu, C., and Slingerland, J. Deregulation of the cell cycle in cancer. Cancer Detect. Prev., 24: 107-118, 2000.
15. Spruck, C. H., Strohmaier, H., Sangfelt, O., Muller, H. M., Hubalek, M., Muller-Holzner, E., Marth, C., Widschwendter, M., and Reed, S. I. hCDC4 gene mutations in endometrial cancer. Cancer Res., 62: 4535-4539, 2002.
16. Singer, J. D., Gurian-West, M., Clurman, B., and Roberts, J. M. Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev., 13: 2375-2387, 1999.
17. Nakayama, K., Nagahama, H., Minamishima, Y. A., Matsumoto, M., Nakamichi, I., Kitagawa, K., Shirane, M., Tsunematsu, R., Tsukiyama, T., Ishida, N., Kitagawa, M., and Hatakeyama, S. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J., 19: 2069-2081, 2000.
18. Yeh, K. H., Kondo, T., Zheng, J., Tsvetkov, L. M., Blair, J., and Zhang, H. The F-box protein SKP2 binds to the phosphorylated threonine 380 in cyclin E and regulates ubiquitin-dependent degradation of cyclin E. Biochem. Biophys. Res. Commun., 281: 884-890, 2001.
19. 2/M-phase transition. Mol. Cell. Biol., 18: 546-557, 1998.
20. Morgenstern, J. P., and Land, H. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res., 18: 3587-3596, 1990.
21. Brummelkamp, T. R., Bernards, R., and Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science (Wash. DC), 296: 550-553, 2002.
22. Pines, J., and Hunter, T. Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J. Cell Biol., 115: 1-17, 1991.
23. Erlandsson, F., Linnman, C., Ekholm, S., Bengtsson, E., and Zetterberg, A. A detailed analysis of cyclin A accumulation at the G(1)/S border in normal and transformed cells. Exp. Cell Res., 259: 86-95, 2000.
24. Spruck, C. H., Won, K. A., and Reed, S. I. Deregulated cyclin E induces chromosome instability. Nature (Lond.), 401: 297-300, 1999.