Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor

Journal of Cell Biology

Volumn 165, Issue 2, 2004, Pages 167-173

  Herlan, Mark ^a   Bornhövd, Carsten ^a   Hell, Kai ^a   Neupert, Walter ^a   Reichert, Andreas S ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Dynamin like protein; Mitochondrial diseases; Mitochondrial fusion; Protein import; Rhomboid protease

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOCHROME C OXIDASE; DYNAMIN; GUANOSINE TRIPHOSPHATASE; HYBRID PROTEIN; MITOCHONDRIAL DNA; PROTEIN; PROTEIN MGM1; PROTEIN PCP1; PROTEINASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CONTROL SYSTEM; EXTRACHROMOSOMAL INHERITANCE; HYDROPHOBICITY; MITOCHONDRIAL MEMBRANE; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; REGULATORY MECHANISM; YEAST;

ADENOSINE TRIPHOSPHATE; GTP-BINDING PROTEINS; HUMANS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MODELS, MOLECULAR; MOLECULAR MOTOR PROTEINS; NUCLEAR PROTEINS; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 2142710081     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200403022     Document Type: Article

References (24)

1. Alexander, C., M. Votruba, U.E. Pesch, D.L. Thiselton, S. Mayer, A. Moore, M. Rodriguez, U. Kellner, B. Leo-Kottler, G. Auburger, et al. 2000. OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28. Nat. Genet. 26:211-215.
2. Delettre, C., G. Lenaers, J.M. Griffoin, N. Gigarel, C. Lorenzo, P. Belenguer, L. Pelloquin, J. Grosgeorge, C. Turc-Carel, E. Perret, et al. 2000. Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy. Nat. Genet. 26:207-210.
3. Dimmer, K.S., S. Fritz, F. Fuchs, M. Messerschmitt, N. Weinbach, W. Neupert, and B. Westermann. 2002. Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol. Biol. Cell. 13:847-853.
4. Esser, K., B. Tursun, M. Ingenhoven, G. Michaelis, and E. Pratje. 2002. A novel two-step mechanism for removal of a mitochondrial signal sequence involves the mAAA complex and the putative rhomboid protease pcp1. J. Mol. Biol. 323:835-843.
5. Foury, F., and A. Tzagoloff. 1976. Localization on mitochondrial DNA of mutations leading to a loss of rutamycin-sensitive adenosine triphosphatase. Eur. J. Biochem. 68:113-119.
6. Gambill, B.D., W. Voos, P.J. Kang, B. Miao, T. Langer, E.A. Craig, and N. Pfanner. 1993. A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins. J. Cell Biol. 123:109-117.
7. Guan, K., L. Farh, T.K. Marshall, and R.J. Deschenes. 1993. Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene. Curr. Genet. 24:141-148.
8. Herlan, M., F. Vogel, C. Bornhövd, W. Neupert, and A.S. Reichert. 2003. Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J. Biol. Chem. 278:27781-27788.
9. Kawai, A., S. Nishikawa, A. Hirata, and T. Endo. 2001. Loss of the mitochondrial Hsp70 functions causes aggregation of mitochondria in yeast cells. J. Cell Sci. 114:3565-3574.
10. Kyte, J., and R.F. Doolittle. 1982. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157:105-132.
11. Lafontaine, D., and D. Tollervey. 1996. One-step PCR mediated strategy for the construction of conditionally expressed and epitope tagged yeast proteins. Nucleic Acids Res. 24:3469-3471.
12. McQuibban, G.A., S. Saurya, and M. Freeman. 2003. Mitochondrial membrane remodelling regulated by a conserved rhomboid protease. Nature. 423:537-541.
13. Milisav, I., F. Moro, W. Neupert, and M. Brunner. 2001. Modular structure of the TIM23 preprotein translocase of mitochondria. J. Biol. Chem. 276:25856-25861.
14. Mokranjac, D., M. Sichting, W. Neupert, and K. Hell. 2003. Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. EMBO J. 22:4945-4956.
15. Neupert, W., and M. Brunner. 2002. The protein import motor of mitochondria. Nat. Rev. Mol. Cell Biol. 3:555-565.
16. Sesaki, H., S.M. Southard, A.E. Hobbs, and R.E. Jensen. 2003a. Cells lacking Pcp1p/Ugo2p, a rhomboid-like protease required for Mgm1p processing, lose mtDNA and mitochondrial structure in a Dnm1p-dependent manner, but remain competent for mitochondrial fusion. Biochem. Biophys. Res. Commun. 308:276-283.
17. Sesaki, H., S.M. Southard, M.P. Yaffe, and R.E. Jensen. 2003b. Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol. Biol. Cell. 14:2342-2356.
18. Shaw, J.M., and J. Nunnari. 2002. Mitochondrial dynamics and division in budding yeast. Trends Cell Biol. 12:178-184.
19. Sirrenberg, C., M.F. Bauer, B. Guiard, W. Neupert, and M. Brunner. 1996. Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22. Nature. 384:582-585.
20. Urban, S., and M. Freeman. 2003. Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain. Mol. Cell. 11:1425-1434.
21. Westermann, B. 2003. Mitochondrial membrane fusion. Biochim. Biophys. Acta. 1641:195-202.
22. Westermann, B., and W. Neupert. 2000. Mitochondria-targeted green fluorescent proteins: convenient tools for the study of organelle biogenesis in Saccharomyces cerevisiae. Yeast. 16:1421-1427.
23. Wong, E.D., J.A. Wagner, S.W. Gorsich, J.M. McCaffery, J.M. Shaw, and J. Nunnari. 2000. The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria. J. Cell Biol. 151:341-352.
24. Wong, E.D., J.A. Wagner, S.V. Scott, V. Okreglak, T.J. Holewinske, A. Cassidy-Stone, and J. Nunnari. 2003. The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion. J. Cell Biol. 160:303-311.