DNA binding cationic bolasomes with delocalized charge center a structure-activity relationship study

S.T.P. Pharma Sciences

Volumn 11, Issue 1, 2001, Pages 91-96

  Weissig, V ^a   Lizano, C ^a   Ganellin, C R ^a   Torchilin, V P ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Bolaamphiphile; Bolasome; Cationic vesicle; Dequalinium; DNA binding; DNA delivery; Mitochondria; Non viral transfection vector

Indexed keywords

AMPHOPHILE; BOLAAMPHIPHILE; DEQUALINIUM; LIPOFECTIN; PLASMID DNA; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BOLASOME; CONTROLLED STUDY; DNA BINDING; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; MEMBRANE VESICLE; MOLECULAR STABILITY; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

EID: 0035129422     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Mitochondrial diseases and aging
2. Mitochondrial diseases in man and mouse
3. Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies
4. Neurological disease and mitochondrial genes
5. Gene therapy for mitochondrial DNA defects: Is it possible?
6. Dequalinium, a topical antimicrobial agent, displays anticarcinoma activity based on selective mitochondrial accumulation
7. DQAsomes: A novel potential drug and gene delivery system made from dequalinium
8. Dequalinium vesicles form stable complexes with plasmid DNA which are protected from DNAse attack
9. Lipofection with DQAsomes: Mitochondria-specific?
10. DQAsomes A strategy for mitochondrial gene therapy
11. Towards mitochondrial gene therapy: DQAsomes as a strategy
12. Selective DNA release from DQAsome / DNA complexes at mitochondria-like membranes
13. Synthesis and structure-activity relationships of dequalinium analogues as K+ channel blockers. Investigations on the role of the charged heterocycle
14. Synthesis and quantitative structure-activity relationships of dequalinium analogues as K+ channel blockers: Investigation into the role of the substituent position 4 of the quinoline ring
15. Synthesis and pharmacological testing of dequalinium analogues as blockers of the apamin-sensitive Ca (2+)-activated K+ channel: Variation of the length of the alkylene chain
16. Liposomes
17. Computer simulations of DQAsomes
18. Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection
19. Synthesis and quantitative structure-activity relationship of a novel series of small conductance Ca2+ -activated K+ channel blockers related to dequalinium
20. Synthesis, molecular modeling, and K+ channel-blocking activity of dequalinium analogues having semirigid linkers
21. The lipophilic behavior of organic compounds. 1. An updating of the hydrophobic fragmental constant approach