Hedgehog signalling in colorectal tumour cells: Induction of apoptosis with cyclopamine treatment

International Journal of Cancer

Volumn 110, Issue 6, 2004, Pages 831-837

  Qualtrough, David ^a   Buda, Andrea ^a   Gaffield, William ^b   Williams, Ann C ^a   Paraskeva, Christos ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b WESTERN REGIONAL RESEARCH CENTER   (United States)

Author keywords

Colon cancer; Cyclopamine; Hedgehog

Indexed keywords

ALKALOID; COMPLEMENTARY DNA; CYCLOPAMINE; MESSENGER RNA; SONIC HEDGEHOG PROTEIN; STEROID; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR CELL;

ADENOMA; APOPTOSIS; CARCINOMA; CELL LINE, TUMOR; COLONIC NEOPLASMS; DNA PRIMERS; HEDGEHOG PROTEINS; HUMANS; INTESTINAL MUCOSA; PROTO-ONCOGENE PROTEINS; RECTAL NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; VERATRUM ALKALOIDS; WNT PROTEINS;

EID: 2942533929     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.20227     Document Type: Article

References (28)

1. Taipale J, Beachy P. The Hedgehog and Wnt signalling pathways in cancer. Nature 2001;411:349-54.
2. Ramalho-Santos M, Melton DA, McMahon AP. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 2000;127:2763-72.
3. Korinek V, Barker N, Moerer P, van Donselaar E, Huls G, Peters P, Clevers H. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 1998;19:379-83.
4. Bitgood MJ, McMahon AP. Hedgehog and BMP genes are co-expressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol 1995;172:126-38.
5. Apelqvist A, Ahlgren U, Edlund H. Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr Biol 1997;7:801-4.
6. Roberts DJ, Johnson RL, Burke AC, Nelson CE, Morgan BA, Tabin C. Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalisation of the chick hindgut. Development 1995;121:3163-74.
7. Roberts DJ, Smith DM, Goff DJ, Tabin CJ. Epithelial-mesenchymal signalling during the regionalization of the chick gut. Development 1998;125:2791-801.
8. van den Brink GR, Hardwick JCH, Nielsen C, Xu C, ten Kate FJ, Glickman J, van Deventer SJH, Roberts DJ, Peppelenbosch MP. Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. Gut 2002;51:628-33.
9. Murone M, Rosenthal A, de Sauvage FJ. Hedgehog signal transduction: from flies to vertebrates. Exp Cell Res 1999;253:25-33.
10. Parisi MJ, Lin H. The role of the hedgehog/patched signalling pathway in epithelial stem cell proliferation: from fly to human. Cell Res 1998;8:15-21.
11. Wicking C, McGlinn E. The role of hedgehog signalling in tumorigenesis. Cancer Lett 2001;173:1-7.
12. Cooper MK, Porter JA, Young KE, Beachy PA. Teratogen-mediated inhibition of target tissue response to Shh signalling. Science 1998;280:1603-7.
13. Incardona JP, Gaffield W, Kapur RP, Roelink H. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development 1998;125:3553-62.
14. Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP, Beachy PA. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 2000;406:1005-9.
15. Berman DM, Karhadkar SS, Hallahan AR, Pritchard JI, Eberhart CG, Watkins DN, Chen JK, Cooper MK, Taipale J, Olson JM, Beachy PA. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 2002;297:1559-61.
16. Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA, Baylin SB. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 2003;422:313-7.
17. Williams AC, Harper SJ, Paraskeva C. Neoplastic transformation of a human colonic epithelial cell line: in vitro evidence for the adenoma-to-carcinoma sequence. Cancer Res 1990;50:4724-30.
18. Lorentz O, Duluc I, De Arcangelis A, Simon-Assmann P, Kedinger M, Freund JN. Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation. J Cell Biol 1997;139:1553-65.
19. Williams AC, Collard TJ, Paraskeva C. An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis. Oncogene 1999;18:3199-204.
20. Gaffield W, Benson M, Lundin RE, Keeler RF. Carbon-13 and proton nuclear magnetic resonance spectra of Veratrum alkaloids. J Nat Prod 1986;49:286-92.
21. Thomas MK, Rastalsky M, Lee JH, Habener JF. Hedgehog signalling regulation of insulin production by pancreatic β-cells. Diabetes 2000;49:2039-47.
22. Hague A, Manning AM, Hanlon KA, Huschtscha LI, Hart D, Paraskeva C. Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: implications for the possible role of dietary fibre in the prevention of large bowel cancer. Int J Cancer 1993;55:498-505.
23. Heerdt BG, Houston MA, Augenlicht LH. Potentiation by short-chain fatty acids of differentiation and apoptosis in human colonic carcinoma cell lines. Cancer Res 1994;54:3288-94.
24. Hague A, Bracey TS, Hicks DJ, Reed JC, Paraskeva C. Decreased levels of p26-Bcl-2, but not p30 phosphorylated Bcl-2, precede TGFβ1-induced apoptosis in colorectal adenoma cells. Carcinogenesis 1998;19:1691-5.
25. Roelink H, Porter JA, Chiang C, Tanabe Y, Chang DT, Beachy PA, Jessell TM. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell 1995;81:445-55.
26. Wicking C, Evans T, Henk B, Hayward N, Simms LA, Chenevix-Trench G, Pietsch T, Wainwright B. No evidence for the H133Y mutation in sonic hedgehog in a collection of common tumour types. Oncogene 1998;16:1091-3.
27. Xie J, Johnson RL, Zhang X, Bare JW, Waldman FM, Cogen PH, Menon AG, Warren RS, Chen LC, Scott MP, Epstein EH. Mutations of the patched gene in several types of sporadic extracutaneous tumours. Cancer Res 1997;57:2369-72.
28. Berman DM, Karhadkar SS, Maitra A, Montes de Oca R, Gerstenblith MR, Briggs K, Parker AR, Shimada Y, Eshleman JR, Watkins DN, Beachy PA. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 2003;425:846-51.