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Volumn 6, Issue 1, 2004, Pages 13-21

Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer

Author keywords

Breast cancer; Cell cycle; Cyclin dependent kinase; Deregulation; p27

Indexed keywords

CYCLIN D; CYCLIN DEPENDENT KINASE; PROTEIN P27; PROTEIN TYROSINE KINASE; RAS PROTEIN; REGULATOR PROTEIN;

EID: 1042280976     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr722     Document Type: Review
Times cited : (104)

References (138)
  • 1
    • 0028171292 scopus 로고
    • G1 phase progression: Cycling on cue
    • Sherr CJ: G1 phase progression: cycling on cue. Cell 1994, 79: 551-555.
    • (1994) Cell , vol.79 , pp. 551-555
    • Sherr, C.J.1
  • 2
    • 0028988585 scopus 로고
    • Inhibitors of mammalian G1 cyclin-dependent kinases
    • Sherr CJ, Roberts JM: Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 1995, 9:1149-1163.
    • (1995) Genes Dev. , vol.9 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 4
    • 0026703325 scopus 로고
    • Creative blocks: Cell cycle checkpoints and feedback controls
    • Murray AW: Creative blocks: cell cycle checkpoints and feedback controls. Nature 1992, 359:599-604.
    • (1992) Nature , vol.359 , pp. 599-604
    • Murray, A.W.1
  • 5
    • 0026452949 scopus 로고
    • Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells
    • Hartwell L: Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell 1992, 71: 543-546.
    • (1992) Cell , vol.71 , pp. 543-546
    • Hartwell, L.1
  • 6
    • 0028931265 scopus 로고
    • Principles of CDK regulation
    • Morgan DO: Principles of CDK regulation. Nature 1995, 374: 131-134.
    • (1995) Nature , vol.374 , pp. 131-134
    • Morgan, D.O.1
  • 7
    • 0034092911 scopus 로고    scopus 로고
    • Regulation of the cdk inhibitor p27 and its deregulation in cancer
    • Slingerland J, Pagano M: Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell Physiol 2000, 183:10-17.
    • (2000) J. Cell Physiol. , vol.183 , pp. 10-17
    • Slingerland, J.1    Pagano, M.2
  • 8
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr CJ, Roberts JM: CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999, 13: 1501-1512.
    • (1999) Genes Dev. , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 11
    • 0027318843 scopus 로고
    • Negative regulation of G1 in mammalian cells: Inhibition of cyclin E-dependent kinase by TGF-β
    • Koff A, Ohtsuki M, Polyak K, Roberts JM, Massagué J: Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-β. Science 1993, 260:536-539.
    • (1993) Science , vol.260 , pp. 536-539
    • Koff, A.1    Ohtsuki, M.2    Polyak, K.3    Roberts, J.M.4    Massagué, J.5
  • 14
    • 0028227197 scopus 로고
    • A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor β-arrested epithelial cells
    • Slingerland JM, Hengst L, Pan CH, Alexander D, Stampfer MR, Reed SI: A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor β-arrested epithelial cells. Mol Cell Biol 1994, 14:3683-3694.
    • (1994) Mol. Cell Biol. , vol.14 , pp. 3683-3694
    • Slingerland, J.M.1    Hengst, L.2    Pan, C.H.3    Alexander, D.4    Stampfer, M.R.5    Reed, S.I.6
  • 16
    • 0029670477 scopus 로고    scopus 로고
    • KiP1 accumulation during the cell cycle
    • KiP1 accumulation during the cell cycle. Science 1996, 271:1861-1864.
    • (1996) Science , vol.271 , pp. 1861-1864
    • Hengst, L.1    Reed, S.I.2
  • 21
    • 0032547894 scopus 로고    scopus 로고
    • KiP1 in cell cycle arrest after androgen depletion in mouse mammary carcinoma cells (SC-3)
    • KiP1 in cell cycle arrest after androgen depletion in mouse mammary carcinoma cells (SC-3). Oncogene 1998, 17: 2619-2627.
    • (1998) Oncogene , vol.17 , pp. 2619-2627
    • Menjo, M.1    Kaneko, Y.2    Ogata, E.3    Ikeda, K.4    Nakanishi, M.5
  • 23
    • 0033600160 scopus 로고    scopus 로고
    • Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1
    • Kortylewski M, Heinrich PC, Mackiewicz A, Schniertshauer U, Klingmuller U, Nakajima K, Hirano T, Horn F, Behrmann I: Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1. Oncogene 1999, 18:3742-3753.
    • (1999) Oncogene , vol.18 , pp. 3742-3753
    • Kortylewski, M.1    Heinrich, P.C.2    Mackiewicz, A.3    Schniertshauer, U.4    Klingmuller, U.5    Nakajima, K.6    Hirano, T.7    Horn, F.8    Behrmann, I.9
  • 28
    • 0042812981 scopus 로고    scopus 로고
    • Cyclin E mediated elimination of p27 requires its interaction with the nuclear pore associated protein mNPAP60
    • Muller D, Thieke K, Burgin A, Dickmanns A, Eilers M: Cyclin E mediated elimination of p27 requires its interaction with the nuclear pore associated protein mNPAP60. EMBO J 2000, 19: 2168-2180.
    • (2000) EMBO J. , vol.19 , pp. 2168-2180
    • Muller, D.1    Thieke, K.2    Burgin, A.3    Dickmanns, A.4    Eilers, M.5
  • 30
    • 0035803593 scopus 로고    scopus 로고
    • p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis
    • Rodier G, Montagnoli A, Di Marcotullio L, Coulombe P, Draetta GF, Pagano M, Meloche S: p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J 2001, 20:6672-6682.
    • (2001) EMBO J. , vol.20 , pp. 6672-6682
    • Rodier, G.1    Montagnoli, A.2    Di Marcotullio, L.3    Coulombe, P.4    Draetta, G.F.5    Pagano, M.6    Meloche, S.7
  • 32
    • 0030847760 scopus 로고    scopus 로고
    • Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27
    • Vlach J, Hennecke S, Amati 8: Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J 1997, 16:5334-5344.
    • (1997) EMBO J. , vol.16 , pp. 5334-5344
    • Vlach, J.1    Hennecke, S.2    Amati, B.3
  • 33
    • 0033135878 scopus 로고    scopus 로고
    • Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation
    • Montagnoli A, Fiore F, Eytan E, Carrano AC, Draetta GF, Hershko A, Pagano M: Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev 1999, 13:1181-1189.
    • (1999) Genes Dev. , vol.13 , pp. 1181-1189
    • Montagnoli, A.1    Fiore, F.2    Eytan, E.3    Carrano, A.C.4    Draetta, G.F.5    Hershko, A.6    Pagano, M.7
  • 34
    • 0033120027 scopus 로고    scopus 로고
    • ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity
    • Ohta T, Michel JJ, Schottelius AJ, Xiong Y: ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Mol Cell 1999, 3:535-541.
    • (1999) Mol. Cell , vol.3 , pp. 535-541
    • Ohta, T.1    Michel, J.J.2    Schottelius, A.J.3    Xiong, Y.4
  • 35
    • 0033176887 scopus 로고    scopus 로고
    • SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
    • Carrano AC, Eytan E, Hershko A, Pagano M: SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1999, 1:193-199.
    • (1999) Nat. Cell Biol. , vol.1 , pp. 193-199
    • Carrano, A.C.1    Eytan, E.2    Hershko, A.3    Pagano, M.4
  • 45
    • 0042532260 scopus 로고    scopus 로고
    • kip1 deregulation in cancer: Down-regulation or mislocalization?
    • kip1 deregulation in cancer: down-regulation or mislocalization? Cell Cycle 2002, 1:394-400.
    • (2002) Cell Cycle , vol.1 , pp. 394-400
    • Viglietto, G.1    Fusco, A.2
  • 58
    • 0031048236 scopus 로고    scopus 로고
    • Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
    • Loda M, Cukor B, Tam SW, Lavin P, Fiorentino M, Draetta GF, Jessup JM, Pagano M: Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med 1997, 3:231-234.
    • (1997) Nat. Med. , vol.3 , pp. 231-234
    • Loda, M.1    Cukor, B.2    Tam, S.W.3    Lavin, P.4    Fiorentino, M.5    Draetta, G.F.6    Jessup, J.M.7    Pagano, M.8
  • 62
    • 0035476237 scopus 로고    scopus 로고
    • High expression of S-phase kinase-interacting protein 2, human F-box protein, correlates with poor prognosis in oral squamous cell carcinomas
    • Kudo Y, Kitajima S, Sato S, Miyauchi M, Ogawa I, Takata T: High expression of S-phase kinase-interacting protein 2, human F-box protein, correlates with poor prognosis in oral squamous cell carcinomas. Cancer Res 2001, 61:7044-7047.
    • (2001) Cancer Res. , vol.61 , pp. 7044-7047
    • Kudo, Y.1    Kitajima, S.2    Sato, S.3    Miyauchi, M.4    Ogawa, I.5    Takata, T.6
  • 65
    • 0036645405 scopus 로고    scopus 로고
    • Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: Modulation of malignant phenotype by SkP2 overexpression, possibly via p27 proteolysis
    • Masuda TA, Inoue H, Sonoda H, Mine S, Yoshikawa Y, Nakayama K, Nakayama K, Mori M: Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by SkP2 overexpression, possibly via p27 proteolysis. Cancer Res 2002, 62:3819-3825.
    • (2002) Cancer Res. , vol.62 , pp. 3819-3825
    • Masuda, T.A.1    Inoue, H.2    Sonoda, H.3    Mine, S.4    Yoshikawa, Y.5    Nakayama, K.6    Nakayama, K.7    Mori, M.8
  • 67
    • 0344731443 scopus 로고    scopus 로고
    • Anomalous high p27/KIP1 expression in a subset of aggressive B-cell lymphomas is associated with cyclin D3 overexpression. p27/KIP1-cyclin D3 colocalization in tumor cells
    • Sanchez-Beato M, Camacho FI, Martinez-Montero JC, Saez AI, Villuendas R, Sanchez-Verde L, Garcia JF, Piris MA: Anomalous high p27/KIP1 expression in a subset of aggressive B-cell lymphomas is associated with cyclin D3 overexpression. p27/KIP1-cyclin D3 colocalization in tumor cells. Blood 1999, 94:765-772.
    • (1999) Blood , vol.94 , pp. 765-772
    • Sanchez-Beato, M.1    Camacho, F.I.2    Martinez-Montero, J.C.3    Saez, A.I.4    Villuendas, R.5    Sanchez-Verde, L.6    Garcia, J.F.7    Piris, M.A.8
  • 71
    • 0037330625 scopus 로고    scopus 로고
    • Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes
    • Gartel AL, Shchors K: Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes. Exp Cell Res 2003, 283:17-21.
    • (2003) Exp. Cell Res. , vol.283 , pp. 17-21
    • Gartel, A.L.1    Shchors, K.2
  • 72
    • 0031453368 scopus 로고    scopus 로고
    • Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27
    • Weber JD, Hu W, Jefcoat SC Jr, Raben DM, Baldassare JJ: Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27. J Biol Chem 1997, 272:32966-32971.
    • (1997) J. Biol. Chem. , vol.272 , pp. 32966-32971
    • Weber, J.D.1    Hu, W.2    Jefcoat Jr., S.C.3    Raben, D.M.4    Baldassare, J.J.5
  • 73
    • 0033587009 scopus 로고    scopus 로고
    • Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells
    • Balmanno K, Cook SJ: Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells. Oncogene 1999, 18: 3085-3097.
    • (1999) Oncogene , vol.18 , pp. 3085-3097
    • Balmanno, K.1    Cook, S.J.2
  • 74
    • 0037023755 scopus 로고    scopus 로고
    • Signaling networks that link cell proliferation and cell fate
    • Sears RC, Nevins JR: Signaling networks that link cell proliferation and cell fate. J Biol Chem 2002, 277:11617-11620.
    • (2002) J. Biol. Chem. , vol.277 , pp. 11617-11620
    • Sears, R.C.1    Nevins, J.R.2
  • 75
    • 0034671768 scopus 로고    scopus 로고
    • Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation
    • Alt JR, Cleveland JL, Hannink M, Diehl JA: Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Genes Dev 2001, 14: 3102-3114.
    • (2001) Genes Dev. , vol.14 , pp. 3102-3114
    • Alt, J.R.1    Cleveland, J.L.2    Hannink, M.3    Diehl, J.A.4
  • 76
    • 0032533225 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization
    • Diehl JA, Cheng M, Roussel MF, Sherr CJ: Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 1998, 12:3499-3511.
    • (1998) Genes Dev. , vol.12 , pp. 3499-3511
    • Diehl, J.A.1    Cheng, M.2    Roussel, M.F.3    Sherr, C.J.4
  • 78
    • 0036796085 scopus 로고    scopus 로고
    • Breast cancer banishes p27 from nucleus
    • Blain SW, Massagué J: Breast cancer banishes p27 from nucleus. Nat Med 2002, 8:1076-1078.
    • (2002) Nat. Med. , vol.8 , pp. 1076-1078
    • Blain, S.W.1    Massagué, J.2
  • 85
    • 0037570624 scopus 로고    scopus 로고
    • p27Kip1 inhibition of GRB2-SOS formation can regulate Ras activation
    • Moeller J, Head D, Sheaff RJ: p27Kip1 inhibition of GRB2-SOS formation can regulate Ras activation. Mol Cell Biol 2003, 23:3735-3752.
    • (2003) Mol. Cell Biol. , vol.23 , pp. 3735-3752
    • Moeller, J.1    Head, D.2    Sheaff, R.J.3
  • 87
    • 0030989155 scopus 로고    scopus 로고
    • Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1
    • Aktas H, Cai H, Cooper GM: Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1. Mol Cell Biol 1997, 17:3850-3857.
    • (1997) Mol. Cell Biol. , vol.17 , pp. 3850-3857
    • Aktas, H.1    Cai, H.2    Cooper, G.M.3
  • 88
    • 0030863161 scopus 로고    scopus 로고
    • Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway
    • Kawada M, Yamagoe S, Murakami Y, Suzuki K, Mizuno S, Uehara Y: Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway. Oncogene 1997, 15:629-637.
    • (1997) Oncogene , vol.15 , pp. 629-637
    • Kawada, M.1    Yamagoe, S.2    Murakami, Y.3    Suzuki, K.4    Mizuno, S.5    Uehara, Y.6
  • 89
    • 0030740210 scopus 로고    scopus 로고
    • Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts
    • Takuwa N, Takuwa Y: Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts. Mol Cell Biol 1997, 17:5348-5358.
    • (1997) Mol. Cell Biol. , vol.17 , pp. 5348-5358
    • Takuwa, N.1    Takuwa, Y.2
  • 91
    • 0030997297 scopus 로고    scopus 로고
    • Regulation of the cyclin-depedent kinase inhibitor p27 by degradation and phosphorylation
    • Alessandrini A, Chiaur DS, Erikson R, Pagano M: Regulation of the cyclin-depedent kinase inhibitor p27 by degradation and phosphorylation. Leukemia 1997, 11:342-345.
    • (1997) Leukemia , vol.11 , pp. 342-345
    • Alessandrini, A.1    Chiaur, D.S.2    Erikson, R.3    Pagano, M.4
  • 92
    • 0034735895 scopus 로고    scopus 로고
    • Disruption of TGF-β growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization
    • Liu X, Sun Y, Ehrlich M, Lu T, Kloog Y, Weinberg RA, Ladish HF, Henis YI: Disruption of TGF-β growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization. Oncogene 2000, 19: 5926-5935.
    • (2000) Oncogene , vol.19 , pp. 5926-5935
    • Liu, X.1    Sun, Y.2    Ehrlich, M.3    Lu, T.4    Kloog, Y.5    Weinberg, R.A.6    Ladish, H.F.7    Henis, Y.I.8
  • 94
    • 0033525188 scopus 로고    scopus 로고
    • Kip degradation through its regulation of cyclin E/CDK2 activity
    • Kip degradation through its regulation of cyclin E/CDK2 activity. J Biol Chem 1999, 274:3396-3401.
    • (1999) J. Biol. Chem. , vol.274 , pp. 3396-3401
    • Hu, W.1    Bellone, C.J.2    Baldassare, J.J.3
  • 96
    • 0034637527 scopus 로고    scopus 로고
    • Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27
    • Yang HY, Zhou BP, Hung MC, Lee MH: Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27. J Biol Chem 2000, 275:24735-24739.
    • (2000) J. Biol. Chem. , vol.275 , pp. 24735-24739
    • Yang, H.Y.1    Zhou, B.P.2    Hung, M.C.3    Lee, M.H.4
  • 97
    • 0035798683 scopus 로고    scopus 로고
    • Kip1 deregulation and antiestrogen resistance in human breast cancer cells
    • Kip1 deregulation and antiestrogen resistance in human breast cancer cells. J Biol Chem 2001, 276:40888-40895.
    • (2001) J. Biol. Chem. , vol.276 , pp. 40888-40895
    • Donovan, J.C.1    Milic, A.2    Slingerland, J.M.3
  • 98
    • 0032445260 scopus 로고    scopus 로고
    • HER-2/neu as a predictive marker of response to breast cancer therapy
    • Pegram MD, Pauletti G, Slamon DJ: HER-2/neu as a predictive marker of response to breast cancer therapy. Breast Cancer Res Treat 1998, 52:65-77.
    • (1998) Breast Cancer Res. Treat. , vol.52 , pp. 65-77
    • Pegram, M.D.1    Pauletti, G.2    Slamon, D.J.3
  • 99
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the Her-2/Neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL: Human breast cancer: correlation of relapse and survival with amplification of the Her-2/Neu oncogene. Science 1987, 235:177-182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 104
  • 106
    • 0028263606 scopus 로고
    • Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: Implication for RAS-dependent Philadelphia chromosome positive cell growth
    • Skorski T, Kanakaraj P, Ku DH, Nieborowska-Skorska M, Canaani E, Zon G, Perussia B, Calabretta B: Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth. J Exp Med 1994, 179:1855-1865.
    • (1994) J. Exp. Med. , vol.179 , pp. 1855-1865
    • Skorski, T.1    Kanakaraj, P.2    Ku, D.H.3    Nieborowska-Skorska, M.4    Canaani, E.5    Zon, G.6    Perussia, B.7    Calabretta, B.8
  • 107
  • 108
    • 0030725775 scopus 로고    scopus 로고
    • The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells
    • Cortez D, Reuther G, Pendergast AM: The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells. Oncogene 1997, 15:2333-2342.
    • (1997) Oncogene , vol.15 , pp. 2333-2342
    • Cortez, D.1    Reuther, G.2    Pendergast, A.M.3
  • 109
    • 0035869212 scopus 로고    scopus 로고
    • 1 arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model
    • 1 arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model. Hum Mol Genet 2001, 10:599-604.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 599-604
    • Weng, L.P.1    Brown, J.L.2    Eng, C.3
  • 110
    • 0037112423 scopus 로고    scopus 로고
    • Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the phosphatidylinositol 3-kinase/Akt pathway in glioblastomas
    • Narita Y, Nagane M, Mishima K, Huang HJ, Furnari FB, Cavenee WK: Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the phosphatidylinositol 3-kinase/Akt pathway in glioblastomas. Cancer Res 2002, 62: 6764-6769.
    • (2002) Cancer Res. , vol.62 , pp. 6764-6769
    • Narita, Y.1    Nagane, M.2    Mishima, K.3    Huang, H.J.4    Furnari, F.B.5    Cavenee, W.K.6
  • 111
    • 0037099532 scopus 로고    scopus 로고
    • Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
    • Yakes FM, Chinratanalab W, Ritter CA, King W, Seelig S, Arteaga CL: Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Res 2002, 62: 4132-4141.
    • (2002) Cancer Res. , vol.62 , pp. 4132-4141
    • Yakes, F.M.1    Chinratanalab, W.2    Ritter, C.A.3    King, W.4    Seelig, S.5    Arteaga, C.L.6
  • 113
    • 0034749615 scopus 로고    scopus 로고
    • Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state
    • Murillo H, Huang H, Schmidt LJ, Smith DI, Tindall DJ: Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state. Endocrinology 2001, 142:4795-4805.
    • (2001) Endocrinology , vol.142 , pp. 4795-4805
    • Murillo, H.1    Huang, H.2    Schmidt, L.J.3    Smith, D.I.4    Tindall, D.J.5
  • 114
    • 0037031262 scopus 로고    scopus 로고
    • Kip1 induction in mouse Y1 adrenocortical tumor cells is dependent on both PKA activation and Akt/PKB inactivation
    • Kip1 induction in mouse Y1 adrenocortical tumor cells is dependent on both PKA activation and Akt/PKB inactivation. Biochemistry 2002, 41:10133-10140.
    • (2002) Biochemistry , vol.41 , pp. 10133-10140
    • Forti, F.L.1    Schwindt, T.T.2    Moraes, M.S.3    Eichler, C.B.4    Armelin, H.A.5
  • 116
    • 0034675922 scopus 로고    scopus 로고
    • The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: Evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts
    • Wirbelauer C, Sutterluty H, Blondel M, Gstaiger M, Peter M, Reymond F, Krek W: The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts. EMBO J 2000, 19:5362-5375.
    • (2000) EMBO J. , vol.19 , pp. 5362-5375
    • Wirbelauer, C.1    Sutterluty, H.2    Blondel, M.3    Gstaiger, M.4    Peter, M.5    Reymond, F.6    Krek, W.7
  • 117
    • 0036847690 scopus 로고    scopus 로고
    • Elevated Skp2 protein expression in human prostate cancer: Association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival
    • Yang G, Ayala G, Marzo AD, Tian W, Frolov A, Wheeler TM, Thompson TC, Harper JW: Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival. Clin Cancer Res 2002, 8: 3419-3426.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 3419-3426
    • Yang, G.1    Ayala, G.2    Marzo, A.D.3    Tian, W.4    Frolov, A.5    Wheeler, T.M.6    Thompson, T.C.7    Harper, J.W.8
  • 118
    • 0036712741 scopus 로고    scopus 로고
    • TSC1-TSC2: A complex tale of PKB-mediated S6K regulation
    • McManus EJ, Alessi DR: TSC1-TSC2: a complex tale of PKB-mediated S6K regulation. Nat Cell Biol 2002, 4:E214-E216.
    • (2002) Nat. Cell Biol. , vol.4
    • McManus, E.J.1    Alessi, D.R.2
  • 119
    • 0037137380 scopus 로고    scopus 로고
    • Growth signaling: TSC takes its place
    • Marygold SJ, Leevers SJ: Growth signaling: TSC takes its place. Curr Biol 2002, 12:R785-R787.
    • (2002) Curr. Biol. , vol.12
    • Marygold, S.J.1    Leevers, S.J.2
  • 120
    • 0032430241 scopus 로고    scopus 로고
    • Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2
    • Soucek T, Yeung RS, Hengstschlager M: Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2. Proc Natl Acad Sci USA 1998, 95:15653-15658.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15653-15658
    • Soucek, T.1    Yeung, R.S.2    Hengstschlager, M.3
  • 122
    • 0028229732 scopus 로고
    • Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes
    • Firpo EJ, Koff A, Solomon MJ, Roberts JM: Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes. Mol Cell Biol 1994, 14:4889-4901.
    • (1994) Mol. Cell Biol. , vol.14 , pp. 4889-4901
    • Firpo, E.J.1    Koff, A.2    Solomon, M.J.3    Roberts, J.M.4
  • 125
    • 0033594395 scopus 로고    scopus 로고
    • Cyclin E dependent kinase activity in human breast cancer in relation to cyclin E, p27 and p21 expression and retinoblastoma protein phosphorylation
    • Loden M, Nielsen NH, Roos G, Emdin SO, Landberg G: Cyclin E dependent kinase activity in human breast cancer in relation to cyclin E, p27 and p21 expression and retinoblastoma protein phosphorylation. Oncogene 1999, 18:2557-2566.
    • (1999) Oncogene , vol.18 , pp. 2557-2566
    • Loden, M.1    Nielsen, N.H.2    Roos, G.3    Emdin, S.O.4    Landberg, G.5
  • 127
    • 0033980241 scopus 로고    scopus 로고
    • Immunohistochemical analysis of Ki-67, p53, p21, and p27 in benign and malignant apocrine lesions of the breast: Its correlation to histologic findings in 43 cases
    • Moriya T, Sakamoto K, Sasano H, Kawanaka M, Sonoo H, Manabe T, Ito J: Immunohistochemical analysis of Ki-67, p53, p21, and p27 in benign and malignant apocrine lesions of the breast: its correlation to histologic findings in 43 cases. Mod Pathol 2000, 13:13-18.
    • (2000) Mod. Pathol. , vol.13 , pp. 13-18
    • Moriya, T.1    Sakamoto, K.2    Sasano, H.3    Kawanaka, M.4    Sonoo, H.5    Manabe, T.6    Ito, J.7
  • 128
    • 0032780931 scopus 로고    scopus 로고
    • Elevated levels of p27, p21 and cyclin D1 correlate with positive oestrogen and progesterone receptor status in node-negative breast carcinoma patients
    • Reed W, Florems VA, Holm R, Hannisdal E, Nesland JM: Elevated levels of p27, p21 and cyclin D1 correlate with positive oestrogen and progesterone receptor status in node-negative breast carcinoma patients. Virchows Arch 1999, 435:116-124.
    • (1999) Virchows Arch. , vol.435 , pp. 116-124
    • Reed, W.1    Florems, V.A.2    Holm, R.3    Hannisdal, E.4    Nesland, J.M.5
  • 130
    • 0032902972 scopus 로고    scopus 로고
    • Kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinoma
    • Kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinoma. J Pathol 1999, 187:200-206.
    • (1999) J. Pathol. , vol.187 , pp. 200-206
    • Gillett, C.E.1    Smith, P.2    Peters, G.3    Lu, X.4    Barnes, D.M.5


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