Microbial and T cell-derived stimuli regulate antigen presentation by dendritic cells in vivo

Journal of Immunology

Volumn 165, Issue 9, 2000, Pages 5027-5034

  Manickasingham, S ^a   Reis e Sousa, C ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CD8 ANTIGEN; LYSOZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; DENDRITIC CELL; FEEDBACK SYSTEM; FEMALE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 0034326647     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.9.5027     Document Type: Article

References (48)

1. The anatomy of T-cell activation and tolerance
2. CD28/B7 system of T cell costimulation
3. MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation
4. Assembly, transport, and function of MHC class II molecules
5. Approaching the asymptote? Evolution and revolution in immunology
6. Antigen-unspecific B cells and lymphoid dendritic cells both show extensive surface expression of processed antigen:MHC class II complexes after soluble protein exposure in vivo or in vitro
7. Analysis of adjuvant function by direct visualization of antigen presentation in vivo: Endotoxin promotes accumulation of antigen-bearing dendritic cells in the T cell areas of lymphoid tissue
8. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
9. Developmental regulation of MHC class II transport in mouse dendritic cells
10. Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells
11. The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli
12. Production, specificity, and functionality of monoclonal antibodies to specific peptide:MHC class II complexes formed by processing of exogenous protein
13. Properties of mouse CD40: Cellular distribution of CD40 and B cell activation by monoclonal anti-mouse CD40 antibodies
14. + T cells
15. Enrichment of dendritic cells by plastic adherence and EA rosetting
16. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors
17. Immunobiology of dendritic cells
18. Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells: An antigen-dependent microenvironment for T cell differentiation
19. Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins
20. Antigen acquisition by dendritic cells: Intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo
21. + T cells to protein antigens in vivo
22. Dendritic cells but not B cells present antigenic complexes to class II-restricted T cells after administration of protein in adjuvant
23. The mode of protein antigen administration determines preferential presentation of peptide-class II complexes by lymph node dendritic or B cells
24. Extracellular antigen processing and presentation by immature dendritic cells
25. The role of dendritic cells in the induction and regulation of immunity to microbial infection
26. The immune system evolved to discriminate infectious nonself from noninfectious self
27. The instructive role of innate immunity in the acquired immune response
28. Microbial induction of co-stimulatory activity for CD4 T-cell growth
29. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo
30. MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding
31. Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules
32. In vivo antagonism of a T cell response by an endogenously expressed ligand
33. Partially phosphorylated T cell receptor ζ molecules can inhibit T cell activation
34. Peptide loading of major histocompatibility complex molecules on RMA-S cells allows the induction of primary cytotoxic T lymphocyte responses
35. Mechanisms of induction of primary virus-specific cytotoxic T lymphocyte responses
36. Induction of primary, human antigen-specific cytotoxic T lymphocytes in vitro using dendritic cells pulsed with peptides
37. Cells treated with TAP-2 antisense oligonucleotides are potent antigen- presenting cells in vitro and in vivo
38. The dendritic cell system and its role in immunogenicity
39. Tolerance, danger, and the extended family
40. Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells
41. Natural adjuvants: Endogenous activators of dendritic cells
42. Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
43. Cross-tolerance: A pathway for inducing tolerance to peripheral tissue antigens
44. TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells
45. TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation
46. Presentation of exogenous protein antigens by dendritic cells to T cell clones: Intact protein is presented best by immature, epidermal Langerhans cells
47. Migration patterns of dendritic leukocytes: Implications for transplantation
48. CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal