Technological considerations related to the up-scaling of protein microencapsulation by spray-drying

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 50, Issue 3, 2000, Pages 413-417

  Johansen, Pål ^a   Merkle, Hans P ^a   Gander, Bruno ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Biodegradable polymer; Emulsion stability; Microspheres; Spray drying; Up scaling

Indexed keywords

HEPTANE; HUMAN SERUM ALBUMIN; MICROSPHERE; POLOXAMER; POLYGLACTIN; POLYVINYL ALCOHOL; PROTEIN; RESOMER RG502H; SYNPERONIC; TETANUS TOXOID; TREHALOSE; UNCLASSIFIED DRUG;

ARTICLE; DRUG INDUSTRY; DRUG MANUFACTURE; DRUG STABILITY; EMULSION; LASER DIFFRACTION; MICROENCAPSULATION; MICROSCOPY; PARTICLE SIZE; SPRAY DRYING; SUSTAINED RELEASE FORMULATION; TECHNIQUE; TECHNOLOGY;

BIOCOMPATIBLE MATERIALS; DRUG STABILITY; EMULSIONS; HUMAN; MICROSPHERES; POLYGLACTIN 910; PROTEINS; SERUM ALBUMIN; SUPPORT, NON-U.S. GOV'T; TECHNOLOGY, PHARMACEUTICAL; TETANUS TOXOID;

EID: 0033791218     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(00)00123-5     Document Type: Article

References (9)

1. Improving stability and release kinetics of microencapsulated tetanus toxoid by co-encapsulation of additives
2. The stability of recombinant human growth hormone in poly(lactic-co-glycolic acid) (PLGA) microspheres
3. Stability of protein and their delivery from biodegradable polymer microspheres
4. A large-scale process to produce microencapsulated proteins
5. Quality improvement of spray-dried, protein-loaded D,L-PLA microspheres by appropriate polymer solvent selection
6. Preparation of coated particles using a spray drying process with an aqueous system
7. Evaluation of spray drying as a method for polylactide and polylactide-co-glycolide microsphere preparation
8. Thermodynamic approach to protein microencapsulation into poly(D,L-lactide) by spray drying
9. Preparation of biodegradable poly(+/-)lactide microparticles using a spray-drying technique