p27(Kip1) expression in breast carcinomas: An immunohistochemical study on 512 patients with long-term follow-up

International Journal of Cancer

Volumn 89, Issue 3, 2000, Pages 236-241

  Barbareschi, Mattia ^a   Van Tinteren, Harm ^b   Mauri, Francesco A ^c   Veronese, Silvio ^d   Peterse, Hans ^b   Maisonneuve, Patrik ^e   Caffo, Orazio ^a   Scaioli, Monica ^b   Doglioni, Claudio ^f   Galligioni, Enzo ^b   Dalla Palma, Paolo ^a   Michalides, Rob ^b  

^a SANTA CHIARA HOSPITAL   (Italy)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c Ospedale SS Trinita   (Italy)

^d OSPEDALE NIGUARDA CA GRANDA   (Italy)

^e EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^f Hospital of Belluno   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN P27;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER SURVIVAL; CELL CYCLE; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION;

ADULT; AGED; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MENOPAUSE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; RECURRENCE; TIME FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 0033917031     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20000520)89:3<236::AID-IJC5>3.0.CO;2-Z     Document Type: Article

References (21)

1. BARBARESCHI, M., PELOSIO, P., CAFFO, O., BUTTITTA, F., PELLEGRINI, S., BARBAZZA, R., DALLA PALMA, P., BEVILACQUA, G., and MARCHETTI, A., Cyclin-Dl-gene amplification and expression in breast carcinoma: relation with clinicopathologic characteristics and with retinoblastoma gene product, p53 and p21(WAF1) immunohistochemical expression Int. J. Cancer, 74, 171-174 (1997).
2. CARIOU, S., and 12 OTHERS, Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer [see comments]. Nature (Med.), 3, 227-230 (1997).
3. CATZAVELOS C., BHATTACHARYA N., UNG Y. C., WILSON J. A., RONCARI L., SANDHU C., SHAW P., YEGER H., MORAVA-PROTZNER I., KAPUSTA L., FRANSSEN E., PRITCHARD K.I. and SLINGERLAND J. M. Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer Nat. Med. 3, 227-230 (1997)
4. CHU, J.S., HUANG, C.S., and CHANG, K.J., p27 expression as a prognostic factor of breast cancer in Taiwan. Cancer Lett., 141, 123-130 (1999).
5. ELLEDGE, S.J., and HARPER, J.W., The role of protein stability in the cell cycle and cancer. Biochim. biophys. Acta, 1377, m61-m70 (1998).
6. FREDERSDORF, S., and 13 OTHERS, High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers. Proc. nat. Acad. Sci. (Wash.), 94, 6380-6385 (1997).
7. GILLETT, C.E., SMITH, P., PETERS, G., LU, X., and BARNES, D.M., Cyclin-dependent kinase inhibitor p27/Kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinoma. J. Pathol., 187, 200-206 (1999).
8. HAN, E.K., BEGEMANN, M., SGAMBATO, A., SOH, J.W., DOKI, Y., XING, W.Q., LIU, W., and WEINSTEIN, I.B., Increased expression of cyclin D1 in a marine mammary epithelial cell line induces p27kip1, inhibits growth, and enhances apoptosis. Cell Growth Differentiation, 1, 699-710 (1996).
9. HAN, S., PARK, K., KIM, H.Y., LEE, M.S., KIM, H.J., and KIM, Y.D., Reduced expression of p27Kip1 protein is associated with poor clinical outcome of breast cancer patients treated with systemic chemotherapy and is linked to cell proliferation and differentiation. Breast Cancer Res. Treat., 55, 161-167 (1999).
10. LLOYD, R.V., ERICKSON, L.A., JIN, L., KULIG, E., QIAN, X., CHEVILLE, J.C., and SCHEITHAUER, B.W., p27(Kip1): a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers Amer. J. Pathol., 154, 313-323 (1999).
11. MICHALIDES, R., HAGEMAN, P., VAN TINTEREN, H., HOUBEN, L., WIENTJENS, E., KLOMPMAKER, R., and PETERSE, J., A clinicopathological study on overexpression of cyclin D1 and of p53 in a series of 248 patients with operable breast cancer Brit. J. Cancer 73, 728-734 (1996).
12. OTIS, C.N., ALBUQUERQUE, A., SANJUAN, X., and MERINO, M.J., Expression od p53 protein and cyclin dependent kinase inhibitors p21 and p27 in breast carcinoma. Arch. Anat. Cytol. pathol., 46, 311 (1998).
13. PAGANO, M., TAM, S.W., THEODORAS, A.M., BEER-ROMERO, P., DEL SAL, G., CHAU, V., YEW, P.R., DRAETTA, G.F., and ROLFE, M., Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science, 269, 682-685 (1995).
14. PORTER, P.L., MALONE, K.E., HEAGERTY, P.J., ALEXANDER, G.M., GATTI, L.A., FIRPO, E.J., DALING, J.R., and ROBERTS, J.M., Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nature (Med.), 3, 222-225 (1997).
15. REED, W., FLOERENES, V.A., HOLM, R., HANNISDAL, E., and NESLAND, J.M., Elevated levels of p27, p21 and cyclin D1 correlate with positive oestrogen and progesterone receptor status in node-negative breast carcinom apatients. Virchows Arch., 435, 116-124 (1999).
16. RUSSELL, A., THOMPSON, A.M., HENDLEY, J., TRUTE, L., ARMES, J., and GERMAIN, D., Cyclin D1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer. Oncogene, 18, 1893-1991 (1999).
17. Kip1 in breast cancers. Clin. Cancer Res., 3, 1879-1887 (1997).
18. SPIRIN, K.S., SIMPSON, J.F., TAKEUCHI, S., KAWAMATA, N., MILLER, C.W., and KOEFFLER, H.P., p27/Kip1 mutation found in breast cancer. Cancer Res., 56, 2400-2404 (1996).
19. TAN, P., CADY, B., WANNER, M., WORLAND, P., CUKOR, B., MAGIGALLUZZI, C. LAVIN, P., DRAETTA, G., PAGANO, M., and LODA, M., The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas. Cancer Res., 57, 1259-1263 (1997).
20. TSUCHIYA, A., ZHANG, G., and KANNO, M., Prognostic impact of cyclin-dependent kinase inhibitor p27kip1 in node-positive breast cancer. J. surg. Oncol., 70, 230-234 (1999).
21. WU, J., SHEN, Z.Z., LU, L.S., JIANG, M., HAN, Q.X., FONTANA, J.A., BARSKY, S.H., and SHAO, Z.M., Prognostic role of p27(Kip1) and apoptosis in human breast cancer. Brit. J. Cancer, 79, 1572-1578 (1999).