O6-methylguanine-DNA methyltransferase protein levels in pediatric brain tumors

Clinical Cancer Research

Volumn 3, Issue 12 I, 1997, Pages 2459-2463

  Hongeng, Suradej ^a   Brent, Thomas P ^a   Sanford, Robert A ^b   Li, Hao ^a   Kun, Larry E ^a   Heideman, Richard L ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O METHYLGUANINE; CHLOROETHYLNITROSOUREA; DNA METHYLTRANSFERASE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE;

ADULT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN TUMOR; CANCER GRADING; CHILDHOOD CANCER; DRUG DNA INTERACTION; DRUG MONITORING; FEMALE; HUMAN; IMMUNOBLOTTING; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN DETERMINATION; ADOLESCENT; CEREBELLUM TUMOR; CHILD; ENZYMOLOGY; EPENDYMOMA; INFANT; MEDULLOBLASTOMA; NEUROECTODERM TUMOR; PRESCHOOL CHILD; RETROSPECTIVE STUDY; WESTERN BLOTTING;

ADOLESCENT; ADULT; BLOTTING, WESTERN; BRAIN NEOPLASMS; CEREBELLAR NEOPLASMS; CHILD; CHILD, PRESCHOOL; EPENDYMOMA; FEMALE; HUMANS; INFANT; MALE; MEDULLOBLASTOMA; NEUROECTODERMAL TUMORS, PRIMITIVE; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; RETROSPECTIVE STUDIES;

EID: 0031292579     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Levin, V. A., and Wilson, C. B. Nitrosourea chemotherapy for primary malignant gliomas. Cancer Treat. Rep., 60: 719-724, 1976.
2. Bodell, W. J., Tokuda, K., and Ludlum, D. B. Differences in DNA alkylation products formed in sensitive and resistant human glioma cells treated with N-(2-chloroethyl)-N-nitrosourea. Cancer Res., 48: 4489-4492, 1988.
3. Smith, D. G., and Brent, T. P. Response of cultured human cell lines from rhabdomyosarcoma xenografts to treatment with chloroethylnitrosourea. Cancer Res., 49: 883-886, 1989.
4. 6-alkylguanine-DNA alkyltransferase activity and susceptibility to chloroethylnitrosourea in several glioma cell lines. J. Neuro-oncol., 17: 1-8, 1993.
5. 6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res., 50: 6119-6129, 1990.
6. 6-alkyltransferase (AT) in cancer therapy. Cancer Treat. Rev., 15: 279-292, 1988.
7. 6-alkylguanine-DNA alkyltransferase activity of human malignant glioma and its clinical implications. J. Neuro-oncol., 21: 135-140, 1994.
8. Belanich, M., Pastor, M., Randall, T., Guerra, D., Kibitel, J., Alas, L., Li, B., Citron, M., Wasserman, P., White, A., Eyre, H., Jaeckle, K., Schulman, S., Rector, D., Prados, M., Coon, S., Shapiro, W., and Yarosh, D. Retrospective study of correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine. Cancer Res., 56: 783-788, 1996.
9. 6-methylguanine-DNA methyltransferase in six human medulloblastoma cell lines. Cancer Res., 52: 1144-1148, 1992.
10. 6-methylguanine-DNA methyltransferase activity in brain tumors and adjacent normal brain. Cancer Res., 53: 3416-3420, 1993.
11. Heideman, R. L., Packer, R. J., Albright, L. A., Freeman, C. R., and Rorke, L. B. Tumors of the central nervous system. In: P. A. Pizzo and D. G. Poplack (eds.), Principles and Practice of Pediatric Oncology, pp. 633-697. Philadelphia: Lippincott-Raven, 1997.
12. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72: 248-254, 1976.
13. Brent, T. P. Suppression of cross-link formation in chloroethyl-nitrosourea-treated DNA by an activity in extracts of human leukemia lymphoblasts. Cancer Res., 44: 1887-1892, 1984.
14. 6-alkylguanine-DNA alkyltransferase from human leukemia cells. Pharmacol. Ther., 31: 121-140, 1985.
15. Laemmli, U. K. Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature (Lond.), 227: 680-685, 1970.
16. 6-methyltransferase expression during immortalization of clonal human fibroblasts. Carcinogenesis (Lond.), 17: 219-224, 1996.
17. Matsudaira, P. Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. J. Biol. Chem., 262: 10035-10038, 1987.
18. - human tumor lines. Biochem. Pharmacol., 39: 959-964, 1990.
19. 6-Methylguanine-DNA methyltransferase in human normal and tumor tissue from brain, lung, and ovary. Cancer Res., 51: 4131-4134, 1991.
20. Gerson, S. L., and Trey, J. E. Modulation of nitrosourea resistance in myeloid leukemia. Blood, 71: 1487-1494, 1988.
21. 6-Methylguanine-DNA methyltransferase in human brain tumors detected by activity assay and monoclonal antibodies. Oncol. Res., 7: 49-55, 1995.
22. 6-methylguanine in human blood leukocyte DNA during exposure to procarbazine and its relationships with dose and repair. Cancer Res., 50: 2759-2764, 1990.
23. 6-alkylguanine-DNA alkyltransferase using newly developed monoclonal antibodies. Cancer Res., 50: 58-61, 1990.
24. 6-Alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts. J. Neurosurg., 70: 573-577, 1989.
25. Friedman, H. S., Dolan, M. E., Moschel, R. C., Pegg, A. E., Felker, G. M., Rich, J., Bigner, D. D., and Schold, S. C. Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme. J. Natl. Cancer Inst., 84: 1926-1931, 1992.
26. 6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea. Cancer Commun., 2: 371-377, 1990.
27. 6-benzylguanine on the sensitivity of tumor xenografts to 1,2-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation. Cancer Res., 52: 1171-1175, 1992.
28. 6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosoureacytotoxicity. Clin. Cancer Res., 3: 301-307, 1997.
29. Allay, J. A., Koç, O. N., Davis, B. M., and Gerson, S. L. Retroviral-mediated gene transduction of human alkyltransferase complementary DNA confers nitrosourea resistance to human hematopoietic progenitors. Clin. Cancer Res., 2: 1353-1359, 1996.
30. Ward, H. W. C. CCNU in treatment of recurrent of medulloblastoma. Br. Med. J., 1: 642, 1974.
31. Lefkowitz, I., Evans, A., Sposto, C., and Hammond, D. Adjuvant chemotherapy of childhood posteria fossa (PF) ependymoma; craniospinal irradiation with and without CCNU, vincristine (VCR), and prednisone (P). Am. Soc. Clin. Oncol., 8: 87, 1989.
32. Sposto, R., Ertel, I. J., Jenkin, R. D. T., Boesel, C. P., Venes, J. L., Ortega, J. A., Evans, A. E., Wara, W., and Hammond, D. The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: results of a randomized trial. J. Neuro-oncol., 7: 165-177, 1989.
33. Finlay, J. L., Boyett, J. M., Yates, A. J., Wisoff, J. H., Milstein, J. M., Geyer, J. R., Bertolone, S. J., McGuire, P., Cherlow, J. M., Tefft, M., Turski, P. A., Wara, W. M., Edwards, M., Sutton, L. N., Berger, M. S., Epstein, F., Ayers, G., Allen, J. C., and Packer, R. J. Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with eight-drugs-in-1-day regimen. J. Clin. Oncol., 13: 112-123, 1995.
34. Packer, R. J., Sutton, L. N., Elterman, R., Lange, B., Goldwein, J., Nicholson, S., Mulne, L., Boyett, J., D'Angio, G., Wechsler-Jentzsch, K., Reaman, G., Cohen, B., Bruce, D. A., Rorke, L. B., Molly, P., Ryan, J., LaFond, D., Evans, A. E., and Schut, L. Outcome for children with medulloblastoma treated with radiation and cisplatin, CCNU, and vincristine chemotherapy. J. Neurosurg., 81: 690-698, 1994.
35. O'Driscoll, B. R., Hasleton, P. S., Taylor, P. M., Poulter, L. W., Gattameneni, H. R., and Woodcock, A. A. Active lung fibrosis up to 17 years after chemotherapy with carmustine (BCNU) in childhood. N. Engl. J. Med., 323: 378-382, 1990.