Cation-π interactions in chemistry and biology: A new view of benzene, Phe, Tyr, and Trp

Science

Volumn 271, Issue 5246, 1996, Pages 163-168

  Dougherty, Dennis A ^a  

^a Califomia Institute of Technology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUND; BENZENE; CATION; PHENYLALANINE; TRYPTOPHAN; TYROSINE;

ARTICLE; CHEMICAL BINDING; HYDROPHOBICITY; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN BINDING;

EID: 0030043489     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.271.5246.163     Document Type: Article

References (113)

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111. Aromatic residues appear with abnormally high frequencies at many types of biological binding sites, even those not necessarily targeted to cations. These include the binding sites of antibodies [I. S. Mian, A. H. Bradwell, A. J. Oleon, J. Mol. Biol. 217, 133 (1991)] and the transmembrane regions of multidrug resistance proteins [A. B. Pawagi, J. Wang, M. Silverman, R. A. F. Reithmeier, C. M. Deber, ibid. 235, 554 (1994)].
112. Aromatic residues appear with abnormally high frequencies at many types of biological binding sites, even those not necessarily targeted to cations. These include the binding sites of antibodies [I. S. Mian, A. H. Bradwell, A. J. Oleon, J. Mol. Biol. 217, 133 (1991)] and the transmembrane regions of multidrug resistance proteins [A. B. Pawagi, J. Wang, M. Silverman, R. A. F. Reithmeier, C. M. Deber, ibid. 235, 554 (1994)].
113. Contribution No. 9016 from the Arnold and Mabel Beckman Laboratories of Chemical Synthesis. Supported by NIH (GM43936), the Office of Naval Research (N00014-91-J-1344), and Zeneca Pharmaceuticals. D.A.D. thanks many outstanding students and postdoctoral colleagues for their contributions to this work.