Discovery of a novel class of reversible non-peptide caspase inhibitors via a structure-based approach

Journal of Medicinal Chemistry

Volumn 48, Issue 5, 2005, Pages 1649-1656

  Fattorusso, Roberto ^a   Jung, Dawoon ^a   Crowell, Kevin J ^a   Forino, Martino ^a   Pellecchia, Maurizio ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BI 7E7; BI 9B11; BI 9B12; BI 9C1; BI 9C10; BI 9C11; BI 9C12; BI 9C2; BI 9C3; BI 9C4; BI 9C5; BI 9C6; BI 9C7; BI 9C8; BI 9C9; CASPASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CALCULATION; DRUG ACTIVITY; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; METHODOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS;

CASPASE 3; CASPASE 7; CASPASE 8; CASPASES; COMPUTER SIMULATION; COUMARINS; DIOXANES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; OLIGOPEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 11144301780     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0493212     Document Type: Article

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