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Volumn 20, Issue 2, 1999, Pages 279-284

Reduced lung tumorigenesis in human methylguanine DNA-methyltransferase transgenic mice achieved by expression of transgene within the target cell

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; ANTIBODY; METHYLTRANSFERASE;

EID: 0032930907     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.2.279     Document Type: Article
Times cited : (76)

References (38)
  • 1
    • 0025195404 scopus 로고
    • 6-alkylguanine - DNA AGT: Regulation and importance in response to alkylating carcinogenic and therapeutic agents
    • 6-alkylguanine - DNA AGT: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res., 50, 6119-6129.
    • (1990) Cancer Res. , vol.50 , pp. 6119-6129
    • Pegg, A.E.1
  • 4
    • 0023919219 scopus 로고
    • Regulation and expression of the adaptive response to alkylating agents
    • Lindahl, T., Sedgwick, B., Sekiguchi, M. and Nakabeppu, Y. (1988) Regulation and expression of the adaptive response to alkylating agents. Annu. Rev. Biochem., 57, 133-157.
    • (1988) Annu. Rev. Biochem. , vol.57 , pp. 133-157
    • Lindahl, T.1    Sedgwick, B.2    Sekiguchi, M.3    Nakabeppu, Y.4
  • 5
    • 0039333555 scopus 로고
    • DNA base changes and alkylation following in vivo exposure of Escherichia colt to N-methyl-N-nitrosourea
    • Richardson, K.K., Richardson, F.C., Crosby, R.M., Swenberg, J.A. and Skopek, T.R. (1987) DNA base changes and alkylation following in vivo exposure of Escherichia colt to N-methyl-N-nitrosourea. Proc. Natl Acad. Sci. USA, 84, 344-348.
    • (1987) Proc. Natl Acad. Sci. USA , vol.84 , pp. 344-348
    • Richardson, K.K.1    Richardson, F.C.2    Crosby, R.M.3    Swenberg, J.A.4    Skopek, T.R.5
  • 7
    • 0014672640 scopus 로고
    • 6 alkylation of deoxyguanosine to the mutagenicity and carcinogenicity of nitrosamines and nitrosamides
    • 6 alkylation of deoxyguanosine to the mutagenicity and carcinogenicity of nitrosamines and nitrosamides. Nature, 223, 206-207.
    • (1969) Nature , vol.223 , pp. 206-207
    • Loveless, A.1
  • 8
  • 9
    • 0021871265 scopus 로고
    • Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats
    • Zarbl, H., Sukumar, S., Arthur, A.V., Martin-Zanca, D. and Barbacid, M. (1985) Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats. Nature, 315, 382-385.
    • (1985) Nature , vol.315 , pp. 382-385
    • Zarbl, H.1    Sukumar, S.2    Arthur, A.V.3    Martin-Zanca, D.4    Barbacid, M.5
  • 10
    • 0023691697 scopus 로고
    • ras oncogenes and phenotypic staging in N-methylnitrosourea and irradiation-induced thymic lymphomas in C57BL/6J mice
    • Newcomb, E.W., Steinberg, J.J. and Pellicer, A. (1988) ras oncogenes and phenotypic staging in N-methylnitrosourea and irradiation-induced thymic lymphomas in C57BL/6J mice. Cancer Res., 48, 5514-5521.
    • (1988) Cancer Res. , vol.48 , pp. 5514-5521
    • Newcomb, E.W.1    Steinberg, J.J.2    Pellicer, A.3
  • 12
    • 0029043657 scopus 로고
    • The immature thymocyte is protected from N-methylnitrosourea-induced lymphoma by the human MGMT-CD2 transgene
    • Zaidi, N.H., Allay, E., Ayi, T.C., Li, B.F.L., Dumenco, L.L., Sy, M.S. and Gerson, S.L. (1995) The immature thymocyte is protected from N-methylnitrosourea-induced lymphoma by the human MGMT-CD2 transgene. Carcinogenesis, 16, 1047-1053.
    • (1995) Carcinogenesis , vol.16 , pp. 1047-1053
    • Zaidi, N.H.1    Allay, E.2    Ayi, T.C.3    Li, B.F.L.4    Dumenco, L.L.5    Sy, M.S.6    Gerson, S.L.7
  • 13
    • 0028169360 scopus 로고
    • 6-methylguanine - DNA adducts protects transgenic mice from N-methylnitrosourea-induced thymic lymphomas
    • 6-methylguanine - DNA adducts protects transgenic mice from N-methylnitrosourea-induced thymic lymphomas. Cancer Res., 54, 4648-4652.
    • (1994) Cancer Res. , vol.54 , pp. 4648-4652
    • Liu, L.1    Allay, E.2    Dumenco, L.L.3    Gerson, S.L.4
  • 14
    • 0001180529 scopus 로고
    • Lung tumors in strain A mice as a bioassay for carcinogenicity
    • Milman, H. and Weisburger, E. (eds) Moves Publications, Park Ridge, NJ
    • Stoner, G. and Shimkin, M.B. (1985) Lung tumors in strain A mice as a bioassay for carcinogenicity. In Milman, H. and Weisburger, E. (eds) Handbook of Carcinogenesis Testing. Moves Publications, Park Ridge, NJ.
    • (1985) Handbook of Carcinogenesis Testing
    • Stoner, G.1    Shimkin, M.B.2
  • 15
    • 0024437222 scopus 로고
    • Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines
    • Belinsky, S.A., Devereux, T.R., Maronpot, R.R., Stoner, G.D. and Anderson, M.W. (1989) Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines. Cancer Res., 49, 5305-5311.
    • (1989) Cancer Res. , vol.49 , pp. 5305-5311
    • Belinsky, S.A.1    Devereux, T.R.2    Maronpot, R.R.3    Stoner, G.D.4    Anderson, M.W.5
  • 16
    • 0027292743 scopus 로고
    • Dose-dependent ras mutation spectra in N-nitrosodiethylamine induced mouse liver tumors and 4-(N-methylnitrosamino)-1-(3-pyridyl)-1-butanone induced mouse lung tumors
    • Chen, B., Liu, L., Castonguay, A., Maronpot, R.R., Anderson, M.W. and You, M. (1993) Dose-dependent ras mutation spectra in N-nitrosodiethylamine induced mouse liver tumors and 4-(N-methylnitrosamino)-1-(3-pyridyl)-1-butanone induced mouse lung tumors. Carcinogenesis, 14, 1603-1608.
    • (1993) Carcinogenesis , vol.14 , pp. 1603-1608
    • Chen, B.1    Liu, L.2    Castonguay, A.3    Maronpot, R.R.4    Anderson, M.W.5    You, M.6
  • 17
    • 0021998299 scopus 로고
    • Nicotine-derived N-nitrosamines and tobacco related cancer: Current status and future directions
    • Hoffmann, D. and Hecht, S.S. (1985) Nicotine-derived N-nitrosamines and tobacco related cancer: current status and future directions. Cancer Res., 45, 935-944.
    • (1985) Cancer Res. , vol.45 , pp. 935-944
    • Hoffmann, D.1    Hecht, S.S.2
  • 18
    • 0023712922 scopus 로고
    • Tobacco-specific nitrosamines: An important group of carcinogens in tobacco and tobacco smoke
    • Hecht, S.S. and Hoffmann, D. (1988) Tobacco-specific nitrosamines: an important group of carcinogens in tobacco and tobacco smoke. Carcinogenesis, 9, 1665-1668.
    • (1988) Carcinogenesis , vol.9 , pp. 1665-1668
    • Hecht, S.S.1    Hoffmann, D.2
  • 19
    • 0024262907 scopus 로고
    • Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines
    • Rivenson, A., Hoffmann, D., Prokopczyk, B., Amin, S. and Hecht, S.S. (1988) Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines. Cancer Res., 48, 6912-6917.
    • (1988) Cancer Res. , vol.48 , pp. 6912-6917
    • Rivenson, A.1    Hoffmann, D.2    Prokopczyk, B.3    Amin, S.4    Hecht, S.S.5
  • 20
    • 0024350057 scopus 로고
    • Rapid single dose model for lung tumor induction in A/J mice by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet
    • Hecht, S.S., Morse, M.A., Amin, S.G., Stoner, G.D., Jordan, K.G., Choi, C.-I. and Chung, F.-L. (1989) Rapid single dose model for lung tumor induction in A/J mice by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet. Carcinogenesis, 10, 1901-1904.
    • (1989) Carcinogenesis , vol.10 , pp. 1901-1904
    • Hecht, S.S.1    Morse, M.A.2    Amin, S.G.3    Stoner, G.D.4    Jordan, K.G.5    Choi, C.-I.6    Chung, F.-L.7
  • 21
    • 0022654007 scopus 로고
    • Comparative tumorigenicity and DNA methylation in F344 rats by 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosodimethylamine
    • Hecht, S.S., Trushin, N., Castonguay, A. and Rivenson, A. (1986) Comparative tumorigenicity and DNA methylation in F344 rats by 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosodimethylamine. Cancer Res., 46, 498-502.
    • (1986) Cancer Res. , vol.46 , pp. 498-502
    • Hecht, S.S.1    Trushin, N.2    Castonguay, A.3    Rivenson, A.4
  • 22
    • 0025925258 scopus 로고
    • 6-methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung
    • 6-methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung. Cancer Res., 51, 5557-5564.
    • (1991) Cancer Res. , vol.51 , pp. 5557-5564
    • Peterson, L.A.1    Hecht, S.S.2
  • 23
    • 0027333129 scopus 로고
    • G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents
    • Ronai, Z.A., Gradia, S., Peterson, L.A. and Hecht, S.S. (1993) G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents. Carcinogenesis, 11, 2419-2422.
    • (1993) Carcinogenesis , vol.11 , pp. 2419-2422
    • Ronai, Z.A.1    Gradia, S.2    Peterson, L.A.3    Hecht, S.S.4
  • 24
    • 0031023711 scopus 로고    scopus 로고
    • Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone: Effects of dose and phenethyl isothiocyanate
    • Staretz, M.E., Foiles, P.G., Miglietta, L.M. and Hecht, S.S. (1997) Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone: effects of dose and phenethyl isothiocyanate. Cancer Res., 57, 259-266.
    • (1997) Cancer Res. , vol.57 , pp. 259-266
    • Staretz, M.E.1    Foiles, P.G.2    Miglietta, L.M.3    Hecht, S.S.4
  • 25
    • 0022931463 scopus 로고
    • 6-alkylguanine - DNA AGT activity based on cellular DNA content in human, rat and mouse tissues
    • 6-alkylguanine - DNA AGT activity based on cellular DNA content in human, rat and mouse tissues. Carcinogenesis, 7, 745-749.
    • (1986) Carcinogenesis , vol.7 , pp. 745-749
    • Gerson, S.L.1    Trey, J.2    Miller, K.3    Berger, N.A.4
  • 27
    • 0029876088 scopus 로고    scopus 로고
    • 6-alkylguanine - DNA alkyltransferase expression in normal and malignant human colon. Clin
    • 6-alkylguanine - DNA alkyltransferase expression in normal and malignant human colon. Clin. Cancer Res., 2, 577-584.
    • (1996) Cancer Res. , vol.2 , pp. 577-584
    • Zaidi, N.H.1    Liu, L.2    Gerson, S.L.3
  • 28
    • 0028904619 scopus 로고
    • Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon
    • Zaidi, N.K. Pretlow, T.P., O'Riordan, M.A., Dumenco, L.L., Allay, E. and Gerson, S.L. (1995) Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon. Carcinogenesis, 16, 451-456.
    • (1995) Carcinogenesis , vol.16 , pp. 451-456
    • Zaidi, N.K.1    Pretlow, T.P.2    O'Riordan, M.A.3    Dumenco, L.L.4    Allay, E.5    Gerson, S.L.6
  • 29
    • 0023132282 scopus 로고
    • Cell selective alkylation of DNA in rat lung following low dose exposure to the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
    • Belinsky, S.A., White, C.M., Devereux, T.R., Swenberg, J.A. and Anderson, M.W. (1987) Cell selective alkylation of DNA in rat lung following low dose exposure to the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res., 47, 1143-1148.
    • (1987) Cancer Res. , vol.47 , pp. 1143-1148
    • Belinsky, S.A.1    White, C.M.2    Devereux, T.R.3    Swenberg, J.A.4    Anderson, M.W.5
  • 30
    • 0026697154 scopus 로고
    • Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone in the A/J mouse
    • Belinsky, S.A., Devereux, T.R., Foley, J.F. Maronpot, R.R. and Anderson, M.W. (1992) Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone in the A/J mouse. Cancer Res., 52, 3164-3173.
    • (1992) Cancer Res. , vol.52 , pp. 3164-3173
    • Belinsky, S.A.1    Devereux, T.R.2    Foley, J.F.3    Maronpot, R.R.4    Anderson, M.W.5
  • 31
    • 0026793493 scopus 로고
    • Kinetics and enzyme involvement in the metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-l-butanone by rat lung and nasal mucosa
    • Simth, T.J., Guo, Z., Hong, J.-Y. Ning, S.M., Thomas, P.E. and Yang, C.S. (1992) Kinetics and enzyme involvement in the metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-l-butanone by rat lung and nasal mucosa. Carcinogenesis, 13, 1409-1414.
    • (1992) Carcinogenesis , vol.13 , pp. 1409-1414
    • Simth, T.J.1    Guo, Z.2    Hong, J.-Y.3    Ning, S.M.4    Thomas, P.E.5    Yang, C.S.6
  • 36
    • 0026096577 scopus 로고
    • Role of ras protooncogene activation in the formation of spontaneous and nitrosamine-induced lung tumors in the resistant C3H mouse
    • Devereux, T.R., Anderson, M.W. and Belinsky, S.A. (1991) Role of ras protooncogene activation in the formation of spontaneous and nitrosamine-induced lung tumors in the resistant C3H mouse. Carcinogenesis, 12, 299-303.
    • (1991) Carcinogenesis , vol.12 , pp. 299-303
    • Devereux, T.R.1    Anderson, M.W.2    Belinsky, S.A.3
  • 37
    • 0027979481 scopus 로고
    • The second intron of the K-ras gene contains regulatory elements associated with mouse lung tumor susceptibility
    • Chen, B., Johanson, L., Wiest, J.S. Anderson, M.W. and You, M. (1994) The second intron of the K-ras gene contains regulatory elements associated with mouse lung tumor susceptibility. Proc. Natl Acad. Sci. USA, 91, 1589-1593.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 1589-1593
    • Chen, B.1    Johanson, L.2    Wiest, J.S.3    Anderson, M.W.4    You, M.5
  • 38
    • 0023605863 scopus 로고
    • K-ras 2 as a genetic marker for lung tumor susceptibility in inbred mice
    • Ryan, J., Barker, P.E., Nesbitt, M.N. and Ruddle, F.H. (1987) K-ras 2 as a genetic marker for lung tumor susceptibility in inbred mice. J. Natl Cancer Inst., 79, 1351-1357.
    • (1987) J. Natl Cancer Inst. , vol.79 , pp. 1351-1357
    • Ryan, J.1    Barker, P.E.2    Nesbitt, M.N.3    Ruddle, F.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.