Identification of a stable chymase inhibitor using a pharmacophore-based database search

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 1, 2003, Pages 25-29

  Koide, Yuuki ^a   Tatsui, Akira ^a   Hasegawa, Takeshi ^a   Murakami, Akira ^a   Satoh, Shoji ^a   Yamada, Hideki ^a   Kazayama, Shin Ichi ^a   Takahashi, Atsuo ^a  

^a TOA EIYO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[B]THIOPHEN 2 SULFONAMIDE; CHYMASE; HYDROGEN; LEAD; SERINE PROTEINASE; SULFONAMIDE; UNCLASSIFIED DRUG; SERINE PROTEINASE INHIBITOR; THIADIAZOLE DERIVATIVE; THIAZOLE DERIVATIVE;

ARTICLE; CHEMICAL MODEL; CHEMICAL STRUCTURE; HYDROGEN BOND; HYDROPHOBICITY; PHARMACOPHORE; ANIMAL; BINDING SITE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; DRUG STABILITY; FACTUAL DATABASE; HUMAN; PROTEIN BINDING;

ANIMALS; BINDING SITES; CHYMASES; DATABASES, FACTUAL; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; THIADIAZOLES; THIAZOLES;

EID: 1842864778     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00853-3     Document Type: Article

References (25)

1. Takai S., Shiota N., Sakaguchi M., Muraguchi H., Matsumura E., Miyazaki M. Clin. Chim. Acta. 264:1997;13.
2. Caughey G.H., Raymond W.W., Wolters P.J. Biochim. Biophys. Acta. 1480:2000;245.
3. Takai S., Shiota N., Yamamoto D., Okunishi H., Miyazaki M. Life Sci. 58:1996;591.
4. Wintroub B.U., Schechter N.B., Lazarus G.S., Kaempfer C.E., Schwartz L.B. J. Invest. Dermatol. 83:1984;336.
5. Ihara M., Urata H., Kinoshita A., Suzumiya J., Sasaguri M., Kikuchi M., Ideishi M., Arakawa K. Hypertension. 33:1999;1399.
6. Nishimoto M., Takai S., Kim S., Jin D., Yuda A., Sakaguchi M., Yamada M., Sawada Y., Kondo K., Asada K., Iwao H., Sasaki S., Miyazaki M. Circulation. 104:2001;1274.
7. Takai S., Yuda A., Jin D., Nishimoto M., Sakagichi M., Sasaki S., Miyazaki M. FEBS Lett. 467:2000;141.
8. Takai S., Shiota N., Kobayashi S., Matsumura E., Miyazaki M. FEBS Lett. 412:1997;86.
9. Shiota N., Fukamizu A., Takai S., Okunishi H., Murakami K., Miyazaki M. J. Hypertens. 15:1997;431.
10. Shiota N., Jin D., Takai S., Kawamura T., Koyama M., Nakamura N., Miyazaki M. FEBS Lett. 406:1997;301.
11. Urata H., Kinoshita A., Misono K.S., Bumpus F.M., Husain A. J. Biol. Chem. 265:1990;22348.
12. Pascale E., Tarani L., Meglio P., Businco L., Battiloro E., Cimino-Reale G., Verna R., D'Ambrosio E. Hum. Hered. 51:2001;177.
13. Kakizoe E., Shiota N., Tanabe Y., Shimoura K., Kobayashi Y., Okunishi H. J. Invest. Dermatol. 116:2001;118.
14. Akahoshi F., Ashimori A., Yoshimura T., Imada T., Nakajima M., Mitsutomi N., Kuwahara S., Ohtsuka T., Fukaya C., Miyazaki M., Nakamura N. Bioorg. Med. Chem. 9:2001;301.
15. Akahoshi F., Ashimori A., Sakashita H., Yoshimura T., Imada T., Nakajima M., Mitsutomi N., Kuwahara S., Ohtsuka T., Fukaya C., Miyazaki M., Nakamura N. J. Med. Chem. 44:2001;1286.
16. Akahoshi F., Ashimori A., Sakashita H., Yoshimura T., Eda M., Imada T., Nakajima M., Mitsutomi N., Kuwahara S., Ohtsuka T., Fukaya C., Miyazaki M., Nakamura N. J. Med. Chem. 44:2001;1297.
17. Aoyama Y., Uenaka M., Kii M., Tanaka M., Konoike T., Hayasaki-Kajiwara Y., Naya N., Nakajima M. Bioorg. Med. Chem. 9:2001;3065.
18. Aoyama Y., Uenaka M., Konoike T., Iso Y., Nishitani Y., Kanda A., Naya N., Nakajima M. Bioorg. Med. Chem. Lett. 10:2000;2397.
19. Aoyama Y., Uenaka M., Konoike T., Iso Y., Nishitani Y., Kanda A., Naya N., Nakajima M. Bioorg. Med. Chem. Lett. 10:2000;2403.
20. Fukami H., Imajo S., Ito A., Kakutani S., Shibata H., Sumida M., Tanaka T., Niwata S., Saitoh M., Kiso Y., Miyazaki M., Okunishi H., Urata H., Arakawa K. Drug Des. Discov. 17:2000;69.
21. Jin D., Takai S., Yamada M., Sakaguchi M., Miyazaki M. Life Sci. 71:2002;437.
22. Takai S., Jin D., Nishimoto M., Yuda A., Sakaguchi M., Kamoshita K., Ishida K., Sukenaga Y., Sasaki S., Miyazaki M. Life Sci. 69:2001;1725.
23. Takai S., Jin D., Sakaguchi M., Kirimura K., Miyazaki M. Jpn. J. Pharmacol. 86:2001;124.
24. Rational Drug Design Software Catalyst®; Accelrys: San Diego, CA, USA. See: http://www.accelrys.com/catalyst/index.html and http://www.accelrys.com/references/rdd_pub.html#catalyst.
25. McGrath M.E., Mirzadegan T., Schmidt B.F. Biochemistry. 36:1997;14318.