Radiosynthesis and preliminary evaluation of 5-[(123/125)I]iodo-3- (2(S)-azetidinylmethoxy)pyridine: A radioligand for nicotinic acetylcholine receptors

Nuclear Medicine and Biology

Volumn 26, Issue 2, 1999, Pages 175-182

  Horti, Andrew G ^a   Koren, Andrei O ^a   Lee, Kan Sam ^b   Mukhin, Alexey G ^a   Vaupel, D Bruce ^a   Kimes, Alane S ^a   Stratton, Morgan ^a   London, Edythe D ^a  

^a Brain Imaging Section   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

123I; 125I; A 85380; Acetylcholine; Nicotinic receptors; Radioiodination; Radiotracer; Receptor binding; SPECT

Indexed keywords

5 IODO 3 (2 AZETIDINYLMETHOXY)PYRIDINE I 123; IODINE 123; NICOTINIC RECEPTOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN MEMBRANE; BRAIN METABOLISM; CONTROLLED STUDY; LIGAND BINDING; NEUROTRANSMISSION; NONHUMAN; RADIOIODINATION; RAT; RECEPTOR BINDING; RECEPTOR UPREGULATION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; AUTORADIOGRAPHY; AZETIDINES; BRAIN; EVALUATION STUDIES; IODINE RADIOISOTOPES; MALE; MICE; MOLECULAR STRUCTURE; RADIOCHEMISTRY; RADIOLIGAND ASSAY; RATS; RATS, INBRED F344; RECEPTORS, NICOTINIC; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0033019825     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(98)00086-9     Document Type: Article

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