The Hedgehog signaling pathway as a target for anticancer drug discovery

Current Topics in Medicinal Chemistry

Volumn 5, Issue 2, 2005, Pages 147-157

  Borzillo, Gary V ^a   Lippa, Blaise ^a  

^a PFIZER INC   (United States)

Author keywords

Agonist; Antagonist; Cancer; Hedgehog; Patched; Smoothened

Indexed keywords

ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; CYCLOPAMINE; JERVINE; MONOCLONAL ANTIBODY 5E1; N (3 METHOXYBENZYL) 3,3 DIMETHYL N [1 (3,4 METHYLENEDIOXYBENZYL) 2 (1 PIPERAZINYLCARBONYL) 4 PYRROLIDINYL]BUTYRAMIDE; PLACEBO; POLYCLONAL ANTIBODY H4; PROTEIN INHIBITOR; PROTEIN PATCHED; PYRROLIDINE DERIVATIVE; QUINAZOLINONE DERIVATIVE; SANT 1; SANT 2; SANT 3; SANT 4; SMALL INTERFERING RNA; SONIC HEDGEHOG PROTEIN; SONIC HEDGEHOG PROTEIN INHIBITOR; TOMATIDINE; UNCLASSIFIED DRUG; VERATRAMINE;

ANTINEOPLASTIC ACTIVITY; BASAL CELL CARCINOMA; BASAL CELL NEVUS SYNDROME; CANCER INHIBITION; CANCER REGRESSION; CANCER RESISTANCE; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CLINICAL TRIAL; COLON CANCER; DIGESTIVE SYSTEM CANCER; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE MUTATION; HETEROZYGOSITY LOSS; HOMEOSTASIS; HUMAN; LUNG SMALL CELL CANCER; MEDULLOBLASTOMA; NONHUMAN; PROSTATE CANCER; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; VALIDATION PROCESS;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG DESIGN; HEDGEHOG PROTEINS; HUMANS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 17144383611     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568026053507732     Document Type: Review

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