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Volumn 102, Issue 2, 2005, Pages 313-332

Microencapsulation by solvent extraction/evaporation: Reviewing the state of the art of microsphere preparation process technology

Author keywords

Biodegradable microspheres; Controlled release; Jet excitation; Membrane extrusion; Microchannel micromixer; Microencapsulation; PLA; PLGA; Solvent evaporation; Solvent extraction; Static mixing

Indexed keywords

BIOACTIVE COMPOUND; MICROENCAPSULATION; MICROSPHERES;

EID: 11844259383     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.10.015     Document Type: Review
Times cited : (815)

References (110)
  • 1
    • 0034601247 scopus 로고    scopus 로고
    • Revisiting PLA/PLGA microspheres: An analysis of their potential in parenteral vaccination
    • P. Johansen, Y. Men, H.P. Merkle, and B. Gander Revisiting PLA/PLGA microspheres: an analysis of their potential in parenteral vaccination Eur. J. Pharm. Biopharm. 50 2000 129 146
    • (2000) Eur. J. Pharm. Biopharm. , vol.50 , pp. 129-146
    • Johansen, P.1    Men, Y.2    Merkle, H.P.3    Gander, B.4
  • 2
    • 0343632356 scopus 로고    scopus 로고
    • New advances in microsphere-based single-dose vaccines
    • J. Hanes, J.L. Cleland, and R. Langer New advances in microsphere-based single-dose vaccines Adv. Drug Deliv. Rev. 28 1997 97 119
    • (1997) Adv. Drug Deliv. Rev. , vol.28 , pp. 97-119
    • Hanes, J.1    Cleland, J.L.2    Langer, R.3
  • 3
    • 0035845758 scopus 로고    scopus 로고
    • Hydrophilic poly(dl-lactide-co-glycolide) microspheres for the delivery of DNA to human-derived macrophages and dendritic cells
    • E. Walter, D. Dreher, M. Kok, L. Thiele, S.G. Kiama, P. Gehr, and H.P. Merkle Hydrophilic poly(dl-lactide-co-glycolide) microspheres for the delivery of DNA to human-derived macrophages and dendritic cells J. Control. Release 76 2001 149 168
    • (2001) J. Control. Release , vol.76 , pp. 149-168
    • Walter, E.1    Dreher, D.2    Kok, M.3    Thiele, L.4    Kiama, S.G.5    Gehr, P.6    Merkle, H.P.7
  • 4
    • 0037331755 scopus 로고    scopus 로고
    • Ligand-specific targeting of microspheres to phagocytes by surface modification with poly(l-lysine)-grafted poly(ethylene glycol) conjugate
    • S. Faraasen, J. Vörös, G. Csucs, M. Textor, H.P. Merkle, and E. Walter Ligand-specific targeting of microspheres to phagocytes by surface modification with poly(l-lysine)-grafted poly(ethylene glycol) conjugate Pharm. Res. 20 2003 237 246
    • (2003) Pharm. Res. , vol.20 , pp. 237-246
    • Faraasen, S.1    Vörös, J.2    Csucs, G.3    Textor, M.4    Merkle, H.P.5    Walter, E.6
  • 5
    • 0141867772 scopus 로고    scopus 로고
    • Lung-targeting microspheres of carboplatin
    • B. Lu, J.Q. Zhang, and H. Yang Lung-targeting microspheres of carboplatin Int. J. Pharm. 265 2003 1 11
    • (2003) Int. J. Pharm. , vol.265 , pp. 1-11
    • Lu, B.1    Zhang, J.Q.2    Yang, H.3
  • 6
    • 0022496987 scopus 로고
    • Evaluation of poly(lactic acid) as a biodegradable drug delivery system for parenteral administration
    • A. Smith, and I.M. Hunneyball Evaluation of poly(lactic acid) as a biodegradable drug delivery system for parenteral administration Int. J. Pharm. 30 1986 215 220
    • (1986) Int. J. Pharm. , vol.30 , pp. 215-220
    • Smith, A.1    Hunneyball, I.M.2
  • 7
    • 0343247711 scopus 로고    scopus 로고
    • Biodegradation and biocompatibility of PLA and PLGA microspheres
    • J.M. Anderson, and M.S. Shive Biodegradation and biocompatibility of PLA and PLGA microspheres Adv. Drug Deliv. Rev. 28 1997 5 24
    • (1997) Adv. Drug Deliv. Rev. , vol.28 , pp. 5-24
    • Anderson, J.M.1    Shive, M.S.2
  • 8
    • 0030867627 scopus 로고    scopus 로고
    • Microparticles of poly(dl-lactic-co-glycolic acid)/poly(ethylene glycol) blends for controlled drug delivery
    • R.L. Cleek, K.C. Ting, S.G. Eskin, and A.G. Mikos Microparticles of poly(dl-lactic-co-glycolic acid)/poly(ethylene glycol) blends for controlled drug delivery J. Control. Release 48 1997 259 268
    • (1997) J. Control. Release , vol.48 , pp. 259-268
    • Cleek, R.L.1    Ting, K.C.2    Eskin, S.G.3    Mikos, A.G.4
  • 9
    • 0141504461 scopus 로고    scopus 로고
    • Application of chitin and chitosan derivatives in the pharmaceutical field
    • Y. Kato, H. Onishi, and Y. Machida Application of chitin and chitosan derivatives in the pharmaceutical field Curr. Pharm. Biotechnol. 4 2003 303 309
    • (2003) Curr. Pharm. Biotechnol. , vol.4 , pp. 303-309
    • Kato, Y.1    Onishi, H.2    MacHida, Y.3
  • 10
    • 0035850227 scopus 로고    scopus 로고
    • Lipid microparticles as a parenteral controlled release device for peptides
    • H. Reithmeier, J. Herrmann, and A. Göpferich Lipid microparticles as a parenteral controlled release device for peptides J. Control. Release 73 2001 339 350
    • (2001) J. Control. Release , vol.73 , pp. 339-350
    • Reithmeier, H.1    Herrmann, J.2    Göpferich, A.3
  • 11
    • 0028907285 scopus 로고
    • Preparation and characterization of 5-fluorouracil-loaded microparticles as biodegradable anticancer drug carriers
    • M. Boisdron-Celle, P. Menei, and J.P. Benoit Preparation and characterization of 5-fluorouracil-loaded microparticles as biodegradable anticancer drug carriers J. Pharm. Pharmacol. 47 1995 108 114
    • (1995) J. Pharm. Pharmacol. , vol.47 , pp. 108-114
    • Boisdron-Celle, M.1    Menei, P.2    Benoit, J.P.3
  • 12
    • 0026442934 scopus 로고
    • Reduction of systemic exposure and toxicity of cisplatin by encapsulation in poly(lactide-co-glycolide)
    • R. Verrijk, I.J. Smolders, N. Bosnie, and A.C. Begg Reduction of systemic exposure and toxicity of cisplatin by encapsulation in poly(lactide-co- glycolide) Cancer Res. 52 1992 6653 6656
    • (1992) Cancer Res. , vol.52 , pp. 6653-6656
    • Verrijk, R.1    Smolders, I.J.2    Bosnie, N.3    Begg, A.C.4
  • 13
    • 0016426141 scopus 로고
    • Long acting delivery systems for narcotic antagonists: 2. Release rates of naltrexone from poly(lactic acid) composites
    • S. Yolles, T.D. Leafe, J.H. Woodland, and F.J. Meyer Long acting delivery systems for narcotic antagonists: 2. Release rates of naltrexone from poly(lactic acid) composites J. Pharm. Sci. 64 1975 348 349
    • (1975) J. Pharm. Sci. , vol.64 , pp. 348-349
    • Yolles, S.1    Leafe, T.D.2    Woodland, J.H.3    Meyer, F.J.4
  • 14
    • 0035895291 scopus 로고    scopus 로고
    • Effects of the rate of solvent evaporation on the characteristics of drug loaded PLLA and PDLLA microspheres
    • T.W. Chung, Y.Y. Huang, and Y.Z. Liu Effects of the rate of solvent evaporation on the characteristics of drug loaded PLLA and PDLLA microspheres Int. J. Pharm. 212 2001 161 169
    • (2001) Int. J. Pharm. , vol.212 , pp. 161-169
    • Chung, T.W.1    Huang, Y.Y.2    Liu, Y.Z.3
  • 15
    • 0342275184 scopus 로고    scopus 로고
    • Multiple emulsion technology for the design of microspheres containing peptides and oligopeptides
    • P. Couvreur, M.J. Blanco-Prieto, F. Puisieux, B. Roques, and E. Fattal Multiple emulsion technology for the design of microspheres containing peptides and oligopeptides Adv. Drug Deliv. Rev. 28 1997 85 96
    • (1997) Adv. Drug Deliv. Rev. , vol.28 , pp. 85-96
    • Couvreur, P.1    Blanco-Prieto, M.J.2    Puisieux, F.3    Roques, B.4    Fattal, E.5
  • 16
    • 0031059837 scopus 로고    scopus 로고
    • Effect of processing parameters on the properties of peptide-containing PLGA microspheres
    • R. Jeyanthi, R.C. Mehta, B.C. Thanoo, and P.P. DeLuca Effect of processing parameters on the properties of peptide-containing PLGA microspheres J. Microencapsulation 14 1997 163 174
    • (1997) J. Microencapsulation , vol.14 , pp. 163-174
    • Jeyanthi, R.1    Mehta, R.C.2    Thanoo, B.C.3    Deluca, P.P.4
  • 17
    • 0035966525 scopus 로고    scopus 로고
    • Stabilizing insulin-like growth factor-I in poly(dl,lactide-co-glycolide) microspheres
    • L. Meinel, O.E. Illi, J. Zapf, M. Malfanti, H.P. Merkle, and B. Gander Stabilizing insulin-like growth factor-I in poly(dl,lactide-co-glycolide) microspheres J. Control. Release 70 2001 193 202
    • (2001) J. Control. Release , vol.70 , pp. 193-202
    • Meinel, L.1    Illi, O.E.2    Zapf, J.3    Malfanti, M.4    Merkle, H.P.5    Gander, B.6
  • 18
    • 0025731293 scopus 로고
    • Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres
    • S. Cohen, T. Yoshioka, M. Lucarelli, L.H. Hwang, and R. Langer Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres Pharm. Res. 8 1991 713 720
    • (1991) Pharm. Res. , vol.8 , pp. 713-720
    • Cohen, S.1    Yoshioka, T.2    Lucarelli, M.3    Hwang, L.H.4    Langer, R.5
  • 19
    • 0033398892 scopus 로고    scopus 로고
    • Comparison of process parameters for microencapsulation of plasmid DNA in poly(d,l-lactic-co-glycolic) acid microspheres
    • Y.Y. Hsu, T. Hao, and M.L. Hedley Comparison of process parameters for microencapsulation of plasmid DNA in poly(d,l-lactic-co-glycolic) acid microspheres J. Drug Target. 7 1999 313 323
    • (1999) J. Drug Target. , vol.7 , pp. 313-323
    • Hsu, Y.Y.1    Hao, T.2    Hedley, M.L.3
  • 20
    • 0032765726 scopus 로고    scopus 로고
    • Influence of formulation parameters on the characteristics of poly(d,l-lactide-co-glycolide) microspheres containing poly(l-lysine) complexed plasmid DNA
    • Y. Capan, B.H. Woo, S. Gebrekidan, S. Ahmed, and P.P. DeLuca Influence of formulation parameters on the characteristics of poly(d,l-lactide-co-glycolide) microspheres containing poly(l-lysine) complexed plasmid DNA J. Control. Release 60 1999 279 286
    • (1999) J. Control. Release , vol.60 , pp. 279-286
    • Capan, Y.1    Woo, B.H.2    Gebrekidan, S.3    Ahmed, S.4    Deluca, P.P.5
  • 22
    • 0030011671 scopus 로고    scopus 로고
    • Preparation and characterization of poly-(d,l-lactide-co-glycolide) and poly-(l-lactic acid) microspheres with entrapped pneumotropic bacterial antigens
    • N. Kofler, C. Ruedl, J. Klima, H. Recheis, G. Böck, G. Wick, and H. Wolf Preparation and characterization of poly-(d,l-lactide-co-glycolide) and poly-(l-lactic acid) microspheres with entrapped pneumotropic bacterial antigens J. Immunol. Methods 192 1996 25 35
    • (1996) J. Immunol. Methods , vol.192 , pp. 25-35
    • Kofler, N.1    Ruedl, C.2    Klima, J.3    Recheis, H.4    Böck, G.5    Wick, G.6    Wolf, H.7
  • 23
  • 24
    • 0026723071 scopus 로고
    • Méthodes de preparation des microparticules biodégradables chargées en principes actifs hydrosolubles
    • C. Aftabrouchad, and E. Doelker Méthodes de preparation des microparticules biodégradables chargées en principes actifs hydrosolubles S.T.P. Pharma Sci. 2 1992 365 380
    • (1992) S.T.P. Pharma Sci. , vol.2 , pp. 365-380
    • Aftabrouchad, C.1    Doelker, E.2
  • 25
    • 0033791218 scopus 로고    scopus 로고
    • Technological considerations related to the up-scaling of protein microencapsulation by spray-drying
    • P. Johansen, H.P. Merkle, and B. Gander Technological considerations related to the up-scaling of protein microencapsulation by spray-drying Eur. J. Pharm. Biopharm. 50 2000 413 417
    • (2000) Eur. J. Pharm. Biopharm. , vol.50 , pp. 413-417
    • Johansen, P.1    Merkle, H.P.2    Gander, B.3
  • 27
    • 0031719033 scopus 로고    scopus 로고
    • Process variable implications for residual solvent removal and polymer morphology in the formation of gentamycin-loaded poly(l-lactide) microparticles
    • R.F. Falk, and T.W. Randolph Process variable implications for residual solvent removal and polymer morphology in the formation of gentamycin-loaded poly(l-lactide) microparticles Pharm. Res. 15 1998 1233 1237
    • (1998) Pharm. Res. , vol.15 , pp. 1233-1237
    • Falk, R.F.1    Randolph, T.W.2
  • 28
    • 0034964315 scopus 로고    scopus 로고
    • Particle design using supercritical fluids: Literature and patent survey
    • J. Jung, and M. Perrut Particle design using supercritical fluids: literature and patent survey J. Supercrit. Fluids 20 2001 179 219
    • (2001) J. Supercrit. Fluids , vol.20 , pp. 179-219
    • Jung, J.1    Perrut, M.2
  • 29
    • 0031837762 scopus 로고    scopus 로고
    • Biodegradable, somatostatin acetate containing microspheres prepared by various aqueous and non-aqueous solvent evaporation methods
    • J. Herrmann, and R. Bodmeier Biodegradable, somatostatin acetate containing microspheres prepared by various aqueous and non-aqueous solvent evaporation methods Eur. J. Pharm. Biopharm. 45 1998 75 82
    • (1998) Eur. J. Pharm. Biopharm. , vol.45 , pp. 75-82
    • Herrmann, J.1    Bodmeier, R.2
  • 30
    • 0032898282 scopus 로고    scopus 로고
    • Performance of sonication and microfluidization for liquid-liquid emulsification
    • Y.F. Maa, and C.C. Hsu Performance of sonication and microfluidization for liquid-liquid emulsification Pharm. Dev. Technol. 4 1999 233 240
    • (1999) Pharm. Dev. Technol. , vol.4 , pp. 233-240
    • Maa, Y.F.1    Hsu, C.C.2
  • 31
    • 11844252758 scopus 로고    scopus 로고
    • Apparatus and method for preparing microparticles using in-line solvent extraction, US Patent 6,495,166, 2002.
    • S.H. Lyons, S.G. Wright, Apparatus and method for preparing microparticles using in-line solvent extraction, US Patent 6,495,166, 2002.
    • Lyons, S.H.1    Wright, S.G.2
  • 32
    • 0031058334 scopus 로고    scopus 로고
    • Effect of primary emulsions on microsphere size and protein-loading in the double emulsion process
    • Y.F. Maa, and C.C. Hsu Effect of primary emulsions on microsphere size and protein-loading in the double emulsion process J. Microencapsul. 14 1997 225 241
    • (1997) J. Microencapsul. , vol.14 , pp. 225-241
    • Maa, Y.F.1    Hsu, C.C.2
  • 33
    • 0031060393 scopus 로고    scopus 로고
    • Protein-loaded poly(dl-lactide-co-glycolide) microparticles for oral administration: Formulation, structural and release characteristics
    • H. Rafati, A.G. Coombes, J. Adler, J. Holland, and S.S. Davis Protein-loaded poly(dl-lactide-co-glycolide) microparticles for oral administration: formulation, structural and release characteristics J. Control. Release 43 1997 89 102
    • (1997) J. Control. Release , vol.43 , pp. 89-102
    • Rafati, H.1    Coombes, A.G.2    Adler, J.3    Holland, J.4    Davis, S.S.5
  • 34
    • 0027937207 scopus 로고
    • Characterization of V3 BRU peptide-loaded small PLGA microspheres prepared by a (w1/o)w2 emulsion solvent evaporation method
    • M.J. Blanco Prieto, F. Delie, E. Fattal, A. Tartar, F. Puisieux, A. Gulik, and P. Couvreur Characterization of V3 BRU peptide-loaded small PLGA microspheres prepared by a (w1/o)w2 emulsion solvent evaporation method Int. J. Pharm. 111 1994 137 145
    • (1994) Int. J. Pharm. , vol.111 , pp. 137-145
    • Blanco Prieto, M.J.1    Delie, F.2    Fattal, E.3    Tartar, A.4    Puisieux, F.5    Gulik, A.6    Couvreur, P.7
  • 35
    • 0035255916 scopus 로고    scopus 로고
    • Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double emulsion solvent extraction/evaporation method
    • Y.Y. Yang, T.S. Chung, and N.P. Ng Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double emulsion solvent extraction/evaporation method Biomaterials 22 2001 231 241
    • (2001) Biomaterials , vol.22 , pp. 231-241
    • Yang, Y.Y.1    Chung, T.S.2    Ng, N.P.3
  • 36
    • 0028234449 scopus 로고
    • The influence of biodegradable microcapsule formulations on the controlled release of a protein
    • H. Sah, R. Toddywala, and Y.W. Chien The influence of biodegradable microcapsule formulations on the controlled release of a protein J. Control. Release 30 1994 201 211
    • (1994) J. Control. Release , vol.30 , pp. 201-211
    • Sah, H.1    Toddywala, R.2    Chien, Y.W.3
  • 37
    • 0027409962 scopus 로고
    • The preparation and characterization of poly(lactide-co-glycolide) microparticles: II. The entrapment of a model protein using a (water-in-oil)-in water emulsion solvent evaporation technique
    • H. Jeffery, S.S. Davis, and D.T. O'Hagan The preparation and characterization of poly(lactide-co-glycolide) microparticles: II. The entrapment of a model protein using a (water-in-oil)-in water emulsion solvent evaporation technique Pharm. Res. 10 1993 362 368
    • (1993) Pharm. Res. , vol.10 , pp. 362-368
    • Jeffery, H.1    Davis, S.S.2    O'Hagan, D.T.3
  • 38
    • 0029802635 scopus 로고    scopus 로고
    • Formulation of bovine serum albumin loaded PLGA microspheres. Influence of the process variables on the loading and in vitro release
    • H. Marchais, F. Boury, C. Damgé, J.E. Proust, and J.P. Benoit Formulation of bovine serum albumin loaded PLGA microspheres. Influence of the process variables on the loading and in vitro release S.T.P. Pharma Sci. 6 1996 417 423
    • (1996) S.T.P. Pharma Sci. , vol.6 , pp. 417-423
    • Marchais, H.1    Boury, F.2    Damgé, C.3    Proust, J.E.4    Benoit, J.P.5
  • 39
    • 0029584204 scopus 로고
    • Somatostatin containing biodegradable microspheres prepared by a modified solvent evaporation method based on W/O/W-multiple emulsions
    • J. Herrmann, and R. Bodmeier Somatostatin containing biodegradable microspheres prepared by a modified solvent evaporation method based on W/O/W-multiple emulsions Int. J. Pharm. 126 1995 129 138
    • (1995) Int. J. Pharm. , vol.126 , pp. 129-138
    • Herrmann, J.1    Bodmeier, R.2
  • 40
    • 0028815624 scopus 로고
    • Optimization of preparative conditions for polylactide (PLA) microspheres containing ovalbumin
    • T. Uchida, K. Yoshida, A. Ninomiya, and S. Goto Optimization of preparative conditions for polylactide (PLA) microspheres containing ovalbumin Chem. Pharm. Bull. 43 1995 1569 1573
    • (1995) Chem. Pharm. Bull. , vol.43 , pp. 1569-1573
    • Uchida, T.1    Yoshida, K.2    Ninomiya, A.3    Goto, S.4
  • 41
    • 0342265154 scopus 로고    scopus 로고
    • Effect of preparation conditions on morphology and release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion method
    • Y.Y. Yang, T.S. Chung, X.L. Bai, and W.K. Chan Effect of preparation conditions on morphology and release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion method Chem. Eng. Sci. 55 2000 2223 2236
    • (2000) Chem. Eng. Sci. , vol.55 , pp. 2223-2236
    • Yang, Y.Y.1    Chung, T.S.2    Bai, X.L.3    Chan, W.K.4
  • 42
    • 0029120167 scopus 로고
    • Preparation of porous and nonporous biodegradable polymeric hollow microspheres
    • G. Crotts, and T.G. Park Preparation of porous and nonporous biodegradable polymeric hollow microspheres J. Control. Release 35 1995 91 105
    • (1995) J. Control. Release , vol.35 , pp. 91-105
    • Crotts, G.1    Park, T.G.2
  • 43
    • 0036670249 scopus 로고    scopus 로고
    • Co-lyophilization of bovine serum albumin (BSA) with poly(ethylene glycol) improves efficiency of BSA encapsulation and stability in polyester microspheres by a solid-in-oil-in-oil technique
    • W. Al-Azzam, E.A. Pastrana, and K. Griebenow Co-lyophilization of bovine serum albumin (BSA) with poly(ethylene glycol) improves efficiency of BSA encapsulation and stability in polyester microspheres by a solid-in-oil-in-oil technique Biotechnol. Lett. 24 2002 1367 1374
    • (2002) Biotechnol. Lett. , vol.24 , pp. 1367-1374
    • Al-Azzam, W.1    Pastrana, E.A.2    Griebenow, K.3
  • 44
    • 0031908630 scopus 로고    scopus 로고
    • Development and scale-up of a microsphere protein delivery system
    • M.A. Tracy Development and scale-up of a microsphere protein delivery system Biotechnol. Prog. 14 1998 108 115
    • (1998) Biotechnol. Prog. , vol.14 , pp. 108-115
    • Tracy, M.A.1
  • 45
    • 11844257128 scopus 로고    scopus 로고
    • Method of producing sub-micron particles of biologically active agents and uses thereof, US Patent 6,284,283, 2001.
    • H.R. Constantino, W.E. Jaworowicz, M.A. Tracy, C.P. Beganski, Method of producing sub-micron particles of biologically active agents and uses thereof, US Patent 6,284,283, 2001.
    • Constantino, H.R.1    Jaworowicz, W.E.2    Tracy, M.A.3    Beganski, C.P.4
  • 46
    • 0034602599 scopus 로고    scopus 로고
    • Protein encapsulation into biodegradable microspheres by a novel S/O/W emulsion method using poly(ethylene glycol) as a protein micronization adjuvant
    • T. Morita, Y. Sakamura, Y. Horikiri, T. Suzuki, and H. Yoshino Protein encapsulation into biodegradable microspheres by a novel S/O/W emulsion method using poly(ethylene glycol) as a protein micronization adjuvant J. Control. Release 69 2000 435 444
    • (2000) J. Control. Release , vol.69 , pp. 435-444
    • Morita, T.1    Sakamura, Y.2    Horikiri, Y.3    Suzuki, T.4    Yoshino, H.5
  • 47
    • 0028020778 scopus 로고
    • Polylactide microparticles prepared by double emulsion/evaporation technique: I. Effect of primary emulsion stability
    • N. Nihant, C. Schugens, C. Grandfils, R. Jérôme, and P. Teyssié Polylactide microparticles prepared by double emulsion/evaporation technique: I. Effect of primary emulsion stability Pharm. Res. 11 1994 1479 1484
    • (1994) Pharm. Res. , vol.11 , pp. 1479-1484
    • Nihant, N.1    Schugens, C.2    Grandfils, C.3    Jérôme, R.4    Teyssié, P.5
  • 48
    • 0027993434 scopus 로고
    • Effect of the emulsion stability on the morphology and porosity of semicrystalline poly l-lactide microparticles prepared by w/o/w double emulsion-evaporation
    • C. Schugens, N. Laruelle, N. Nihant, C. Grandfils, R. Jérome, and P. Teyssié Effect of the emulsion stability on the morphology and porosity of semicrystalline poly l-lactide microparticles prepared by w/o/w double emulsion-evaporation J. Control. Release 32 1994 161 176
    • (1994) J. Control. Release , vol.32 , pp. 161-176
    • Schugens, C.1    Laruelle, N.2    Nihant, N.3    Grandfils, C.4    Jérome, R.5    Teyssié, P.6
  • 49
    • 0023901210 scopus 로고
    • A new technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly(lactic/glycolic) acid
    • Y. Ogawa, M. Yamamoto, H. Okada, T. Yashiki, and T. Shimamoto A new technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly(lactic/glycolic) acid Chem. Pharm. Bull. 36 1988 1095 1103
    • (1988) Chem. Pharm. Bull. , vol.36 , pp. 1095-1103
    • Ogawa, Y.1    Yamamoto, M.2    Okada, H.3    Yashiki, T.4    Shimamoto, T.5
  • 50
    • 0343113396 scopus 로고    scopus 로고
    • Couvreur, Characterization and morphological analysis of cholecystokinin derivative peptide-loaded poly(lactide-co-glycolide) microspheres prepared by a water-in-oil-in-water emulsion solvent evaporation method
    • M.J. Blanco Prieto, E. Fattal, A. Gulik, J.C. Dedieu, and B.P. Roques Couvreur, Characterization and morphological analysis of cholecystokinin derivative peptide-loaded poly(lactide-co-glycolide) microspheres prepared by a water-in-oil-in-water emulsion solvent evaporation method J. Control. Release 43 1997 81 87
    • (1997) J. Control. Release , vol.43 , pp. 81-87
    • Blanco Prieto, M.J.1    Fattal, E.2    Gulik, A.3    Dedieu, J.C.4    Roques, B.P.5
  • 51
  • 52
    • 0032078351 scopus 로고    scopus 로고
    • Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: Effect of the protein and polymer properties and of co-encapsulation of surfactants
    • D. Blanco, and M.J. Alonso Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: effect of the protein and polymer properties and of co-encapsulation of surfactants Eur. J. Pharm. Biopharm. 45 1998 285 294
    • (1998) Eur. J. Pharm. Biopharm. , vol.45 , pp. 285-294
    • Blanco, D.1    Alonso, M.J.2
  • 53
    • 0027327772 scopus 로고
    • Influence of manufacturing parameters on the size characteristics and the release profiles of nifedipine from poly(dl-lactide-co-glycolide) microspheres
    • P. Sansdrap, and A.J. Moës Influence of manufacturing parameters on the size characteristics and the release profiles of nifedipine from poly(dl-lactide-co-glycolide) microspheres Int. J. Pharm. 98 1993 157 164
    • (1993) Int. J. Pharm. , vol.98 , pp. 157-164
    • Sansdrap, P.1    Moës, A.J.2
  • 54
    • 0032902466 scopus 로고    scopus 로고
    • Ketoprofen-poly(d,l-lactic-co-glycolic acid) microspheres: Influence of manufacturing parameters and type of polymer on the release characteristics
    • F. Gabor, B. Ertl, M. Wirth, and R. Mallinger Ketoprofen-poly(d,l-lactic- co-glycolic acid) microspheres: influence of manufacturing parameters and type of polymer on the release characteristics J. Microencapsulation 16 1999 1 12
    • (1999) J. Microencapsulation , vol.16 , pp. 1-12
    • Gabor, F.1    Ertl, B.2    Wirth, M.3    Mallinger, R.4
  • 55
    • 0036155616 scopus 로고    scopus 로고
    • The influence of stirring rate on biopharmaceutical properties of Eudragit RS microspheres
    • T. Mateovic, B. Kriznar, M. Bogataj, and A. Mrhar The influence of stirring rate on biopharmaceutical properties of Eudragit RS microspheres J. Microencapsulation 19 2002 29 36
    • (2002) J. Microencapsulation , vol.19 , pp. 29-36
    • Mateovic, T.1    Kriznar, B.2    Bogataj, M.3    Mrhar, A.4
  • 56
    • 0028472623 scopus 로고
    • Resorbable polymeric microspheres for drug delivery-production and simultaneous surface modification using PEO-PPO surfactants
    • A.G. Coombes, P.D. Scholes, M.C. Davies, L. Illum, and S.S. Davis Resorbable polymeric microspheres for drug delivery-production and simultaneous surface modification using PEO-PPO surfactants Biomaterials 15 1994 673 680
    • (1994) Biomaterials , vol.15 , pp. 673-680
    • Coombes, A.G.1    Scholes, P.D.2    Davies, M.C.3    Illum, L.4    Davis, S.S.5
  • 57
    • 0344931751 scopus 로고    scopus 로고
    • Preparation of non-porous microspheres with high entrapment efficiency of proteins by a (water-in-oil)-in-oil emulsion technique
    • N. Badri Viswanathan, P.A. Thomas, J.K. Pandit, M.G. Kulkarni, and R.A. Mashelkar Preparation of non-porous microspheres with high entrapment efficiency of proteins by a (water-in-oil)-in-oil emulsion technique J. Control. Release 58 1999 9 20
    • (1999) J. Control. Release , vol.58 , pp. 9-20
    • Badri Viswanathan, N.1    Thomas, P.A.2    Pandit, J.K.3    Kulkarni, M.G.4    Mashelkar, R.A.5
  • 58
    • 0028862142 scopus 로고
    • Preparation and degradation of surfactant-free PLAGA microspheres
    • A. Carrio, G. Schwach, J. Coudane, and M. Vert Preparation and degradation of surfactant-free PLAGA microspheres J. Control. Release 37 1995 113 121
    • (1995) J. Control. Release , vol.37 , pp. 113-121
    • Carrio, A.1    Schwach, G.2    Coudane, J.3    Vert, M.4
  • 59
    • 0026060542 scopus 로고
    • The preparation and characterisation of poly(lactide-co-glycolide) microparticles: I. Oil-in-water emulsion solvent evaporation
    • H. Jeffery, S.S. Davis, and D.T. O'Hagan The preparation and characterisation of poly(lactide-co-glycolide) microparticles: I. Oil-in-water emulsion solvent evaporation Int. J. Pharm. 77 1991 169 175
    • (1991) Int. J. Pharm. , vol.77 , pp. 169-175
    • Jeffery, H.1    Davis, S.S.2    O'Hagan, D.T.3
  • 60
    • 0031005033 scopus 로고    scopus 로고
    • Microencapsulation techniques using ethyl acetate as a dispersed solvent: Effects of its extraction rate on the characteristics of PLGA microspheres
    • H. Sah Microencapsulation techniques using ethyl acetate as a dispersed solvent: effects of its extraction rate on the characteristics of PLGA microspheres J. Control. Release 47 1997 233 245
    • (1997) J. Control. Release , vol.47 , pp. 233-245
    • Sah, H.1
  • 61
    • 0030068534 scopus 로고    scopus 로고
    • Microencapsulation reactor scale-up by dimensional analysis
    • Y.F. Maa, and C. Hsu Microencapsulation reactor scale-up by dimensional analysis J. Microencapsul. 13 1996 53 66
    • (1996) J. Microencapsul. , vol.13 , pp. 53-66
    • Maa, Y.F.1    Hsu, C.2
  • 62
    • 0030035242 scopus 로고    scopus 로고
    • Liquid-liquid emulsification by static mixers for use in microencapsulation
    • Y.F. Maa, and C. Hsu Liquid-liquid emulsification by static mixers for use in microencapsulation J. Microencapsulation 13 1996 419 433
    • (1996) J. Microencapsulation , vol.13 , pp. 419-433
    • Maa, Y.F.1    Hsu, C.2
  • 63
    • 11844250099 scopus 로고    scopus 로고
    • Apparatus and method for preparing microparticles, US Patent 6,331,317, 2001.
    • S.L. Lyons, S.G. Wright, Apparatus and method for preparing microparticles, US Patent 6,331,317, 2001.
    • Lyons, S.L.1    Wright, S.G.2
  • 64
    • 11844250740 scopus 로고    scopus 로고
    • Emulsion-based processes for making microparticles, US Patent 6,291,013, 2001.
    • J.W. Gibson, R.J. Holl, A.J. Tipton, Emulsion-based processes for making microparticles, US Patent 6,291,013, 2001.
    • Gibson, J.W.1    Holl, R.J.2    Tipton, A.J.3
  • 65
    • 0023935689 scopus 로고
    • A method for the preparation of polylactic acid microcapsules of controlled particle size and drug loading
    • N. Leelarasamee, S.A. Howard, C.J. Malanga, and J.K. Ma A method for the preparation of polylactic acid microcapsules of controlled particle size and drug loading J. Microencapsulation 5 1988 147 157
    • (1988) J. Microencapsulation , vol.5 , pp. 147-157
    • Leelarasamee, N.1    Howard, S.A.2    Malanga, C.J.3    Ma, J.K.4
  • 66
    • 0032812727 scopus 로고    scopus 로고
    • The production of uniformly sized polymer microspheres
    • B. Amsden The production of uniformly sized polymer microspheres Pharm. Res. 16 1999 1140 1143
    • (1999) Pharm. Res. , vol.16 , pp. 1140-1143
    • Amsden, B.1
  • 67
    • 11844306779 scopus 로고    scopus 로고
    • Methods for microsphere production, US Patent 6,224,794, 2001.
    • B.G. Amsden, R.T. Liggins, Methods for microsphere production, US Patent 6,224,794, 2001.
    • Amsden, B.G.1    Liggins, R.T.2
  • 68
    • 0037275378 scopus 로고    scopus 로고
    • Solvent extraction employing a static micromixer: A simple robust and versatile technology for the microencapsulation of proteins
    • S. Freitas, A. Walz, H.P. Merkle, and B. Gander Solvent extraction employing a static micromixer: a simple robust and versatile technology for the microencapsulation of proteins J. Microencapsulation 20 2003 67 85
    • (2003) J. Microencapsulation , vol.20 , pp. 67-85
    • Freitas, S.1    Walz, A.2    Merkle, H.P.3    Gander, B.4
  • 70
    • 0035807144 scopus 로고    scopus 로고
    • Interfacial tension driven monodispersed droplet formation from microfabricated channel array
    • S. Sugiura, M. Nakajima, S. Iwamoto, and M. Seki Interfacial tension driven monodispersed droplet formation from microfabricated channel array Langmuir 17 2001 5562 5566
    • (2001) Langmuir , vol.17 , pp. 5562-5566
    • Sugiura, S.1    Nakajima, M.2    Iwamoto, S.3    Seki, M.4
  • 71
    • 0242369938 scopus 로고    scopus 로고
    • Preparation characteristics of lipid microspheres using microchannel emulsification and solvent evaporation methods
    • I. Kobayashi, Y. Iitaka, S. Iwamoto, S. Kimura, and M. Nakajima Preparation characteristics of lipid microspheres using microchannel emulsification and solvent evaporation methods J. Chem. Eng. Jpn. 36 2003 996 1000
    • (2003) J. Chem. Eng. Jpn. , vol.36 , pp. 996-1000
    • Kobayashi, I.1    Iitaka, Y.2    Iwamoto, S.3    Kimura, S.4    Nakajima, M.5
  • 72
    • 0032855274 scopus 로고    scopus 로고
    • Production of monodispersed oil-in-water emulsion using crossflow-type silicon microchannel plate
    • T. Kawakatsu, H. Komori, M. Nakajima, Y. Kikuchi, and T. Yonemoto Production of monodispersed oil-in-water emulsion using crossflow-type silicon microchannel plate J. Chem. Eng. Jpn. 32 1999 241 244
    • (1999) J. Chem. Eng. Jpn. , vol.32 , pp. 241-244
    • Kawakatsu, T.1    Komori, H.2    Nakajima, M.3    Kikuchi, Y.4    Yonemoto, T.5
  • 73
    • 0036572010 scopus 로고    scopus 로고
    • Preparation of monodispersed emulsion with large droplets using microchannel emulsification
    • S. Sugiura, M. Nakajima, and M. Seki Preparation of monodispersed emulsion with large droplets using microchannel emulsification J. Am. Oil Chem. Soc. 79 2002 515 519
    • (2002) J. Am. Oil Chem. Soc. , vol.79 , pp. 515-519
    • Sugiura, S.1    Nakajima, M.2    Seki, M.3
  • 74
    • 0037162610 scopus 로고    scopus 로고
    • Effect of channel structure in microchannel emulsification
    • S. Sugiura, M. Nakajima, and M. Seki Effect of channel structure in microchannel emulsification Langmuir 18 2002 5708 5712
    • (2002) Langmuir , vol.18 , pp. 5708-5712
    • Sugiura, S.1    Nakajima, M.2    Seki, M.3
  • 75
    • 0037076620 scopus 로고    scopus 로고
    • Prediction of droplet diameter for microchannel emulsification
    • S. Sugiura, M. Nakajima, and M. Seki Prediction of droplet diameter for microchannel emulsification Langmuir 18 2002 3854 3859
    • (2002) Langmuir , vol.18 , pp. 3854-3859
    • Sugiura, S.1    Nakajima, M.2    Seki, M.3
  • 76
    • 0037068864 scopus 로고    scopus 로고
    • Characterization of spontaneous transformation-based droplet formation during microchannel emulsification
    • S. Sugiura, M. Nakajima, N. Kumazawa, S. Iwamoto, and M. Seki Characterization of spontaneous transformation-based droplet formation during microchannel emulsification J. Phys. Chem., B 106 2002 9405 9409
    • (2002) J. Phys. Chem., B , vol.106 , pp. 9405-9409
    • Sugiura, S.1    Nakajima, M.2    Kumazawa, N.3    Iwamoto, S.4    Seki, M.5
  • 77
    • 0028910621 scopus 로고
    • An approach to prepare microparticles of uniform size
    • N. Muramatsu, and T. Kondo An approach to prepare microparticles of uniform size J. Microencapsulation 12 1995 129 136
    • (1995) J. Microencapsulation , vol.12 , pp. 129-136
    • Muramatsu, N.1    Kondo, T.2
  • 78
    • 0029857395 scopus 로고    scopus 로고
    • Preparation of poly(d,l-lactide) and copoly(lactide-glycolide) microspheres of uniform size
    • K. Shiga, N. Muramatsu, and T. Kondo Preparation of poly(d,l-lactide) and copoly(lactide-glycolide) microspheres of uniform size J. Pharm. Pharmacol. 48 1996 891 895
    • (1996) J. Pharm. Pharmacol. , vol.48 , pp. 891-895
    • Shiga, K.1    Muramatsu, N.2    Kondo, T.3
  • 79
    • 0032775836 scopus 로고    scopus 로고
    • Preparation of uniform poly(lactide) microspheres by employing the Shirasu Porous Glass (SPG) emulsification technique
    • G. Ma, M. Nagai, and S. Omi Preparation of uniform poly(lactide) microspheres by employing the Shirasu Porous Glass (SPG) emulsification technique Colloids Surf., A 153 1999 383 394
    • (1999) Colloids Surf., a , vol.153 , pp. 383-394
    • Ma, G.1    Nagai, M.2    Omi, S.3
  • 80
  • 81
    • 0036706717 scopus 로고    scopus 로고
    • Silicon array of elongated through-holes for monodisperse emulsion droplets
    • I. Kobayashi, M. Nakajima, K. Chun, Y. Kikuchi, and H. Fujita Silicon array of elongated through-holes for monodisperse emulsion droplets AIChE J. 48 2002 1639 1644
    • (2002) AIChE J. , vol.48 , pp. 1639-1644
    • Kobayashi, I.1    Nakajima, M.2    Chun, K.3    Kikuchi, Y.4    Fujita, H.5
  • 82
    • 0031060124 scopus 로고    scopus 로고
    • An examination of factors affecting the size, distribution and release characteristics of polymer microbeads made using electrostatics
    • B.G. Amsden, and M.F. Goosen An examination of factors affecting the size, distribution and release characteristics of polymer microbeads made using electrostatics J. Control. Release 43 1997 183 196
    • (1997) J. Control. Release , vol.43 , pp. 183-196
    • Amsden, B.G.1    Goosen, M.F.2
  • 83
    • 0028918329 scopus 로고
    • Properties of multiphase microspheres of poly(d,l-lactic-co-glycolic acid) prepared by a potentiometric dispersion technique
    • P.B. O'Donnell, M. Iwata, and J.W. McGinity Properties of multiphase microspheres of poly(d,l-lactic-co-glycolic acid) prepared by a potentiometric dispersion technique J. Microencapsulation 12 1995 155 163
    • (1995) J. Microencapsulation , vol.12 , pp. 155-163
    • O'Donnell, P.B.1    Iwata, M.2    McGinity, J.W.3
  • 86
    • 0035907177 scopus 로고    scopus 로고
    • Fabrication of PLG microspheres with precisely controlled and monodisperse size distributions
    • C. Berkland, K. Kim, and D.W. Pack Fabrication of PLG microspheres with precisely controlled and monodisperse size distributions J. Control. Release 73 2001 59 74
    • (2001) J. Control. Release , vol.73 , pp. 59-74
    • Berkland, C.1    Kim, K.2    Pack, D.W.3
  • 87
    • 0037130249 scopus 로고    scopus 로고
    • Precise control of PLG microsphere size provides enhanced control of drug release rate
    • C. Berkland, M. King, A. Cox, K. Kim, and D.W. Pack Precise control of PLG microsphere size provides enhanced control of drug release rate J. Control. Release 82 2002 137 147
    • (2002) J. Control. Release , vol.82 , pp. 137-147
    • Berkland, C.1    King, M.2    Cox, A.3    Kim, K.4    Pack, D.W.5
  • 88
    • 0000069254 scopus 로고    scopus 로고
    • Monodisperse sprays for various purposes-their production and characteristics
    • G. Brenn, F. Durst, and C. Tropea Monodisperse sprays for various purposes-their production and characteristics Part. Part. Syst. Charact. 13 1996 179 185
    • (1996) Part. Part. Syst. Charact. , vol.13 , pp. 179-185
    • Brenn, G.1    Durst, F.2    Tropea, C.3
  • 89
    • 0033622760 scopus 로고    scopus 로고
    • On the controlled production of sprays with discrete polydisperse drop size spectra
    • G. Brenn On the controlled production of sprays with discrete polydisperse drop size spectra Chem. Eng. Sci. 55 2000 5437 5444
    • (2000) Chem. Eng. Sci. , vol.55 , pp. 5437-5444
    • Brenn, G.1
  • 90
    • 11844292950 scopus 로고    scopus 로고
    • Method for producing uniform particles, US Patent 4,162,282, 1979.
    • C.W. Hatcher, M.J. Fulwyler, Method for producing uniform particles, US Patent 4,162,282, 1979.
    • Hatcher, C.W.1    Fulwyler, M.J.2
  • 91
    • 11844280486 scopus 로고    scopus 로고
    • Methods for promoting the formation of microparticles, US Patent 4,390,484, 1983.
    • I. Lombardo, P.J. Natale, Methods for promoting the formation of microparticles, US Patent 4,390,484, 1983.
    • Lombardo, I.1    Natale, P.J.2
  • 92
    • 11844252759 scopus 로고    scopus 로고
    • Microparticles, PCT Patent Application WO 02/13786, 2002.
    • K. Kyekyoon, D.W. Pack, C.J. Berkland, Microparticles, PCT Patent Application WO 02/13786, 2002.
    • Kyekyoon, K.1    Pack, D.W.2    Berkland, C.J.3
  • 93
    • 0027533694 scopus 로고
    • Preparation of biodegradable poly(lactic-co-glycolic) acid microspheres and their in vitro release of timolol maleate
    • C. Sturesson, J. Carlfors, K. Edsman, and M. Andersson Preparation of biodegradable poly(lactic-co-glycolic) acid microspheres and their in vitro release of timolol maleate Int. J. Pharm. 89 1993 235 244
    • (1993) Int. J. Pharm. , vol.89 , pp. 235-244
    • Sturesson, C.1    Carlfors, J.2    Edsman, K.3    Andersson, M.4
  • 94
    • 0025917416 scopus 로고
    • Influence of formulation methods on the in vitro controlled release of protein from poly(ester) microspheres
    • H.T. Wang, E. Schmitt, D.R. Flanagan, and R.J. Linhardt Influence of formulation methods on the in vitro controlled release of protein from poly(ester) microspheres J. Control. Release 17 1991 23 31
    • (1991) J. Control. Release , vol.17 , pp. 23-31
    • Wang, H.T.1    Schmitt, E.2    Flanagan, D.R.3    Linhardt, R.J.4
  • 95
    • 0030249739 scopus 로고    scopus 로고
    • Peptide containing microspheres from low molecular weight and hydrophilic poly(dl-lactide-co-glycolide)
    • R.C. Metha, B.C. Thanoo, and P.P. DeLuca Peptide containing microspheres from low molecular weight and hydrophilic poly(dl-lactide-co-glycolide) J. Control. Release 41 1996 249 257
    • (1996) J. Control. Release , vol.41 , pp. 249-257
    • Metha, R.C.1    Thanoo, B.C.2    Deluca, P.P.3
  • 96
    • 0032994945 scopus 로고    scopus 로고
    • Optimization of preparative conditions for poly-dl-lactide-polyethylene glycol microspheres with entrapped Vibrio Cholera antigens
    • X.M. Deng, X.H. Li, M.L. Yuan, C.D. Xiong, Z.T. Huang, W.X. Jia, and Y.H. Zhang Optimization of preparative conditions for poly-dl-lactide-polyethylene glycol microspheres with entrapped Vibrio Cholera antigens J. Control. Release 58 1999 123 131
    • (1999) J. Control. Release , vol.58 , pp. 123-131
    • Deng, X.M.1    Li, X.H.2    Yuan, M.L.3    Xiong, C.D.4    Huang, Z.T.5    Jia, W.X.6    Zhang, Y.H.7
  • 97
    • 0033919959 scopus 로고    scopus 로고
    • Effects of salt addition on the microencapsulation of proteins using W/O/W double emulsion technique
    • K.F. Pistel, and T. Kissel Effects of salt addition on the microencapsulation of proteins using W/O/W double emulsion technique J. Microencapsulation 17 2000 467 483
    • (2000) J. Microencapsulation , vol.17 , pp. 467-483
    • Pistel, K.F.1    Kissel, T.2
  • 98
    • 0034601833 scopus 로고    scopus 로고
    • Improvement of the encapsulation efficiency of oligonucleotide-containing biodegradable microspheres
    • T. Freytag, A. Dashevsky, L. Tillman, G.E. Hardee, and R. Bodmeier Improvement of the encapsulation efficiency of oligonucleotide-containing biodegradable microspheres J. Control. Release 69 2000 197 207
    • (2000) J. Control. Release , vol.69 , pp. 197-207
    • Freytag, T.1    Dashevsky, A.2    Tillman, L.3    Hardee, G.E.4    Bodmeier, R.5
  • 99
    • 0342265154 scopus 로고    scopus 로고
    • Effect of preparation conditions on morphology and release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion method
    • Y.Y. Yang, T.S. Chung, X.L. Bai, and W.K. Chan Effect of preparation conditions on morphology and release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion method Chem. Eng. Sci. 55 2000 2223 2236
    • (2000) Chem. Eng. Sci. , vol.55 , pp. 2223-2236
    • Yang, Y.Y.1    Chung, T.S.2    Bai, X.L.3    Chan, W.K.4
  • 100
    • 0034601882 scopus 로고    scopus 로고
    • Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method
    • Y.Y. Yang, H.H. Chia, and T.S. Chung Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method J. Control. Release 69 2000 81 96
    • (2000) J. Control. Release , vol.69 , pp. 81-96
    • Yang, Y.Y.1    Chia, H.H.2    Chung, T.S.3
  • 101
    • 0029914208 scopus 로고    scopus 로고
    • Effect of solvent removal technique on the matrix characteristics of polylactide/glycolide microspheres for peptide delivery
    • R. Jeyanthi, B.C. Thanoo, R.C. Metha, and P.P. DeLuca Effect of solvent removal technique on the matrix characteristics of polylactide/glycolide microspheres for peptide delivery J. Control. Release 38 1996 235 244
    • (1996) J. Control. Release , vol.38 , pp. 235-244
    • Jeyanthi, R.1    Thanoo, B.C.2    Metha, R.C.3    Deluca, P.P.4
  • 102
    • 0036658462 scopus 로고    scopus 로고
    • Effects of solvent evaporation rate on the properties of protein-loaded PLLA and PDLLA microspheres fabricated by emulsion-solvent evaporation process
    • T.W. Chung, Y.Y. Huang, Y.L. Tsai, and Y.Z. Liu Effects of solvent evaporation rate on the properties of protein-loaded PLLA and PDLLA microspheres fabricated by emulsion-solvent evaporation process J. Microencapsulation 19 2002 463 471
    • (2002) J. Microencapsulation , vol.19 , pp. 463-471
    • Chung, T.W.1    Huang, Y.Y.2    Tsai, Y.L.3    Liu, Y.Z.4
  • 103
    • 0026068802 scopus 로고
    • Preparation of poly(l-lactide) microspheres of different crystalline morphology and effect of crystalline morphology on drug release rate
    • S. Izumikawa, S. Yoshioka, Y. Aso, and Y. Takeda Preparation of poly(l-lactide) microspheres of different crystalline morphology and effect of crystalline morphology on drug release rate J. Control. Release 15 1991 133 140
    • (1991) J. Control. Release , vol.15 , pp. 133-140
    • Izumikawa, S.1    Yoshioka, S.2    Aso, Y.3    Takeda, Y.4
  • 104
    • 11844252760 scopus 로고    scopus 로고
    • One-step dispersion method for the microencapsulation of water soluble substances, European Patent Application 1,044,683, 1999.
    • E. Vuaridel, P. Orsolini, One-step dispersion method for the microencapsulation of water soluble substances, European Patent Application 1,044,683, 1999.
    • Vuaridel, E.1    Orsolini, P.2
  • 105
    • 11844261650 scopus 로고    scopus 로고
    • Microencapsulation process and products therefrom, US Patent 5,407,609, 1995.
    • T.R. Tice, R.M. Gilley, Microencapsulation process and products therefrom, US Patent 5,407,609, 1995.
    • Tice, T.R.1    Gilley, R.M.2
  • 106
    • 0028924264 scopus 로고
    • A novel emulsification-solvent extraction technique for production of protein loaded biodegradable microparticles for vaccine and drug delivery
    • M.K. Yeh, A.G. Coombes, P.G. Jenkins, and S.S. Davis A novel emulsification-solvent extraction technique for production of protein loaded biodegradable microparticles for vaccine and drug delivery J. Control. Release 33 1995 437 445
    • (1995) J. Control. Release , vol.33 , pp. 437-445
    • Yeh, M.K.1    Coombes, A.G.2    Jenkins, P.G.3    Davis, S.S.4
  • 107
    • 11844268764 scopus 로고    scopus 로고
    • Method for preparing microsphere, European Patent Application 1,277,787, 2001.
    • T. Suzuki, Y. Matsukawa, A. Suzuki, Method for preparing microsphere, European Patent Application 1,277,787, 2001.
    • Suzuki, T.1    Matsukawa, Y.2    Suzuki, A.3
  • 108
    • 11844303630 scopus 로고    scopus 로고
    • Apparatus and method for preparing microparticles using liquid-liquid extraction, US Patent 6,471,995, 2002.
    • J.M. Ramstack, Apparatus and method for preparing microparticles using liquid-liquid extraction, US Patent 6,471,995, 2002.
    • Ramstack, J.M.1
  • 109
    • 11844282288 scopus 로고    scopus 로고
    • Preparation of biodegradable, biocompatible microparticles containing a biologically active agent, US Patent 6,290,983, 2001.
    • M.E. Rickey, J.M. Ramstack, D.H. Lewis, Preparation of biodegradable, biocompatible microparticles containing a biologically active agent, US Patent 6,290,983, 2001.
    • Rickey, M.E.1    Ramstack, J.M.2    Lewis, D.H.3
  • 110
    • 0035907179 scopus 로고    scopus 로고
    • An investigation into the effects of residual water on the glass transition temperature of polylactide microspheres using modulated temperature DSC
    • N. Passerini, and D.Q. Craig An investigation into the effects of residual water on the glass transition temperature of polylactide microspheres using modulated temperature DSC J. Control. Release 73 2001 111 115
    • (2001) J. Control. Release , vol.73 , pp. 111-115
    • Passerini, N.1    Craig, D.Q.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.