Synthesis of a [2-Pyridinyl-18F]-labelled fluoro derivative of (-)-cytisine as a candidate radioligand for brain nicotinic α4β2 receptor imaging with PET

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 24, 2003, Pages 5333-5343

  Roger, Gaëlle ^a   Lagnel, Béatrice ^a   Rouden, Jacques ^b   Besret, Laurent ^a   Valette, Héric ^a   Demphel, Stéphane ^a   Gopisetti, Jaganmohan ^b   Coulon, Christine ^a   Ottaviani, Michele ^a   Wrenn, Lori A ^c   Letchworth, Sharon R ^c   Bohme, Georg A ^d   Benavides, Jesus ^d   Lasne, Marie Claire ^b   Bottlaender, Michel ^a   Dollé, Frédéric ^a  

^a DIF   (France)

^b UNIVERSITÉ DE CAEN   (France)

^c TARGACEPT INC   (United States)

^d SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

9 (2 FLUOROPYRIDINYL)CYTISINE F18; BRAIN RECEPTOR; FLUORINE 18; NICOTINE; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA4 BETA2; NICOTINIC RECEPTOR; NITRO DERIVATIVE; RADIOLIGAND; RECEPTOR SUBTYPE; TRACER; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL LABELING; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; CYCLOTRON; DENDRITE; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG SYNTHESIS; DRUG UPTAKE; FEMALE; FLUORINATION; MICROANALYSIS; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RADIOCHEMISTRY; RAT;

EID: 0345283018     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.09.042     Document Type: Article

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