Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation

Molecular Biology of the Cell

Volumn 13, Issue 9, 2002, Pages 3064-3077

  Bolton, Margaret A ^a   Lan, Weijie ^a   Powers, Shannon E ^a   McCleland, Mark L ^a   Kuang, Jian ^a   Stukenberg, P Todd ^a  

^a UNIVERSITY OF VIRGINIA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA B KINASE; CELL EXTRACT; CELL PROTEIN; INNER CENTROMERE PROTEIN; PHOSPHATASE; REGULATOR PROTEIN; SURVIVIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL CYCLE; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; HYDRODYNAMICS; MITOSIS; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; CELL CYCLE; CELLS, CULTURED; CHROMATOGRAPHY, GEL; CHROMOSOMAL PROTEINS, NON-HISTONE; CLONING, MOLECULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE TRANSFERASE; HUMANS; IMMUNOBLOTTING; MICROSCOPY, FLUORESCENCE; MICROTUBULE-ASSOCIATED PROTEINS; MITOSIS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS; XENOPUS LAEVIS;

ANIMALIA; XENOPUS LAEVIS;

EID: 0036732808     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E02-02-0092     Document Type: Article

References (52)

1. Chromosomal passengers and the (aurora) ABCs of mitosis
2. Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes, and is overexpressed in tumor cells
3. Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation
4. INCENP binds the aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow
5. Assay of proteins in the presence of interfering materials
6. The budding yeast protein kinase Ip11/Aurora allows the absence of tension to activate the spindle checkpoint
7. The conserved protein kinase Ip11 regulates microtubule binding to kinetochores in budding yeast
8. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
9. Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual α-helical extensions
10. The inner centromere protein (INCENP) antigens: Movement from inner centromere to midbody during mitosis
11. The localization of human cyclins B1 and B2 determines CDK1 substrate specificity and neither enzyme requires MEK to disassemble the Golgi apparatus
12. Programmed cell death in C. elegans
13. Cyclin is a component of maturation promoting factor from Xenopus
14. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2
15. Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis
16. SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling
17. Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
18. Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis
19. Functional cooperation of Dam1, Ip11, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation
20. Sli15 associates with the ipll protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae
21. MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B
22. Control of apoptosis and mitotic spindle checkpoint by survivin
23. Cell division regulation by BIR1, a member of the inhibitor of apoptosis family in yeast
24. A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis
25. The INCENPs: Structural and functional analysis of a family of chromosome passenger proteins
26. Molecular analysis of the INCENPs (inner centromere proteins): Separate domains are required for association with microtubules during interphase and with the central spindle during anaphase
27. Bir1/Cut17 moving from chromosome to spindle upon the loss of cohesion is required for condensation, spindle elongation and repair
28. Chromatin-associated protein phosphatase 1 regulates aurora-B and histone H3 phosphorylation
29. The role of cyclin synthesis and degradation in the control of maturation promoting factor activity
30. Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin
31. Functional analysis of kinetochore assembly in Caenorhabditis elegans
32. ProMod and Swiss-Model: Internet-based tools for automated comparative protein modeling
33. BIRinging chromosomes through cell division: And survivin' the experience
34. The vertebrate cell kinetochore and its roles during mitosis
35. +, a gene encoding a protein kinase homolog
36. A highly conserved centrosomal kinase, AIR-1, is required for accurate cell cycle progression and segregation of developmental factors in Caenorhabditis elegans embryos
37. AIR-2: An Aurora/Ip11-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos
38. Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation: Application to crude preparations of sulfite and hydroxylamine reductases
39. + of fission yeast encodes a protein kinase potentially regulated by phosphorylation
40. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
41. Cyclin activation of p34cdc2
42. The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone
43. Systematic identification of mitotic phosphoproteins
44. Evidence that the Ip11-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections
45. Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype
46. Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement
47. Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs
48. The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation
49. INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis
50. INCENP binds directly to tubulin and requires dynamic microtubules to target to the cleavage furrow
51. Participation of Bir1p, a member of the inhibitor of apoptosis family, in yeast chromosome segregation events