Preparation of non-porous microspheres with high entrapment efficiency of proteins by a (water-in-oil)-in-oil emulsion technique

Journal of Controlled Release

Volumn 58, Issue 1, 1999, Pages 9-20

  Badri Viswanathan, N ^a   Thomas, P A ^a   Pandit, J K ^b   Kulkarni, M G ^a   Mashelkar, R A ^c  

^a NATIONAL CHEMICAL LABORATORY   (India)

^b BANARAS HINDU UNIVERSITY   (India)

^c NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

Biodegradable polymers; Emulsification solvent removal; Entrapment efficiency; Mechanism of encapsulation; Microencapsulation techniques; Poly(lactic co glycolic acid); Protein polypeptide encapsulation

Indexed keywords

GELATIN; LIQUID PARAFFIN; LYSOZYME; MICROSPHERE; ORGANIC SOLVENT; POLYGLACTIN; POLYPEPTIDE; WATER OIL CREAM;

ARTICLE; DEGRADATION; EVAPORATION; MICROENCAPSULATION; MOLECULAR WEIGHT; PARTICLE SIZE; PRECIPITATION; PRIORITY JOURNAL; TECHNIQUE;

DRUG COMPOUNDING; EMULSIONS; MICROSPHERES; MOLECULAR WEIGHT; OILS; PARTICLE SIZE; POLYMERS; POROSITY; PROTEINS; SOLVENTS; WATER;

EID: 0344931751     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(98)00140-0     Document Type: Article

References (22)

1. L.M. Sanders, J.S. Kent, G.L. McRae, B.H. Vickery, T.R. Tice, D.H. Lewis, Controlled release of lutinizing hormone-releasing analogue from poly(DL-lactide-co-glycolide) microspheres, J. Pharm. Sci. 73 (1984) 1294-1297.
2. Y. Ogawa, M. Yamamoto, H. Okada, T. Yashiki, T. Shimamoto, A new technique to efficiently entrap leuprolide acetate into microcapsules of poly lactics or co-polylactic/glycolic acid, Chem. Pharm. Bull. 36 (1988) 1095-1103.
3. F.G. Hutchinson, B.J.A. Furr, Biodegradable polymers for controlled release of peptides and proteins, in: F.H.D. Roerdink, A.M. Kroon (Eds.), Horizons in Biochemistry and Biophysics, Vol. 9. Drug Carrier Systems, John Wiley, 1989, pp. 11-29.
4. J.H. Eldridge, J.K. Staas, J.A. Meulbroek, T.R. Tice, R.M. Gilley, Biodegradable and biocompatible poly (DL-lactide-co-glycolide) microspheres as an adjuvant for Staphylococcal Enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies, Infection Immunity 59 (1991) 2978-2986.
5. D.T. O'Hagan, D. Rahman, J.P. McGee, H. Jefferey, M.C. Davies, P. Williams, S.S. Davis, S.J. Challacombe, Biodegradable microparticles as controlled release antigen delivery systems, Immunology 73 (1991) 239-242.
6. A. Sanchez, R.K. Gupta, M.J. Alonso, G.R. Siber, R. Langer, Pulsed Controlled-Release Systems for Potential Use in Vaccine Delivery, J. Pharm. Sci. 85 (1996) 547-552.
7. L.R. Beck, D.R. Cowsar, D.H. Lewis, J.W. Gibson, C.E. Flowers, New long acting injectable microcapsule contraceptive system, Am. J. Obstet. Gynecol. 135 (1979) 419-426.
8. C. Thies, Formation of degradable drug-loaded microparticles by in-liquid drying processes, in: M. Donbrow (Ed.), Microparticles in Medicine and Pharmacy, CRC Press, London, 1992; pp. 47-74.
9. S. Cohen, T. Yoshioka, M. Lucarelli, G.H. Hwang, R. Langer, Controlled release systems for proteins based on poly(lactic/glycolic acids) microspheres, Pharm. Res. 8 (1991) 713-720.
10. H. Jeffery, S.S. Davis, D.T. O'Hagan, The preparation and characterization of poly(lactide-co-glycolide) microparticles. II. The entrapment of a model protein using a (water-in-oil)-in-water emulsion solvent evaporation technique, Pharm. Res. 10 (1993) 362-368.
11. R. Bodmeier, J.W. McGinity, Solvent selection in the preparation of poly(D,L Lactide) microspheres prepared by the solvent evaporation method, Int. J. Pharm. 43 (1988) 179-186.
12. G. Crotts, T.G. Park, Preparation of porous and nonporous biodegradable polymeric hollow microspheres, J. Controlled Rel. 35 (1995) 91-105.
13. R. Jalil, J.R. Nixon, Microencapsulation using poly(L-lactic acid), 1: Microcapsule properties affected by the preparative technique, J. Microencap 6 (1989) 473-484.
14. R. Wada, S.H. Hyon, Y. Ikada, Lactic acid oligomer microspheres containing hydrophilic drugs, J. Pharm. Sci. 79 (1990) 919-924.
15. D.K. Gilding, A.M. Reed, Biodegradable polymers for use in surgery-polyglycolic/polylactic acid homo and copolymers: 1, Polymer 20 (1979) 1459-1464.
16. D.R. Cowsar, T.R. Tice, R.M. Gilley, J.P. English, Poly(lactide-co-glycolide) microspheres for controlled release steroids, in: K.J. Widder and R. Green (Eds.), Methods in Enzymology, Vol. 112 Drug and Enzyme Targeting, Part A, Academic Press, London, 1985, pp. 101-116.
17. S. Englard, S. Seifter in: M.P. Beutscher (Ed.), Methods in Enzymology, Vol. 182, Chapter 22, Guide to Protein Purification, Academic Press Inc. 1990.
18. S. Loeb, S. Sourirajan. Sea water desalination by means of an osmotic membrane ACS Advances in Chemistry Series No 38 Washington DC, ACS, 1963, pp. 117-132.
19. I.M. Wienk, R.M. Boom, M.A.M. Beerlage, A.M.W. Bulte, C.A. Smolders, H. Strathmann, Recent advances in the formation in phase inversion membranes made from amorphous or semi-crystalline polymers, J. Memb. Sci. 113(2) (1996) 361-371.
20. N. Badri Viswanathan, S.S. Patil, J.K. Pandit, M.G. Kulkarni, R.A. Mashelkar, Morphological changes in degrading PLGA and P(DL)LA microspheres: Implications on release of entrapped proteins, J. Control. Rel. (Submitted).
21. W Lu, T.G. Park, In vitro release profiles of Eristostatin from Biodegradable polymeric microspheres: Protein aggregation problems, Biotech. Prog. 11 (1995) 224-227.
22. A. Chang, R.K. Gupta, Biodegradable semipermeable microcapsules containing enzymes, hormones, vaccines and other biologicals, J. Pharm. Sci. 85 (1996) 129-132.