Blockade of the extracellular signal-regulated kinase pathway induces marked G1 cell cycle arrest and apoptosis in tumor cells in which the pathway is constitutively activated. Up-regulation of p27Kip1

Journal of Biological Chemistry

Volumn 276, Issue 4, 2001, Pages 2686-2692

  Hoshino, Rika ^c   Tanimura, Susumu ^c   Watanabe, Kazushi ^c   Kataoka, Tadashi ^a   Kohno, Michiaki ^b  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; COMPLEXATION; ENZYME INHIBITION; TUMORS;

PHOSPHORYLATION;

ENZYMES;

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYCLIN DEPENDENT KINASE 2; CYCLIN E; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P27; RETINOBLASTOMA PROTEIN; 1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; FLAVONOID; NITRILE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE G1 PHASE; CELL LINE; COMPLEX FORMATION; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUMOR CELL DESTRUCTION; UPREGULATION; CELL CULTURE; DRUG ANTAGONISM; METABOLISM; NEOPLASM; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BUTADIENES; ENZYME INHIBITORS; FLAVONOIDS; G1 PHASE; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASMS; NITRILES; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0035951784     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M006132200     Document Type: Article

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