메뉴 건너뛰기




Volumn 4, Issue 1, 2003, Pages 37-44

Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway

Author keywords

[No Author keywords available]

Indexed keywords

6 O 4 BROMOTHEYLGUANINE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE INHIBITOR; 6 O BENZYLGUANINE; ALKYLATING AGENT; ALTRETAMINE; ANTINEOPLASTIC AGENT; AZIRIDINE DERIVATIVE; BISCHLOROETHYLAMINE DERIVATIVE; BUSULFAN; CARBOPLATIN; CARMUSTINE; CHLORAMBUCIL; CISPLATIN; CYCLOPHOSPHAMIDE; DACARBAZINE; FOTEMUSTINE; GUANINE DERIVATIVE; LOMUSTINE; MELPHALAN; METHYLNITROSOUREA; MITOZOLOMIDE; NITROSOUREA; PLATINUM DERIVATIVE; PROCARBAZINE; STREPTOZOCIN; SULFONIC ACID DERIVATIVE; TEMOZOLOMIDE; TETRAZINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 0037243405     PISSN: 14702045     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1470-2045(03)00959-8     Document Type: Review
Times cited : (101)

References (58)
  • 2
    • 0000017747 scopus 로고
    • Biological consequences of reactions with DNA: Role of specific lesions
    • Cooper CS, Grover PL, (Eds). Berlin: Springer
    • Margison GP, O'Connor PJ. Biological consequences of reactions with DNA: role of specific lesions. In: Cooper CS, Grover PL, (Eds). Handbook of Experimental Pharmacology. Berlin: Springer, 1990: 547-71.
    • (1990) Handbook of Experimental Pharmacology , pp. 547-571
    • Margison, G.P.1    O'Connor, P.J.2
  • 3
    • 85031267723 scopus 로고    scopus 로고
    • Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage
    • (in press)
    • Trewick SC, Henshaw TF, Hausinger RP, et al. Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature (in press).
    • Nature
    • Trewick, S.C.1    Henshaw, T.F.2    Hausinger, R.P.3
  • 4
    • 73649185176 scopus 로고
    • Experimental evaluation of potential anticancer agents: VIII, effects of certain nitrosoureas on intracerebral L1210
    • Schabel FM Jr. Experimental evaluation of potential anticancer agents: VIII, effects of certain nitrosoureas on intracerebral L1210. Cancer Res 1963; 23: 725-31.
    • (1963) Cancer Res. , vol.23 , pp. 725-731
    • Schabel F.M., Jr.1
  • 5
    • 0019957212 scopus 로고
    • Formation of the cross-link 1-[N3-Deoxycytidyl],2-N1-deoxyguanosinyl]-ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea
    • Tong WP, Kirk MC, Ludlum DB. Formation of the cross-link 1-[N3-Deoxycytidyl],2-N1-deoxyguanosinyl]-ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea. Cancer Res 1982; 42: 3102-05.
    • (1982) Cancer Res. , vol.42 , pp. 3102-3105
    • Tong, W.P.1    Kirk, M.C.2    Ludlum, D.B.3
  • 6
    • 0032931714 scopus 로고    scopus 로고
    • Mismatch repair and differential sensitivity of mouse and human cells to methylating agents
    • Humbert O, Fiumicino S, Aquilina G, et al. Mismatch repair and differential sensitivity of mouse and human cells to methylating agents. Carcinogenesis 1999; 20: 205-14.
    • (1999) Carcinogenesis , vol.20 , pp. 205-214
    • Humbert, O.1    Fiumicino, S.2    Aquilina, G.3
  • 7
    • 0026472177 scopus 로고
    • Intracellular localisation of human DNA repair enzyme O6-methylguanine-DNA methyltransferase by antibodies and its importance
    • Ayi TC, Loh KC, Ali RB, Li BFL. Intracellular localisation of human DNA repair enzyme O6-methylguanine-DNA methyltransferase by antibodies and its importance. Cancer Res 1992; 52: 6423-30.
    • (1992) Cancer Res. , vol.52 , pp. 6423-6430
    • Ayi, T.C.1    Loh, K.C.2    Ali, R.B.3    Li, B.F.L.4
  • 8
    • 0022706698 scopus 로고
    • Inactivation of O6-methylguanine-DNA methyltransferase and sensitization of human tumour cells to killing by chloroethylnitrosourea by O6-methylguanine as a free base
    • Yarosh DB, Hurst-Calderone S, Babich MA, Day RS III. Inactivation of O6-methylguanine-DNA methyltransferase and sensitization of human tumour cells to killing by chloroethylnitrosourea by O6-methylguanine as a free base. Cancer Res 1986; 46: 1663-68.
    • (1986) Cancer Res. , vol.46 , pp. 1663-1668
    • Yarosh, D.B.1    Hurst-Calderone, S.2    Babich, M.A.3    Day R.S. III4
  • 9
    • 0025195404 scopus 로고
    • Mammalian O6-alkylguanine-DNA alkyltransferase: Regulation and importance in response to alkylating carcinogenic and therapeutic agents
    • Pegg AE. Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res 1990; 50: 6119-29.
    • (1990) Cancer Res. , vol.50 , pp. 6119-6129
    • Pegg, A.E.1
  • 10
    • 0021264521 scopus 로고
    • Sensitivity of human cell strains having different abilities to repair O6-methylguanine in DNA to inactivation by alkylating agents including chlorethyinitrosoureas
    • Scudiero DA, Meyer SA, Clatterbuck BE, et al. Sensitivity of human cell strains having different abilities to repair O6-methylguanine in DNA to inactivation by alkylating agents including chlorethyinitrosoureas. Cancer Res 1984; 44: 2467-74.
    • (1984) Cancer Res. , vol.44 , pp. 2467-2474
    • Scudiero, D.A.1    Meyer, S.A.2    Clatterbuck, B.E.3
  • 11
    • 0028986307 scopus 로고
    • Chemosensitivity to triazine compounds and O6-alkylguanine-DNA alkyltransferase levels: Studies with blasts of leukaemia patients
    • D'Atri S, Piccioni D, Castellano A, et al. Chemosensitivity to triazine compounds and O6-alkylguanine-DNA alkyltransferase levels: studies with blasts of leukaemia patients. Ann Oncol 1995; 6: 389-93.
    • (1995) Ann. Oncol. , vol.6 , pp. 389-393
    • D'Atri, S.1    Piccioni, D.2    Castellano, A.3
  • 12
    • 0024532767 scopus 로고
    • Hypersensitivity of human tumour xenografts lacking O6-alkylguanine-DNA alkyltransferase to the anti-tumour agent 1-(4-amino-2-methyl-5-pyridinyl)methyl-3-(2-chloroethyl)-3-nitrosourea
    • Fujio C, Chang HR, Tsujimura T, et al. Hypersensitivity of human tumour xenografts lacking O6-alkylguanine-DNA alkyltransferase to the anti-tumour agent 1-(4-amino-2-methyl-5-pyridinyl)methyl-3-(2-chloroethyl)-3-nitrosourea. Carcinogenesis 1989; 10: 351-56.
    • (1989) Carcinogenesis , vol.10 , pp. 351-356
    • Fujio, C.1    Chang, H.R.2    Tsujimura, T.3
  • 13
    • 0027339636 scopus 로고
    • Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chlorethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone
    • Gerson SL, Zborowska E, Norton K, et al. Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chlorethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone. Biochem Pharm 1993; 45: 483-91.
    • (1993) Biochem. Pharm. , vol.45 , pp. 483-491
    • Gerson, S.L.1    Zborowska, E.2    Norton, K.3
  • 14
    • 0022631066 scopus 로고
    • Expression of the E. coli O6-methylguanine-DNA methylphosphotriester methyltransferase gene in mammalian cells
    • Brennand J, Margison GP. Expression of the E. coli O6-methylguanine-DNA methylphosphotriester methyltransferase gene in mammalian cells. Carcinogenesis 1986; 7: 185-88.
    • (1986) Carcinogenesis , vol.7 , pp. 185-188
    • Brennand, J.1    Margison, G.P.2
  • 15
    • 0022994130 scopus 로고
    • Transfer of the E. coli O6-methylguanine methyltransferase gene into repair-deficient human cells and restoration of cellular resistance to N-methyl-N-nitro-N-nitrosoguanidine
    • Ishizaki K, Tsujimura T, Yawata H, et al. Transfer of the E. coli O6-methylguanine methyltransferase gene into repair-deficient human cells and restoration of cellular resistance to N-methyl-N-nitro-N-nitrosoguanidine. Mutat Res 1986; 166: 135-41.
    • (1986) Mutat. Res. , vol.166 , pp. 135-141
    • Ishizaki, K.1    Tsujimura, T.2    Yawata, H.3
  • 16
    • 0032587774 scopus 로고    scopus 로고
    • Relationship between O6-methylguanine-DNA methyltransferase levels and clinical response induced by chloroethylnitrosourea therapy in glioma patients
    • Chen ZP, Yarosh D, Garcia Y, et al. Relationship between O6-methylguanine-DNA methyltransferase levels and clinical response induced by chloroethylnitrosourea therapy in glioma patients. Can J Neurol Sci 1999; 26: 104-09.
    • (1999) Can. J. Neurol. Sci. , vol.26 , pp. 104-109
    • Chen, Z.P.1    Yarosh, D.2    Garcia, Y.3
  • 17
    • 0031595389 scopus 로고    scopus 로고
    • Correlation of tumor O6-methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: A Southwest Oncology Group Study
    • Jaeckle KA, Harmon JE, Townsend JJ, et al. Correlation of tumor O6-methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group Study. J Clin Oncol 1998; 16: 3310-15.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 3310-3315
    • Jaeckle, K.A.1    Harmon, J.E.2    Townsend, J.J.3
  • 18
    • 0032435612 scopus 로고    scopus 로고
    • DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to temodal in newly diagnosed malignant glioma
    • Friedman HS, McLendon RE, Kerby T, et al. DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to temodal in newly diagnosed malignant glioma. J Clin Oncol 1998; 16: 3851-57.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 3851-3857
    • Friedman, H.S.1    McLendon, R.E.2    Kerby, T.3
  • 19
    • 13344282752 scopus 로고    scopus 로고
    • Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumour patients treated with carmustine
    • Belanich M, Pastor M, Randall T, et al. Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumour patients treated with carmustine. Cancer Res 1996; 56: 783-88.
    • (1996) Cancer Res. , vol.56 , pp. 783-788
    • Belanich, M.1    Pastor, M.2    Randall, T.3
  • 20
    • 0034626988 scopus 로고    scopus 로고
    • Inactivation of the DNA repair gene MGMT and the clinical response of gliomas to alkylating agents
    • Esteller M, Garcia-Foncillas J, Andion E, et al. Inactivation of the DNA repair gene MGMT and the clinical response of gliomas to alkylating agents. N Eng J Med 2000; 343: 1350-54.
    • (2000) N. Eng. J. Med. , vol.343 , pp. 1350-1354
    • Esteller, M.1    Garcia-Foncillas, J.2    Andion, E.3
  • 21
    • 85031258996 scopus 로고    scopus 로고
    • Immunohistochemical detection of DNA mismatch repair and O6-methylguanine-DNA methyltransferase expression in melanoma metastases in relation to clinical response to DTIC-based chemotherapy
    • Abstr 3484
    • Ma S, Egyhazi S, Ringborg U, Hanson J. Immunohistochemical detection of DNA mismatch repair and O6-methylguanine-DNA methyltransferase expression in melanoma metastases in relation to clinical response to DTIC-based chemotherapy. Proc Amer Assoc Cancer Res 2001; 42: Abstr 3484
    • (2001) Proc. Amer. Assoc. Cancer Res. , vol.42
    • Ma, S.1    Egyhazi, S.2    Ringborg, U.3    Hanson, J.4
  • 22
    • 0031597371 scopus 로고    scopus 로고
    • O6-Methylguanine-DNA methyltransferase in pretreatment tumor biopsies as a predictor of response to temozolomide in melanoma
    • Middleton MR, Lunn JM, Morris C, et al. O6-Methylguanine-DNA methyltransferase in pretreatment tumor biopsies as a predictor of response to temozolomide in melanoma. Br J Cancer 1998; 78: 1199-202.
    • (1998) Br. J. Cancer , vol.78 , pp. 1199-1202
    • Middleton, M.R.1    Lunn, J.M.2    Morris, C.3
  • 23
    • 0028177572 scopus 로고
    • O6-methylguannine-DNA methyltransferase in ovarian malignancy and its correlation with postoperative response to chemotherapy
    • Chen S, Citron M, Spiegel G, Yarosh D. O6-methylguannine-DNA methyltransferase in ovarian malignancy and its correlation with postoperative response to chemotherapy. Gynaecol Oncol 1994; 52: 172-74.
    • (1994) Gynaecol. Oncol. , vol.52 , pp. 172-174
    • Chen, S.1    Citron, M.2    Spiegel, G.3    Yarosh, D.4
  • 24
    • 0032766511 scopus 로고    scopus 로고
    • Activity of O6-methylguanine-DNA methyltransferase in relation to p53 status and therapeutic response in ovarian cancer
    • Hengstler JG, Tanner B, Moller L, et al. Activity of O6-methylguanine-DNA methyltransferase in relation to p53 status and therapeutic response in ovarian cancer. Int J Cancer 1999; 84: 388-95.
    • (1999) Int. J. Cancer , vol.84 , pp. 388-395
    • Hengstler, J.G.1    Tanner, B.2    Moller, L.3
  • 25
    • 0031594831 scopus 로고    scopus 로고
    • O6-methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tmour xenografts
    • Mattern J, Eichhorn U, Kaina B, Volm M. O6-methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tmour xenografts. Int J Cancer 1998; 77: 919-22.
    • (1998) Int. J. Cancer , vol.77 , pp. 919-922
    • Mattern, J.1    Eichhorn, U.2    Kaina, B.3    Volm, M.4
  • 26
    • 0026612039 scopus 로고
    • O6-methylguanine-DNA methyltransferase activity in human tumors
    • Chen JM, Zhang YP, Want C, et al. O6-methylguanine-DNA methyltransferase activity in human tumors. Carcinogenesis 1992; 13: 1503-07.
    • (1992) Carcinogenesis , vol.13 , pp. 1503-1507
    • Chen, J.M.1    Zhang, Y.P.2    Want, C.3
  • 27
    • 0031283135 scopus 로고    scopus 로고
    • Expression of the O6-alkylguanine-DNA alkyltransferase gene is elevated in human breast tumor cells
    • Wani G, D'Ambrosio SM. Expression of the O6-alkylguanine-DNA alkyltransferase gene is elevated in human breast tumor cells. Anticancer Res 1997; 17: 4311-15.
    • (1997) Anticancer Res. , vol.17 , pp. 4311-4315
    • Wani, G.1    D'Ambrosio, S.M.2
  • 28
    • 0029935385 scopus 로고    scopus 로고
    • Inter and intracellular heterogeneity of O6-alkylguanine-DNA alkyltransferase in human brain tumors: Possible significance in nitrosourea therapy
    • Lee SM, Reid H, Elder RH, et al. Inter and intracellular heterogeneity of O6-alkylguanine-DNA alkyltransferase in human brain tumors: possible significance in nitrosourea therapy. Carcinogenesis 1996; 17: 637-41.
    • (1996) Carcinogenesis , vol.17 , pp. 637-641
    • Lee, S.M.1    Reid, H.2    Elder, R.H.3
  • 29
    • 0012667645 scopus 로고
    • O6-methylguanine-DNA methyltransferase in human normal and tumor tissue from brain, lung and ovary
    • Citron M, Decker R, Chen S, et al. O6-methylguanine-DNA methyltransferase in human normal and tumor tissue from brain, lung and ovary. Cancer Res 1994; 54: 4131-34.
    • (1994) Cancer Res. , vol.54 , pp. 4131-4134
    • Citron, M.1    Decker, R.2    Chen, S.3
  • 30
    • 0025923139 scopus 로고
    • O6-methylguanine-DNA methyltransferase activity in human liver tumors
    • Isowa G, Ishizaki K, Sadamoto T, et al. O6-methylguanine-DNA methyltransferase activity in human liver tumors. Carcinogenesis 1991; 12: 1313-17.
    • (1991) Carcinogenesis , vol.12 , pp. 1313-1317
    • Isowa, G.1    Ishizaki, K.2    Sadamoto, T.3
  • 31
    • 0033557903 scopus 로고    scopus 로고
    • Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia
    • Esteller M, Hamilton SR, Burger PC, et al. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 1999; 59: 793-97.
    • (1999) Cancer Res. , vol.59 , pp. 793-797
    • Esteller, M.1    Hamilton, S.R.2    Burger, P.C.3
  • 32
    • 0029664677 scopus 로고    scopus 로고
    • Changes in O6-methylguanine-DNA methyltransferase expression during immortalization of cloned human fibroblasts
    • Harris LC, von-Wronski MA, Venable CC, et al. Changes in O6-methylguanine-DNA methyltransferase expression during immortalization of cloned human fibroblasts. Carcinogenesis 1996; 17: 219-24.
    • (1996) Carcinogenesis , vol.17 , pp. 219-224
    • Harris, L.C.1    von-Wronski, M.A.2    Venable, C.C.3
  • 33
    • 0030611736 scopus 로고    scopus 로고
    • Understanding and manipulating O6-methylguanine-DNA ethyltransferase expression
    • Pieper RO. Understanding and manipulating O6-methylguanine-DNA ethyltransferase expression. Pharm Ther 1997; 74: 285-97.
    • (1997) Pharm. Ther. , vol.74 , pp. 285-297
    • Pieper, R.O.1
  • 34
    • 0026554643 scopus 로고
    • Phase I study of streptozocin and carmustine-sequenced administration in patients with advanced cancer
    • Micetich KC, Futscher B, Koch D, et al. Phase I study of streptozocin and carmustine-sequenced administration in patients with advanced cancer. J Natl Cancer Inst 1992; 84: 256-60.
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 256-260
    • Micetich, K.C.1    Futscher, B.2    Koch, D.3
  • 35
    • 0026611148 scopus 로고
    • Modulation of O6-alkylguanine-DNA alkyltransferase-mediated carmustine resistance using streptozotocin: A phase I trial
    • Panella TJ, Smith DC, Clifford Schold S, et al. Modulation of O6-alkylguanine-DNA alkyltransferase-mediated carmustine resistance using streptozotocin: a phase I trial. Camcer Res 1992; 52: 2456-59.
    • (1992) Camcer Res. , vol.52 , pp. 2456-2459
    • Panella, T.J.1    Smith, D.C.2    Clifford Schold, S.3
  • 36
    • 0029937517 scopus 로고    scopus 로고
    • Carmustine and streptozocin in refractory melanoma: An attempt at modulation of O6-alkylguanine-DNA alkyltransferase
    • Smith DC, Gerson SL, Liu L, et al. Carmustine and streptozocin in refractory melanoma: an attempt at modulation of O6-alkylguanine-DNA alkyltransferase. Clin Cancer Res 1996; 2: 1129-34.
    • (1996) Clin. Cancer Res. , vol.2 , pp. 1129-1134
    • Smith, D.C.1    Gerson, S.L.2    Liu, L.3
  • 37
    • 0027292859 scopus 로고
    • Sequential administration of varying doses of dacarbazine and fotemustine in advanced malignant melanoma
    • Lee SM, Margison GP, Woodcock A, Thatcher N. Sequential administration of varying doses of dacarbazine and fotemustine in advanced malignant melanoma. Br J Cancer 1993; 67: 1356-60.
    • (1993) Br. J. Cancer , vol.67 , pp. 1356-1360
    • Lee, S.M.1    Margison, G.P.2    Woodcock, A.3    Thatcher, N.4
  • 38
    • 0025924721 scopus 로고
    • O6-alkylguanine-DNA alkyltransferase depletion and regeneration in human peripheral lymphocytes following dacarbazine and fotemustine
    • Lee SM, Thatcher N, Margison GP. O6-alkylguanine-DNA alkyltransferase depletion and regeneration in human peripheral lymphocytes following dacarbazine and fotemustine. Cancer Res 1991; 51: 619-23.
    • (1991) Cancer Res. , vol.51 , pp. 619-623
    • Lee, S.M.1    Thatcher, N.2    Margison, G.P.3
  • 39
    • 0032793312 scopus 로고    scopus 로고
    • Sequential administration of temozolomide and fotemustine: Depletion of O6-alkyguanine-DNA alkyltransferase in blood lymphocytes and in tumours
    • Gander M, Leyvraz S, Decosterd L, et al. Sequential administration of temozolomide and fotemustine: depletion of O6-alkyguanine-DNA alkyltransferase in blood lymphocytes and in tumours. Ann Oncol 1999; 10: 831-38.
    • (1999) Ann. Oncol. , vol.10 , pp. 831-838
    • Gander, M.1    Leyvraz, S.2    Decosterd, L.3
  • 40
    • 0033623440 scopus 로고    scopus 로고
    • O6-Methylguanine formation, repair protein depletion and clinical outcome with a 4-hourly schedule of temozolomide in the treatment of advanced melanoma: Results ofa phase II study
    • Middleton MR, Lee SM, Arance A, et al. O6-Methylguanine formation, repair protein depletion and clinical outcome with a 4-hourly schedule of temozolomide in the treatment of advanced melanoma: results ofa phase II study. Int J Cancer 2000; 88: 469-73.
    • (2000) Int. J. Cancer , vol.88 , pp. 469-473
    • Middleton, M.R.1    Lee, S.M.2    Arance, A.3
  • 41
    • 0022190351 scopus 로고
    • Reduction of O6-alkylguanine DNA alkyltransferase activity in HeLa cells treated with O6-alkylguanines
    • Dolan ME, Morimoto K, Pegg AE. Reduction of O6-alkylguanine DNA alkyltransferase activity in HeLa cells treated with O6-alkylguanines. Cancer Res 1985; 45: 6413-17.
    • (1985) Cancer Res. , vol.45 , pp. 6413-6417
    • Dolan, M.E.1    Morimoto, K.2    Pegg, A.E.3
  • 42
    • 0027337683 scopus 로고
    • Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU)
    • Dolan ME, Pegg AE, Moschel RC, Grindey GB. Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU). Biochem Pharamacol 1993; 46: 285-90.
    • (1993) Biochem. Pharamacol. , vol.46 , pp. 285-290
    • Dolan, M.E.1    Pegg, A.E.2    Moschel, R.C.3    Grindey, G.B.4
  • 43
    • 0027079969 scopus 로고
    • Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme
    • Friedman HS, Dolan ME, Moschel RC, et al. Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme. J Natl Cancer Inst 1992; 84: 1926-31.
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 1926-1931
    • Friedman, H.S.1    Dolan, M.E.2    Moschel, R.C.3
  • 44
    • 0029664326 scopus 로고    scopus 로고
    • O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU
    • Wedge SR, Newlands ES. O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU. Brit J Cancer 1996; 73: 1049-52.
    • (1996) Brit. J. Cancer , vol.73 , pp. 1049-1052
    • Wedge, S.R.1    Newlands, E.S.2
  • 45
    • 0028047230 scopus 로고
    • Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine
    • Elder RH, Margison GP, Rafferty JA. Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine. Biochem J 1994; 298: 231-35.
    • (1994) Biochem. J. , vol.298 , pp. 231-235
    • Elder, R.H.1    Margison, G.P.2    Rafferty, J.A.3
  • 46
    • 0034668064 scopus 로고    scopus 로고
    • Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressie malignant glioma
    • Friedman HS, Pluda J, Quinn JA, et al. Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressie malignant glioma. J Clin Oncol 2000; 18: 3522-28.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 3522-3528
    • Friedman, H.S.1    Pluda, J.2    Quinn, J.A.3
  • 47
    • 0343953050 scopus 로고    scopus 로고
    • Phase I clinical trial and pharmacological study of O6-benzylguanine followed by carmustine in patients with advanced cancer
    • Schilsky RL, Dolan ME, Bertucci D, et al. Phase I clinical trial and pharmacological study of O6-benzylguanine followed by carmustine in patients with advanced cancer. Clin Cancer Res 2000; 6: 3025-31.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 3025-3031
    • Schilsky, R.L.1    Dolan, M.E.2    Bertucci, D.3
  • 48
    • 0033561807 scopus 로고    scopus 로고
    • O6-benzylguanine: A clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair
    • Spiro TP, Gerson SL, Liu L, et al. O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair. Cancer Res 1999; 59: 2402-10.
    • (1999) Cancer Res. , vol.59 , pp. 2402-2410
    • Spiro, T.P.1    Gerson, S.L.2    Liu, L.3
  • 49
    • 0031734148 scopus 로고    scopus 로고
    • Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma
    • Friedman HS, Kokkinakis DM, Pluda J, et al. Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma. J Clin Oncol 1998; 16: 3570-75.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 3570-3575
    • Friedman, H.S.1    Kokkinakis, D.M.2    Pluda, J.3
  • 50
    • 0036570292 scopus 로고    scopus 로고
    • Phase II trial of carmustine plus O6-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma
    • Quinn JA, Pluda J, Dolan ME, et al. Phase II trial of carmustine plus O6-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma. J Clin Oncol 2002; 20: 2277-783.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 2277-2783
    • Quinn, J.A.1    Pluda, J.2    Dolan, M.E.3
  • 51
    • 0000287736 scopus 로고    scopus 로고
    • Phase I study of 4-bromothenylguanine (4-BTG) and temozolomide: Preliminary results and O6-alkylguanine-DNA alkyltransferase (ATase) depletion
    • (Abstr 3878)
    • Middleton MR, Ranson M, Bowen R, et al. Phase I study of 4-bromothenylguanine (4-BTG) and temozolomide: preliminary results and O6-alkylguanine-DNA alkyltransferase (ATase) depletion. Proc Am Assoc Cancer Res 2000; 41: (Abstr 3878)
    • (2000) Proc. Am. Assoc. Cancer Res. , vol.41
    • Middleton, M.R.1    Ranson, M.2    Bowen, R.3
  • 52
    • 0028985112 scopus 로고
    • O6-benzylguanine increases the sensitivity of human primary bone marrow cells to the cytotoxic effects of temozolomide
    • Fairbairn L, Watson AJ, Rafferty J, et al. O6-benzylguanine increases the sensitivity of human primary bone marrow cells to the cytotoxic effects of temozolomide. Exp Haematol 1995; 23: 112-16.
    • (1995) Exp. Haematol. , vol.23 , pp. 112-116
    • Fairbairn, L.1    Watson, A.J.2    Rafferty, J.3
  • 54
    • 0035935676 scopus 로고    scopus 로고
    • Monosaccharide-linked inhibitors of O6-methylguanine-DNA methyltransferase (MGMT): Synthesis, molecular modeling, and structure-activity relationships
    • Reinhard J, Hull WE, von der Lieth CW, et al. Monosaccharide-linked inhibitors of O6-methylguanine-DNA methyltransferase (MGMT): synthesis, molecular modeling, and structure-activity relationships. J Med Chem 2001; 44: 4050-61.
    • (2001) J. Med. Chem. , vol.44 , pp. 4050-4061
    • Reinhard, J.1    Hull, W.E.2    von der Lieth, C.W.3
  • 55
    • 0036463566 scopus 로고    scopus 로고
    • Genetic chemoprotection with mutant O6-alkylguanine-DNA-alkyltransferases
    • Hobin DA, Fairbairn LJ. Genetic chemoprotection with mutant O6-alkylguanine-DNA-alkyltransferases. Curr Gene Ther 2002; 2: 1-8.
    • (2002) Curr. Gene Ther. , vol.2 , pp. 1-8
    • Hobin, D.A.1    Fairbairn, L.J.2
  • 56
    • 0036570062 scopus 로고    scopus 로고
    • Clinical relevance of MGMT in the treatment of cancer
    • Gerson SL. Clinical relevance of MGMT in the treatment of cancer. J Clin Oncol 2002; 20: 2388-99.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 2388-2399
    • Gerson, S.L.1
  • 57
    • 0032962702 scopus 로고    scopus 로고
    • Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase
    • Friedman HS, Pegg AE, Johnson SP, et al. Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase, Cancer Chemother Plarm 1999; 43: 80-85.
    • (1999) Cancer Chemother. Plarm. , vol.43 , pp. 80-85
    • Friedman, H.S.1    Pegg, A.E.2    Johnson, S.P.3
  • 58
    • 0036160987 scopus 로고    scopus 로고
    • O6-methylguanine-DNA methyltransferase (MGMT) as a determinant of resistance to camptothecin derivatives
    • Okamoto R, Takano H, Okamura T, et al. O6-methylguanine-DNA methyltransferase (MGMT) as a determinant of resistance to camptothecin derivatives. Jpn J Cancer Res 2002; 93: 93-102.
    • (2002) Jpn. J. Cancer Res. , vol.93 , pp. 93-102
    • Okamoto, R.1    Takano, H.2    Okamura, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.