Specific targeting of a DNA-alkylating reagent to mitochondria: Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4] benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide

European Journal of Biochemistry

Volumn 270, Issue 13, 2003, Pages 2827-2836

  James, Andrew M ^a   Blaikie, Frances H ^b   Smith, Robin A J ^b   Lightowlers, Robert N ^c   Smith, Paul M ^c   Murphy, Michael P ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Membrane potential; Mitochondria; Mitochondrial DNA; Targeting

Indexed keywords

1,2,3,11A TETRAHYDRO 8 HYDROXY 7 METHOXY 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; [4 (7 METHOXY 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ON 8 OXY)BUTYL]TRIPHENYLPHOSPHONIUM IODIDE; ALKYLATING AGENT; CATION; GUANINE; MITOCHONDRIAL DNA; PHOSPHONIUM DERIVATIVE; PLASMID DNA; REAGENT; TRIPHENYLPHOSPHINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL RESPIRATION; CHEMICAL ANALYSIS; CONTROLLED STUDY; DNA ALKYLATION; DNA REPLICATION; DNA SYNTHESIS INHIBITION; GENETIC MANIPULATION; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; SYNTHESIS;

ALKYLATING AGENTS; ANIMALS; BENZODIAZEPINES; CATIONS; CELL RESPIRATION; DNA, MITOCHONDRIAL; HUMANS; IODIDES; MITOCHONDRIA, LIVER; MOLECULAR STRUCTURE; ORGANOPHOSPHORUS COMPOUNDS; RATS; TUMOR CELLS, CULTURED;

ANIMALIA; MAMMALIA;

EID: 0038722195     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2003.03660.x     Document Type: Article

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