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Volumn 2, Issue 1, 2005, Pages 89-102

Targeted drug delivery to mammalian mitochondria in living cells

Author keywords

Delocalised cations; Drug targeting; Gene therapy; Intracellular drug delivery; Mitochondria; Mitochondrial diseases; Mitochondrial medicine; Mitochondrial transfection vector; Mitochondriotropic molecules

Indexed keywords

1,1' BIS(2 ETHYL 1,3 DIOXOLAN 2 YL)CRYPTOCYANINE; ANTISENSE OLIGONUCLEOTIDE; CALCIUM CHANNEL BLOCKING AGENT; CARBOXYFLUORESCEIN; CYANINE DYE; CYCLOPHILIN; CYCLOSPORIN A; DEQUALINIUM; DEXTRAN DERIVATIVE; DICHLOROACETIC ACID; DRUG CARRIER; DYNEIN ADENOSINE TRIPHOSPHATASE; FICOLL; HYPOGLYCINE A; LIPOSOME; METHYLTRIPHENYLPHOSPHONIUM; MILDRONATE; MITOCHONDRIAL PROTEIN; PACLITAXEL; PEPTIDE DERIVATIVE; PEPTIDE NUCLEIC ACID; PERHEXILINE; PHOSPHOLIPID; PLASMID DNA; POLYMER; RANOLAZINE; RHODAMINE 123; RIBOZYME; TRIMETAZIDINE; UNINDEXED DRUG;

EID: 12344302096     PISSN: 17425247     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425247.2.1.89     Document Type: Review
Times cited : (42)

References (102)
  • 1
    • 0032783476 scopus 로고    scopus 로고
    • Revolution in mitochondrial medicine
    • LARSSON N-G, LUFT R: Revolution in mitochondrial medicine. FEBS Lett. (1999) 455:199-202.
    • (1999) FEBS Lett. , vol.455 , pp. 199-202
    • Larsson, N.-G.1    Luft, R.2
  • 2
    • 0344393075 scopus 로고    scopus 로고
    • Medicinal and genetic approaches to the treatment of mitochondrial disease
    • SCHON EA, DIMAURO S: Medicinal and genetic approaches to the treatment of mitochondrial disease. Curr. Med. Chem. (2003) 10 1241-1253.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1241-1253
    • Schon, E.A.1    Dimauro, S.2
  • 3
    • 0343986284 scopus 로고    scopus 로고
    • Drug delivery to mitochondria: The key to mitochondrial medicine
    • MURPHY MP, SMITH RA: Drug delivery to mitochondria: the key to mitochondrial medicine. Adv. Drug Deliv. Rev. (2000) 41 235-250.
    • (2000) Adv. Drug Deliv. Rev. , vol.41 , pp. 235-250
    • Murphy, M.P.1    Smith, R.A.2
  • 4
    • 0034011512 scopus 로고    scopus 로고
    • Our changing views of mitochondria
    • MANELLA CA: Our changing views of mitochondria. J. Bioenerg. Biomembr. (2000) 32:1-4.
    • (2000) J. Bioenerg. Biomembr. , vol.32 , pp. 1-4
    • Manella, C.A.1
  • 5
    • 0345493814 scopus 로고    scopus 로고
    • Recent structural insight into mitochondria gained by microscopy
    • PERKINS GA, FREY TG: Recent structural insight into mitochondria gained by microscopy. Micron (2000) 31:97-111.
    • (2000) Micron , vol.31 , pp. 97-111
    • Perkins, G.A.1    Frey, T.G.2
  • 6
    • 0035797119 scopus 로고    scopus 로고
    • Mitochondria make a come back
    • SCHEFFLER IE: Mitochondria make a come back. Adv. Drug Deliv. Rev. (2001) 49:3-26.
    • (2001) Adv. Drug Deliv. Rev. , vol.49 , pp. 3-26
    • Scheffler, I.E.1
  • 8
    • 0344393079 scopus 로고    scopus 로고
    • Mitochondria-targeting therapeutic strategies for overcoming chemoresistance and progression of cancer
    • MORISAKI T, KATANO M: Mitochondria-targeting therapeutic strategies for overcoming chemoresistance and progression of cancer. Curr. Med. Chem. (2003) 10:2517-2521.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 2517-2521
    • Morisaki, T.1    Katano, M.2
  • 9
    • 0344824689 scopus 로고    scopus 로고
    • MPP+ analogs acting on mitochondria and inducing neuro-degeneration
    • KOTAKE Y. OHTA S: MPP+ analogs acting on mitochondria and inducing neuro-degeneration. Curr. Med. Chem. (2003) 10 2507-2516.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 2507-2516
    • Kotake, Y.1    Ohta, S.2
  • 10
    • 0042310971 scopus 로고    scopus 로고
    • The mitochondrial permeability transition pore complex as a pharmacological target. An introduction
    • KROEMER G: The mitochondrial permeability transition pore complex as a pharmacological target. An introduction. Curr. Med. Chem. (2003) 10:1469-1472.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1469-1472
    • Kroemer, G.1
  • 11
    • 0042811006 scopus 로고    scopus 로고
    • Mitochondrial lipids as apoptosis regulators
    • MALISAN F, TESTI R: Mitochondrial lipids as apoptosis regulators. Curr. Med. Chem. (2003) 10:1573-1580.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1573-1580
    • Malisan, F.1    Testi, R.2
  • 12
    • 0041809082 scopus 로고    scopus 로고
    • The peripheral benzodiazepine receptor: A promising therapeutic drug target
    • GALIEGUE S, TINEL N, CASELLAS P: The peripheral benzodiazepine receptor: a promising therapeutic drug target. Curr. Med. Chem. (2003) 10:1563-1572.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1563-1572
    • Galiegue, S.1    Tinel, N.2    Casellas, P.3
  • 13
    • 0041809088 scopus 로고    scopus 로고
    • Bcl-2-related proteins as drug targets
    • O'NEILL JW, HOCKENBERY DM: Bcl-2-related proteins as drug targets. Curr. Med. Chem. (2003) 10:1553-1562.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1553-1562
    • O'Neill, J.W.1    Hockenbery, D.M.2
  • 14
    • 0041309460 scopus 로고    scopus 로고
    • Hexokinase II: The integration of energy metabolism and control of apoptosis
    • PASTORINO JG, HOEK JB: Hexokinase II: the integration of energy metabolism and control of apoptosis. Curr. Med. Chem. (2003) 10:1535-1551.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1535-1551
    • Pastorino, J.G.1    Hoek, J.B.2
  • 15
    • 0041810124 scopus 로고    scopus 로고
    • The mitochondrial voltage-dependent anion channel (VDAC) as a therapeutic target for initiating cell death
    • GRANVILLE DJ, GOTTLIEB RA: The mitochondrial voltage-dependent anion channel (VDAC) as a therapeutic target for initiating cell death. Curr. Med. Chem. (2003) 10:1527-1533.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1527-1533
    • Granville, D.J.1    Gottlieb, R.A.2
  • 16
    • 0041810128 scopus 로고    scopus 로고
    • The adenine nucleotide translocase: A central component of the mitochondrial permeability transition pore and key player in cell death
    • HALESTRAP AP, BRENNERB C: The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death. Curr. Med. Chem. 2003; 10:1507-1525.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1507-1525
    • Halestrap, A.P.1    Brennerb, C.2
  • 18
    • 0042526700 scopus 로고    scopus 로고
    • On the involvement of mitochondrial intermembrane junctional complexes in apoptosis
    • CROMPTON M: On the involvement of mitochondrial intermembrane junctional complexes in apoptosis. Curr. Med. Chem. (2003) 10 1473-1484.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1473-1484
    • Crompton, M.1
  • 20
    • 0033288336 scopus 로고    scopus 로고
    • Mitochondrial control of apoptosis: An overview
    • Brown GC, Nicholls DG, Cooper CE (Eds.). Princton University Press: Princton, NJ
    • KROEMER G: Mitochondrial control of apoptosis: an overview. In: Mitochondria and Cell Death. Brown GC, Nicholls DG, Cooper CE (Eds.). Princton University Press: Princton, NJ (1999):1-15.
    • (1999) Mitochondria and Cell Death , pp. 1-15
    • Kroemer, G.1
  • 21
    • 1042278892 scopus 로고    scopus 로고
    • Antioxidant and prooxidant properties of mitochondrial Coenzyme Q
    • JAMES AM, SMITH RA, MURPHY MP: Antioxidant and prooxidant properties of mitochondrial Coenzyme Q. Arch. Biochem. Biophys. (2004) 423:47-56.
    • (2004) Arch. Biochem. Biophys. , vol.423 , pp. 47-56
    • James, A.M.1    Smith, R.A.2    Murphy, M.P.3
  • 22
    • 0842328003 scopus 로고    scopus 로고
    • Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes
    • GREEN K, BRAND MD, MURPHY MP: Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes (2004) 53(Suppl. 1):S110-S118.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Green, K.1    Brand, M.D.2    Murphy, M.P.3
  • 24
    • 4444297565 scopus 로고    scopus 로고
    • Mitochondria: Are they the seat of senescence?
    • FRIDOVICH I: Mitochondria: are they the seat of senescence? Aging Cell (2004) 3:13-16.
    • (2004) Aging Cell , vol.3 , pp. 13-16
    • Fridovich, I.1
  • 25
    • 0036194529 scopus 로고    scopus 로고
    • Mitochondria as a pharmacological target
    • SZEWCZYK A, WOJTCZAK L: Mitochondria as a pharmacological target. Pharmacol. Rev. (2002) 54:101-127.
    • (2002) Pharmacol. Rev. , vol.54 , pp. 101-127
    • Szewczyk, A.1    Wojtczak, L.2
  • 27
    • 0034951327 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in human disease
    • DIMAURO S, SCHON EA: Mitochondrial DNA mutations in human disease. Am. J. Med. Genet. (2001) 106:18-26.
    • (2001) Am. J. Med. Genet. , vol.106 , pp. 18-26
    • Dimauro, S.1    Schon, E.A.2
  • 28
    • 0026624980 scopus 로고
    • Diseases of the mitochondrial DNA
    • WALLACE DC: Diseases of the mitochondrial DNA. Ann. Rev. Biochem. (1992) 61:1175-1212.
    • (1992) Ann. Rev. Biochem. , vol.61 , pp. 1175-1212
    • Wallace, D.C.1
  • 29
    • 0035234813 scopus 로고    scopus 로고
    • A mitochondrial paradigm for degenerative diseases and ageing
    • WALLACE DC: A mitochondrial paradigm for degenerative diseases and ageing. Novartis Found. Symp. (2001) 235 247-263.
    • (2001) Novartis Found. Symp. , vol.235 , pp. 247-263
    • Wallace, D.C.1
  • 31
    • 0033937733 scopus 로고    scopus 로고
    • The role of mitochondria in the pathogenesis of neurodegenerative diseases
    • MANFREDI G, BEAL MF: The role of mitochondria in the pathogenesis of neurodegenerative diseases. Brain Pathol. (2000) 10:462-472.
    • (2000) Brain Pathol. , vol.10 , pp. 462-472
    • Manfredi, G.1    Beal, M.F.2
  • 32
    • 4444334765 scopus 로고    scopus 로고
    • Approaches to mitochondrial gene therapy
    • D'SOUZA GGM, WEISSIG V: Approaches to mitochondrial gene therapy. Curr. Gene Ther. (2004) 4:317-328.
    • (2004) Curr. Gene Ther. , vol.4 , pp. 317-328
    • D'Souza, G.G.M.1    Weissig, V.2
  • 34
    • 0042335811 scopus 로고    scopus 로고
    • Bench to bedside: The role of mitochondrial medicine in the pathogenesis and treatment of cellular injury
    • WATTS JA, KLINE JA: Bench to bedside: the role of mitochondrial medicine in the pathogenesis and treatment of cellular injury. Acad. Emerg. Med. (2003) 10:985-997.
    • (2003) Acad. Emerg. Med. , vol.10 , pp. 985-997
    • Watts, J.A.1    Kline, J.A.2
  • 35
    • 0034668946 scopus 로고    scopus 로고
    • Mitochondria as all-round players of the calcium game
    • RIZZUTO R, BERNARDI P, POZZAN T: Mitochondria as all-round players of the calcium game. J. Physiol. (2000) 529 (Pt 1):37-47.
    • (2000) J. Physiol. , vol.529 , Issue.PART 1 , pp. 37-47
    • Rizzuto, R.1    Bernardi, P.2    Pozzan, T.3
  • 36
    • 0032827410 scopus 로고    scopus 로고
    • Mitochondrial transport of cations: Channels, exchangers, and permeability transition
    • BERNARDI P: Mitochondrial transport of cations: channels, exchangers, and permeability transition. Physiol. Rev. (1999) 79 1127-1155.
    • (1999) Physiol. Rev. , vol.79 , pp. 1127-1155
    • Bernardi, P.1
  • 37
    • 1642540210 scopus 로고    scopus 로고
    • The mitochondrial calcium uniporter is a highly selective ion channel
    • KIRICHOK Y, KRAPIVlNSKY G, CLAPHAM DE: The mitochondrial calcium uniporter is a highly selective ion channel. Nature (2004) 427:360-364.
    • (2004) Nature , vol.427 , pp. 360-364
    • Kirichok, Y.1    Krapivlnsky, G.2    Clapham, D.E.3
  • 38
    • 0036859102 scopus 로고    scopus 로고
    • The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure
    • RUPP H, ZARAIN-HERZBERG A, MAISCH B: The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure. Herz (2002) 27:621-636.
    • (2002) Herz , vol.27 , pp. 621-636
    • Rupp, H.1    Zarain-Herzberg, A.2    Maisch, B.3
  • 39
    • 1642579666 scopus 로고    scopus 로고
    • A cell fractionation approach for the quantitative analysis of subcellular drug disposition
    • DUVVURI M, FENG W, MATHIS A, KRISE JP: A cell fractionation approach for the quantitative analysis of subcellular drug disposition. Pharm. Res. (2004) 21:26-32.
    • (2004) Pharm. Res. , vol.21 , pp. 26-32
    • Duvvuri, M.1    Feng, W.2    Mathis, A.3    Krise, J.P.4
  • 41
    • 0030742748 scopus 로고    scopus 로고
    • Translational diffusion of macromolecule-sized solutes in cytoplasm and nucleus
    • SEKSEK O, BIWERSI J, VERKMAN AS: Translational diffusion of macromolecule-sized solutes in cytoplasm and nucleus. J. Cell Biol. (1997) 138:131-142.
    • (1997) J. Cell Biol. , vol.138 , pp. 131-142
    • Seksek, O.1    Biwersi, J.2    Verkman, A.S.3
  • 42
    • 0025976539 scopus 로고
    • Low viscosity in the aqueous domain of cell cytoplasm measured by picosecond polarization microfluorimetry
    • FUSHIMI K, VERKMAN AS: Low viscosity in the aqueous domain of cell cytoplasm measured by picosecond polarization microfluorimetry. J. Cell Biol. (1991) 112:719-725.
    • (1991) J. Cell Biol. , vol.112 , pp. 719-725
    • Fushimi, K.1    Verkman, A.S.2
  • 43
    • 0030896925 scopus 로고    scopus 로고
    • Microtubule-mediated transport of incoming herpes simplex virus 1 capsids to the nucleus
    • SODEIK B, EBERSOLD MW. HELENIUS A: Microtubule-mediated transport of incoming herpes simplex virus 1 capsids to the nucleus. J. Cell Biol. (1997) 136:1007-1021.
    • (1997) J. Cell Biol. , vol.136 , pp. 1007-1021
    • Sodeik, B.1    Ebersold, M.W.2    Helenius, A.3
  • 44
    • 0027529545 scopus 로고
    • Determinants of the translational mobility of a small solute in cell cytoplasm
    • KAO HP, ABNEY JR, VERKMAN AS: Determinants of the translational mobility of a small solute in cell cytoplasm. J. Cell Biol. (1993) 120:175-184.
    • (1993) J. Cell Biol. , vol.120 , pp. 175-184
    • Kao, H.P.1    Abney, J.R.2    Verkman, A.S.3
  • 45
    • 0030482720 scopus 로고    scopus 로고
    • Pharmaceutical approach to somatic gene therapy
    • LEDLEY FD: Pharmaceutical approach to somatic gene therapy. Pharm. Res. (1996) 13:1595-1614.
    • (1996) Pharm. Res. , vol.13 , pp. 1595-1614
    • Ledley, F.D.1
  • 46
    • 0036204856 scopus 로고    scopus 로고
    • Biological staining: Mechanisms and theory
    • HOROBIN RW: Biological staining: mechanisms and theory. Biotech. Histochem. (2002) 77:3-13.
    • (2002) Biotech. Histochem. , vol.77 , pp. 3-13
    • Horobin, R.W.1
  • 47
    • 0008700109 scopus 로고    scopus 로고
    • Uptake, distribution and accumulation of dyes and fluorescent probes within living cells: A structure-activity modelling approach
    • HOROBIN RW: Uptake, distribution and accumulation of dyes and fluorescent probes within living cells: a structure-activity modelling approach. Adv. Colour Sci. Technol. (2001) 4:101-107.
    • (2001) Adv. Colour Sci. Technol. , vol.4 , pp. 101-107
    • Horobin, R.W.1
  • 48
    • 0032387842 scopus 로고    scopus 로고
    • Direct demonstration of a specific interaction between cyclophilin D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition
    • WOODFIELD K, RUCK A, BRDICZKA D, HALESTRAP AP: Direct demonstration of a specific interaction between cyclophilin D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition. Biochem. J. (1998) 336:287-290.
    • (1998) Biochem. J. , vol.336 , pp. 287-290
    • Woodfield, K.1    Ruck, A.2    Brdiczka, D.3    Halestrap, A.P.4
  • 50
    • 0018854310 scopus 로고
    • The infrastructure of the mitochondrial matrix
    • SRERE PA: The infrastructure of the mitochondrial matrix. Trends Biochem. Sci. (1980) 5:120-121.
    • (1980) Trends Biochem. Sci. , vol.5 , pp. 120-121
    • Srere, P.A.1
  • 52
    • 0042711191 scopus 로고    scopus 로고
    • Mitochondrial-targeted drug and DNA delivery
    • WEISSIG V: Mitochondrial-targeted drug and DNA delivery. Crit. Rev. Ther. Drug Carrier Syst. (2003) 20:1-62.
    • (2003) Crit. Rev. Ther. Drug Carrier Syst. , vol.20 , pp. 1-62
    • Weissig, V.1
  • 54
    • 0030872907 scopus 로고    scopus 로고
    • Selective targeting of bioactive compounds to mitochondria
    • MURPHY MP: Selective targeting of bioactive compounds to mitochondria. Trends Biotechnol. (1997) 15:326-330.
    • (1997) Trends Biotechnol. , vol.15 , pp. 326-330
    • Murphy, M.P.1
  • 56
    • 12344302513 scopus 로고    scopus 로고
    • Development of nanocomposites with mitochondrial specifity
    • (Abstract)
    • PAUNESKU T, VOGT S, MASER J et al.: Development of nanocomposites with mitochondrial specifity (Abstract). Mitochondrion 2004) 4:75-76.
    • (2004) Mitochondrion , vol.4 , pp. 75-76
    • Paunesku, T.1    Vogt, S.2    Maser, J.3
  • 57
    • 0024422115 scopus 로고
    • Slip and leak in mitochondrial oxidative phosphorylation
    • MURPHY MP: Slip and leak in mitochondrial oxidative phosphorylation. Biochim. Biophys. Acta (1989) 977:123-141.
    • (1989) Biochim. Biophys. Acta , vol.977 , pp. 123-141
    • Murphy, M.P.1
  • 58
    • 0034733819 scopus 로고    scopus 로고
    • Protein translocation pathways of the mitochondrion
    • KOEHLER CM: Protein translocation pathways of the mitochondrion. FEBS Lett. (2000) 476:27-31.
    • (2000) FEBS Lett. , vol.476 , pp. 27-31
    • Koehler, C.M.1
  • 59
    • 0034734011 scopus 로고    scopus 로고
    • Targeting of proteins to mitochondria
    • LITHGOW T: Targeting of proteins to mitochondria. FEBS Lett. (2000) 476:22-26.
    • (2000) FEBS Lett. , vol.476 , pp. 22-26
    • Lithgow, T.1
  • 61
    • 0038365420 scopus 로고    scopus 로고
    • Targeted delivery of DNA to the mitochondrial compartment via import sequence-conjugated peptide nucleic acid
    • FLIERL A, JACKSON C, COTTRELL B, MURDOCK D, SEIBEL P, WALLACE DC: Targeted delivery of DNA to the mitochondrial compartment via import sequence-conjugated peptide nucleic acid. Mol. Ther. (2003) 7 550-557.
    • (2003) Mol. Ther. , vol.7 , pp. 550-557
    • Flierl, A.1    Jackson, C.2    Cottrell, B.3    Murdock, D.4    Seibel, P.5    Wallace, D.C.6
  • 62
    • 0034959104 scopus 로고    scopus 로고
    • Mitochondria transfection by oligonucleotides containing a signal peptide and vectorized by cationic liposomes
    • GEROMEL V, CAO A, BRIANE D: Mitochondria transfection by oligonucleotides containing a signal peptide and vectorized by cationic liposomes. Antisense Nucleic Acid Drug Dev. (2001) 11 175-180.
    • (2001) Antisense Nucleic Acid Drug Dev. , vol.11 , pp. 175-180
    • Geromel, V.1    Cao, A.2    Briane, D.3
  • 63
    • 0030021114 scopus 로고    scopus 로고
    • Cytoplasmic chaperones in precursor targeting to mitochondria: The role of MSF and hsp 70
    • MIHARA K, OMURA T: Cytoplasmic chaperones in precursor targeting to mitochondria: the role of MSF and hsp 70. Trends Cell Biol. (1996) 6:104-108.
    • (1996) Trends Cell Biol. , vol.6 , pp. 104-108
    • Mihara, K.1    Omura, T.2
  • 64
    • 0030475160 scopus 로고    scopus 로고
    • Cytosolic factors in mitochondrial protein import
    • MIHARA K, OMURA T: Cytosolic factors in mitochondrial protein import. Experientia (1996) 52:1063-1068.
    • (1996) Experientia , vol.52 , pp. 1063-1068
    • Mihara, K.1    Omura, T.2
  • 65
    • 0038730828 scopus 로고    scopus 로고
    • A novel TAT-Mitochondrial signal sequence fusion protein is processed, stays in mitochondria, and crosses the placenta
    • DEL GAIZO V, PAYNE RM: A novel TAT-Mitochondrial signal sequence fusion protein is processed, stays in mitochondria, and crosses the placenta. Mol. Ther. (2003) 7:720-730.
    • (2003) Mol. Ther. , vol.7 , pp. 720-730
    • Del Gaizo, V.1    Payne, R.M.2
  • 67
    • 9144230176 scopus 로고    scopus 로고
    • Cell-penetrating peptides do not cross mitochondrial membranes even when conjugated to a lipophilic cation: Evidence against direct passage through phospholipid bilayers
    • ROSS MF, FILIPOVSKA A, SMITH RA, GAIT MJ, MURPHY MP: Cell-penetrating peptides do not cross mitochondrial membranes even when conjugated to a lipophilic cation: evidence against direct passage through phospholipid bilayers. Biochem. J. (2004).
    • (2004) Biochem. J.
    • Ross, M.F.1    Filipovska, A.2    Smith, R.A.3    Gait, M.J.4    Murphy, M.P.5
  • 69
    • 0014674557 scopus 로고
    • Mechanism of coupling of oxidative phosphorylation and the membrane potential of mitochondria
    • LIBERMAN EA, TOPALY VP, TSOFINA LM, JASAITIS AA, SKULACHEV VP: Mechanism of coupling of oxidative phosphorylation and the membrane potential of mitochondria. Nature (1969) 222:1076-1078.
    • (1969) Nature , vol.222 , pp. 1076-1078
    • Liberman, E.A.1    Topaly, V.P.2    Tsofina, L.M.3    Jasaitis, A.A.4    Skulachev, V.P.5
  • 70
    • 0347644172 scopus 로고
    • Dequalinium, a topical antimicrobial agent, displays anticarcinoma activity based on selective mitochondrial accumulation
    • WEISS MJ, WONG JR, HA CS: Dequalinium, a topical antimicrobial agent, displays anticarcinoma activity based on selective mitochondrial accumulation. Proc. Natl. Acad. Sci. USA (1987) 84 5444-5448.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 5444-5448
    • Weiss, M.J.1    Wong, J.R.2    Ha, C.S.3
  • 72
    • 0031602936 scopus 로고    scopus 로고
    • GRP78 induction by calcium ionophore potentiates photodynamic therapy using the mitochondrial targeting dye victoria blue BO
    • MORGAN J, WHITAKER JE, OSEROFF AR: GRP78 induction by calcium ionophore potentiates photodynamic therapy using the mitochondrial targeting dye victoria blue BO. Photochem. Photobiol. (1998) 67 155-164.
    • (1998) Photochem. Photobiol. , vol.67 , pp. 155-164
    • Morgan, J.1    Whitaker, J.E.2    Oseroff, A.R.3
  • 73
    • 0035460705 scopus 로고    scopus 로고
    • Development of lipophilic cations as therapies for disorders due to mitochondrial dysfunction
    • MURPHY MP: Development of lipophilic cations as therapies for disorders due to mitochondrial dysfunction. Expert Opin. Biol. Ther. (2001) 1:753-764.
    • (2001) Expert Opin. Biol. Ther. , vol.1 , pp. 753-764
    • Murphy, M.P.1
  • 74
    • 0038722195 scopus 로고    scopus 로고
    • Specific targeting of a DNA-alkylating reagent to mitochondria. Synthesis and characterization of [4-((11aS -7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiaze pin-5-on-8-oxy)butyl]-triphenylphosphonium iodide
    • JAMES AM, BLAIKIE FH, SMITH RA, LIGHTOWLERS RN, SMITH PM, MURPHY MP: Specific targeting of a DNA-alkylating reagent to mitochondria. Synthesis and characterization of [4-((11aS -7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiaze pin-5-on-8-oxy)butyl]-triphenylphosphonium iodide. Eur. J. Biochem. (2003) 270:2827-2836.
    • (2003) Eur. J. Biochem. , vol.270 , pp. 2827-2836
    • James, A.M.1    Blaikie, F.H.2    Smith, R.A.3    Lightowlers, R.N.4    Smith, P.M.5    Murphy, M.P.6
  • 75
    • 0035895888 scopus 로고    scopus 로고
    • Selective targeting of a redox-active ubiquinone to mitochondria within cells: Antioxidant and antiapoptotic properties
    • KELSO GF, PORTEOUS CM, COULTER CV, SMITH RA, MURPHY MP: Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J. Biol. Chem. (2001) 276:4588-4596.
    • (2001) J. Biol. Chem. , vol.276 , pp. 4588-4596
    • Kelso, G.F.1    Porteous, C.M.2    Coulter, C.V.3    Smith, R.A.4    Murphy, M.P.5
  • 76
    • 0029090125 scopus 로고
    • Synthesis and characterization of thiobutyltriphenylphosphonium bromide, a novel thiol reagent targeted to the mitochondrial matrix
    • BURNS RJ, SMITH RA, MURPHY MP: Synthesis and characterization of thiobutyltriphenylphosphonium bromide, a novel thiol reagent targeted to the mitochondrial matrix. Arch. Biochem. Biophys. (1995) 322 60-68.
    • (1995) Arch. Biochem. Biophys. , vol.322 , pp. 60-68
    • Burns, R.J.1    Smith, R.A.2    Murphy, M.P.3
  • 77
    • 0035339611 scopus 로고    scopus 로고
    • Targeting peptide nucleic acid (PNA) oligomers to mitochondria within cells by conjugation to lipophilic cations: Implications for mitochondrial DNA replication, expression and disease
    • MURATOVSKA A, LIGHTOWLERS RN, TAYLOR RW, SMITH RA, MURPHY MP: Targeting peptide nucleic acid (PNA) oligomers to mitochondria within cells by conjugation to lipophilic cations: implications for mitochondrial DNA replication, expression and disease. Nucleic Acids Res. (2001) 29:1852-1863.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 1852-1863
    • Muratovska, A.1    Lightowlers, R.N.2    Taylor, R.W.3    Smith, R.A.4    Murphy, M.P.5
  • 80
    • 0034003553 scopus 로고    scopus 로고
    • Selective DNA release from DQAsome/DNA complexes at mitochondria-like membranes
    • WEISSIG V, LIZANO C, TORCHILIN VP: Selective DNA release from DQAsome/ DNA complexes at mitochondria-like membranes. Drug Deliv. (2000) 7:1-5.
    • (2000) Drug Deliv. , vol.7 , pp. 1-5
    • Weissig, V.1    Lizano, C.2    Torchilin, V.P.3
  • 81
    • 0035839167 scopus 로고    scopus 로고
    • DQAsome/DNA complexes release DNA upon contact with isolated mouse liver mitochondria
    • WEISSIG V, D'SOUZA GG, TORCHILIN VP: DQAsome/DNA complexes release DNA upon contact with isolated mouse liver mitochondria. J. Control. Release (2001) 75:401-408.
    • (2001) J. Control. Release , vol.75 , pp. 401-408
    • Weissig, V.1    D'Souza, G.G.2    Torchilin, V.P.3
  • 82
    • 0035129422 scopus 로고    scopus 로고
    • DNA binding cationic bolasomes with delocalized charge center: A structure-activity relationship study
    • WEISSIG V, LIZANO C, GANELLIN CR, TORCHILIN VP: DNA binding cationic bolasomes with delocalized charge center: a structure-activity relationship study. S.T.P. Pharma Sciences (2001) 11:91-96.
    • (2001) S.T.P. Pharma Sciences , vol.11 , pp. 91-96
    • Weissig, V.1    Lizano, C.2    Ganellin, C.R.3    Torchilin, V.P.4
  • 83
    • 0031916033 scopus 로고    scopus 로고
    • DQAsomes: A novel potential drug and gene delivery system made from Dequalinium
    • WEISSIG V, LASCH J, ERDOS G, MEYER HW, ROWE TC, HUGHES J: DQAsomes: a novel potential drug and gene delivery system made from Dequalinium. Pharm. Res. (1998) 15:334-337.
    • (1998) Pharm. Res. , vol.15 , pp. 334-337
    • Weissig, V.1    Lasch, J.2    Erdos, G.3    Meyer, H.W.4    Rowe, T.C.5    Hughes, J.6
  • 85
    • 0032586976 scopus 로고    scopus 로고
    • Dequalinium vesicles form stable complexes with plasmid DNA which are protected from DNase attack
    • LASCH J, MEYE A, TAUBERT H, KOELSCH R, MANSA-ARD J, WEISSIG V: Dequalinium vesicles form stable complexes with plasmid DNA which are protected from DNase attack. Biol. Chem. (1999) 380:647-652.
    • (1999) Biol. Chem. , vol.380 , pp. 647-652
    • Lasch, J.1    Meye, A.2    Taubert, H.3    Koelsch, R.4    Mansa-Ard, J.5    Weissig, V.6
  • 86
    • 0034989736 scopus 로고    scopus 로고
    • Towards mitochondrial gene therapy: DQAsomes as a strategy
    • WEISSIG V, TORCHILIN VP: Towards mitochondrial gene therapy: DQAsomes as a strategy. J. Drug Target. (2001) 9:1-13.
    • (2001) J. Drug Target. , vol.9 , pp. 1-13
    • Weissig, V.1    Torchilin, V.P.2
  • 87
    • 0035797116 scopus 로고    scopus 로고
    • Cationic bolasomes with delocalized charge centers as mitochondria-specific DNA delivery systems
    • WEISSIG V, TORCHILIN VP: Cationic bolasomes with delocalized charge centers as mitochondria-specific DNA delivery systems. Adv. Drug Deliv. Rev. (2001) 49:127-149.
    • (2001) Adv. Drug Deliv. Rev. , vol.49 , pp. 127-149
    • Weissig, V.1    Torchilin, V.P.2
  • 89
    • 0031973791 scopus 로고    scopus 로고
    • The taxoids. Comparative clinical pharmacology and therapeutic potential
    • EISENHAUER EA, VERMORKEN JB: The taxoids. Comparative clinical pharmacology and therapeutic potential. Drugs (1998) 55 5-30.
    • (1998) Drugs , vol.55 , pp. 5-30
    • Eisenhauer, E.A.1    Vermorken, J.B.2
  • 90
    • 0037021417 scopus 로고    scopus 로고
    • Paclitaxel targets mitochondria upstream of caspase activation in intact human neuroblastoma cells
    • ANDRE N, CARRE M, BRASSEUR G: Paclitaxel targets mitochondria upstream of caspase activation in intact human neuroblastoma cells. FEBS Lett. (2002) 532:256-260.
    • (2002) FEBS Lett. , vol.532 , pp. 256-260
    • Andre, N.1    Carre, M.2    Brasseur, G.3
  • 92
    • 0024148694 scopus 로고
    • Mitochondrial membrane potential in living cells
    • CHEN LB: Mitochondrial membrane potential in living cells. Ann. Rev. Cell Biol. (1988) 4:155-181.
    • (1988) Ann. Rev. Cell Biol. , vol.4 , pp. 155-181
    • Chen, L.B.1
  • 93
    • 0035797118 scopus 로고    scopus 로고
    • Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells
    • MODICA-NAPOLITANO JS, APRILLE JR: Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells. Adv. Drug Deliv. Rev. (2001) 49:63-70.
    • (2001) Adv. Drug Deliv. Rev. , vol.49 , pp. 63-70
    • Modica-Napolitano, J.S.1    Aprille, J.R.2
  • 94
    • 0023227833 scopus 로고
    • Basis for the selective cytotoxicity of rhodamine 123
    • MODICA-NAPOLITANO JS, APRILLE JR: Basis for the selective cytotoxicity of rhodamine 123. Cancer Res. (1987) 47 4361-4365.
    • (1987) Cancer Res. , vol.47 , pp. 4361-4365
    • Modica-Napolitano, J.S.1    Aprille, J.R.2
  • 95
    • 0025341615 scopus 로고
    • Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
    • KLIBANOV AL, MARUYAMA K, TORCHILIN VP, HUANG L: Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett. (1990) 268:235-237.
    • (1990) FEBS Lett. , vol.268 , pp. 235-237
    • Klibanov, A.L.1    Maruyama, K.2    Torchilin, V.P.3    Huang, L.4
  • 96
    • 0141480605 scopus 로고    scopus 로고
    • Preparation of liposomes
    • Torchilin VP, Weissig V (Eds). Oxford University Press, Oxford
    • LASCH J, WEISSIG V, BRANDL M: Preparation of liposomes. In: Liposomes - A Practical Approach. Torchilin VP, Weissig V (Eds). Oxford University Press, Oxford (2003):3-30.
    • (2003) Liposomes - A Practical Approach , pp. 3-30
    • Lasch, J.1    Weissig, V.2    Brandl, M.3
  • 98
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: Delivery of a biologically active protein into the mouse
    • SCHWARZE SR, HO A, VOCERO-AKBANI A, DOWDY SF: In vivo protein transduction: delivery of a biologically active protein into the mouse. Science (1999) 285:1569-1572.
    • (1999) Science , vol.285 , pp. 1569-1572
    • Schwarze, S.R.1    Ho, A.2    Vocero-Akbani, A.3    Dowdy, S.F.4
  • 99
    • 3843092828 scopus 로고    scopus 로고
    • Chances and pitfalls of cell penetrating peptides for cellular drug delivery
    • TREHIN R, MERKLE HP: Chances and pitfalls of cell penetrating peptides for cellular drug delivery. Eur. J. Pharm. Biopharm. (2004) 58:209-223.
    • (2004) Eur. J. Pharm. Biopharm. , vol.58 , pp. 209-223
    • Trehin, R.1    Merkle, H.P.2
  • 100
    • 1542721107 scopus 로고    scopus 로고
    • Cell penetrating peptides in drug delivery
    • SNYDER EL, DOWDY SF: Cell penetrating peptides in drug delivery. Pharm. Res. (2004) 21:389-393.
    • (2004) Pharm. Res. , vol.21 , pp. 389-393
    • Snyder, E.L.1    Dowdy, S.F.2
  • 101
    • 11144356131 scopus 로고    scopus 로고
    • The use of cell-penetrating peptides as a tool for gene regulation
    • JARVER P, LANGEL U: The use of cell-penetrating peptides as a tool for gene regulation. Drug Discov. Today (2004) 9 395-402.
    • (2004) Drug Discov. Today , vol.9 , pp. 395-402
    • Jarver, P.1    Langel, U.2


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