Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division

Journal of Cell Biology

Volumn 151, Issue 2, 2000, Pages 353-365

  Tieu, Q ^a   Nunnari, J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Fission; Membrane remodeling; Morphology; Organelle; Outer membrane

Indexed keywords

DYNAMIN; GENE PRODUCT; GUANOSINE TRIPHOSPHATASE; PROTEIN DNM1P; PROTEIN MDV1; PROTEIN MDV1P; PROTEIN MDV2; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIVISION; GENETIC ANALYSIS; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING;

CELL COMPARTMENTATION; DYNAMINS; GENES, FUNGAL; GTP PHOSPHOHYDROLASES; INTRACELLULAR MEMBRANES; MEMBRANE FUSION; MEMBRANE PROTEINS; MITOCHONDRIA; MODELS, BIOLOGICAL; PROTEIN BINDING; PROTEIN CONFORMATION; REPETITIVE SEQUENCES, AMINO ACID; SACCHAROMYCES CEREVISIAE; SUPPORT, U.S. GOV'T, NON-P.H.S.; ZYGOTE;

EID: 0034676101     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.151.2.353     Document Type: Article

References (47)

1. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
2. Processing of adenovirus-2 induced proteins
3. The dynamin-related GTPases, Dnm1, regulates mitoehondrial fission in yeast
4. Sequencing analysis of a 40.2 kb fragment of yeast chromosome X reveals 19 open reading frames including URA2 (5' end), TRK1, PBS2, SPT10, GCD14, RPE1, PH086, NCA3, ASF1, CCT7, CZF3, two tRNA genes, three remnant delta elements and a Ty4 transposon
5. Transforming yeast with DNA
6. Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene
7. Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase
8. Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p
9. Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding
10. Mitochondrion of yeast: Ultrastructural evidence for one giant, branched organelle per cell
11. Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
12. Localization of mitochondria in living cells with rhodamine 123
13. Mitochondrial DNA maintenance in yeast requires a protein containing a region related to the GTP-binding domain of dynamin
14. C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane
15. The 2.0 Å crystal structure of a heterotrimeric G protein
16. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
17. Predicting coiled coils from protein sequences
18. Fluorescent proteins from nonbioluminescent Anthozoa species
19. Mgm101p is a novel component of the mitochondrial nucleoid that binds DNA and is required for the repair of oxidatively damaged mitochondrial DNA
20. Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p
21. A mitochondrial protease with two catalytic subunits of nonoverlapping specificities
22. Mitochondrial transmission during mating in S. cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mtDNA
23. Conserved cell and organelle division
24. Chloroplast division in higher plants requires members of two functionally divergent gene families with homology to bacterial ftsZ
25. The dynamin GTPase, Dnm1p, controls mitochondrial morphology in yeast
26. Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae
27. Cloning genes by complementation in yeast
28. A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector
29. Dynamin and its partners: A progress report
30. Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid
31. Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape
32. Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis
33. Garrotes, springs, ratchets, and whips: Putting dynamin models to the test
34. The yeast dynamin-like protein, Mgm1p, functions on the mitochondrial outer membrane to mediate mitochondrial inheritance
35. A human dynamin-related protein controls the distribution of mitochondria
36. The WD repeat: A common architecture for diverse functions
37. Crystal structure of a G-A protein beta-gamma dimer at 2.1Å resolution
38. Computer reconstruction of mitochondria from yeast
39. Recovery of plasmids from yeast into Escherichia coli shuttle vectors
40. Dynamin undergoes a GTP-dependent conformational change causing vesiculation
41. Tubular membrane invaginations coated by dynamin rings are induced by GTP-gamma-S in nerve terminals
42. A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae
43. The structure of the G protein heterotrimer Gi-alpha-1-beta-1-gamma-2
44. CtBP/BARS induces fission of Golgi membranes by acylating lysophosphatidic acid
45. The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria