Deficient expression of O6-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma

Annals of Surgical Oncology

Volumn 9, Issue 4, 2002, Pages 371-379

  Kohya, Naohiko ^a   Miyazaki, Kohji ^a   Matsukura, Shiroh ^a   Yakushiji, Hiroyuki ^a   Kitajima, Yoshihiko ^a   Kitahara, Kenji ^a   Fukuhara, Masao ^b   Nakabeppu, Yusaku ^b   Sekiguchi, Mutsuo ^c  

^a SAGA UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c FUKUOKA DENTAL COLLEGE   (Japan)

Author keywords

Biliary tract carcinoma; hMLH1; hMSH2; MGMT

Indexed keywords

ALKYLATING AGENT; BIOLOGICAL MARKER; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN; PROTEIN MLH1; PROTEIN MSH2; UNCLASSIFIED DRUG;

AGED; ARTICLE; BILE DUCT CARCINOMA; CANCER INVASION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA ALKYLATION; DNA REPAIR; FEMALE; GALLBLADDER CARCINOMA; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MISMATCH REPAIR; PROGNOSIS; PROTEIN EXPRESSION;

AGED; BASE PAIR MISMATCH; BILE DUCT NEOPLASMS; CARCINOMA; CARRIER PROTEINS; CHI-SQUARE DISTRIBUTION; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; GALLBLADDER NEOPLASMS; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PROGNOSIS; PROTO-ONCOGENE PROTEINS; STATISTICS, NONPARAMETRIC;

EID: 0036256948     PISSN: 10689265     EISSN: None     Source Type: Journal    
DOI: 10.1245/aso.2002.9.4.371     Document Type: Article

References (54)

1. Genetic studies of the lac repressor. IV. Mutagenic specificity in the lacI gene of Escherichia coli
2. 6-alkylguanine-DNA alkyltransferase: Regulation and importance in response to alkylating carcinogenic and therapeutic agents
3. 6-Methylguanine-DNA methyltransferase in human normal and tumor tissue from brain, lung, and ovary
4. 6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues
5. Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains
6. 6-Methylguanine methyltransferase activity and sensitivity of Japanese tumor cell strains to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride
7. 6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines
8. 6-methylguanine-DNA-methyltransferase activity and resistance of human cells to the cytotoxic and mutagenic effect of N-methyl-N′-nitro-N-nitrosoguanidine
9. - human tumor cell strains
10. Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage
11. Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis
12. Biochemistry and genetics of eukaryotic mismatch repair
13. Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes
14. Biliary tract tumors
15. K-ras codon 12 mutations in biliary tract tumors detected by polymerase chain reaction denaturing gradient gel electrophoresis
16. K-ras and p53 mutations in stage I gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct
17. APC, K-ras codon 12 mutations and p53 gene expression in carcinoma and adenoma of the gall-bladder suggest two genetic pathways in gall-bladder carcinogenesis
18. Precancerous conditions of gallbladder carcinoma: Overview of histopathologic characteristics and molecular genetic findings
19. p53 protein expression and prognosis in gallbladder carcinoma and premalignant lesions
20. Mutations of p16Ink4/ CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers
21. Genetic abnormalities involved in the pathogenesis of gallbladder carcinoma
22. A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity
23. Use of T7 RNA polymerase to direct expression of cloned genes
24. 4-methylthymine in DNA
25. Intracellular localization and function of DNA repair methyltransferase in human cells
26. -
27. 6-methylguanine-DNA methyltransferase in hepatocellular, gastric, and breast cancers
28. 6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: The role of MGMT in protection against the genotoxic effects of alkylating agents
29. - human tumor cells
30. - human tumor cell lines containing the MGMT gene by the polymerase chain reaction technique
31. + human tumor cells
32. Alterations in DNA methylation: A fundamental aspect of neoplasia
33. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
34. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
35. Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression
36. 6-methylguanine-DNA methyltransferase gene
37. 6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells
38. 6-methylguanine-DNA methyltransferase gene
39. 6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene
40. 6-methylguanine-DNA methyltransferase gene MGMT in human normal and tumor tissues
41. 6-alkylguanine-DNA alkyltransferase expression in normal and malignant human colon
42. 6-Methylguanine-DNA methyltransferase activity in adult gliomas: Relation to patient and tumor characteristics
43. 6-methylguanine-DNA methyltransferase expression in human lung carcinomas
44. 6-Alkylguanine-DNA alkyltransferase activity in human brain tumors
45. 6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia
46. Hypermethylation of multiple genes in pancreatic adenocarcinoma
47. 6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis
48. Activity of O(6)-methylguanine-DNA methyltransferase in relation to p53 status and therapeutic response in ovarian cancer
49. Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice
50. High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase
51. An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair
52. DNA damage tolerance, mismatch repair and genome instability
53. Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes