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Volumn 68, Issue 6, 2004, Pages 1055-1060

Hedgehog signalling in foregut malignancy

Author keywords

Cancer; Cyclopamine; desert hedgehog; Dhh; Foregut; hedgehog; Hedgehog; Hh; Ihh; Indian hedgehog; resistance nodulation division; RND; SCLC; small cell lung cancer; Stem cell; Therapy

Indexed keywords

ALKALOID; CYCLOPAMINE; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

EID: 4143114809     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.04.025     Document Type: Conference Paper
Times cited : (69)

References (70)
  • 1
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nusslein-Volhard C., Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature. 287(5785):1980;795-801
    • (1980) Nature , vol.287 , Issue.5785 , pp. 795-801
    • Nusslein-Volhard, C.1    Wieschaus, E.2
  • 2
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signalling in animal development: Paradigms and principles
    • Ingham P.W., McMahon A.P. Hedgehog signalling in animal development: paradigms and principles. Genes Dev. 15(23):2001;3059-3087
    • (2001) Genes Dev. , vol.15 , Issue.23 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 4
    • 0029777408 scopus 로고    scopus 로고
    • Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    • Chiang C., Litingtung Y., Lee E., Young K.E., Corden J.L., Westphal H., et al. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature. 383(6599):1996;407-413
    • (1996) Nature , vol.383 , Issue.6599 , pp. 407-413
    • Chiang, C.1    Litingtung, Y.2    Lee, E.3    Young, K.E.4    Corden, J.L.5    Westphal, H.6
  • 5
    • 0033695047 scopus 로고    scopus 로고
    • Sonic hedgehog signalling pathway in vertebrate epithelial appendage morphogenesis: Perspectives in development and evolution
    • Chuong C.M., Patel N., Lin J., Jung H.S., Widelitz R.B. Sonic hedgehog signalling pathway in vertebrate epithelial appendage morphogenesis: perspectives in development and evolution. Cell Mol. Life Sci. 57(12):2000;1672-1681
    • (2000) Cell Mol. Life Sci. , vol.57 , Issue.12 , pp. 1672-1681
    • Chuong, C.M.1    Patel, N.2    Lin, J.3    Jung, H.S.4    Widelitz, R.B.5
  • 6
    • 0032409157 scopus 로고    scopus 로고
    • Hedgehog and patched in neural development and disease
    • Goodrich L.V., Scott M.P. Hedgehog and patched in neural development and disease. Neuron. 21(6):1998;1243-1257
    • (1998) Neuron , vol.21 , Issue.6 , pp. 1243-1257
    • Goodrich, L.V.1    Scott, M.P.2
  • 7
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • Taipale J., Beachy P.A. The Hedgehog and Wnt signalling pathways in cancer. Nature. 411(6835):2001;349-354
    • (2001) Nature , vol.411 , Issue.6835 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2
  • 8
    • 0033754122 scopus 로고    scopus 로고
    • The sonic hedgehog-patched-gli pathway in human development and disease
    • Villavicencio E.H., Walterhouse D.O., Iannaccone P.M. The sonic hedgehog-patched-gli pathway in human development and disease. Am J. Hum. Genet. 67(5):2000;1047-1054
    • (2000) Am J. Hum. Genet. , vol.67 , Issue.5 , pp. 1047-1054
    • Villavicencio, E.H.1    Walterhouse, D.O.2    Iannaccone, P.M.3
  • 9
    • 0029844192 scopus 로고    scopus 로고
    • Cholesterol modification of hedgehog signalling proteins in animal development
    • Porter J.A., Young K.E., Beachy P.A. Cholesterol modification of hedgehog signalling proteins in animal development. Science. 274(5285):1996;255-259
    • (1996) Science , vol.274 , Issue.5285 , pp. 255-259
    • Porter, J.A.1    Young, K.E.2    Beachy, P.A.3
  • 10
    • 15844386540 scopus 로고    scopus 로고
    • Hedgehog patterning activity: Role of a lipophilic modification mediated by the carboxy-terminal auto-processing domain
    • Porter J.A., Ekker S.C., Park W.J., von Kessler D.P., Young K.E., Chen C.H., et al. Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal auto-processing domain. Cell. 86(1):1996;21-34
    • (1996) Cell , vol.86 , Issue.1 , pp. 21-34
    • Porter, J.A.1    Ekker, S.C.2    Park, W.J.3    Von Kessler, D.P.4    Young, K.E.5    Chen, C.H.6
  • 11
    • 0035860538 scopus 로고    scopus 로고
    • Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal
    • Chamoun Z., Mann R.K., Nellen D., von Kessler D.P., Bellotto M., Beachy P.A., et al. Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science. 293(5537):2001;2080-2084
    • (2001) Science , vol.293 , Issue.5537 , pp. 2080-2084
    • Chamoun, Z.1    Mann, R.K.2    Nellen, D.3    Von Kessler, D.P.4    Bellotto, M.5    Beachy, P.A.6
  • 12
    • 0037020216 scopus 로고    scopus 로고
    • Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched
    • Ma Y., Erkner A., Gong R., Yao S., Taipale J., Basler K., et al. Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell. 111(1):2002;63-75
    • (2002) Cell , vol.111 , Issue.1 , pp. 63-75
    • Ma, Y.1    Erkner, A.2    Gong, R.3    Yao, S.4    Taipale, J.5    Basler, K.6
  • 13
    • 1242329977 scopus 로고    scopus 로고
    • Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process
    • Han C., Belenkaya T.Y., Wang B., Lin X. Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process. Development. 131(3):2004;601-611
    • (2004) Development , vol.131 , Issue.3 , pp. 601-611
    • Han, C.1    Belenkaya, T.Y.2    Wang, B.3    Lin, X.4
  • 14
    • 0037470952 scopus 로고    scopus 로고
    • Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells
    • Lum L., Yao S., Mozer B., Rovescalli A., Von Kessler D., Nirenberg M., et al. Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science. 299(5615):2003;2039-2045
    • (2003) Science , vol.299 , Issue.5615 , pp. 2039-2045
    • Lum, L.1    Yao, S.2    Mozer, B.3    Rovescalli, A.4    Von Kessler, D.5    Nirenberg, M.6
  • 15
    • 0037158748 scopus 로고    scopus 로고
    • Patched acts catalytically to suppress the activity of Smoothened
    • Taipale J., Cooper M.K., Maiti T., Beachy P.A. Patched acts catalytically to suppress the activity of Smoothened. Nature. 418(6900):2002;892-897
    • (2002) Nature , vol.418 , Issue.6900 , pp. 892-897
    • Taipale, J.1    Cooper, M.K.2    Maiti, T.3    Beachy, P.A.4
  • 16
    • 0032780648 scopus 로고    scopus 로고
    • The patched signalling pathway in tumorigenesis and development: Lessons from animal models
    • Hahn H., Wojnowski L., Miller G., Zimmer A. The patched signalling pathway in tumorigenesis and development: lessons from animal models. J. Mol. Med. 77(6):1999;459-468
    • (1999) J. Mol. Med. , vol.77 , Issue.6 , pp. 459-468
    • Hahn, H.1    Wojnowski, L.2    Miller, G.3    Zimmer, A.4
  • 17
    • 0033404607 scopus 로고    scopus 로고
    • The subcellular localization and activity of Drosophila Cubitus interruptus are regulated at multiple levels
    • Wang Q.T., Holmgren R.A. The subcellular localization and activity of Drosophila Cubitus interruptus are regulated at multiple levels. Development. 126(22):1999;5097-5106
    • (1999) Development , vol.126 , Issue.22 , pp. 5097-5106
    • Wang, Q.T.1    Holmgren, R.A.2
  • 18
    • 10744233219 scopus 로고    scopus 로고
    • Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2
    • Lum L., Zhang C., Oh S., Mann R.K., von Kessler D.P., Taipale J., et al. Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol. Cell. 12(5):2003;1261-1274
    • (2003) Mol. Cell , vol.12 , Issue.5 , pp. 1261-1274
    • Lum, L.1    Zhang, C.2    Oh, S.3    Mann, R.K.4    Von Kessler, D.P.5    Taipale, J.6
  • 19
    • 0242361620 scopus 로고    scopus 로고
    • Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
    • Jia J., Tong C., Jiang J. Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev. 17(21):2003;2709-2720
    • (2003) Genes Dev. , vol.17 , Issue.21 , pp. 2709-2720
    • Jia, J.1    Tong, C.2    Jiang, J.3
  • 20
    • 0033679196 scopus 로고    scopus 로고
    • Hedgehog signalling and the axial patterning of Drosophila wings
    • Brook W.J. Hedgehog signalling and the axial patterning of Drosophila wings. Biochem. Cell. Biol. 78(5):2000;585-591
    • (2000) Biochem. Cell. Biol. , vol.78 , Issue.5 , pp. 585-591
    • Brook, W.J.1
  • 21
    • 0041919389 scopus 로고    scopus 로고
    • Hedgehog signalling: Off the shelf modulation
    • van den Heuvel M. Hedgehog signalling: off the shelf modulation. Curr. Biol. 13(17):2003;R686-R688
    • (2003) Curr. Biol. , vol.13 , Issue.17 , pp. 686-R688
    • Van Den Heuvel, M.1
  • 22
    • 0037106234 scopus 로고    scopus 로고
    • Degrading Ci: Who is Cul-pable?
    • Jiang J. Degrading Ci: who is Cul-pable? Genes Dev. 16(18):2002;2315-2321
    • (2002) Genes Dev. , vol.16 , Issue.18 , pp. 2315-2321
    • Jiang, J.1
  • 23
    • 0033230757 scopus 로고    scopus 로고
    • Ci: A complex transducer of the hedgehog signal
    • Aza-Blanc P., Kornberg T.B. Ci: a complex transducer of the hedgehog signal. Trends Genet. 15(11):1999;458-462
    • (1999) Trends Genet , vol.15 , Issue.11 , pp. 458-462
    • Aza-Blanc, P.1    Kornberg, T.B.2
  • 24
    • 0032728958 scopus 로고    scopus 로고
    • Protein kinase a antagonizes Hedgehog signalling by regulating both the activator and repressor forms of Cubitus interruptus
    • Wang G., Wang B., Jiang J. Protein kinase A antagonizes Hedgehog signalling by regulating both the activator and repressor forms of Cubitus interruptus. Genes Dev. 13(21):1999;2828-2837
    • (1999) Genes Dev. , vol.13 , Issue.21 , pp. 2828-2837
    • Wang, G.1    Wang, B.2    Jiang, J.3
  • 25
    • 0037041470 scopus 로고    scopus 로고
    • Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
    • Jia J., Amanai K., Wang G., Tang J., Wang B., Jiang J. Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature. 416(6880):2002;548-552
    • (2002) Nature , vol.416 , Issue.6880 , pp. 548-552
    • Jia, J.1    Amanai, K.2    Wang, G.3    Tang, J.4    Wang, B.5    Jiang, J.6
  • 26
    • 0037173126 scopus 로고    scopus 로고
    • Ci proteolysis: Regulation by a constellation of phosphorylation sites
    • Lefers M.A., Holmgren R. Ci proteolysis: regulation by a constellation of phosphorylation sites. Curr. Biol. 12(12):2002;R422-R423
    • (2002) Curr. Biol. , vol.12 , Issue.12 , pp. 422-R423
    • Lefers, M.A.1    Holmgren, R.2
  • 27
    • 0037155737 scopus 로고    scopus 로고
    • Proteolysis of the Hedgehog signalling effector Cubitus interruptus requires phosphorylation by glycogen synthase kinase 3 and casein kinase 1
    • Price M.A., Kalderon D. Proteolysis of the Hedgehog signalling effector Cubitus interruptus requires phosphorylation by glycogen synthase kinase 3 and casein kinase 1. Cell. 108(6):2002;823-835
    • (2002) Cell , vol.108 , Issue.6 , pp. 823-835
    • Price, M.A.1    Kalderon, D.2
  • 28
    • 0037007231 scopus 로고    scopus 로고
    • Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila
    • Yanagawa S., Matsuda Y., Lee J.S., Matsubayashi H., Sese S., Kadowaki T., et al. Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila. EMBO J. 21(7):2002;1733-1742
    • (2002) EMBO J. , vol.21 , Issue.7 , pp. 1733-1742
    • Yanagawa, S.1    Matsuda, Y.2    Lee, J.S.3    Matsubayashi, H.4    Sese, S.5    Kadowaki, T.6
  • 29
    • 0034721665 scopus 로고    scopus 로고
    • Transducing the hedgehog signal
    • Kalderon D. Transducing the hedgehog signal. Cell. 103(3):2000;371-374
    • (2000) Cell , vol.103 , Issue.3 , pp. 371-374
    • Kalderon, D.1
  • 30
    • 0030805592 scopus 로고    scopus 로고
    • Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
    • Lee J., Platt K.A., Censullo P., Ruiz-i-Altaba A. Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development. 124(13):1997;2537-2552
    • (1997) Development , vol.124 , Issue.13 , pp. 2537-2552
    • Lee, J.1    Platt, K.A.2    Censullo, P.3    Ruiz-I-Altaba, A.4
  • 31
    • 0023930186 scopus 로고
    • The GLI gene is a member of the Kruppel family of zinc finger proteins
    • Kinzler K.W., Ruppert J.M., Bigner S.H., Vogelstein B. The GLI gene is a member of the Kruppel family of zinc finger proteins. Nature. 332(6162):1988;371-374
    • (1988) Nature , vol.332 , Issue.6162 , pp. 371-374
    • Kinzler, K.W.1    Ruppert, J.M.2    Bigner, S.H.3    Vogelstein, B.4
  • 32
    • 0034055649 scopus 로고    scopus 로고
    • Mouse Gli1 mutants are viable but have defects in SHH signalling in combination with a Gli2 mutation
    • Park H.L., Bai C., Platt K.A., Matise M.P., Beeghly A., Hui C.C., et al. Mouse Gli1 mutants are viable but have defects in SHH signalling in combination with a Gli2 mutation. Development. 127(8):2000;1593-1605
    • (2000) Development , vol.127 , Issue.8 , pp. 1593-1605
    • Park, H.L.1    Bai, C.2    Platt, K.A.3    Matise, M.P.4    Beeghly, A.5    Hui, C.C.6
  • 33
    • 0025156778 scopus 로고
    • The GLI gene encodes a nuclear protein which binds specific sequences in the human genome
    • Kinzler K.W., Vogelstein B. The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Mol. Cell. Biol. 10(2):1990;634-642
    • (1990) Mol. Cell. Biol. , vol.10 , Issue.2 , pp. 634-642
    • Kinzler, K.W.1    Vogelstein, B.2
  • 34
    • 0031683165 scopus 로고    scopus 로고
    • Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus
    • Motoyama J., Liu J., Mo R., Ding Q., Post M., Hui C.C. Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat. Genet. 20(1):1998;54-57
    • (1998) Nat. Genet , vol.20 , Issue.1 , pp. 54-57
    • Motoyama, J.1    Liu, J.2    Mo, R.3    Ding, Q.4    Post, M.5    Hui, C.C.6
  • 35
    • 0025172883 scopus 로고
    • GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity
    • Ruppert J.M., Vogelstein B., Arheden K., Kinzler K.W. GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity. Mol. Cell. Biol. 10(10):1990;5408-5415
    • (1990) Mol. Cell. Biol. , vol.10 , Issue.10 , pp. 5408-5415
    • Ruppert, J.M.1    Vogelstein, B.2    Arheden, K.3    Kinzler, K.W.4
  • 36
    • 0032848136 scopus 로고    scopus 로고
    • Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: Implication of Gli2 and Gli3 as primary mediators of Shh signalling
    • Sasaki H., Nishizaki Y., Hui C., Nakafuku M., Kondoh H. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signalling. Development. 126(17):1999;3915-3924
    • (1999) Development , vol.126 , Issue.17 , pp. 3915-3924
    • Sasaki, H.1    Nishizaki, Y.2    Hui, C.3    Nakafuku, M.4    Kondoh, H.5
  • 37
    • 0034681266 scopus 로고    scopus 로고
    • Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
    • Wang B., Fallon J.F., Beachy P.A. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell. 100(4):2000;423-434
    • (2000) Cell , vol.100 , Issue.4 , pp. 423-434
    • Wang, B.1    Fallon, J.F.2    Beachy, P.A.3
  • 39
    • 0031711075 scopus 로고    scopus 로고
    • Sonic hedgehog is essential to foregut development
    • Litingtung Y., Lei L., Westphal H., Chiang C. Sonic hedgehog is essential to foregut development. Nat. Genet. 20(1):1998;58-61
    • (1998) Nat. Genet. , vol.20 , Issue.1 , pp. 58-61
    • Litingtung, Y.1    Lei, L.2    Westphal, H.3    Chiang, C.4
  • 40
    • 0034071348 scopus 로고    scopus 로고
    • The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium
    • Sukegawa A., Narita T., Kameda T., Saitoh K., Nohno T., Iba H., et al. The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium. Development. 127(9):2000;1971-1980
    • (2000) Development , vol.127 , Issue.9 , pp. 1971-1980
    • Sukegawa, A.1    Narita, T.2    Kameda, T.3    Saitoh, K.4    Nohno, T.5    Iba, H.6
  • 41
    • 0033916281 scopus 로고    scopus 로고
    • Hedgehog signals regulate multiple aspects of gastrointestinal development
    • Ramalho-Santos M., Melton D.A., McMahon A.P. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development. 127(12):2000;2763-2772
    • (2000) Development , vol.127 , Issue.12 , pp. 2763-2772
    • Ramalho-Santos, M.1    Melton, D.A.2    McMahon, A.P.3
  • 42
    • 0032563948 scopus 로고    scopus 로고
    • Sonic hedgehog regulates branching morphogenesis in the mammalian lung
    • Pepicelli C.V., Lewis P.M., McMahon A.P. Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr. Biol. 8(19):1998;1083-1086
    • (1998) Curr. Biol. , vol.8 , Issue.19 , pp. 1083-1086
    • Pepicelli, C.V.1    Lewis, P.M.2    McMahon, A.P.3
  • 43
    • 0031034866 scopus 로고    scopus 로고
    • Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis
    • Bellusci S., Furuta Y., Rush M.G., Henderson R., Winnier G., Hogan B.L. Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development. 124(1):1997;53-63
    • (1997) Development , vol.124 , Issue.1 , pp. 53-63
    • Bellusci, S.1    Furuta, Y.2    Rush, M.G.3    Henderson, R.4    Winnier, G.5    Hogan, B.L.6
  • 44
  • 45
    • 0037212983 scopus 로고    scopus 로고
    • Hedgehog signalling in pancreas development
    • Hebrok M. Hedgehog signalling in pancreas development. Mech. Dev. 120(1):2003;45-57
    • (2003) Mech. Dev. , vol.120 , Issue.1 , pp. 45-57
    • Hebrok, M.1
  • 46
    • 0031260579 scopus 로고    scopus 로고
    • Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas
    • Apelqvist A., Ahlgren U., Edlund H. Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr. Biol. 7(10):1997;801-804
    • (1997) Curr. Biol. , vol.7 , Issue.10 , pp. 801-804
    • Apelqvist, A.1    Ahlgren, U.2    Edlund, H.3
  • 47
    • 2642589990 scopus 로고    scopus 로고
    • Notochord repression of endodermal Sonic hedgehog permits pancreas development
    • Hebrok M., Kim S.K., Melton D.A. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev. 12(11):1998;1705-1713
    • (1998) Genes Dev. , vol.12 , Issue.11 , pp. 1705-1713
    • Hebrok, M.1    Kim, S.K.2    Melton, D.A.3
  • 48
    • 0032573227 scopus 로고    scopus 로고
    • Pancreas development is promoted by cyclopamine, a hedgehog signalling inhibitor
    • Kim S.K., Melton D.A. Pancreas development is promoted by cyclopamine, a hedgehog signalling inhibitor. Proc. Natl. Acad. Sci. U.S.A. 95(22):1998;13036-13041
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , Issue.22 , pp. 13036-13041
    • Kim, S.K.1    Melton, D.A.2
  • 49
    • 0242669237 scopus 로고    scopus 로고
    • Hedgehog signalling within airway epithelial progenitors and in small cell lung cancer
    • Watkins D.N., Berman D.M., Burkholder S.G., Wang B., Beachy P.A., Baylin S.B. Hedgehog signalling within airway epithelial progenitors and in small cell lung cancer. Nature. 422:2003;313-317
    • (2003) Nature , vol.422 , pp. 313-317
    • Watkins, D.N.1    Berman, D.M.2    Burkholder, S.G.3    Wang, B.4    Beachy, P.A.5    Baylin, S.B.6
  • 50
    • 0242268525 scopus 로고    scopus 로고
    • Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    • Berman D.M., Karhadkar S.S., Maitra A., Montes De Oca R., Gerstenblith M.R., Briggs K., et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature. 425(6960):2003;846-851
    • (2003) Nature , vol.425 , Issue.6960 , pp. 846-851
    • Berman, D.M.1    Karhadkar, S.S.2    Maitra, A.3    Montes De Oca, R.4    Gerstenblith, M.R.5    Briggs, K.6
  • 51
    • 0036839405 scopus 로고    scopus 로고
    • Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract
    • van den Brink G.R., Hardwick J.C., Nielsen C., Xu C., ten Kate F.J., Glickman J., et al. Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. Gut. 51(5):2002;628-633
    • (2002) Gut , vol.51 , Issue.5 , pp. 628-633
    • Van Den Brink, G.R.1    Hardwick, J.C.2    Nielsen, C.3    Xu, C.4    Ten Kate, F.J.5    Glickman, J.6
  • 54
    • 0027760995 scopus 로고
    • Sonic hedgehog mediates the polarizing activity of the ZPA
    • Riddle R.D., Johnson R.L., Laufer E., Tabin C. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell. 75(7):1993;1401-1416
    • (1993) Cell , vol.75 , Issue.7 , pp. 1401-1416
    • Riddle, R.D.1    Johnson, R.L.2    Laufer, E.3    Tabin, C.4
  • 55
    • 0036161517 scopus 로고    scopus 로고
    • A critical role for sonic hedgehog signalling in the early expansion of the developing brain
    • Britto J., Tannahill D., Keynes R. A critical role for sonic hedgehog signalling in the early expansion of the developing brain. Nat. Neurosci. 5(2):2002;103-110
    • (2002) Nat. Neurosci. , vol.5 , Issue.2 , pp. 103-110
    • Britto, J.1    Tannahill, D.2    Keynes, R.3
  • 56
    • 0032796826 scopus 로고    scopus 로고
    • Sonic hedgehog regulates the growth and patterning of the cerebellum
    • Dahmane N., Ruiz-i-Altaba A. Sonic hedgehog regulates the growth and patterning of the cerebellum. Development. 126(14):1999;3089-3100
    • (1999) Development , vol.126 , Issue.14 , pp. 3089-3100
    • Dahmane, N.1    Ruiz-I-Altaba, A.2
  • 57
    • 0034461606 scopus 로고    scopus 로고
    • Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors
    • Kenney A.M., Rowitch D.H. Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors. Mol. Cell. Biol. 20(23):2000;9055-9067
    • (2000) Mol. Cell. Biol. , vol.20 , Issue.23 , pp. 9055-9067
    • Kenney, A.M.1    Rowitch, D.H.2
  • 58
    • 0032959871 scopus 로고    scopus 로고
    • Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog
    • Wechsler-Reya R.J., Scott M.P. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron. 22(1):1999;103-114
    • (1999) Neuron , vol.22 , Issue.1 , pp. 103-114
    • Wechsler-Reya, R.J.1    Scott, M.P.2
  • 59
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • Reya T., Morrison S.J., Clarke M.F., Weissman I.L. Stem cells, cancer, and cancer stem cells. Nature. 414(6859):2001;105-111
    • (2001) Nature , vol.414 , Issue.6859 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 60
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • Goodrich L.V., Milenkovic L., Higgins K.M., Scott M.P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science. 277(5329):1997;1109-1113
    • (1997) Science , vol.277 , Issue.5329 , pp. 1109-1113
    • Goodrich, L.V.1    Milenkovic, L.2    Higgins, K.M.3    Scott, M.P.4
  • 61
    • 0034927062 scopus 로고    scopus 로고
    • The developmental biology of brain tumors
    • Wechsler-Reya R., Scott M.P. The developmental biology of brain tumors. Ann. Rev. Neurosci. 24:2001;385-428
    • (2001) Ann. Rev. Neurosci. , vol.24 , pp. 385-428
    • Wechsler-Reya, R.1    Scott, M.P.2
  • 62
    • 0037089999 scopus 로고    scopus 로고
    • Teratogenesis of holoprosencephaly
    • Cohen M.M. Jr., Shiota K. Teratogenesis of holoprosencephaly. Am. J. Med. Genet. 109(1):2002;1-15
    • (2002) Am. J. Med. Genet. , vol.109 , Issue.1 , pp. 1-15
    • Cohen Jr., M.M.1    Shiota, K.2
  • 63
    • 0034739045 scopus 로고    scopus 로고
    • Sheep, lilies and human genetics
    • Bale A.E. Sheep, lilies and human genetics. Nature. 406(6799):2000;944- 945
    • (2000) Nature , vol.406 , Issue.6799 , pp. 944-945
    • Bale, A.E.1
  • 64
    • 0032486433 scopus 로고    scopus 로고
    • Teratogen-mediated inhibition of target tissue response to Shh signalling
    • Cooper M.K., Porter J.A., Young K.E., Beachy P.A. Teratogen-mediated inhibition of target tissue response to Shh signalling. Science. 280(5369):1998;1603-1607
    • (1998) Science , vol.280 , Issue.5369 , pp. 1603-1607
    • Cooper, M.K.1    Porter, J.A.2    Young, K.E.3    Beachy, P.A.4
  • 65
    • 0034738979 scopus 로고    scopus 로고
    • Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
    • Taipale J., Chen J.K., Cooper M.K., Wang B., Mann R.K., Milenkovic L., et al. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature. 406(6799):2000;1005-1009
    • (2000) Nature , vol.406 , Issue.6799 , pp. 1005-1009
    • Taipale, J.1    Chen, J.K.2    Cooper, M.K.3    Wang, B.4    Mann, R.K.5    Milenkovic, L.6
  • 66
    • 0036829397 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signalling by direct binding of cyclopamine to Smoothened
    • Chen J.K., Taipale J., Cooper M.K., Beachy P.A. Inhibition of Hedgehog signalling by direct binding of cyclopamine to Smoothened. Genes Dev. 16(21):2002;2743-2748
    • (2002) Genes Dev. , vol.16 , Issue.21 , pp. 2743-2748
    • Chen, J.K.1    Taipale, J.2    Cooper, M.K.3    Beachy, P.A.4
  • 70
    • 0141834796 scopus 로고    scopus 로고
    • Hedgehog signalling: Progenitor phenotype in small-cell lung cancer
    • Watkins D.N., Berman D.M., Baylin S.B. Hedgehog signalling: progenitor phenotype in small-cell lung cancer. Cell Cycle. 2(3):2003;196-198
    • (2003) Cell Cycle , vol.2 , Issue.3 , pp. 196-198
    • Watkins, D.N.1    Berman, D.M.2    Baylin, S.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.