The yeast gene, MDM20, is necessary for mitochondrial inheritance and organization of the actin cytoskeleton

Journal of Cell Biology

Volumn 137, Issue 1, 1997, Pages 141-153

  Hermann, Greg J ^a   King, Edward J ^a   Shaw, Janet M ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; KERATIN; TROPOMYOSIN; VIMENTIN;

ARTICLE; CELL MOTILITY; CYTOSKELETON; ELECTRON MICROSCOPY; GENE EXPRESSION; GENE MUTATION; MOLECULAR CLONING; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; YEAST;

ACTINS; AMINO ACID SEQUENCE; CARRIER PROTEINS; CELL DIVISION; CELL NUCLEUS; CYTOSKELETON; DNA, MITOCHONDRIAL; FUNGAL PROTEINS; GENE DOSAGE; GENES, FUNGAL; GENETIC COMPLEMENTATION TEST; GENETIC SCREENING; GTPASE-ACTIVATING PROTEINS; MEMBRANE GLYCOPROTEINS; MICROFILAMENT PROTEINS; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MYOSIN HEAVY CHAINS; MYOSIN TYPE II; MYOSIN TYPE V; PHENOTYPE; PROTEINS; RHO FACTOR; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES POMBE PROTEINS; SEQUENCE ANALYSIS, DNA; TEMPERATURE; TROPOMYOSIN;

EID: 0030951615     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.137.1.141     Document Type: Article

References (81)

1. Adams, A.E.M., and J.R. Pringle. 1984. Relationship of actin and tubulin distribution in wild-type and morphogenetic mutant Saccharomyces cerevisiae. J. Cell Biol. 98:934-945.
2. Adams, A.E.M., and J.R. Pringle. 1991. Staining of actin with fluorochromeconjugated phalloidin. Methods Enzymol. 194:729-731.
3. Adams, A.E.M., D. Botstein, and D.G. Drubin. 1991. Requirement of yeast fimbrin for actin organization and morphogenesis in vivo. Nature (Lond.). 354:404-408.
4. Adams, A.E.M., J.A. Cooper, and D.G. Drubin. 1993. Unexpected combinations of null mutations in genes encoding the actin cytoskeleton are lethal in yeast. Mol. Biol. Cell. 4:459-468.
5. Altschul, S.F., W. Gish, W. Miller, E.W. Meyers, and D.J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
6. Backer, J.S. 1995. New alleles of mgm1: a gene encoding a protein with a GTP-binding domain related to dynamin. Curr. Genet. 28:499-501.
7. Bairoch, A., P. Bucher, and K. Hofmann. 1995. The PROSITE database, its status in 1995. Nucleic Acids Res. 24:189-196.
8. Ball, E.H., and S.J. Singer. 1982. Mitochondria are associated with microtubules and not with intermediate filaments in cultured fibroblasts. Proc. Natl. Acad. Sci. USA. 79:123-126.
9. Baudin, A., O. Ozier-Kalogeropoulos, A. Denouel, F. Lacroute, and C. Cullin. 1993. A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae. Nucleic Acids Res. 21:3329-3330.
10. Bereiter-Hahn, J. 1990. Behavior of mitochondria in the living cell. Int. Rev. Cytol. 122:1-63.
11. Bereiter-Hahn, J., and M. Voth. 1994. Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria. Microsc. Res. Tech. 27:198-219.
12. Bretscher, A., B. Drees, E. Harsay, D. Schott, and T. Wang. 1994. What are the basic functions of microfilaments? Insights from studies in budding yeast. J. Cell Biol. 126:821-825.
13. Burgess, S.M., M. Delannoy, and R.E. Jensen. 1994. MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria. J. Cell Biol. 126:1375-1391.
14. Cigan, A.M., and T.F. Donahue. 1987. Sequence and structural features associated with translational initiator regions in yeast: a review. Gene (Amst.). 59: 1-18.
15. Cohen, C., and D.A.D. Parry. 1986. α-helical coiled coils: a widespread motif in proteins. Trends Biochem. Sci. 11:245-248.
16. Cohen, C., and D.A.D. Parry. 1990. α-helical coiled coils and bundles: how to design an α-helical protein. Proteins Struct. Funct. Genet. 7:1-15.
17. Diffley, J.F., and B. Stillman. 1991. A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria. Proc. Natl. Acad. Sci. USA. 88:7864-7868.
18. Diffley, J.F., and B. Stillman. 1992. DNA binding properties of an HMGl-related protein from yeast mitochondria. J. Biol. Chem. 267:3368-3374.
19. Drees, B., C. Brown, B.G. Barrell, and A. Bretscher. 1995. Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions. J. Cell Biol. 128:383-392.
20. Drubin, D.G., H.D. Jones, and K.F. Wertman. 1993. Actin structure and function: roles in mitochondrial organization and morphogenesis in budding yeast and identification of the phalloidin-binding site. Mol. Biol. Cell. 4: 1227-1294.
21. Guan, K., L. Farh, T.K. Marshall, and R.J. Deschenes. 1993. Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene. Curr. Genet. 24:141-148.
22. Hannavy, K., S. Rospert, and G. Schatz. 1993. Protein import into mitochondria: a paradigm for the translocation of polypeptides across membranes. Curr. Opin. Cell Biol. 5:694-700.
23. Harlow, E., and D. Lane. 1988. Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. 726 pp.
24. Heggeness, M.H., M. Simon, and S.J. Singer. 1978. Association of mitochondria with microtubules in cultured cells. Proc. Natl. Acad. Sci. USA. 75:3863-3866.
25. Hoffman, H., and C.J. Avers. 1973. Mitochondrion of yeast: ultrastructural evidence for one giant, branched organelle per cell. Science (Wash. DC). 181: 749-751.
26. Hollenbeck, P.J. 1996. The pattern and mechanism of mitochondrial transport in axons. Front. Biosci. 1:91-102.
27. Ito, H., Y. Fukuda, K. Murata, and A. Kimura. 1983. Transformation of intact yeast cells with alkali cations. J. Bacteriol. 153:163-168.
28. Johnston, G.C., J.A. Prendergast, and R.A. Singer. 1991. The Saccharomyces cerevisiae MYO2 gene encodes an essential myosin for vectorial transport of vesicles. J. Cell Biol. 113:539-551.
29. Jones, B.A., and W.L. Fangman. 1992. Mitochondrial DNA maintenance in yeast requires a protein containing a region related to the GTP-binding domain of dynamin. Genes & Dev. 6:380-389.
30. Kilmartin, J., and A.E.M. Adams. 1984. Structural rearrangements of tubulin and actin during the cell cycle of the yeast Saccharomyces. J. Cell Biol. 98: 922-933.
31. Kim, Y., L. Francisco, G. Chen, E. Marcotte, and C.S.M. Chan. 1994. Control of cellular morphogenesis by the Ip12/Bem2 GTPase-activating protein: possible role of protein phosphorylation. J. Cell Biol. 127:1381-1394.
32. 6 staining reveals organelle structure and dynamics in living yeast cells. Cell Motil. Cytoskeleton. 25:111-128.
33. Kubrich, M., K. Dietmeier, and N. Pfanner. 1995. Genetic and biochemical dissection of the mitochondrial protein-import machinery. Curr. Genet. 27: 393-403.
34. Kuznetsov, S.A., G.M. Langford, and D.G. Weiss. 1992. Actin-dependent organelle movement in squid axoplasm. Nature (Lond.). 356:722-725.
35. Lazzarino, D.A., I. Boldogh, M.G. Smith, J. Rosand, and L.A. Pon. 1994. Yeast mitochondria contain ATP-sensitive, reversible actin-binding activity. Mol. Biol. Cell. 5:807-818.
36. Lill, R., and W. Neupert. 1996. Mechanisms of protein import across the mitochondrial outer membrane. Trends Cell Biol. 6:56-61.
37. Lillie, S.H., and S.S. Brown. 1994. Immunofluorescence localization of the unconventional myosin, Myo2p, and the putative kinesin-related protein, Smy1p, to the same regions of polarized growth in Saccharomyces cerevisiae. J. Cell Biol. 125:825-842.
38. Liu, H., and A. Bretscher. 1989. Disruption of the single tropomyosin gene in yeast results in the disappearance of actin cables from the cytoskeleton. Cell. 57:233-242.
39. Liu, H., and A. Bretscher. 1992. Characterization of TPM1 disrupted yeast cells indicates an involvement of tropomyosin in directed vesicular transport. J. Cell Biol. 118:285-299.
40. Lupas, A., M. Van Dyke, and J. Stock. 1991. Predicting coiled coils from protein sequences. Science (Wash. DC). 252:1162-1164.
41. Maniatis, T., E.F. Fritsch, and J. Sambrook. 1982. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory. Cold Spring Harbor, NY. 545 pp.
42. McConnell, S.J., and M.P. Yaffe. 1992. Nuclear and mitochondrial inheritance in yeast depends on novel cytoplasmic structures defined by the MDM1 protein. J. Cell Biol. 118:385-395.
43. McConnell, S.J., and M.P. Yaffe. 1993. Intermediate filament formation by a yeast protein essential for organelle inheritance. Science (Wash. DC). 260: 687-689.
44. McConnell, S.J., L.C. Stewart, A. Talin, and M.P. Yaffe. 1990. Temperature-sensitive yeast mutants defective in mitochondrial inheritance. J. Cell Biol. 111:967-976.
45. Morris, R.L., and P.J. Hollenbeck. 1995. Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons. J. Cell Biol. 131: 1315-1326.
46. Mose-Larsen, P., R. Bravo, S.J. Fey, J.V. Small, and J.E. Celis. 1982. Putative association of mitochondria with a subpopulation of intermediate-sized filaments in cultured human skin fibroblasts. Cell. 31:681-692.
47. Mulholland, J., D. Preuss, A. Moon, A. Wong, D. Drubin, and D. Botstein. 1994. Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane. J. Cell Biol. 125:381-391.
48. Nangaku, M., R. Sato-Yoshitake, Y. Okada, Y. Noda, R. Takemura, H. Yamazaki, and N. Hirokawa. 1994. KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria. Cell. 79: 1209-1220.
49. Palmer, R.E., D.S. Sullivan, T. Huffaker, and D. Koshland. 1992. Role of astral microtubules and actin in spindle orientation and migration in the budding yeast, Saccharomyces cerevisiae. J. Cell Biol. 119:583-593.
50. Pearson, W.R., and D.J. Lipman. 1988. Improved tools for biological sequence analysis. Proc. Natl. Acad. Sci. USA. 85:2444-2448.
51. Peterson, J., Y. Zheng, L. Bender, A. Myers, R. Cerione, and A. Bender. 1994. Interactions between the bud emergence proteins Bem1p and Bem2p and the Rho-type GTPases in yeast. J. Cell Biol. 127:1395-1406.
52. Pittenger, M.F., J. A. Kazzaz, and D.M. Helfman. 1994. Functional properties of nonmuscle tropomyosin isoforms. Curr. Opin. Cell Biol. 6:96-104.
53. Pringle, J.R., R.A. Preston, A.E.M. Adams, T. Stearns, D.G. Drubin, B.K. Haarer, and E.W. Jones. 1989. Fluorescence microscopy methods for yeast. Methods Cell Biol. 31:357-435.
54. Pringle, J.R., A.E.M. Adams, D.G. Drubin, and B.K. Haarer. 1991. Immunofluorescence methods for yeast. Methods Enzymol. 194:565-602.
55. Rayment, I., H.M. Holden, M. Whittaker, C.B. Yohn, M. Lorenz, K.C. Holmes, and R.A. Milligan. 1993. Structure of the actin-myosin complex and its implications for muscle contraction. Science (Wash. DC). 261:58-65.
56. Roeder, A.D., and J.M. Shaw. 1996. Vacuole partitioning during meiotic division in yeast. Genetics. 144:445-458.
57. Rose, M.D., and J.R. Broach. 1991. Cloning genes by complemenation in yeast. Methods Enzymol. 194:195-230.
58. Rose, M.D., P. Novick, J.H. Thomas, D. Botstein, and G.R. Fink. 1987. A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector. Gene (Amst.). 60:237-243.
59. Rothstein, R. 1991. Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. Methods Enzymol. 194:281-301.
60. Ryan, K.R., and R.E. Jensen. 1995. Protein translocation across mitochondrial membranes: what a long, strange trip it is. Cell. 83:517-519.
61. Schroder, R.R., D.J. Manstein, W. Jahn, H. Holden. I. Rayment, K.C. Holmes, and J.A. Spudich. 1993. Three-dimensional atomic model of F-actin decorated with Dictyostelium myosin S1. Nature (Lond.). 364:171-174.
62. Schwarz, E., and W. Neupert. 1994. Mitochondrial protein import: mechanisms, components and energetics. Biochim. Biophys. Acta. 1187:270-274.
63. Sedgwick, S.G., and B.A. Morgan. 1994. Locating, DNA sequencing, and disrupting yeast genes using tagged Tn1000. Methods Mol. Genet. 3:131-140.
64. Shaw, J.M., and W.T. Wickner. 1991. vac2: a yeast mutant which distinguishes vacuole segregation from Golgi-to-vacuole protein targeting. EMBO (Eur. Mol. Biol. Organ.) J. 10:1741-1748.
65. Sherman, F., G.R. Fink, and J.B. Hicks. 1986. Methods in Yeast Genetics. Cold Spring Harbor Press, Cold Spring Harbor, NY. 186 pp.
66. Shortle, D., J.E. Haber, and D. Botstein. 1982. Lethal disruption of the yeast actin gene by integrative DNA transformation. Science (Wash. DC). 217:371-373.
67. Simon, V.R., T.C. Swayne, and L.A. Pon. 1995. Actin-dependent mitochondrial motility in mitotic yeast and cell-free systems: identification of a motor activity on the mitochondrial surface. J. Cell Biol. 130:345-354.
68. Sogo, L.F., and M.P. Yaffe. 1994. Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane. J. Cell Biol. 126:1361-1373.
69. Stevens, B. 1981. Mitochondrial structure. In Molecular Biology of the Yeast Saccharomyces. J.M. Strathern, E.W. Jones, and J.R. Broach, editors. Cold Spring Harbor Press, Cold Spring Harbor, NY. 471-504.
70. Stewart, L.C., and M.P. Yaffe. 1991. A role for unsaturated fatty acids in mitochondrial movement and inheritance. J. Cell Biol. 115:1249-1257.
71. Stromer, M.H., and M. Bendayan. 1990. Immunocytochemical identification of cytoskeletal linkages to smooth muscle cell nuclei and mitochondria. Cell Motil. Cytoskeleton. 17:11-18.
72. Stukey, J.E., V.M. McDonough, and C.E. Martin. 1989. Isolation and characterization of OLE1, a gene affecting fatty acid desaturation from Saccharomyces cerevisiae. J. Biol. Chem. 264:16537-16544.
73. Stukey, J.E., V.M. McDonough, and C.E. Martin. 1990. The OLE1 gene of Saccharomyces cerevisiae encodes the Δ9 fatty acid desaturase and can be functionally replaced by the rat stearoyl-CoA desaturase gene. J. Biol. Chem. 265:20144-20149.
74. Summerhayes, I.C., D. Wong, and L.B. Chen. 1983. Effect of microtubules and intermediate filaments on mitochondrial distribution. J. Cell Sci. 61:87-105.
75. Thorsness, P.E. 1992. Structural dynamics of the mitochondrial compartment. Mutat. Res. 275:237-241.
76. Wang, T., and A. Bretscher. 1995. The rho-GAP encoded by BEM2 regulates cytoskeletal structure in budding yeast. Mol. Biol. Cell. 6:1011-1024.
77. Warren, G., and W. Wickner. 1996. Organelle inheritance. Cell. 84:395-400.
78. Welch, M.D., D.A. Holtzman, and D.G. Drubin. 1994. The yeast actin cytoskeleton. Curr. Opin. Cell Biol. 6:110-119.
79. Winston, F., C. Dollard, and S.L. Ricupero-Hovasse. 1995. Construction of a set of convenient Saccharomyces cerevisiae strains that are isogenic to S228C. Yeast. 11:53-55.
80. Yaffe, M.P. 1991. Organelle inheritance in the yeast cell cycle. Trends Cell Biol. 1:160-163.
81. Zelenaya-Troitskaya, O., P.S. Perlman, and R.A. Butow. 1995. An enzyme in yeast mitochondria that catalyzes a step in branched-chain amino acid biosynthesis also functions in mitochondrial DNA stability. EMBO (Eur. Mol. Biol. Organ.) J. 14:3268-3276.