The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis

Molecular Biology of the Cell

Volumn 13, Issue 4, 2002, Pages 1132-1143

  Leverson, Joel D ^a   Huang, Han Kuei ^a   Forsburg, Susan L ^a   Hunter, Tony ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA B KINASE; AURORA RELATED KINASE 1P; CELL PROTEIN; INNER CENTROMERE PROTEIN; PHOSPHOTRANSFERASE; SURVIVIN; UNCLASSIFIED DRUG;

ARTICLE; CELL DIVISION; CENTROMERE; CHROMOSOME SEGREGATION; CYTOKINESIS; GENE OVEREXPRESSION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; SCHIZOSACCHAROMYCES POMBE; YEAST;

CELL DIVISION; CENTROMERE; CHROMOSOME SEGREGATION; CHROMOSOMES; CLONING, MOLECULAR; GENES, DOMINANT; GLUTATHIONE TRANSFERASE; MICROSCOPY, FLUORESCENCE; MODELS, GENETIC; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHOSPHORYLATION; POTASSIUM CHANNELS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SUMO-1 PROTEIN; TIME FACTORS; TWO-HYBRID SYSTEM TECHNIQUES;

FUNGI; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE;

EID: 0036223874     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.01-07-0330     Document Type: Article

References (71)

1. Chromosomal passengers and the (aurora) ABCs of mitosis
2. Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation
3. INCENP binds the aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow
4. The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast
5. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
6. The aurora/Ipl1p kinase family: Regulators of chromosome segregation and cytokinesis
7. D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p
8. Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast
9. Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions
10. Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice
11. Chromosomal proteins and cytokinesis: Patterns of cleavage furrow formation and inner centromere protein positioning in mitotic heterokaryons and mid-anaphase cells
12. Cdc20 associates with the kinase aurora2/Aik
13. General purpose tagging vectors for fission yeast
14. Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis
15. Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways
16. Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis
17. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases
18. The Xenopus laevis aurora/Ipl1p-related kinase pEg2 participates in the stability of the bipolar mitotic spindle
19. The non-catalytic domain of the Xenopus laevis aurora A kinase localizes the protein to the centrosome
20. The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein YlEg5
21. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
22. The centrosome-associated aurora/Ip1-like kinase family
23. The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification
24. The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner
25. Degradation of human aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway
26. Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and G1c7/PP1 phosphatase in budding yeast and nematodes
27. Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis
28. Human AIM-1: cDNA cloning and reduced expression during endomitosis in megakaryocyte-lineage cells
29. Downregulation of an AIM-1 kinase couples with megakaryocytic polyploidization of human hematopoietic cells
30. Sli15 associates with the Ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae
31. Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to aurora of Drosophila and yeast Ipl1
32. The APC11 RING-H2 finger mediates E2-dependent ubiquitination
33. Cell division regulation by BIR1, a member of the inhibitor of apoptosis family in yeast
34. A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis
35. Do centrosome abnormalities lead to cancer?
36. Thiamine-repressible expression vectors pREP and pRIP for fission yeast
37. Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers
38. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe
39. Bir1/Cut17 moving from chromosome to spindle upon the loss of cohesion is required for condensation, spindle elongation and repair
40. Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin
41. Myosin II regulatory light chain as a novel substrate for AIM-1, an aurora/Ipl1-related kinase from rat
42. Mitotic kinases as regulators of cell division and its checkpoints
43. The KEN box: An APC recognition signal distinct from the D box targeted by Cdh1
44. Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex
45. S. pombe Pbh1p: An inhibitor of apoptosis domain containing protein is essential for chromosome segregation
46. BIRinging chromosomes through cell division-and survivin' the experience
47. The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly
48. Tumor-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation
49. Identification of seven new cut genes involved in Schizosaccharomyces pombe mitosis
50. Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p
51. A highly conserved centrosomal kinas, AIR-1, is required for accurate cell cycle progression and segregation of developmental factors in Caenorhabditis elegans embryos
52. AIR-2: An aurora/Ipl1-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos
53. Yeast Hctl recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC
54. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines
55. The aurora-related kinase AIR-2 recruits ZEN-4/ CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis
56. Two kinds of BIR-containing protein: Inhibitors of apoptosis, or required for mitosis
57. Human survivin is a kinetochore-associated passenger protein
58. The survivin-like C. elegans BIR-1 protein acts with the aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone
59. Centrosomal kinases, HsAIRK1 and HsAIRK3, are overexpressed in primary colorectal cancers
60. Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast
61. AIM-1: A mammalian midbody-associated protein required for cytokinesis
62. Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division
63. Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype
64. Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement
65. The mitotic serine/threonine kinase aurora2/AIK is regulated by phosphorylation and degradation
66. Phosphorylation of histone H3 is required for proper chromosome condensation and segregation
67. INCENP is required for proper targeting of survivin to the centromeres and the anaphase spindle during mitosis
68. Stu-7/air-2 is a C. elegans aurora homologue essential for chromosome segregation during embryonic and post-embryonic development
69. Fission yeast cut mutations revisited: Control of anaphase
70. Participation of Bir1p, a member of the inhibitor of apoptosis family, in yeast chromosome segregation events
71. Tumor amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation