Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in Drosophila

Genetics

Volumn 144, Issue 3, 1996, Pages 1075-1085

  Kurd, Daryl D ^a   Saxton, William M ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KINESIN;

ARTICLE; GENE MUTATION; MOTOR NEURON DISEASE; NERVE CELL DIFFERENTIATION; NERVE FIBER TRANSPORT; NEUROTRANSMITTER RELEASE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN TRANSPORT; SYNAPSE VESICLE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; AXONS; BIOLOGICAL TRANSPORT; CALCIUM-BINDING PROTEINS; CELL ADHESION MOLECULES, NEURONAL; DROSOPHILA; FEMALE; HSP40 HEAT-SHOCK PROTEINS; KINESIN; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MOTOR NEURON DISEASE; MUTAGENESIS; NERVE TISSUE PROTEINS; ORGANELLES; PARALYSIS; PHENOTYPE; PRESYNAPTIC TERMINALS; QA-SNARE PROTEINS; RABBITS; SYNAPTOTAGMINS;

VERTEBRATA;

EID: 0029911064     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. AMARATUNGA, A., S. E. LEEMAN, K. S. KOSIK and R. E. FINE, 1995 Inhibition of kinesin synthesis in vivo inhibits the rapid transport of representative proteins for three transport vesicle classes into the axon. J. Neurochem. 64: 2374-2376.
2. ATWOOD, H. L., C. K. Govixn and C.-F. Wu, 1993 Differential ultrastmcture of s)Tiaptic terminals on ventral longitudinal abdominal muscles in Drosophila larvae. J. Ncurobiol. 24: 1008-1024.
3. BLOOM, G., and S. ENDOW, 1994 Motor Proteins J. Kinesins. Academic Press, London.
4. BOSTOCK, H., M. K. SHARIEF, G. REID and N. M. F. MURRAY, 1995 Axonal ion channel dysfunction in amyotrophic later sclerosis. Brain 118: 217-225.
5. BRADY, S. T., 1991 Molecular motors in the nervous system. Neuron 7:521-533.
6. BRADY, S. T., 1995 Interfering with the runners. Nature 375: 12-13.
7. BROWN, R. H., 1995 Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice. Cell 80: 687-692.
8. BUDNIK, V., Y. ZHONG and C.-F. Wu, 1990 Morphological plasticity of motor axons in Drosojihila mutants with altered excitibility. J. Neurosci. 10: 3754-3768.
9. CLEVELAND, D. W., 1996 Neuronal growth and death: order and disorder in the axoplasm. Cell 84: 663-666.
10. COLLARD,J.-F., F. COTE and J.-P. JULIEN, 1995 Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis. Nature 375: 61-64.
11. CONNOR, E. A., and M. A. SMITH, 1994 Retrograde signalling in the formation and maintenance of the neuromuscular junction. J. Neurobiol. 25: 722-739.
12. CORNBIATH, D. R., R. W. KUNCL, E. D. MKLLITS, S. A. QUASKEY, I.. CLAWSON et al., 1992 Nerve conduction studies in amyotrophic lateral sclerosis. Muscle Nerve 15: 1111-1115.
13. COTE, F.,J.-F.COLLARD and J.-P. JULIEN, 1993 Progressive neuropathy in transgenic mice expressing the human neurofilament heavy chain gene: a mouse model of amyotrophic lateral sclerosis. Cell 73: 35-46.
14. DAMS, G. W., and R. K. MURPIIEY, 1994 Long-term regulation of short-term transmitter release proerties: retrograde signalling and synaptic development. Trends Neurosci. 17: 9-13.
15. DETTMAX, R. W., F. R. TURNER and E. C. RAFF, 1996 Genetic analysis of the Diosophita(i3-ti\b\i\\n gene demonstrates that the microtubule cytoskeleton in the cells of the visceral mesoderm is required for morphogenesis of the midgut endoderm. Dev. Biol. 177: 117-135.
16. DUBREUH., R. R., and J. Yu, 1994 Ankyrin and β-spectrin accumulate independently of a-spectrin in Drosophila. Proc. Natl. Acad. Sci. USA 91: 10285-10289.
17. DVCK, P.J., P. CHANCE, R. LEBO andj. A. CARNEY, 1993 Hereditary motor and sensory neuropathies, pp. 1094-1136 in Peripheral Neuropathy, edited by P. J. DVCK, P. K. THOMAS, J. W. GRIFFIN, P. A. Low andj. F. PODUSI.O. W. B. Saunders, Philadelphia.
18. EISEN, A., 1995 Amyotrophic lateral sclerosis is a multifactorial disease. Muscle Nerve 16: 741-752.
19. FERREIRA, A., J. NICLAS, R. D. VALE, G. BANKER and K. S. KOSIK, 1992 Suppression of kinesin expression in cultured hippocampal neurons using antisense oligonucleotides.J. Cell Biol. 117: 595-606.
20. GHO, M., K. MCDONALD, B. GANETZKY and W. M. SAXTON, 1992 Effects of kinesin mutations on neuronal functions. Science 258: 313-316.
21. GOLDSTEIN, L. S. B., 1993 With apologies to Scheherazade: tails of 1001 kinesin motors. Annu. Rev. Genet. 27: 319-351.
22. HAHN, A. F., 1993 Hereditäry sensory and motor neuropathy: HMSN type II (neuronal type) and X-linked HMSN. Brain Pathol. 3: 147-155.
23. HALL, D. H., and E. M. HEDGECOCK, 1991 Kinesin-related gene unc104 is required for axonal transport of synaptic vesicles in C. elegans. Cell 65: 837-847.
24. HATA, Y., C. L. SLAUGHTER and T. C. SUDHOF, 1993 Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature 366: 347-350.
25. HEIDEMANN, S. R.,J. M. LANDERS and M. A. HAMBURG, 1981 Polarity orientation of axonal microtubules. J. Cell Biol. 91: 661-665.
26. HIRANO, A., 1991 Cytopathology of amyotrophic lateral sclerosis. Adv. Neurol. 56: 91-101.
27. HIROKAWA, N., 1996 Organelle transport along microtubules-the role of KIFs. Trends Cell Biol. 6: 135-140.
28. HIROKAWA, N., R. SATO-YOSHITAKE, N. KOBAYASHI, K. K. PFISTER, G. S. Bl.OOM et al., 1991 Kinesin associates with anterogradely transported membranous organelles in vivo.]. Cell Biol. 114: 295-302.
29. HOHENBECK, P. J., 1993 Products of endocytosis and autophagy are retrieved from axons by regulated retrograde axonal transport. J. Cell Biol. 121: 305-315.
30. HURD, D. D., M. STERN and W. M. SAXTON, 1996 Mutation of the axonal transport motor kinesin enhances para and suppresses Skaker in Drosophila. Genetics 142: 195-204.
31. JAN, L. Y., and Y. N. JAN, 1982 Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos. Proc. Natl. Acad. Sci. USA 79: 2700-2704.
32. JAN, Y. N., and L. Y.JAN, 1976 Properties of the larval neuromuscular junction in Drosophila melanogasler. J. Physiol. 262: 189-214.
33. LAMBERT, E. H., and P. J. DVCK, 1993 Compound action potentials of sural nerve in vitro in peripheral neuropathy, pp. 672-685 in Peripheral Neuropathy, edited by P. J. DVCK, P. K. THOMAS, J. W. GRIFFIN, P. A. Low andj. F. PODUSI.O. W. B. Saunders, Philadelphia.
34. LASER, R. J., M. M. OBUNGER and P. F. DRAKE, 1983 Molecular biology of neuronal geometry: expression of ncurofilament genes influences axonal diameter. Cold Spring Harbor Symp. Quant. Biol. 48: 731-744.
35. LEE, M. K., J. R. MARSZALEK and D. W. CLEVELAND, 1994 A mutant neurofilamcnt subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease. Neuron 13: 975-988.
36. LIN, D. M., and C. S. GOODMAN. 1993 Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance. Neuron 13: 507-523.
37. LIN, D. M., R. D. FETTER, C. KOPCZYNSKI, G. GRENNINGLOH and C. S. GOODMAN, 1993 Genetic analyis of Fasciclin II in Drosophila: defasciculation, refasciculation, and altered fasciculation. Neuron 13: 1055-1069.
38. LIXDSLEY, D. L., and G. G. ZIMM, 1992 The Genome of Drosopliila melanogaster. Academic Press, San Diego.
39. LITTLETON.J. T., H.J. BELLEN and M. S. PERIN, 1993 Expression of synaplotagmin in Drosophila reveals transport and localization of s)Tiaptic vesicles to the synapse. Development 118: 1077-1088.
40. MASELLI, R. A., R. L. WOLLMAN, C. LEUNG, B. DISTAD, S. PALOMBI et al., 1993 Neuromuscular transmission in amyotrophic lateral sclerosis. Muscle Nerve 16: 1193-1203.
41. MCDONALD, K. I,., 1994 Electron microscopy and EM immunocytochemistry, pp. 411-444 in Drosophila melanogasler: Practical Uses in Cell and Molecular Biology, edited by L. S. B. GOLDSTEIN" and E. A. FRYBERG. Academic Press, San Diego.
42. NANGAKU, M., R. SATO-YOSHITAIJE, Y. OKADA, Y. NOUA, R. TAKEMURA et al., 1995 KIF1B, a novel microttibulc plus end-directed monomeric motor protein for mitochondria transport. Cell 79: 120-91220.
43. NIXON, R. A., and A. M. CATALDO, 1995 The endosomal-lysosomal system of neurons: new roles. Trends Neurosci. 18: 489-496.
44. OCHS, S., and W. S. BRIMIJOIN, 1993 Axonal transport, pp. 331-360 in Peripheral Neuropathy, edited by P.J. DVCK, P. K. THOMAS.J. W. GRIFFIN, P. A. Low and J. F. Poousi.o. \V. B. Saunders, Philadelphia.
45. OKADA, Y., H. YAMAZAKJ, Y. SEKINE-AIZAWA and N. HIROKAWA, 1995 The neuron-specific kincsin superfamily protein KIF1A is a unique monomeric motor for anterogradc transport of synaptic vesicle precursors. Cell 81: 769-780.
46. QUATACKER, J., W. ANNAERT and W. DEPOTTER, 1995 The organization of the axonal reticulum at a ligation, in in vitro incubated bovine splenic nerves. Brain Res. 680: 36-42.
47. RODIONOV, V. I., F. K. GYOEVA, E. TANAKA, A. D. BERSILVDSKY, J. M. VASIIJEV et al., 1993 Microtubule-dependent control of cell shape and pseudopodial activity is inhibited by the antibody to kinesin motor domain. J. Cell Biol. 123: 1811-1820.
48. ROWLAND, L. P., 1994 Natural history and clinical features of amyotrophic lateral sclerosis, pp. 507-522 in Neurodegenerative Diseases, edited by D. B. CAI.XE. W. B. Saunders Co., Philadelphia.
49. SAXTON, W. M., M. E. PORTER, S. A. Coiix.J. M. SCHOLEY, E. C. RAFF et al., 1988 Orosophila kincsin: characterization of microtubule motility and ATPasc. Proc. Natl. Acacl. Sci. USA 85: 1109-1113.
50. SAXTOX, W. M., J. HICKS, L. S. B. GOLDSTEIN and E. C. RAFF, 1991 Kincsin heavy chain is essential for viability and neuroinuscular functions in Drosophila, but mutants show no defects in mitosis. Cell 64: 1093-1102.
51. SCHOLEY, J. M., 199G Kinesin-II, a membrane traffic motor in axons, axonemes, and spindles. J. Cell Biol. 133: 1-4.
52. SCHULZE, K. L., K. BROADIE, M. S. PERIN and H. J. BELLEX, 1995 Genetic and electrophysiological studies of Drosophila syntaxin1A demostrate its role in nonneuronal secretion and neurotransmission. Cell 80: 311-320.
53. SNOW, P. M., N. H. PATEL, A. L. HARREISON and C. S. GOODMAX, 1987 Neural-specific carbohydrate moiety shared by many surface glycoproteins in Dnxophilaand grasshopper embryos. J. Neurosci. 7: 4137-4144.
54. STEWART, B. A., C. M. SCHUSTER, C. S. GOODMAX and H. L. ATWOOD, 1996 Homeostatsis of synaptic transmission in Drosopliila with genetically altered nerve terminal morphology. J. Neurosci. 16: 3877-3886.
55. TSUKITA, S., and H. ISHIKAWA, 1980 The movement of membranous organcllcs in axons. J. Cell Biol. 84: 513-530.
56. VALLEE, R. B., and G. S. BLOOM, 1991 Mechanisms of fast and slow axonal transport. Annu. Rev. Neurosci. 14: 59-92.
57. WAKIMOTO, B. T., F. R. TURNER and T. C. KAUFMAX, 1984 Defects in embryogenesis in mutants associated with the antennapedia gene complex of Dnaophila melmwgaster. Dev. Biol. 102: 147-172.
58. XU, Z., L. C. CORK.J. W. GRIFFIN and D. \V. CLEVEIAXD, 1993 Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell 73: 23-33.
59. ZHONG, Y., V. BUDNIK and C.-F. Wu, 1992 Synaptic plasticity in Droiophila memory and hyperexcitible mutants: role of cAMP cascade. J. Neurosci. 12: 644-651.
60. ZINSMAIER, K. E., K. K. EBERLE, E. BÜCHNER, N. WALTER and S. BENXER, 1994 Paralysis antl early death in cysteine string protein mutants of Dmsophila. Science 263: 977-980.