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Volumn 36, Issue 4, 2001, Pages 375-388
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Syntheses and evaluation of halogenated cytisine derivatives and of bioisosteric thiocytisine as potent and selective nAChR ligands
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Author keywords
Bioisosterism; Halocytisines; nAChR subtype selectivity; Thiocytisines
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Indexed keywords
2 PYRIDONE DERIVATIVE;
3 BROMOCYTISINE (9 BROMO 1,2,3,4,5,6 HEXAHYDRO 1,5 METHANOPYRIDO[1.2 A][1.5]DIAZOCIN 8 ONE);
3,5 DIBROMOCYTISINE (9,11 DIBROMO 1,2,3,4,5,6 HEXAHYDRO 1,5 METHANOPYRIDO[1.2 A][1.5]DIAZOCIN 8 ONE);
3,5 DICHLOROCYTISINE (9,11 DICHLORO 1,2,3,4,5,6 HEXAHYDRO 1,5 METHANOPYRIDO[1,2 A][1,5]DIAZOCIN 8 ONE);
5 BROMOCYTISINE (11 BROMO 1,2,3,4,5,6 HEXAHYDRO 1,5 METHANOPYRIDO[1.2 A][1.5]DIAZOCIN 8 ONE);
CYTISINE;
EPIBATIDINE;
HALIDE;
LACTAM DERIVATIVE;
METHYLLYCACONITINE;
NICOTINIC AGENT;
NICOTINIC RECEPTOR;
OXYGEN;
RECEPTOR SUBTYPE;
SULFUR;
THIOCYTISINE (1,2,3,4,5,6 HEXAHYDRO 1,5 METHANOPYRIDO[1.2 A][1.5]DIAZOCIN 8 THIONE);
THIOCYTISINE DERIVATIVE;
THIOLACTAM;
TRITIUM;
UNCLASSIFIED DRUG;
ANIMAL TISSUE;
ARTICLE;
BINDING COMPETITION;
BRAIN MEMBRANE;
CONTROLLED STUDY;
DRUG POTENCY;
DRUG RECEPTOR BINDING;
DRUG SCREENING;
DRUG SELECTIVITY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
FOREBRAIN;
MOLECULE;
NONHUMAN;
PHARMACOPHORE;
RAT;
REACTION ANALYSIS;
RECEPTOR AFFINITY;
STRUCTURE ACTIVITY RELATION;
ACONITINE;
ALKALOIDS;
ANIMALS;
AZOCINES;
BICYCLO COMPOUNDS, HETEROCYCLIC;
BINDING, COMPETITIVE;
BRAIN;
BRIDGED COMPOUNDS;
CELL MEMBRANE;
DRUG EVALUATION, PRECLINICAL;
HALOGENS;
LIGANDS;
NICOTINIC AGONISTS;
PYRIDINES;
QUINOLIZINES;
RATS;
RATS, SPRAGUE-DAWLEY;
RECEPTORS, NICOTINIC;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 0034918683
PISSN: 02235234
EISSN: None
Source Type: Journal
DOI: 10.1016/S0223-5234(01)01222-3 Document Type: Article |
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Times cited : (87)
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References (65)
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