Involvement of hMSH6 in the development of hereditary and sporadic colorectal cancer revealed by immunostaining is based on germline mutations, but rarely on somatic inactivation

International Journal of Cancer

Volumn 97, Issue 5, 2002, Pages 643-648

  Plaschke, Jens ^a   Krüger, Stefan ^a   Pistorius, Steffen ^a   Theissig, Franz ^a   Saeger, Hans D ^a   Schackert, Hans K ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

Colorectal cancer; Germline mutations; hMSH6; Microsatellite instability; Mismatch repair; Protein expression

Indexed keywords

GENE PRODUCT; PROTEIN HMSH6; PROTEIN HPMS2; PROTEIN MLH1; PROTEIN MSH2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER GROWTH; CARCINOGENESIS; COLORECTAL CARCINOMA; CONTROLLED STUDY; DIMERIZATION; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; FEMALE; GENE MUTATION; GENETIC ANALYSIS; GENETIC PREDISPOSITION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOMATIC CELL GENETICS;

ADENOSINE TRIPHOSPHATASES; ADULT; CARRIER PROTEINS; COLORECTAL NEOPLASMS; DNA MUTATIONAL ANALYSIS; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; GENE SILENCING; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSATELLITE REPEATS; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PHENOTYPE; PREDICTIVE VALUE OF TESTS; PROTO-ONCOGENE PROTEINS;

EID: 0037050722     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10097     Document Type: Article

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