An examination of factors affecting the size, distribution and release characteristics of polymer microbeads made using electrostatics

Journal of Controlled Release

Volumn 43, Issue 2-3, 1997, Pages 183-196

  Amsden, B G ^a   Goosen, M F A ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Critical volumetric loading; Electrostatic extrusion; Microbeads; Protein delivery

Indexed keywords

BOVINE SERUM ALBUMIN; DICHLOROMETHANE; POLYMER; VINYL ACETATE;

ARTICLE; DRUG RELEASE; ELECTRICITY; ENCAPSULATION; PARTICLE SIZE; PRIORITY JOURNAL; STRENGTH; SURFACE TENSION; TECHNIQUE;

EID: 0031060124     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(96)01483-6     Document Type: Article

References (23)

1. W.M. Saltzman, Antibodies for treating and preventing disease: The potential role of polymeric controlled release. Crit. Rev. Ther. Drug Carrier Sys. 10(2) (1993) 111-142.
2. M. MacKay, Delivery of recombinant peptide and protein drugs. Biotechnol. Genet. Eng. Rev. 8 (1990) 251.
3. R.S. Langer and J. Folkman, Polymers for the sustained release of proteins and other macromolecules. Nature 263 (1976) 797-800.
4. X. Zhang, U.P. Wyss, D. Pichora, B. Amsden and M.F.A. Uoosen, Controlled release of albumin from biodegradable poly(DL-lactide) cylinders. J. Control. Release 25 (1993) 61-69.
5. D.S.T. Hsieh, W.D. Rhine and R. Langer, Zero-order controlled release polymer matrices for micro- and macro-molecules. J. Pharm. Sci. 72 (1983) 17-22.
6. M.V. Sefton, L.R. Brown and R.S. Langer, Ethylene-vinyl acetate microspheres for controlled release of macromolecules. J. Pharm. Sci. 73 (1984) 1859-1861.
7. B. Bugarski, Q. Li, M.F.A. Goosen, D. Poncelet, R.J. Neufeld and G. Vunjak, Electrostatic droplet generation: mechanism of polymer droplet formation. MChE J. 40 (1994) 1026-1031.
8. B. Bugarski, B. Amsden, R.J. Neufeld, D. Poncelet and M.F.A. Goosen, Effect of electrode geometry and charge on the production of polymer microbeads by electrostatics. Can. J. Chem. Eng. 72 (1994) 517-521.
9. G.E.P. Box, W.G. Hunter and J.S. Hunter, Statistics for Experimenters. An Introduction to Design, Data Analysis, and Model Building, John Wiley, New York, 1978.
10. W.M. Saltzman and R. Langer, Transport rates of proteins in porous polymers with known microgeometry. Biophys. J. 55 (1989) 163-171.
11. R. Siegel, J. Kost and R. Langer, Mechanistic studies of macromolecular drug release from macroporous polymers I. Experiments and preliminary theory concerning completeness of drug release. J. Control. Release 8 (1989) 223-236.
12. H. Leuenberger, J.D. Bonny and M. Kolb, Percolation effects in matrix-type controlled drug release systems. Int. J. Pharm. 115 (1995) 217-224.
13. B.G. Amsden and Y-L. Cheng, Enhanced fraction releasable above percolation threshold from monoliths containing osmotic excipients. J. Control. Release 31 (1994) 21-32.
14. G. Golomb, P. Fisher and E. Rahamim, The relationship between drug release rate, particle size and swelling of silicone matrices. J. Control. Release 12 (1990) 121-132.
15. W.D. Rhine, D.S.T. Hsieh and R. Langer, Kinetics of polymeric delivery systems for proteins and other macro-molecules. J. Pharm. Sci. 69 (1980) 265-270.
16. E.S. Miller and N.A. Peppas, Diffusional release of water-soluble bioactive agents from ethylene-vinyl acetate co-polymers. Chem. Eng. Commun. 22 (1983) 303-315.
17. E.S. Miller, N.A. Peppas and D.N. Winslow, Morphological changes of ethylene/vinyl acetate based controlled delivery systems during release of water-soluble solutes. J. Membr. Sci. 14 (1983) 79-92.
18. R.A. Siegel and R. Langer, Controlled release of polypeptides and other macromolecules. Pharm. Res. 1 (1984) 2-10.
19. R. Bawa, R.A. Siegel, B. Marasca, M. Karel and R. Langer, An explanation for the controlled release of macromolecules from polymers. J. Control. Release 1 (1985) 259-267.
20. R. Siegel and R. Langer, Mechanistic studies of macro-molecular drug release from macroporous polymers II. Models for the slow kinetics of drug release. J. Control. Release 14 (1990) 153-167.
21. R.A. Siegel, Modelling of drug release from porous polymers, in: M. Rosoff (Ed.) Controlled Release of Drugs: Polymers and Aggregate Systems, VCH Publishers, New York, 1989.
22. D. Stauffer and A. Aharony, Introduction to Percolation Theory, Taylor and Francis Ltd., London, 1992.
23. J. Crank, The Mathematics of Diffusion, Clarendon Press, Oxford, 1975.