Proteasome-mediated effects on amyloid precursor protein processing at the γ-secretase site

Biochemical Journal

Volumn 385, Issue 2, 2005, Pages 545-550

  Flood, Fiona ^a   Murphy, Suzanne ^b   Cowburn, Richard F ^a   Lannfelt, Lars ^c   Walkers, Brian ^b   Johnston, Janet A ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

amyloid peptide; secretase; Alzheimer's disease; Caspase 3; Neuroblastoma; Proteasome

Indexed keywords

CELLS; DISEASES; PATHOLOGY; SUBSTRATES;

AMYLOID; CELL DEATH; LACTACYSTIN; PROTEASOME;

ENZYMES;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BENZOYLLEUCYLLEUCYLLEUCYLGLYOXAL; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; COUMARIN DERIVATIVE; GAMMA SECRETASE; LACTACYSTIN; N ACETYLASPARTYLGLUTAMYLVALYLASPARTYL 7 AMINO 4 METHYLCOUMARIN; NEUTRAL RED; PROTEASOME; PROTEASOME INHIBITOR; UNCLASSIFIED DRUG;

AGING; ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CELL LYSATE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN PROCESSING;

ACETYLCYSTEINE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; CULTURE MEDIA; ENDOPEPTIDASES; HUMANS; MULTIENZYME COMPLEXES; NEUROBLASTOMA; PEPTIDE HYDROLASES; PROTEASOME ENDOPEPTIDASE COMPLEX;

EID: 12844282223     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041145     Document Type: Article

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