Effect of processing parameters on the properties of peptide-containing PLGA microspheres

Journal of Microencapsulation

Volumn 14, Issue 2, 1997, Pages 163-174

  Jeyanthi, R ^a,b   Mehta, R C ^a,c   Thanoo, B C ^a   Deluca, P P ^a  

^a University of Kentucky   (United States)

^b Bldg 2832 ^*  (United States)

^c ISIS PHARMACEUTICALS   (United States)

Author keywords

Biodegradable; Microspheres; Peptide; Poly(lactide glycolide); Salmon calcitonin; Sustained release

Indexed keywords

METHANOL; MICROSPHERE; PEPTIDE; POLYGLACTIN; POLYMER; SALCATONIN;

ARTICLE; BIODEGRADATION; MOLECULAR WEIGHT; PARTICLE SIZE; PHYSICAL CHEMISTRY; PHYSICAL PHENOMENA; VISCOSITY;

EID: 0031059837     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.3109/02652049709015330     Document Type: Article

References (13)

1. BODMEIER, R., OH, K. H., and CHEN, H., 1989, The effect of the addition of low molecular weight poly(DL-lactide) on drug release from biodegradable poly(DL-lactide) drug delivery systems. International Journal of Pharmaceutics, 51, 1-8.
2. CALIS, S., JEYANTHI, R., TSAI, T., MEHTA, R. C., and DELUCA, P. P., 1995, Adsorption of salmon calcitonin to PLGA microspheres. Pharmaceutical Research, 12, 1072-1076.
3. CHA, Y., and PITT, C. G., 1989, The acceleration of degradation controlled drug delivery from polyester microspheres. Journal of Controlled Release, 8, 259-265.
4. DELUCA, P. P., KANKE, M., SATO, T., and SCHROEDER, H. G., 1990, Porous microspheres for drug delivery and methods for making same, US Patent 4, 818, 542.
5. DELUCA, P. P., MEHTA, R. C., HAUSBERGER, A. G., and THANOO, B. C., 1993, Biodegradable polyesters for drug and polypeptide delivery. Polymeric Delivery Systems, Properties and Applications, edited by M. A. El-Nokaly, D. M. Piatt, B. A. Charpentier, (American Chemical Society, Washington, DC) pp. 53-79.
6. FRAZZA, E. J., and SCHMITT, E. E., 1971, New absorbable suture. Journal of Biomedical Materal Research Symposium, 1, 43-58.
7. JEYANTHI, R., THANOO, B. C., MEHTA, R. C., and DELUCA, P. P., 1996, Effect of solvent removal technique on the matrix characteristics of polylactide/glycolide microspheres for peptide delivery. Journal of Controlled Release, 38, 235-244.
8. MEHTA, R. C., JEYANTHI, R., CALIS, S., THANOO, B. C., BURTON, K. W., and DELUCA, P. P., 1994, Biodegradable microspheres as depot system for parenteral delivery of peptide drugs. Journal of Controlled Release, 29, 375-384.
9. PITT, C. G., GRATZI, M. M., JEFFCOAT, A. R., ZWEIDINGER, R., and SCHINDLER, A., 1979, Sustained drug delivery systems II. Factors affecting release rates from poly (ε-caprolactone) and related biodegradable polyester. Journal of Pharmaceutical Sciences, 68, 1534-1538.
10. SATO, T., SCHROEDER, H. G., KANKE, M., and DELUCA, P. P., 1988, Porous biodegradable microspheres for controlled drug delivery. I. Assessment of processing conditions and solvent removal techniques. Pharmaceutical Research, 5, 21-30.
11. SPENLEHAUER, G., VERT, M., BENOIT, J. P., CHABOT, F., and VEILLARD, M., 1988, Biodegradable cisplatin microspheres prepared by the solvent evaporation method: morphology and release characteristics. Journal of Controlled Release, 7, 217-219.
12. TSAI, T., MEHTA, R. C., and DELUCA, P. P., 1996a, Adsorption of peptides to Poly(d,1-lactide-co-glycolide): 1. Effect of physical factors on the adsorption. International Journal of Pharmaceutics, 127, 31-42.
13. TSAI, T., MEHTA, R. C., and DELUCA, P. P., 1996b, Adsorption of peptides to Poly(d,1-lactide-co-glycolide): 2. Effect of solution properties on the adsorption. International Journal of Pharmaceutics, 127, 43-52.